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Pharma Sector
S e p t e m b e r ,1 2 2 0 1 1   S a l im H a j ia n i
                                   P r it i P iy u s h
                                    Jig a r S h a h
Pharma Business Basics
       Formulation Business ( Glenmark,Lupin)
       API ( Active Pharma Ingredient)
       NCE ( New Chemical Entity)
       NME ( New Molecular Entity)




3
Pharma Business Basics
1 .F o r m u l a t io n b u s in e s s :
F o r m u l a t io n is t h e p r o c e s s in w h ic h d if f e r e n t
c h e m ic a l s u b s t a n c e s ,in c l u d in g t h e a c t iv e d r u g
,a r e c o m b in e d t o t o p r o d u c e f in a l m e d ic a l p r o d u c t .
2 .AP I :
An a c t iv e P h a r m a in g r e d ie n t (AP I)is t h e s u b s t a n c e
o f a p h a r m a c e u t ic a l d r u g o r a p e s t ic id e t h a t is
b io l o g ic a l l y a c t iv e . T e r m s in s im il a r u s e in c l u d e
a c t iv e p h a r m a c e u t ic a l in g r e d ie n t (AP I)a n d b u l k
a c t iv e in m e d ic in e ; in p e s t ic id e f o r m u l a t io n s a c t iv e
s ubs tan ce may be us ed .

3 .N C E /N M E :
A N e w c h e m ic a l e n t it y (N C E ), o r n e w m o l e c u l a r
e n t it y (N M E ), is , a c c o r d in g t o t h e u .s . F o o d a n d d r u g
a d m in is t r a t io n , a d r u g t h a t c o n t a in s n o a c t iv e
m o ie t y t h a t h a s b e e n a p p r o v e d b y t h e F D A in a n y
o t h e r a p p l ic a t io n s u b m it t e d u n d e r s e c t io n 5 0 5 (b )
o f t h e F e d e r a l f o o d , d r u g , a n d c o s m e t ic a c t .
Drug
     Develo pmen t
F o r m u l a t io n s t u d ie s in v o l v e d e v e l o p in g a
p r e p a r a t io n o f t h e d r u g w h ic h is b o t h s t a b l e
a n d a c c e p t a b l e t o t h e p a t ie n t . F o r o r a l l y
taken             d r u g s ,t h is    us ually            in v o l v e s
in c o r p o r a t in g t h e d r u g in t o a t a b l e t o r a
c a p s u l e . It is im p o r t a n t t o a p p r e c ia t e t h a t a
tablet          c o n t a in s      a   v a r ie t y    of      other
s u b s t a n c e s a p a r t f r o m t h e d r u g it s e l f ,a n d
s t u d ie s h a v e t o b e c a r r ie d o u t t o e n s u r e
th at th e d rug
is c o m p a t ib l e w it h t h eDrugo t h e r s u b s t a n c e s .
Phase Manner Development of s e

    C l in ic a l T r ia l P h a s e I D r u g L o a d

    C l in ic a l T r ia l P h a s e II

    C l in ic a l T r ia l P h a s e III
(F e a s ib il it y o n t h e b a s is o f
T e m p e r a t u r e ,h u m id it y ,o x id a t io n
 a n d p h o t o l y s is (U l t r a v io l e t c l e a r a n c e )
Indian Pharma Story


 India Pharma sector will lead to US $ 21 b by 2015

The Indian Domestic Pharma Story is founded
on 4 Pillars,What we call as 4 A'
 
  Affordabability
 
  Access
 
  Awareness
 
  Ailments
Indian Pharma Market is growing CAGR @ 6% & will
reach to 12,72,121,cr. Market by 2015.
More Details on Ailments.
USFDA Approval in Pharma sector?

1. USFDA approval is needed for launching medicine in open market in
   US.


2. Drugs are feasible on Temperature,Humidity,Oxidation.


3. Drugs are in line with Medical Formulation for curing the disease or
   reducing the impact of the diseases.
Latest FDA Approvals ,Launch & Tie ups in Pharma Sector.

