SlideShare ist ein Scribd-Unternehmen logo

STRING - Modeling of biological systems through cross-species data integration

•Als PPT, PDF herunterladen•
•
Lars Juhl Jensen
Lars Juhl Jensen

The document discusses modeling biological systems through integrating cross-species data. It presents several methods for data integration, including analyzing genomic neighborhood, species co-occurrence, gene fusions, literature co-mentioning, and experimental interaction data. It stresses that quality control is crucial for large-scale data integration to improve data quality through scoring, benchmarking, and filtering. Integrating data across multiple species and automated literature mining can generate novel biological discoveries and highly specific hypotheses about protein networks.

Technologie
1 von 14
STRING Modeling of biological systems through cross-species data integration Lars Juhl Jensen EMBL Heidelberg
Jensen et al., Drug Discovery Today: Targets, 2004
de Lichtenberg et al., Science, 2005
TOM MRPL Ribosome Related MRPS Vacuolar Acidification Fatty Acid Biosynth. Secondary RCC_Asy RCC_Asy RCCII RCCIV RCCV RCC_Asy HAP Complex Arg Biosynth. PDH/KGD/ GCV Cell Wall & pH Reg. DNA Repair Glucose sensing and CH remodelling APC Fission/ Fusion rRNA Processing mRNA Processing TFIIIC Complex m-AAA Complex TCA Cycle Iron Homeostasis/ Chaperone Activity RCCI rRNA Processing Leu/Val/Ile Biosynth. DNA Repair GARP Complex Cytosolic Ribosome TIM RCC_Asy Actin tRNA Splicing RCCIII NUP Replication/ DNA Repair
TOM MRPL Ribosome Related MRPS Vacuolar Acidification Fatty Acid Biosynth. Secondary RCC_Asy RCC_Asy RCCII RCCIV RCCV RCC_Asy HAP Complex Arg Biosynth. PDH/KGD/ GCV Cell Wall & pH Reg. DNA Repair Glucose sensing and CH remodelling APC Fission/ Fusion rRNA Processing mRNA Processing TFIIIC Complex m-AAA Complex TCA Cycle Iron Homeostasis/ Chaperone Activity RCCI rRNA Processing Leu/Val/Ile Biosynth. DNA Repair GARP Complex Cytosolic Ribosome TIM RCC_Asy Actin tRNA Splicing RCCIII NUP Replication/ DNA Repair Protobacterial orthologs
TOM MRPL Ribosome Related MRPS Vacuolar Acidification Fatty Acid Biosynth. Secondary RCC_Asy RCCII RCCIV RCCV RCC_Asy HAP Complex Arg Biosynth. PDH/KGD/ GCV Cell Wall & pH Reg. DNA Repair Glucose sensing and CH remodelling APC Fission/ Fusion rRNA Processing mRNA Processing TFIIIC Complex m-AAA Complex TCA Cycle Iron Homeostasis/ Chaperone Activity RCCI rRNA Processing Leu/Val/Ile Biosynth. DNA Repair GARP Complex Cytosolic Ribosome TIM RCC_Asy Actin tRNA Splicing RCCIII NUP Replication/ DNA Repair Human disease orthologs RCC_Asy
Genomic neighborhood Species co-occurrence Gene fusions Database imports Exp. interaction data Microarray expression data Literature co-mentioning von Mering et al., Nucleic Acids Res., 2005
T Resting protuberances Protracted protuberance Cellulose © Trends Microbiol, 1999 Cell Cell wall Anchoring proteins Cellulosomes Cellulose The “Cellulosome”
 
Jensen et al., to appear in Nat. Rev. Genet., 2005
Networ-Kin™ Phospho-peptide data (from MS) Predict the kinase class (NetPhosK and Scansite)
Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acknowledgments ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thank you!

Empfohlen

Cancer-an overview by Prof Viyatprajna Acharya, KIMS, Bhubaneswar
Cancer-an overview by Prof Viyatprajna Acharya, KIMS, BhubaneswarCancer-an overview by Prof Viyatprajna Acharya, KIMS, Bhubaneswar
Cancer-an overview by Prof Viyatprajna Acharya, KIMS, BhubaneswarProf Viyatprajna Acharya
 
Dna replication, repair, recombination
Dna replication, repair, recombinationDna replication, repair, recombination
Dna replication, repair, recombinationAlbert
 
7.3 transcription
7.3 transcription7.3 transcription
7.3 transcriptioncartlidge
 
Dna Repair Mechanisms
Dna Repair MechanismsDna Repair Mechanisms
Dna Repair MechanismsMaria Camila Ocampo Yepes
 
IB Chromosomes & Meiosis Review (3.1-3.3)
IB Chromosomes & Meiosis Review (3.1-3.3)IB Chromosomes & Meiosis Review (3.1-3.3)
IB Chromosomes & Meiosis Review (3.1-3.3)Jacob Cedarbaum
 
Genes And Gene Technology
Genes And Gene TechnologyGenes And Gene Technology
Genes And Gene Technologymlong24
 
Protein Synthesis Review (2.7-7.2-7.3)
Protein Synthesis Review (2.7-7.2-7.3)Protein Synthesis Review (2.7-7.2-7.3)
Protein Synthesis Review (2.7-7.2-7.3)Jacob Cedarbaum
 
