2. Complementary and Alternative Therapies (CAM) Deborah Rothman, Ph.D. , M.D. Shriners Hospital for Children Springfield, MA JA 2011 National Conference Arlington, VA

25. GLA suppresses acute and chronic inflammation in animal models of arthritis. It has also been shown in placebo-controlled double-blind trials to reduce synovitis in adults with rheumatoid arthritis These promising results were the basis for this clinical trial to study borage oil for the treatment of JIA.

30. Results

31. Outcome Variable Borage Oil Placebo P value Physician ’ s global assessment (0-4) 0.38 (1.02) 0.92 ( 1.20) 0.002 Parent ’ s global assessment (0-100) 10.82 (13.78) 17.46 (22.40) 0.069 Functional ability scale (0-3) 0.34 (.40 ) 0.42 (.47) 0.113 Number of joints with active arthritis 4.39 ( 9.75) 5.68 ( 9.85) 0.045 Number of joints with limited range of motion 2.75 (5.37) 3.54 (4.80) 0.117 Number of swollen joints 4.25 ( 9.72) 5.46 (9.91) 0.371 Number of tender joints 0.57 (2.10) 0.25 (.84) 0.825

32. Changing Gears