Role of antioxidants in female infertility Dr. Jyoti AgarwalLifecare Centre
Role of antioxidants in female infertility Dr. Jyoti Agarwal
3 Concepts
Oxygen toxicity is an inherent challenge to aerobic life
Oxygen is essential for life.
Excess oxygen can have harmful effects.
When oxygen is metabolised in the body , it produces substances called FREE RADICALS which damage our cells.
Role of antioxidants in female infertility Dr. Jyoti AgarwalLifecare Centre
Role of antioxidants in female infertility Dr. Jyoti Agarwal
3 Concepts
Oxygen toxicity is an inherent challenge to aerobic life
Oxygen is essential for life.
Excess oxygen can have harmful effects.
When oxygen is metabolised in the body , it produces substances called FREE RADICALS which damage our cells.
Did you know that we are built to live to 120? Did you know we are built to be sexually active til the day we die? Learn the natural ways to fight erectile disfunction, bladder insufficiency and other embarassing conditions so many mature people have today.
Role of adjuvants in poor ovarian responders , undergoing infertility treatment , in terms of Intra uterine inseminations ( IUI ) to In Vitro Fertilization ( IVF )
Workshop on Management of poor prognosis patientsMatheus Roque
In this presentation, it was discussed new concepts in stratification of low prognosis patients. It was also discussed the differences between LH and hCG, and how they can have an influence during COS.
A slight description on contraception, its types along with a brief explanation on Oral Contraceptives. Types of oral contraceptives, it's types, mechanism of action, contraindications, dosing, advantages, disadvantages, risk, benefit amd recent research trends.
Did you know that we are built to live to 120? Did you know we are built to be sexually active til the day we die? Learn the natural ways to fight erectile disfunction, bladder insufficiency and other embarassing conditions so many mature people have today.
Role of adjuvants in poor ovarian responders , undergoing infertility treatment , in terms of Intra uterine inseminations ( IUI ) to In Vitro Fertilization ( IVF )
Workshop on Management of poor prognosis patientsMatheus Roque
In this presentation, it was discussed new concepts in stratification of low prognosis patients. It was also discussed the differences between LH and hCG, and how they can have an influence during COS.
A slight description on contraception, its types along with a brief explanation on Oral Contraceptives. Types of oral contraceptives, it's types, mechanism of action, contraindications, dosing, advantages, disadvantages, risk, benefit amd recent research trends.
Update on LETROZOLE Current Guidelines for Ovulation Induction Dr. Sharda Jain Lifecare Centre
Update on LETROZOLE Current Guidelines for Ovulation Induction
LET NOT FORGET
WHY
??
LETROZOLE was withdrawn from
Indian market (2012)
“SAFETY ISSUES”
“Could Be Teratogenic In Human”?
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is an open access international journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Polycystic Ovary Syndrome (PCOS) is the hormonal imbalance in females, producing cyst in the ovaries and making it the leading cause of infertility in females. PCOS contributes towards 75% of female infertility.
Menopause role of isoflavones by dr alka mukherjee nagpur m.s.indiaalka mukherjee
Soy-based isoflavones are modestly effective in relieving menopausal symptoms; supplements providing higher proportions of genistein or increased in S(-)-equol may provide more benefits. Soy food consumption is associated with lower risk of breast and endometrial cancer in observational studies. The efficacy of isoflavones on bone has not been proven, and the clinical picture of whether soy has cardiovascular benefits is still evolving. Preliminary findings on cognitive benefit from isoflavone therapy support a "critical window" hypothesis wherein younger postmenopausal women derive more than older women
Several areas for further research have been identified on soy and midlife women. More clinical studies are needed that compare outcomes among women whose intestinal bacteria have the ability to convert daidzein to equol (equol producers) with those that lack that ability (equol nonproducers) in order to determine if equol producers derive greater benefits from soy supplementation. Larger studies are needed in younger postmenopausal women, and more research is needed to understand the modes of use of soy isoflavone supplements in women. The interrelations of other dietary components on soy isoflavones consumed as a part of diet or by supplement on equol production also require further study, as do potential interactions with prescription and over-the-counter medications. And finally, greater standardization and documentation of clinical trial data of soy are needed.