DNA REPAIR MECHANISMS - Plegable Biología Molecular
DNA REPAIR MECHANISMS - Plegable Biología MolecularDNA REPAIR MECHANISMS - Plegable Biología Molecular
DNA REPAIR MECHANISMS - Plegable Biología MolecularLuisa María Mesa Díaz
 

Empfohlen

Cancer-an overview by Prof Viyatprajna Acharya, KIMS, Bhubaneswar
Cancer-an overview by Prof Viyatprajna Acharya, KIMS, BhubaneswarCancer-an overview by Prof Viyatprajna Acharya, KIMS, Bhubaneswar
Cancer-an overview by Prof Viyatprajna Acharya, KIMS, BhubaneswarProf Viyatprajna Acharya
 
Dna replication, repair, recombination
Dna replication, repair, recombinationDna replication, repair, recombination
Dna replication, repair, recombinationAlbert
 
7.3 transcription
7.3 transcription7.3 transcription
7.3 transcriptioncartlidge
 
Dna Repair Mechanisms
Dna Repair MechanismsDna Repair Mechanisms
Dna Repair MechanismsMaria Camila Ocampo Yepes
 
IB Chromosomes & Meiosis Review (3.1-3.3)
IB Chromosomes & Meiosis Review (3.1-3.3)IB Chromosomes & Meiosis Review (3.1-3.3)
IB Chromosomes & Meiosis Review (3.1-3.3)Jacob Cedarbaum
 
Genes And Gene Technology
Genes And Gene TechnologyGenes And Gene Technology
Genes And Gene Technologymlong24
 
Protein Synthesis Review (2.7-7.2-7.3)
Protein Synthesis Review (2.7-7.2-7.3)Protein Synthesis Review (2.7-7.2-7.3)
Protein Synthesis Review (2.7-7.2-7.3)Jacob Cedarbaum
 
DNA REPAIR MECHANISMS - Plegable Biología Molecular
DNA REPAIR MECHANISMS - Plegable Biología MolecularDNA REPAIR MECHANISMS - Plegable Biología Molecular
DNA REPAIR MECHANISMS - Plegable Biología MolecularLuisa María Mesa Díaz
 
3.5 Notes
3.5 Notes3.5 Notes
3.5 NotesJacob Cedarbaum
 
Central dogma of molecular biology with video slide.
Central dogma of molecular biology with video slide.Central dogma of molecular biology with video slide.
Central dogma of molecular biology with video slide.Asheesh Pandey
 
Analysis of gene expression
Analysis of gene expressionAnalysis of gene expression
Analysis of gene expressionTapeshwar Yadav
 
Powerpoint Final Paper RISE 2010
Powerpoint Final Paper RISE 2010Powerpoint Final Paper RISE 2010
Powerpoint Final Paper RISE 2010ipezpagn91
 
Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...
Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...
Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...enamifat
 
Gendoo: Functional profiling of gene and disease features for omics analysis
Gendoo: Functional profiling of gene and disease features for omics analysisGendoo: Functional profiling of gene and disease features for omics analysis
Gendoo: Functional profiling of gene and disease features for omics analysisTakeru Nakazato
 
Light Regulates Plant Alternative Splicing through the Control of Transcripti...
Light Regulates Plant Alternative Splicing through the Control of Transcripti...Light Regulates Plant Alternative Splicing through the Control of Transcripti...
Light Regulates Plant Alternative Splicing through the Control of Transcripti...ShreyaMandal4
 
PhD Abstract
PhD AbstractPhD Abstract
PhD AbstractJessica Scoullar
 
Studying gene expression and function
Studying gene expression and functionStudying gene expression and function
Studying gene expression and functionMd Murad Khan
 
Dna replication recombination
Dna replication recombinationDna replication recombination
Dna replication recombinationjamlessenudi
 
Markus Zweckstetter
Markus ZweckstetterMarkus Zweckstetter
Markus ZweckstetterAlzforum
 
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...Juan Diego Villegas
 
10 mutation
10 mutation10 mutation
10 mutationmirellqfb
 
Kenyatta university. hmb201 dna repairdocx
Kenyatta university. hmb201 dna repairdocxKenyatta university. hmb201 dna repairdocx
Kenyatta university. hmb201 dna repairdocxLando Elvis
 
Dna Repair Pathways
Dna Repair PathwaysDna Repair Pathways
Dna Repair Pathwaysluisa3001
 
Regulation of gene expression and gene therapy in dentistry
Regulation of gene expression and gene therapy in dentistryRegulation of gene expression and gene therapy in dentistry
Regulation of gene expression and gene therapy in dentistryMammootty Ik
 
Analysis of gene expression
Analysis of gene expressionAnalysis of gene expression
Analysis of gene expressionuniversity of education,Lahore
 
Correction IARS syndrome using CRISPR/Cas9 in Japanese Black Cattle
Correction IARS syndrome using CRISPR/Cas9 in Japanese Black CattleCorrection IARS syndrome using CRISPR/Cas9 in Japanese Black Cattle
Correction IARS syndrome using CRISPR/Cas9 in Japanese Black CattleBoon Keat Ngan
 
Genetic technology
Genetic technologyGenetic technology
Genetic technologymiller4075
 
Proposal for Protein-DNA Mapping using AFM for Lab on a Chip
Proposal for Protein-DNA Mapping using AFM for Lab on a ChipProposal for Protein-DNA Mapping using AFM for Lab on a Chip
Proposal for Protein-DNA Mapping using AFM for Lab on a ChipAnthony Salvagno
 
Interaction prediction with STRING - Principles and examples
Interaction prediction with STRING - Principles and examplesInteraction prediction with STRING - Principles and examples
Interaction prediction with STRING - Principles and examplesLars Juhl Jensen
 
DisEMBL - Artificial neural network prediction of protein disorder
DisEMBL - Artificial neural network prediction of protein disorderDisEMBL - Artificial neural network prediction of protein disorder
DisEMBL - Artificial neural network prediction of protein disorderLars Juhl Jensen
 

Weitere ähnliche Inhalte

Was ist angesagt?

