6. “Cellular defense against fatal
associations between proteins
and DNA”
DNA is constantly
threatened by damage
originating from
exogenous and
endogenous sources. It
could modify its
structure and
functionality.
Very special DNA lesions
are DNA-protein
crosslinks , proteins
covalently linked to DNA.
7. A special class of damage is
caused by reactive compounds,
such as formaldehyde, which
are produced as byproducts of
cellular reactions and cause
the crosslinking (a formation of
a covalent linkage) of proteins
to DNA.
“Cellular defense
against fatal
associations between
proteins and DNA”
Importantly, these so-called DNA-
protein crosslinks are also caused
by several anti-cancer drugs and
are extremely toxic as they
interfere with essential processes
such as DNA replication.
9. OBSERVATION
“This kind of findings have a
big importance in the medicine
today. Because of the cancer
or the impairment of the DNA
is a big problem and we
should find the cure.”
11. DNA origami nano-tool provides
important clue to cáncer
It was previously known that
the EphA2 receptor played a
part in several forms of
cancer, such as breast
cancer. The ligand, i.e., the
protein that communicates
with the receptor, is known
as an ephrin molecule
12. DNA origami nano-tool provides
important clue to cáncer
The researchers used the
method of DNA origami, in
which a DNA molecule is
shaped into a
nanostructure, and used
these structures to test
theories about cell
signalling
13. DNA origami nano-tool provides
important clue to cáncer
Result of the experiment:
It turned out that if the ephrin
molecules were placed close
together on the DNA rod, the
receptor in question became more
active in the cancer cells, and the
cells also became less invasive in
respect of the surrounding cells,
which could be an indication that
they became less prone to
metastasis
14. OBSERVATION
“Some laboratory techniques
improve the posibility to
understand the process or some
mechanism of specific diseases,
like the cancer. So this is the form
to identify the cure of a lot of
diseases like this”.
16. Medical Utility
“Cellular defense against fatal
associations between proteins and DNA”
We can now use this findings, as base to find in a
short future the cure for a lot of diseases that
have a common origin. Of this reason we could
repair or control our genetic problems with a so
easy procedure.
17. “DNA origami nano-tool provides
important clue to cáncer”
Medical Utility
Over the years, scientists have designed
new highly specialized techniques with
which we know the function of many
microstructures, both fundamental
metabolic processes in certain pathological.
Thus we can understand the origin of many
disorders and provide a possible solution to
the problem
18. Medical Utility
Through the years we have seen the need to find
new solutions to potentially lethal diseases before.
For this reason highly qualified scientists have
developed multiple techniques that have improved
understanding of the pathophysiology of many
disorders and a possible cure this, maybe not now,
maybe not in a year but if, in a future not too distant
19. Bibliography
• MARTINEZ SANCHEZ, LINA
MARIA. BIOLOGIA MOLECULAR.
7ma Edicion.Medellin. UPB.
Facultad de medicina. 2012.
Paginas 74-83
• “Cellular defense against fatal
associations between proteins
and DNA” Science daily. July 3,
2014
• “DNA origami nano-tool provides
important clue to cancer”
Science daily. July 7, 2014
