1. Will it be just a scare ⊠or a scar on human history? Bird flu
2. It has become the headlines of news channels Itâs circulating largely among bird flocks in Asia ⊠Thailand on Monday 7/11/05 reported its 20 th human victim since 2003 ⊠China reports sixth case in this year ⊠Itâs bird flu âŠthatâs spreading through ! High mortality rate : 62% human fatal cases WHO
3. â A pandemic of bird fluâ Health experts fear that the avian flu virus could mutate and acquire the ability to infect large numbers of people ... Should that happen, without immediate and effective interventions to contain it ⊠the Global Impact could be incalculable
15. Circulating influenza strains and pandemics in 20 th century 1920 1940 1960 1980 2000 H1N1 1918: âSpanish Fluâ 20-40 million deaths WHO H2N2 1957: âAsian Fluâ 1 million deaths H3N2 1968: âHong Kong Fluâ 1 million deaths
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20. NEJM 2005 Fusion with host cell Attachment to host cell receptor â sialic acids Virus Replicates its genetic material inside host cell Viral progeny Attached to host cell receptor-sialic acids Releases the attached progeny; removing sialic acid LIFE CYCLE OF INFLUENZA H spike N spike M 2 protein NEURAMINIDASE INHIBITORS Prevent the virus from infecting new cell