Central dogma of molecular biology with video slide.
Central dogma of molecular biology with video slide.Central dogma of molecular biology with video slide.
Central dogma of molecular biology with video slide.Asheesh Pandey
 
Analysis of gene expression
Analysis of gene expressionAnalysis of gene expression
Analysis of gene expressionTapeshwar Yadav
 
Powerpoint Final Paper RISE 2010
Powerpoint Final Paper RISE 2010Powerpoint Final Paper RISE 2010
Powerpoint Final Paper RISE 2010ipezpagn91
 
Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...
Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...
Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...enamifat
 
Gendoo: Functional profiling of gene and disease features for omics analysis
Gendoo: Functional profiling of gene and disease features for omics analysisGendoo: Functional profiling of gene and disease features for omics analysis
Gendoo: Functional profiling of gene and disease features for omics analysisTakeru Nakazato
 
Light Regulates Plant Alternative Splicing through the Control of Transcripti...
Light Regulates Plant Alternative Splicing through the Control of Transcripti...Light Regulates Plant Alternative Splicing through the Control of Transcripti...
Light Regulates Plant Alternative Splicing through the Control of Transcripti...ShreyaMandal4
 
Studying gene expression and function
Studying gene expression and functionStudying gene expression and function
Studying gene expression and functionMd Murad Khan
 
Dna replication recombination
Dna replication recombinationDna replication recombination
Dna replication recombinationjamlessenudi
 
Markus Zweckstetter
Markus ZweckstetterMarkus Zweckstetter
Markus ZweckstetterAlzforum
 
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...Juan Diego Villegas
 
Kenyatta university. hmb201 dna repairdocx
Kenyatta university. hmb201 dna repairdocxKenyatta university. hmb201 dna repairdocx
Kenyatta university. hmb201 dna repairdocxLando Elvis
 
Dna Repair Pathways
Dna Repair PathwaysDna Repair Pathways
Dna Repair Pathwaysluisa3001
 
Regulation of gene expression and gene therapy in dentistry
Regulation of gene expression and gene therapy in dentistryRegulation of gene expression and gene therapy in dentistry
Regulation of gene expression and gene therapy in dentistryMammootty Ik
 
Correction IARS syndrome using CRISPR/Cas9 in Japanese Black Cattle
Correction IARS syndrome using CRISPR/Cas9 in Japanese Black CattleCorrection IARS syndrome using CRISPR/Cas9 in Japanese Black Cattle
Correction IARS syndrome using CRISPR/Cas9 in Japanese Black CattleBoon Keat Ngan
 
Genetic technology
Genetic technologyGenetic technology
Genetic technologymiller4075
 
Proposal for Protein-DNA Mapping using AFM for Lab on a Chip
Proposal for Protein-DNA Mapping using AFM for Lab on a ChipProposal for Protein-DNA Mapping using AFM for Lab on a Chip
Proposal for Protein-DNA Mapping using AFM for Lab on a ChipAnthony Salvagno
 

Was ist angesagt? (20)

3.5 Notes
3.5 Notes3.5 Notes
3.5 Notes
 
Central dogma of molecular biology with video slide.
Central dogma of molecular biology with video slide.Central dogma of molecular biology with video slide.
Central dogma of molecular biology with video slide.
 
Analysis of gene expression
Analysis of gene expressionAnalysis of gene expression
Analysis of gene expression
 
Powerpoint Final Paper RISE 2010
Powerpoint Final Paper RISE 2010Powerpoint Final Paper RISE 2010
Powerpoint Final Paper RISE 2010
 
Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...
Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...
Central Dogma, Gene, Genetic Code, Codon, Genome, Genotype, Phenotype , Trai...
 
Gendoo: Functional profiling of gene and disease features for omics analysis
Gendoo: Functional profiling of gene and disease features for omics analysisGendoo: Functional profiling of gene and disease features for omics analysis
Gendoo: Functional profiling of gene and disease features for omics analysis
 
Light Regulates Plant Alternative Splicing through the Control of Transcripti...
Light Regulates Plant Alternative Splicing through the Control of Transcripti...Light Regulates Plant Alternative Splicing through the Control of Transcripti...
Light Regulates Plant Alternative Splicing through the Control of Transcripti...
 
PhD Abstract
PhD AbstractPhD Abstract
PhD Abstract
 
Studying gene expression and function
Studying gene expression and functionStudying gene expression and function
Studying gene expression and function
 
Dna replication recombination
Dna replication recombinationDna replication recombination
Dna replication recombination
 
Markus Zweckstetter
Markus ZweckstetterMarkus Zweckstetter
Markus Zweckstetter
 
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...
Alteration of BRCA1 expression affects alcohol-induced transcription of RNA P...
 