Soy products can take several weeks or more to reach their maximal benefit. For example, a 2015 review found that soy isoflavones take more than 13 weeks to reach just half of their maximum effect. Traditional hormone therapy, on the other hand, takes about three weeks to show the same benefit.
It’s packed with nutrition
Soy is low in saturated fat and calories. It’s also high in these beneficial nutrients:
• fiber
• protein
• omega-3 fatty acids
• antioxidants
It may help to reduce your risk of heart disease
Eating tofu and other soy-based foods a few times a week can help you cut back on some animal-based protein sources, such as steak or hamburger, that are high in saturated fat and cholesterol.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
NVBDCP.pptx Nation vector borne disease control program
5 srm 1108_eroc
1. This supplement to Sexuality, Reproduction and Menopause
is supported by a grant from Duramed Pharmaceuticals, Inc.
Alteration of the hormone-free interval
during oral contraception
Dr Sulak: The estrogen and progestin doses in oral con-
traceptives (OCs) have steadily decreased since the 1960s;
however, until recently, we’ve kept the same 21/7-day regimen. Due to the high doses in the first-generation OCs, the
hormones lingered into the week off. With the low-dose
pills and a 7-day hormone-free interval (HFI), we have
seen problems such as ovulation, estrogen withdrawal
symptoms, and unscheduled bleeding (ie, breakthrough
bleeding or spotting).
Dr LIU: The physiology of ovarian follicle development
explains why many of these problems occur. In the normal menstrual cycle, follicle-stimulating hormone (FSH)
levels increase dramatically during the first 2 days of
menses, driving the development of as many as 10 early
(primordial) follicles. As estrogen and inhibin B levels
increase and suppress FSH, only the follicle with the
greatest ability to generate FSH receptors within itself
survives this low-FSH environment to become the “egg of
the month.”
During the HFI of an OC regimen, FSH begins to
rebound just as it does in a normal menstrual cycle. With
very-low-dose estrogen/progestin OCs, this rebound
occurs rapidly and follicles begin to develop. If the follicle
develops to a critical stage—which might be as small as 14
mm—escape ovulation may occur, despite the resumption of active OC pills and dampening of FSH.1 In fact, up
to 30% of women may ovulate on OCs when the HFI is
increased.1
Dr Sulak: It is amazing how rapidly the pituitary wakes
up and starts producing FSH—and how responsive the
ovary is! Studies have shown that the dramatic rise in FSH
occurs around the fourth day of a 7-day HFI, followed
rapidly by the rise in 17-beta estradiol from the ovarian
Patricia J. Sulak, MD
James H. Liu, MD
Professor, Texas A&M College of Medicine
Arthur H. Bill Professor and Chair
Medical Director, Division of
Departments of Reproductive Biology
Departmental Research
and Obstetrics and Gynecology
Director, Adolescent Sex Education Program
Case Medical Center
Department of Obstetrics and Gynecology
MacDonald Women’s Hospital
Scott and White Hospital
Cleveland, Ohio
Temple, Texas
Dr Sulak reports that she has received grant/research support from Duramed, Organon,
and Warner Chilcott; has served as a consultant to Duramed and Warner Chilcott; and is
a member of the speakers’ bureau of Bayer, Duramed, Warner Chilcott, and Wyeth.
Dr Liu reports that he has received grant/research support from Barr-Duramed, Procter
& Gamble, and Solvay; and has served as a consultant to Barr, Novagyn, and Solvay.
Nov 2008 | Supplement to SRM
follicles.2,3 We reported a 500% increase in estradiol, from
10 pg to almost 60 pg—and that was using a 30 mcg pill.2
I am amazed that more people taking OCs do not
conceive. The reason failure rates are not higher is due in
large part to the “backup mechanisms” of the pill, such as
cervical mucous thickening and thinning of the endometrial lining.
Development of extended-regimen OCs
Dr LIU: Starting in 1998 with the approval of Mircette,
we’ve begun to see a number of modifications to the 21/7
regimen.
