This presentation provides an overview of HAPPYneuron PRO cognitive therapy platform for professionals and their patients. The presentation was given at a conference dedicated to cognitive fitness - The Shaprbrains Summit - in Jan 2010.

1. A Professional Destination for Cognitive Training, Remediation and Rehabilitation Laura Fay, CEO, HAPPYneuron, Inc. Laura.fay@happy-neuron.com +650-209-8304 HAPPYneuron PRO

2. 2 Scientific Brain Training Group Founding Product Team Bernard Croisile, M.D. Neurology, Ph.D. Neuropsychology M.D. Neurology, Ph.D. Neuropsychology Neuropsychology Department Head, Lyon Hospital Over 70 published books & papers on memory and dementia topics Franck Tarpin-Bernard, Ph.D. Computer Science : Human-Computer Interaction specialty Over 12 published papers on scientific interactive casual game topics Michel Noir, Ph.D. Cognitive & Educational Sciences Over 10 published books on cognitive game topics 10 Year History 1998 Collaborative Research at University of Lyon, France 2000 Scientific Brain Training founded in Lyon, France 2002 First products introduced Global Footprint Cognitive Interaction: Assessment – Training - Rehabilitation Markets: Consumer - Clinical – Corporate Languages: French - German – English – Japan – Korea – Dutch – Spanish HAPPYneuron, Inc. is part of the Scientific Brain Training Group of companies

3. 3 Cognitive Interventions

4. Personalized Cognitive Cross Training for Healthy Adults Play what you like OR take the Coach’s advise www.happy-neuron.com Coach provides tips for performance improvement and application to every day life. Performance analysis is done based on age, gender & education level. Virtual Coach consultation Scientific Performance Analysis Coach recommends certain exercises for a thorough cross-training cognitive workout, according to the your performance and preference. Normalized comparisons are performed with others in your demographic group. 4 Track your activity & performance over time

5. HAPPYneuron PRO Professional Cognitive Therapy Solutions

6. Professions administering cognitive therapies Cognitive Training/Rem/Rehab Programs Neurologists Psychiatrists Geriatricians Speech Therapists Education Therapists Language Therapists Occupational Therapists Cognitive Psychologists Nurse Managers ……and growing

7. Key Platform Features Clinician Managed Manage Patient Accounts/Access Assign Programs / Modules/Exercises Patients Communication Continuous monitoring Adaptive therapies - Treatment can be continually, progressively improved Personalized AND scalable Guided Programs Evidence based Reliable & effective Large engaging game variety Validated by research & years of successful use Additional Data Exports for Researchers

8. Programs Program Examples We welcome partnerships with researchers and clinicians in the creation and validation of clinical cognitive therapy programs .

9. Developing a Condition Specific Program Select Cognitive Functions to be stimulated Define Game Parameter Sets Define Results-Based Progression Rules Clinician / Specialist / Researcher Research Validation Evidence based Intervention Condition Specific Cognitive Program Condition Specific Cognitive Program Condition Specific Cognitive Program

10. Cognitive Remediation In Schizophrenia The need for effective cognitive remediation is great Schizophrenia is a chronic and profoundly disabling psychiatric disorder. 70–80% of patients with schizophrenia are unemployed at any one time deficits in neurocognition are linked to social disability as many as 70% of patients with schizophrenia exhibit neurocognitive deficits on measures of attention, learning and memory, problem-solving, language and/or sensory-motor skill

11. Schizophrenia Program Development Training Modules (18 games) Verbal Memory Visual Spatial Working Memory Selective Attention Reasoning Start at level 1, Each game @ 100% accuracy advances to next level 10 levels, each consisting of specific parameters Dr. Pascal Vianin, Lausanne Switzerland Dr. Pascal Vianin Lausanne Hospital, Switzerland 28 subjects Comparison with RehaCom Showed significant improvement Publication pending ------------------------------------------------- Schizophrenia Program Dr. Nicolas Franck Institute for Cognitive Science Lyon, France 280 subjects, multi-site, 3-yr Comparison with CRT Positive preliminary results ------------------------------------------------- US based multi-site, drug-combo study starts in Spring 2010

12. Remediation for Schizophrenia Patient View

13. Remediation for Schizophrenia Clinical & (optional) Patient View

14. Rehabilitation Program An open tool with extensive customizability by the clinician Suitable for cognitive stimulation of TBI, Stroke and other patient-unique impairments Task rich: 27 exercises, 9 modules, hundreds of unique combinations Precise customization to patient's specific needs Clinician control difficulty levels, pacing and goal setting

15. Rehabilitation Program For all exercise, multiple levels of data analysis available Activity level Total time spent Progress over time / play Accuracy Reaction / Processing Speed Game Parameters Trend Analysis

18. Monitor

19. Coach

20. Evidence Based

22. Each Program costs $50 per month includes 10 active accounts Additional account packs can be added for $40 per month. 30 day FREE trial Pricing for practitioners

23. Independent Research Independent Research partners Geriatrics, Psychiatry, Neurology, Occupational Rehab, ADHD Boston University, MA Columbia University, NY Hartford Hospital (Institute of the Living), CT Johnny Orr Memory Center, IA Queens University, Toronto, Canada UCLA, CA Veteran’s Administration, PA Lausanne Hospital, Switzerland Lyon Hospital, France Pierre & Marie Curie Hospital, Paris France St. Anne Hospital, Paris, France University at La Pitié-Salpêtrière Hospital, Paris, France 18

24. Endorsements “The advantage of the HAPPYneuron PRO platform is that it allows individuals to receive a more consistent dose of cognitive enhancement, thereby enabling the flexibility to design innovative research studies not previously possible.” Christopher R. Bowie, PhD, Dept Psychiatry & Psychology, Queen’s University, Ontario, Canada. "The HAPPYneuron PRO platform delivers engaging cognitive skills training programs. Our patients are motivated to work on these web-based exercises because of the appeal of the exercises themselves, and because they are able to track their own progress and performance.“ Enid Gertmenian, LMSW, Lieber Recovery and Rehabilitation Clinic, New York City. "The program for schizophrenia offered at www.happy-neuron-pro.com is the best material I have ever seen for cognitive remediation for my patients." Torben Christensen, Ph.D., Clinical psychologist. Aarhus University Hospital, Risskov, Denmark

25. Thank You Laura Fay HAPPYneuron, Inc. Laura.fay@happy-neuron.com +650-209-8304