10 mutation
10 mutation10 mutation
10 mutation
 
Kenyatta university. hmb201 dna repairdocx
Kenyatta university. hmb201 dna repairdocxKenyatta university. hmb201 dna repairdocx
Kenyatta university. hmb201 dna repairdocx
 
Dna Repair Pathways
Dna Repair PathwaysDna Repair Pathways
Dna Repair Pathways
 
Regulation of gene expression and gene therapy in dentistry
Regulation of gene expression and gene therapy in dentistryRegulation of gene expression and gene therapy in dentistry
Regulation of gene expression and gene therapy in dentistry
 
Analysis of gene expression
Analysis of gene expressionAnalysis of gene expression
Analysis of gene expression
 
Correction IARS syndrome using CRISPR/Cas9 in Japanese Black Cattle
Correction IARS syndrome using CRISPR/Cas9 in Japanese Black CattleCorrection IARS syndrome using CRISPR/Cas9 in Japanese Black Cattle
Correction IARS syndrome using CRISPR/Cas9 in Japanese Black Cattle
 
Genetic technology
Genetic technologyGenetic technology
Genetic technology
 
Proposal for Protein-DNA Mapping using AFM for Lab on a Chip
Proposal for Protein-DNA Mapping using AFM for Lab on a ChipProposal for Protein-DNA Mapping using AFM for Lab on a Chip
Proposal for Protein-DNA Mapping using AFM for Lab on a Chip
 

Andere mochten auch

Interaction prediction with STRING - Principles and examples
Interaction prediction with STRING - Principles and examplesInteraction prediction with STRING - Principles and examples
Interaction prediction with STRING - Principles and examplesLars Juhl Jensen
 
DisEMBL - Artificial neural network prediction of protein disorder
DisEMBL - Artificial neural network prediction of protein disorderDisEMBL - Artificial neural network prediction of protein disorder
DisEMBL - Artificial neural network prediction of protein disorderLars Juhl Jensen
 
Dynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleDynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleLars Juhl Jensen
 
From ELMs to function: interaction networks and feature spaces
From ELMs to function: interaction networks and feature spacesFrom ELMs to function: interaction networks and feature spaces
From ELMs to function: interaction networks and feature spacesLars Juhl Jensen
 
Varsovia
VarsoviaVarsovia
VarsoviaJaguit
 
Vertical Math Aliignment Teaming
Vertical Math Aliignment TeamingVertical Math Aliignment Teaming
Vertical Math Aliignment TeamingMr Kimmi
 
Publicdesign Presentacion 2008
Publicdesign Presentacion 2008Publicdesign Presentacion 2008
Publicdesign Presentacion 2008Jimenosky
 
Black Ink Cashflow Secrets Your Accountant Never Shared
Black Ink Cashflow Secrets Your Accountant Never SharedBlack Ink Cashflow Secrets Your Accountant Never Shared
Black Ink Cashflow Secrets Your Accountant Never SharedTom Shay
 
Prediction of protein function from sequence derived protein features
Prediction of protein function from sequence derived protein featuresPrediction of protein function from sequence derived protein features
Prediction of protein function from sequence derived protein featuresLars Juhl Jensen
 

Andere mochten auch (9)

Interaction prediction with STRING - Principles and examples
Interaction prediction with STRING - Principles and examplesInteraction prediction with STRING - Principles and examples
Interaction prediction with STRING - Principles and examples
 
DisEMBL - Artificial neural network prediction of protein disorder
DisEMBL - Artificial neural network prediction of protein disorderDisEMBL - Artificial neural network prediction of protein disorder
DisEMBL - Artificial neural network prediction of protein disorder
 
Dynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycleDynamic complex formation during the yeast cell cycle
Dynamic complex formation during the yeast cell cycle
 
From ELMs to function: interaction networks and feature spaces
From ELMs to function: interaction networks and feature spacesFrom ELMs to function: interaction networks and feature spaces
From ELMs to function: interaction networks and feature spaces
 
Varsovia
VarsoviaVarsovia
Varsovia
 
Vertical Math Aliignment Teaming
Vertical Math Aliignment TeamingVertical Math Aliignment Teaming
Vertical Math Aliignment Teaming
 
Publicdesign Presentacion 2008
Publicdesign Presentacion 2008Publicdesign Presentacion 2008
Publicdesign Presentacion 2008
 
Black Ink Cashflow Secrets Your Accountant Never Shared
Black Ink Cashflow Secrets Your Accountant Never SharedBlack Ink Cashflow Secrets Your Accountant Never Shared
Black Ink Cashflow Secrets Your Accountant Never Shared
 
Prediction of protein function from sequence derived protein features
Prediction of protein function from sequence derived protein featuresPrediction of protein function from sequence derived protein features
Prediction of protein function from sequence derived protein features
 

Ähnlich wie STRING - Modeling of biological systems through cross-species data integration

STRING - Prediction of a functional association network for the yeast mitocho...
STRING - Prediction of a functional association network for the yeast mitocho...STRING - Prediction of a functional association network for the yeast mitocho...
STRING - Prediction of a functional association network for the yeast mitocho...Lars Juhl Jensen
 
Beyond transcription: RNA-binding proteins as emerging regulator of plant res...
Beyond transcription: RNA-binding proteins as emerging regulator of plant res...Beyond transcription: RNA-binding proteins as emerging regulator of plant res...
Beyond transcription: RNA-binding proteins as emerging regulator of plant res...BALASAHEB BIRADAR
 
