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Pharma-Cycle, Inc. (PCI) Presentation to Senator  Sheldon Whitehouse Member Senate Committee on Environment  & Public Works July 11, 2011
USED Pharmaceuticals U listed and P listed What about process waste? How do you use a drug? Did you ever take a vitamin and a couple of hours later your urine looks like you ate your highlighter? That is the vitamin passing through your body unaltered. What if that drug was also used in Chemical Warfare?
The Problem ,[object Object],[object Object],[object Object],[object Object]
Background ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Who is watching “ Some of these drugs have been known to cause cancer, reproductive and developmental problems, allergic reactions, and other adverse effects that can be irreversible even after low-level exposures.” April, 4 2011  OSHA, Niosh and the Joint Commission.
[object Object],[object Object],[object Object],[object Object],[object Object],This Drug May Cause:
How the drugs are made Doxorubicin manufacturing from June 2008  Chemical and engineering news
A Pharmacist prepares the drugs in a level 3 Biological safety cabinet ,[object Object],[object Object],[object Object]
OSHA  SECTION VI: CHAPTER 2  CONTROLLING OCCUPATIONAL EXPOSURE TO HAZARDOUS DRUGS ,[object Object]
Drugs and the Environment: Stewardship & Sustainability Christian G. Daughton, PhD National Exposure Research Laboratory Office of Research and Development U.S. Environmental Protection Agency 944 East Harmon Las Vegas, NV 89119 12 September 2010 Only 5% of the drugs in the environment come from dumping unused drugs. 85% comes from direct excretion and 10% from bathing
Pee Lab ,[object Object],[object Object],[object Object]
Excretion times Mechlorethamine hydrochloride excreted in urine in 48 hrs. Chlorambucil excreted in urine in 48 hrs. Cistplatin excreted in urine in 7 days Megestrol Acetate excreted in urine 57-78% Citrate excreted in feces and urine Melphalan excreted in urine 48 hrs. Mercaptopurine excreted in urine in 72 hrs. Cyclophosphamide excreted in urine 72 hrs. (i.v.) Methotrexate excreted in the urine 72 hrs. Mitomycin excreted in urine first day Cytarabine hydrochloride excreted in the urine within 1st day Mitoxantrone-Hydrochloride excreted in urine Dacarbazine excreted in the urine 30-46% within 6 hrs. Plicamycin excreted in urine 40% in 15 hrs. Dactinomycin excreted in urine in 5 days 20% in first 24 hrs. Tamoxifen Research not completed Daunorubicin excreted in feces 7 days 48 hrs. Thiotepa excreted in urine in 72 hrs. Doxorubicin excreted in feces 7 days urine 6 days Thioguanine excreted in urine in 72 hrs. Epirubicin Hydo excreted in urine 7 days and feces 5 days Streptozocin excreted principally in urine Etoposide excreted in urine in 4 days feces in 7 days Vincristine sulfate excreted in urine 4 days Fluorouracil excreted in urine in 48 hrs.
Google “Chemical Warfare” ,[object Object],[object Object],[object Object],Radioactive  vs. Cytotoxic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],In 2000 EPA found mutated lower level species and traced the cause back to hospitals administering chemotherapy
The collection of human excrement with cytotoxic drugs will happen ,[object Object],[object Object],[object Object],The Pharma-Cycle, Inc. solution
The Pharma-Cycle, Inc. Solution ,[object Object],[object Object],[object Object],“ We put a car on the moon, we can handle this problem”
Size of the problem ,[object Object],[object Object],[object Object],[object Object]
Thank you. ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Cytotoxin dangers presentation to Senate

  • 1. Pharma-Cycle, Inc. (PCI) Presentation to Senator Sheldon Whitehouse Member Senate Committee on Environment & Public Works July 11, 2011
  • 2. USED Pharmaceuticals U listed and P listed What about process waste? How do you use a drug? Did you ever take a vitamin and a couple of hours later your urine looks like you ate your highlighter? That is the vitamin passing through your body unaltered. What if that drug was also used in Chemical Warfare?
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  • 5. Who is watching “ Some of these drugs have been known to cause cancer, reproductive and developmental problems, allergic reactions, and other adverse effects that can be irreversible even after low-level exposures.” April, 4 2011 OSHA, Niosh and the Joint Commission.
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  • 7. How the drugs are made Doxorubicin manufacturing from June 2008 Chemical and engineering news
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  • 10. Drugs and the Environment: Stewardship & Sustainability Christian G. Daughton, PhD National Exposure Research Laboratory Office of Research and Development U.S. Environmental Protection Agency 944 East Harmon Las Vegas, NV 89119 12 September 2010 Only 5% of the drugs in the environment come from dumping unused drugs. 85% comes from direct excretion and 10% from bathing
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  • 12. Excretion times Mechlorethamine hydrochloride excreted in urine in 48 hrs. Chlorambucil excreted in urine in 48 hrs. Cistplatin excreted in urine in 7 days Megestrol Acetate excreted in urine 57-78% Citrate excreted in feces and urine Melphalan excreted in urine 48 hrs. Mercaptopurine excreted in urine in 72 hrs. Cyclophosphamide excreted in urine 72 hrs. (i.v.) Methotrexate excreted in the urine 72 hrs. Mitomycin excreted in urine first day Cytarabine hydrochloride excreted in the urine within 1st day Mitoxantrone-Hydrochloride excreted in urine Dacarbazine excreted in the urine 30-46% within 6 hrs. Plicamycin excreted in urine 40% in 15 hrs. Dactinomycin excreted in urine in 5 days 20% in first 24 hrs. Tamoxifen Research not completed Daunorubicin excreted in feces 7 days 48 hrs. Thiotepa excreted in urine in 72 hrs. Doxorubicin excreted in feces 7 days urine 6 days Thioguanine excreted in urine in 72 hrs. Epirubicin Hydo excreted in urine 7 days and feces 5 days Streptozocin excreted principally in urine Etoposide excreted in urine in 4 days feces in 7 days Vincristine sulfate excreted in urine 4 days Fluorouracil excreted in urine in 48 hrs.
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