    Glenmark gets USFDA approval for hypertensive drug.


    Sun Pharma receive USFDA nod for generic proscar tablet.


    Dr. Reddy's resolve patent litigation of generic Lipitor with Pfizer.


    Lupin to Market Sanofi's CNS brands in Phillippines.


    Dr. Reddy's launches Allegra D24 OTC Tablet in US Market.


    Rainbaxy Launches Painkiller in Domestic Market.


    Orchid restarts production of API Facility.
The upcoming patent cliff :
 T h e l e a d in g g l o b a l p h a r m a c e u t ic a l f ir m s a r e f a c in g
   s o m e c h a l l e n g in g t im e s a s a s ig n if ic a n t n u m b e r o f
   p a t e n t s f o r b r a n d e d d r u g s a r e s e t t o e x p ir e o v e r
   t h e n e x t f iv e y e a r s . F r o m 2 0 1 1 -2 0 1 5 , t h e t o t a l
   v a l u e (a s m e a s u r e d b y a n n u a l s a l e s )o f p a t e n t
   e x p ir a t io n s is e x p e c t e d t o b e a r o u n d $ 1 0 0 b il l io n , a
   s ig n if ic a n t in c r e a s e f r o m $ 7 3 b il l io n in p a t e n t
   e x p ir a t io n s o v e r t h e p r e v io u s f iv e y e a r s . In d ia n
   p h a r m a c e u t ic a l c o m p a n ie s c a n c a p it a l iz e o n t h is
   o p p o r t u n it y d u e t o t h e ir f ir s t m o v e r a d v a n t a g e ,
   s t r o n g p r o c e s s e n g in e e r in g s k il l s a n d a c c e s s t o
   l o w -c o s t t a l e n t .E x a :
Benefits & Precautions of Patent Expiration to
Indian Companies
1.Globally Competitive in the   1.Focus on Long Term & Niche
   generic business                Segment.
2.The First Mover Advantage     2.Strong Competitive position
3.Low-Cost Manufacturing        3.Backward integration.
   Base
4.Deep and Low-cost talent
   Pool.
Details on Precautions

          1.Focus on Complex & Niche Segment :
Long-term growth can be generated by focusing in specialized therapeutic
                  areas and/or more complex molecules.
             2.Strong Competitive Positioning :
  New drug delivery systems can be used to compete with drugs whose
   formulation patents have not expired. These segments tend to be less
   competitive, but development of such applications requires significant
                capabilities in both research and marketing.
                    3.Backward integration:
Backward-integrated generic players with captive Active Pharmaceutical
   Ingredient ( API) manufacturing capabilities are likely to enjoy higher
                                 margins.
Domestic Pharma Sector


Growth Rate : 16.5% in 2010.

Highest Market Share : Cipla

Larges selling Brands : Cough Medication “Corex” ( Pfizer)

Largest Growing Drugs : Abbott's insulin ( 27% rise)
                         Novartis Voveran ( 6%)
Important comments by Azaz Motiwala
on Indian Pharma
•     T h e G l o b a l m a r k e t is e x p e c t e d t o g r o w b y 7 %
     t o 8 % o v e r n e x t 5 y r s . R e a c h in g a n a n t ic ip a t e d
     $ 1 .7 t r il l io n
2 . In d ia n c o n s u m e r s p e n d 1 % o f h is t o t a l in c o m e o n
     D r u g s & P h a r m a c e u t ic a l ,h o w e v e r r is e in p e r
     c a p it a in c o m e w il l t r ip l e t h e s a m e b y 2 0 2 0 .
3 . G o v e r n m e n t s l o n g t e r m v is io n o f m a k in g
     q u a l it y h e a l t h c a r e a f f o r d a b l e ,a t l e a s t 5 0 %
     o f In d ia n p o p u l a t io n s h o u l d b e c o v e r e d u n d e r
     h e a l t h in s u r a n c e b y 2 0 2 0 a g a in s t 1 5 % t o d a y .
4 . In d ia n h e a l t h c a r e in d u s t r y is e s t im a t e d t o b e
     w o r t h o f $ 2 7 5 .6 b il l io n .
5 . In d ia n p h a r m a in d u s t r y w il l b e in T o p 5 in t h e
     w o r l d b y 2 02 0.