Mol. Biol. Cell-2015-Ayache-2579-95
Mol. Biol. Cell-2015-Ayache-2579-95Mol. Biol. Cell-2015-Ayache-2579-95
Mol. Biol. Cell-2015-Ayache-2579-95Jessica Ayache
 
Roth and Hennig 2010
Roth and Hennig 2010Roth and Hennig 2010
Roth and Hennig 2010Braden Roth
 
JBEI Research Highlights - April 2017
JBEI Research Highlights - April 2017JBEI Research Highlights - April 2017
JBEI Research Highlights - April 2017Irina Silva
 
Bio390 final paper
Bio390 final paperBio390 final paper
Bio390 final paperlcklemm
 
PPAR alpha final research paper
PPAR alpha final research paperPPAR alpha final research paper
PPAR alpha final research paperEric Cobb
 
iGEM Paper (more pretty)
iGEM Paper (more pretty)iGEM Paper (more pretty)
iGEM Paper (more pretty)David Dinh
 
2016 RBC RETREAT POSTER TEMPLATE_SMP
2016 RBC RETREAT POSTER TEMPLATE_SMP2016 RBC RETREAT POSTER TEMPLATE_SMP
2016 RBC RETREAT POSTER TEMPLATE_SMPSagar M. Patel
 
JBEI Highlights September 2015
JBEI Highlights September 2015JBEI Highlights September 2015
JBEI Highlights September 2015Irina Silva
 
Gutell 089.book bioinfomaticsdictionary.2004
Gutell 089.book bioinfomaticsdictionary.2004Gutell 089.book bioinfomaticsdictionary.2004
Gutell 089.book bioinfomaticsdictionary.2004Robin Gutell
 
2009 CSBB LAB 新生訓練
2009 CSBB LAB 新生訓練2009 CSBB LAB 新生訓練
2009 CSBB LAB 新生訓練Abner Huang
 
132 gene expression in atherosclerotic plaques
132 gene expression in atherosclerotic plaques132 gene expression in atherosclerotic plaques
132 gene expression in atherosclerotic plaquesSHAPE Society
 

Ähnlich wie STRING - Modeling of biological systems through cross-species data integration (20)

STRING - Prediction of a functional association network for the yeast mitocho...
STRING - Prediction of a functional association network for the yeast mitocho...STRING - Prediction of a functional association network for the yeast mitocho...
STRING - Prediction of a functional association network for the yeast mitocho...
 
Beyond transcription: RNA-binding proteins as emerging regulator of plant res...
Beyond transcription: RNA-binding proteins as emerging regulator of plant res...Beyond transcription: RNA-binding proteins as emerging regulator of plant res...
Beyond transcription: RNA-binding proteins as emerging regulator of plant res...
 
Mol. Biol. Cell-2015-Ayache-2579-95
Mol. Biol. Cell-2015-Ayache-2579-95Mol. Biol. Cell-2015-Ayache-2579-95
Mol. Biol. Cell-2015-Ayache-2579-95
 
Roth and Hennig 2010
Roth and Hennig 2010Roth and Hennig 2010
Roth and Hennig 2010
 
CRISPR.pdf
CRISPR.pdfCRISPR.pdf
CRISPR.pdf
 
MGG2003-cDNA-AFLP
MGG2003-cDNA-AFLPMGG2003-cDNA-AFLP
MGG2003-cDNA-AFLP
 
JBEI Research Highlights - April 2017
JBEI Research Highlights - April 2017JBEI Research Highlights - April 2017
JBEI Research Highlights - April 2017
 
Synthetic biology
Synthetic biologySynthetic biology
Synthetic biology
 
Bio390 final paper
Bio390 final paperBio390 final paper
Bio390 final paper
 
PPAR alpha final research paper
PPAR alpha final research paperPPAR alpha final research paper
PPAR alpha final research paper
 
sequencing-methods-review
sequencing-methods-reviewsequencing-methods-review
sequencing-methods-review
 
ABRCMS Poster2012
ABRCMS Poster2012ABRCMS Poster2012
ABRCMS Poster2012
 
iGEM Paper (more pretty)
iGEM Paper (more pretty)iGEM Paper (more pretty)
iGEM Paper (more pretty)
 
2016 RBC RETREAT POSTER TEMPLATE_SMP
2016 RBC RETREAT POSTER TEMPLATE_SMP2016 RBC RETREAT POSTER TEMPLATE_SMP
2016 RBC RETREAT POSTER TEMPLATE_SMP
 
JBEI Highlights September 2015
JBEI Highlights September 2015JBEI Highlights September 2015
JBEI Highlights September 2015
 
Gutell 089.book bioinfomaticsdictionary.2004
Gutell 089.book bioinfomaticsdictionary.2004Gutell 089.book bioinfomaticsdictionary.2004
Gutell 089.book bioinfomaticsdictionary.2004
 
2009 CSBB LAB 新生訓練
2009 CSBB LAB 新生訓練2009 CSBB LAB 新生訓練
2009 CSBB LAB 新生訓練
 
CHEM3204_PRAC_Manual_2016
CHEM3204_PRAC_Manual_2016CHEM3204_PRAC_Manual_2016
CHEM3204_PRAC_Manual_2016
 