Dr Sulak: Mircette is a regimen
of 21 days of 20 mcg ethinyl estradiol (EE) and 0.15 mg desogestrel, 2 placebo days, and 5 days of
10 mcg EE pills. Comparing Mircette with a 21/7 regimen of the
srm-ejournal.com
same hormones, researchers found
that women experienced greater ovarian suppression
and less follicular development when a 10 mcg EE pill
replaced the last 5 placebo pills.4
Interestingly, even though Mircette is a 20 mcg EE
pill, its bleeding profile is comparable to many OCs with
30 mcg EE.5,6 Adding that low dose of estrogen suppresses
the ovary and prevents “rebound” FSH and estrogen production; it is the production of endogenous estrogen that
interferes with the next cycle and causes breakthrough
bleeding.6,7
All of the OCs that have been approved since 2003
feature modifications of the 21/7 regimen. Seasonale
extended the OC regimen to 84 days of active pills followed by 7 days off. Loestrin 24 and Yaz shortened the
HFI of a 28-day regimen and demonstrated that 20 mcg
EE pills can have a good bleeding profile if the HFI is
decreased.
Seasonique (84 days of levonorgestrel, 0.15 mg, and
EE, 30 mcg; followed by 7 days of EE, 10 mcg) was developed when it became apparent that after prolonged suppression, FSH rises very quickly and the ovary is even
more responsive; a 7-day HFI could lead to escape ovulation and other problems.2,3,8 The most recently approved
OC regimen is Lybrel, a continuous ultra-low-dose regimen of EE and levonorgestrel.
Listen to
the discussion
online
Dr LIU: So the modifications to the HFI have been made
based on our understanding of how follicular development
2. can be suppressed and why escape ovulation occurs.
Altering the HFI can address some of these problems.
The use of a very-low-dose estrogen in place of the placebo suppresses the pituitary and attenuates the rise of
FSH and inhibin B, so that a new crop of follicles does not
begin to develop.9
Importance of correct, consistent use
With a low-dose regimen and a 7-day HFI, we were
actually creating estrogen-withdrawal headaches, cramps,
bloating, and other symptoms.13 In our prospective randomized trial of Seasonale vs Seasonique, we observed a
tendency toward fewer headaches during the estrogensupplemented week.7 And we weren’t even looking at
headaches in that study! Adding estrogen during that typical week off may have the potential to decrease some of
these withdrawal symptoms, but this needs further study.
Dr LIU: For patients using an OC with an HFI, during
which days of the regimen is missing a pill most likely to
cause contraceptive failure?
Bleeding and spotting: Managing expectations
Dr Sulak: The first pill is the most important one in the
pack! Particularly with low-dose OCs, it’s especially a
problem if a patient misses a pill during the first week
after a 7-day HFI.
Dr LIU: I tell patients that it takes several tablets to suppress FSH; no single tablet will maintain a persistent
effect. Missing a pill during the first 5 days is probably
more risky than missing 1 or more in the second or third
week.
Dr Sulak: The rise in FSH and 17-beta estradiol during
the 7-day HFI continues into the first week of active pills
and takes 5 to 7 days to decrease significantly.2
Reducing hormone withdrawal symptoms
Dr LIU: Clinicians started extending OC regimens for
patients with endometriosis or suspected endometriosis,
whose pelvic pain flared up with the onset of bleeding.
Dr Sulak: Then we realized that the benefits of extended
regimens went beyond endometriosis and could help
patients with menstrual migraine headaches or severe
premenstrual syndrome. With extended regimens, we
have shown reductions in mood swings, pain, headaches,
bloating, and swelling.6,10-12
Dr LIU: When a patient begins an extended-regimen OC,
how do you manage her expectations about spotting and
bleeding?
Dr Sulak: Any patient on an extended-regimen OC has
to be a great pill-taker, so I suggest that she put her pills
somewhere she’ll see them at about the same time everyday. I tell patients that particularly during that first cycle,
there is a high incidence of unscheduled bleeding. When
I prescribe an OC regimen that substitutes a low-dose
estrogen pill for the traditional placebo week, I explain that
the patient will have a progestin withdrawal bleed during
the estrogen-only pills. I also mention that in subsequent
packs, the unscheduled bleeding is greatly reduced.14,15
Conclusions
Dr LIU: The modifications to the HFI that we’ve seen in
recently approved OCs represent an incremental advance
in our understanding of the physiology of ovarian follicle
development. Experience and studies have shown how
altering the HFI can optimize patient outcomes.