132 gene expression in atherosclerotic plaques
132 gene expression in atherosclerotic plaques132 gene expression in atherosclerotic plaques
132 gene expression in atherosclerotic plaques
 
132 gene expression in atherosclerotic plaques
132 gene expression in atherosclerotic plaques132 gene expression in atherosclerotic plaques
132 gene expression in atherosclerotic plaques
 

Mehr von Lars Juhl Jensen

One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...Lars Juhl Jensen
 
One tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineOne tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineLars Juhl Jensen
 
Extract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationExtract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationLars Juhl Jensen
 
Network visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeNetwork visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeLars Juhl Jensen
 
STRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous dataSTRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous dataLars Juhl Jensen
 
Biomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textBiomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textLars Juhl Jensen
 
Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Lars Juhl Jensen
 
Network Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeNetwork Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeLars Juhl Jensen
 
Cellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textCellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textLars Juhl Jensen
 
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Lars Juhl Jensen
 
STRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataSTRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataLars Juhl Jensen
 
Tagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionTagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionLars Juhl Jensen
 
Network Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textNetwork Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textLars Juhl Jensen
 
Medical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsMedical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsLars Juhl Jensen
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textLars Juhl Jensen
 
Medical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsMedical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsLars Juhl Jensen
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textLars Juhl Jensen
 
Biomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationBiomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationLars Juhl Jensen
 

Mehr von Lars Juhl Jensen (20)

One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...One tagger, many uses: Illustrating the power of dictionary-based named entit...
One tagger, many uses: Illustrating the power of dictionary-based named entit...
 
One tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicineOne tagger, many uses: Simple text-mining strategies for biomedicine
One tagger, many uses: Simple text-mining strategies for biomedicine
 
Extract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotationExtract 2.0: Text-mining-assisted interactive annotation
Extract 2.0: Text-mining-assisted interactive annotation
 
Network visualization: A crash course on using Cytoscape
Network visualization: A crash course on using CytoscapeNetwork visualization: A crash course on using Cytoscape
Network visualization: A crash course on using Cytoscape
 
STRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous dataSTRING & STITCH : Network integration of heterogeneous data
STRING & STITCH : Network integration of heterogeneous data
 
Biomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured textBiomedical text mining: Automatic processing of unstructured text
Biomedical text mining: Automatic processing of unstructured text
 
Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...Medical network analysis: Linking diseases and genes through data and text mi...
Medical network analysis: Linking diseases and genes through data and text mi...
 
Network Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and CytoscapeNetwork Biology: A crash course on STRING and Cytoscape
Network Biology: A crash course on STRING and Cytoscape
 
Cellular networks
Cellular networksCellular networks
Cellular networks
 
Cellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and textCellular Network Biology: Large-scale integration of data and text
Cellular Network Biology: Large-scale integration of data and text
 
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
Statistics on big biomedical data: Methods and pitfalls when analyzing high-t...
 
STRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous dataSTRING & related databases: Large-scale integration of heterogeneous data
STRING & related databases: Large-scale integration of heterogeneous data
 
Tagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognitionTagger: Rapid dictionary-based named entity recognition
Tagger: Rapid dictionary-based named entity recognition
 
Network Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and textNetwork Biology: Large-scale integration of data and text
Network Biology: Large-scale integration of data and text
 
Medical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactionsMedical text mining: Linking diseases, drugs, and adverse reactions
Medical text mining: Linking diseases, drugs, and adverse reactions
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and text
 
Medical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactionsMedical data and text mining: Linking diseases, drugs, and adverse reactions
Medical data and text mining: Linking diseases, drugs, and adverse reactions
 
Cellular Network Biology
Cellular Network BiologyCellular Network Biology
Cellular Network Biology
 
Network biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and textNetwork biology: Large-scale integration of data and text
Network biology: Large-scale integration of data and text
 
Biomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritizationBiomarker bioinformatics: Network-based candidate prioritization
Biomarker bioinformatics: Network-based candidate prioritization
 

Kürzlich hochgeladen

unit 4 immunoblotting technique complete.pptx
unit 4 immunoblotting technique complete.pptxunit 4 immunoblotting technique complete.pptx
unit 4 immunoblotting technique complete.pptxBkGupta21
 
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptx
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptxPasskey Providers and Enabling Portability: FIDO Paris Seminar.pptx
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptxLoriGlavin3
 
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek SchlawackFwdays
 
What is DBT - The Ultimate Data Build Tool.pdf
What is DBT - The Ultimate Data Build Tool.pdfWhat is DBT - The Ultimate Data Build Tool.pdf
What is DBT - The Ultimate Data Build Tool.pdfMounikaPolabathina
 
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)Mark Simos
 
SIP trunking in Janus @ Kamailio World 2024
SIP trunking in Janus @ Kamailio World 2024SIP trunking in Janus @ Kamailio World 2024
SIP trunking in Janus @ Kamailio World 2024Lorenzo Miniero
 
The Ultimate Guide to Choosing WordPress Pros and Cons
The Ultimate Guide to Choosing WordPress Pros and ConsThe Ultimate Guide to Choosing WordPress Pros and Cons
The Ultimate Guide to Choosing WordPress Pros and ConsPixlogix Infotech
 