Dr Sulak: We do need to see the demise of the 7-day HFI.
Practitioners should realize that these changes in OCs are
not arbitrary. They are substantiated by real science and
will mean a true improvement in the symptoms and quality of life our patients experience. n
References
1. Baerwald AR, Olatunbosun OA, Pierson RA. Effects of
6. Rosenberg MJ, Meyers A, Roy V. Efficacy, cycle con-
oral contraceptives administered at defined stages of ovarian follicular development. Fertil Steril. 2006;86:27-35.
2. Willis SA, Kuehl TJ, Spiekerman AM, Sulak PJ.
Greater inhibition of the pituitary—ovarian axis in oral
contraceptive regimens with a shortened hormone-free
interval. Contraception. 2006;74:100-103.
3. Sullivan H, Furniss H, Spona J, Elstein M. Effect of 21day and 24-day oral contraceptive regimens containing
gestodene (60 microg) and ethinyl estradiol (15 microg)
on ovarian activity. Fertil Steril. 1999;72:115-120.
4. Killick SR, Fitzgerald C, Davis A. Ovarian activity in
women taking an oral contraceptive containing 20 microg ethinyl estradiol and 150 microg desogestrel: effects
of low estrogen doses during the hormone-free interval.
Am J Obstet Gynecol. 1998;179:S18-S24.
5. The Mircette Study Group. An open-label, multicenter, noncomparative safety and efficacy study of Mircette, a low-dose estrogen-progestin oral contraceptive.
Am J Obstet Gynecol. 1998;179:S2-S8.
trol, and side effects of low- and lower-dose oral contraceptives: a randomized trial of 20 microgram and
35 microgram estrogen preparations. Contraception.
1999;60:321-329.
7. Vandever MA, Kuehl TJ, Sulak PJ, et al. Evaluation of
pituitary-ovarian axis suppression with three oral contraceptive regimens. Contraception. 2008;77:162-170.
8. van Heusden AM, Fauser BC. Residual ovarian activity during oral steroid contraception. Hum Reprod Update. 2002;8:345-358.
9. Reape KZ, DiLiberti CE, Hendy CH, Volpe EJ. Effects
on serum hormone levels of low-dose estrogen in place
of placebo during the hormone-free interval of an oral
contraceptive. Contraception. 2008;77:34-39.
10. Coffee AL, Kuehl TJ, Willis S, Sulak PJ. Oral contraceptives and premenstrual symptoms: comparison
of a 21/7 and extended regimen. Am J Obstet Gynecol.
2006;195:1311-1319.
11. Coffee AL, Sulak PJ, Kuehl TJ. Long-term assessment
of symptomatology and satisfaction of an extended oral
contraceptive regimen. Contraception. 2007;75:444-449.
12. Sulak P, Willis S, Kuehl T, Coffee A, Clark J. Headaches and oral contraceptives: impact of eliminating the
standard 7-day placebo interval. Headache. 2007;47:2737.
13. Sulak PJ, Scow RD, Preece C, Riggs MW, Kuehl TJ.
Hormone withdrawal symptoms in oral contraceptive
users. Obstet Gynecol. 2000;95:261-266.
14. Anderson FD, Gibbons W, Portman D. Safety and
efficacy of an extended-regimen oral contraceptive utilizing continuous low-dose ethinyl estradiol. Contraception. 2006;73:229-234.
15. Kaunitz AM, Reape KZ, Portman D, Hait H. The
impact of altering the hormone free interval on bleeding patterns in users of a 91-day extended regimen oral
contraceptive. Presented at: Annual Meeting of the Association of Reproductive Health Professionals; September 26-29, 2007; Minneapolis, MN. Contraception.
2007;76:157.
S u p p l e m e n t t o S R M | N OV 2 0 0 8