Transcript: New from BookNet Canada for 2024: BNC CataList - Tech Forum 2024
Transcript: New from BookNet Canada for 2024: BNC CataList - Tech Forum 2024Transcript: New from BookNet Canada for 2024: BNC CataList - Tech Forum 2024
Transcript: New from BookNet Canada for 2024: BNC CataList - Tech Forum 2024BookNet Canada
 
Unraveling Multimodality with Large Language Models.pdf
Unraveling Multimodality with Large Language Models.pdfUnraveling Multimodality with Large Language Models.pdf
Unraveling Multimodality with Large Language Models.pdfAlex Barbosa Coqueiro
 
Advanced Computer Architecture – An Introduction
Advanced Computer Architecture – An IntroductionAdvanced Computer Architecture – An Introduction
Advanced Computer Architecture – An IntroductionDilum Bandara
 
New from BookNet Canada for 2024: Loan Stars - Tech Forum 2024
New from BookNet Canada for 2024: Loan Stars - Tech Forum 2024New from BookNet Canada for 2024: Loan Stars - Tech Forum 2024
New from BookNet Canada for 2024: Loan Stars - Tech Forum 2024BookNet Canada
 
From Family Reminiscence to Scholarly Archive .
From Family Reminiscence to Scholarly Archive .From Family Reminiscence to Scholarly Archive .
From Family Reminiscence to Scholarly Archive .Alan Dix
 
WordPress Websites for Engineers: Elevate Your Brand
WordPress Websites for Engineers: Elevate Your BrandWordPress Websites for Engineers: Elevate Your Brand
WordPress Websites for Engineers: Elevate Your Brandgvaughan
 
DevEX - reference for building teams, processes, and platforms
DevEX - reference for building teams, processes, and platformsDevEX - reference for building teams, processes, and platforms
DevEX - reference for building teams, processes, and platformsSergiu Bodiu
 
"ML in Production",Oleksandr Bagan
"ML in Production",Oleksandr Bagan"ML in Production",Oleksandr Bagan
"ML in Production",Oleksandr BaganFwdays
 
Nell’iperspazio con Rocket: il Framework Web di Rust!
Nell’iperspazio con Rocket: il Framework Web di Rust!Nell’iperspazio con Rocket: il Framework Web di Rust!
Nell’iperspazio con Rocket: il Framework Web di Rust!Commit University
 
SAP Build Work Zone - Overview L2-L3.pptx
SAP Build Work Zone - Overview L2-L3.pptxSAP Build Work Zone - Overview L2-L3.pptx
SAP Build Work Zone - Overview L2-L3.pptxNavinnSomaal
 
Ensuring Technical Readiness For Copilot in Microsoft 365
Ensuring Technical Readiness For Copilot in Microsoft 365Ensuring Technical Readiness For Copilot in Microsoft 365
Ensuring Technical Readiness For Copilot in Microsoft 3652toLead Limited
 
Commit 2024 - Secret Management made easy
Commit 2024 - Secret Management made easyCommit 2024 - Secret Management made easy
Commit 2024 - Secret Management made easyAlfredo García Lavilla
 

Kürzlich hochgeladen (20)

unit 4 immunoblotting technique complete.pptx
unit 4 immunoblotting technique complete.pptxunit 4 immunoblotting technique complete.pptx
unit 4 immunoblotting technique complete.pptx
 
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptx
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptxPasskey Providers and Enabling Portability: FIDO Paris Seminar.pptx
Passkey Providers and Enabling Portability: FIDO Paris Seminar.pptx
 
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack
"Subclassing and Composition – A Pythonic Tour of Trade-Offs", Hynek Schlawack
 
What is DBT - The Ultimate Data Build Tool.pdf
What is DBT - The Ultimate Data Build Tool.pdfWhat is DBT - The Ultimate Data Build Tool.pdf
What is DBT - The Ultimate Data Build Tool.pdf
 
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)
Tampa BSides - Chef's Tour of Microsoft Security Adoption Framework (SAF)
 
SIP trunking in Janus @ Kamailio World 2024
SIP trunking in Janus @ Kamailio World 2024SIP trunking in Janus @ Kamailio World 2024
SIP trunking in Janus @ Kamailio World 2024
 
The Ultimate Guide to Choosing WordPress Pros and Cons
The Ultimate Guide to Choosing WordPress Pros and ConsThe Ultimate Guide to Choosing WordPress Pros and Cons
The Ultimate Guide to Choosing WordPress Pros and Cons
 
Transcript: New from BookNet Canada for 2024: BNC CataList - Tech Forum 2024
Transcript: New from BookNet Canada for 2024: BNC CataList - Tech Forum 2024Transcript: New from BookNet Canada for 2024: BNC CataList - Tech Forum 2024
Transcript: New from BookNet Canada for 2024: BNC CataList - Tech Forum 2024
 
Unraveling Multimodality with Large Language Models.pdf
Unraveling Multimodality with Large Language Models.pdfUnraveling Multimodality with Large Language Models.pdf
Unraveling Multimodality with Large Language Models.pdf
 
Advanced Computer Architecture – An Introduction
Advanced Computer Architecture – An IntroductionAdvanced Computer Architecture – An Introduction
Advanced Computer Architecture – An Introduction
 
DMCC Future of Trade Web3 - Special Edition
DMCC Future of Trade Web3 - Special EditionDMCC Future of Trade Web3 - Special Edition
DMCC Future of Trade Web3 - Special Edition
 
New from BookNet Canada for 2024: Loan Stars - Tech Forum 2024
New from BookNet Canada for 2024: Loan Stars - Tech Forum 2024New from BookNet Canada for 2024: Loan Stars - Tech Forum 2024
New from BookNet Canada for 2024: Loan Stars - Tech Forum 2024
 
From Family Reminiscence to Scholarly Archive .
From Family Reminiscence to Scholarly Archive .From Family Reminiscence to Scholarly Archive .
From Family Reminiscence to Scholarly Archive .
 
WordPress Websites for Engineers: Elevate Your Brand
WordPress Websites for Engineers: Elevate Your BrandWordPress Websites for Engineers: Elevate Your Brand
WordPress Websites for Engineers: Elevate Your Brand
 
DevEX - reference for building teams, processes, and platforms
DevEX - reference for building teams, processes, and platformsDevEX - reference for building teams, processes, and platforms
DevEX - reference for building teams, processes, and platforms
 
"ML in Production",Oleksandr Bagan
"ML in Production",Oleksandr Bagan"ML in Production",Oleksandr Bagan
"ML in Production",Oleksandr Bagan
 
Nell’iperspazio con Rocket: il Framework Web di Rust!
Nell’iperspazio con Rocket: il Framework Web di Rust!Nell’iperspazio con Rocket: il Framework Web di Rust!
Nell’iperspazio con Rocket: il Framework Web di Rust!
 
SAP Build Work Zone - Overview L2-L3.pptx
SAP Build Work Zone - Overview L2-L3.pptxSAP Build Work Zone - Overview L2-L3.pptx
SAP Build Work Zone - Overview L2-L3.pptx
 
Ensuring Technical Readiness For Copilot in Microsoft 365
Ensuring Technical Readiness For Copilot in Microsoft 365Ensuring Technical Readiness For Copilot in Microsoft 365
Ensuring Technical Readiness For Copilot in Microsoft 365
 
Commit 2024 - Secret Management made easy
Commit 2024 - Secret Management made easyCommit 2024 - Secret Management made easy
Commit 2024 - Secret Management made easy
 

STRING - Modeling of biological systems through cross-species data integration

  • 1. STRING Modeling of biological systems through cross-species data integration Lars Juhl Jensen EMBL Heidelberg
  • 2. Jensen et al., Drug Discovery Today: Targets, 2004
  • 3. de Lichtenberg et al., Science, 2005
  • 4. TOM MRPL Ribosome Related MRPS Vacuolar Acidification Fatty Acid Biosynth. Secondary RCC_Asy RCC_Asy RCCII RCCIV RCCV RCC_Asy HAP Complex Arg Biosynth. PDH/KGD/ GCV Cell Wall & pH Reg. DNA Repair Glucose sensing and CH remodelling APC Fission/ Fusion rRNA Processing mRNA Processing TFIIIC Complex m-AAA Complex TCA Cycle Iron Homeostasis/ Chaperone Activity RCCI rRNA Processing Leu/Val/Ile Biosynth. DNA Repair GARP Complex Cytosolic Ribosome TIM RCC_Asy Actin tRNA Splicing RCCIII NUP Replication/ DNA Repair
  • 5. TOM MRPL Ribosome Related MRPS Vacuolar Acidification Fatty Acid Biosynth. Secondary RCC_Asy RCC_Asy RCCII RCCIV RCCV RCC_Asy HAP Complex Arg Biosynth. PDH/KGD/ GCV Cell Wall & pH Reg. DNA Repair Glucose sensing and CH remodelling APC Fission/ Fusion rRNA Processing mRNA Processing TFIIIC Complex m-AAA Complex TCA Cycle Iron Homeostasis/ Chaperone Activity RCCI rRNA Processing Leu/Val/Ile Biosynth. DNA Repair GARP Complex Cytosolic Ribosome TIM RCC_Asy Actin tRNA Splicing RCCIII NUP Replication/ DNA Repair Protobacterial orthologs
  • 6. TOM MRPL Ribosome Related MRPS Vacuolar Acidification Fatty Acid Biosynth. Secondary RCC_Asy RCCII RCCIV RCCV RCC_Asy HAP Complex Arg Biosynth. PDH/KGD/ GCV Cell Wall & pH Reg. DNA Repair Glucose sensing and CH remodelling APC Fission/ Fusion rRNA Processing mRNA Processing TFIIIC Complex m-AAA Complex TCA Cycle Iron Homeostasis/ Chaperone Activity RCCI rRNA Processing Leu/Val/Ile Biosynth. DNA Repair GARP Complex Cytosolic Ribosome TIM RCC_Asy Actin tRNA Splicing RCCIII NUP Replication/ DNA Repair Human disease orthologs RCC_Asy
  • 7. Genomic neighborhood Species co-occurrence Gene fusions Database imports Exp. interaction data Microarray expression data Literature co-mentioning von Mering et al., Nucleic Acids Res., 2005
  • 8. T Resting protuberances Protracted protuberance Cellulose © Trends Microbiol, 1999 Cell Cell wall Anchoring proteins Cellulosomes Cellulose The “Cellulosome”
  • 9.  
  • 10. Jensen et al., to appear in Nat. Rev. Genet., 2005
  • 11. Networ-Kin™ Phospho-peptide data (from MS) Predict the kinase class (NetPhosK and Scansite)
  • 12.
  • 13.