Azaz Motiwala ,F o u n d e r ,Ik o n M a r k e t in g C o n s u l t a n t
Key Success factor for evaluation of Indian Pharma companies
Price Movements for BSE Health care Index v/s BSE Sensex
G L E N M AR K P H AR M A
Introduction
•   R e s e a r c h -d r iv e n , g l o b a l , in t e g r a t e d     p h a r m a c e u t ic a l
    co mpan y

•   L e a d in g p l a y e r in d is c o v e r y o f n e w m o l e c u l e s
     – N C E s (n e w c h e m ic a l e n t it y )
     – N B E s (n e w b io l o g ic a l e n t it y )
     – 1 3 m o l e c u l e s in v a r io u s s t a g e s o f p r e c l in ic a l &
       c l in ic a l d e v e l o p m e n t

•   S ig n if ic a n t p r e s e n c e     in   Br a n d e d         G e n e r ic s   acro s s
    E m e r g in g E c o n o m ie s



•    O u t -l ic e n s in g d e a l s w it h G l o b a l P h a r m a m a j o r s r e -
    a f f ir m s G l e n m a r k ’s s t r e n g t h in d is c o v e r y

•   1 2 M a n u f a c t u r in g f a c il it ie s l o c a t e d in 4 c o u n t ir e s
B u s in e s s M o d e l
   E l u c id a t e d
Specialty Business : Drug Discovery

•   P r im a r il y f o c u s e d in t h e a r e a s o f
     – in f l a m m a t io n
     – m e t a b o l ic d is o r d e r s
     – p a in
•   R o b u s t p ip e l in e o f m o l e c u l e s (N C E ’s & N B E ’s )
     – 7 m o l e c u l e s a r e in c l in ic a l t r ia l s s t a g e
•   P o t e n t ia l p e a k s a l e s o p p o r t u n it y f o r e a c h m o l e c u l e
    b e in g in t h e r a n g e o f U S D 1 -1 0 b il l io n
Molecules under research
Specialty Business :Formulations Business
•    C u r r e n t l y o r g a n iz e d a r o u n d f o u r r e g io n s
      – In d ia
      – L a t in Am e r ic a
      – Ce n t r a l Ea s t e r n Eu r o p e
      – S e m i R e g u l a t e d M a r k e t s o f Af r ic a /As ia

F o c u s o n t h e r a p e u t ic a r e a s
d ermato lo gy
                            -c a r d ia c
    – a n t i-in f e c t iv e s
                            -d ia b e t e s
   r e s p ir a t o r y
                            -g y n e c o l o g y
                              -C N S
Specialty Business : Generics
•   G l e n m a r k G e n e r ic s L t d (G G L ), a s u b s id ia r y o f G l e n m a r k
    Ph a r m a

•   It c o m p r is e s o f U S G e n e r ic s , E u r o p e G e n e r ic s , AP I a n d
    O n c o l o g y b u s in e s s e s
•   G G L s M a r k e t in g S t r a t e g y :
     – d e v e l o p in g , m a n u f a c t u r in g , s e l l in g , a n d d is t r ib u t in g
        g e n e r ic p r o d u c t s t h r o u g h w h o l e s a l e r s , r e t a il e r s
        a n d p h a r m a c y c h a in s

•   G G L s f o c u s o n n ic h e b u s in e s s s e g m e n t s :
     – D e r m a t o l o g y ,H o r m o n e s ,C o n t r o l l e d S u b s t a n c e s ,
        O n c o l o g y , M o d if ie d R e l e a s e P r o d u c t s
•   It m a r k e t s a r o u n d 6 5 AP Is g l o b a l l y , in c l u d in g t h e U S ,
    v a r io u s c o u n t r ie s in t h e E U , S o u t h Am e r ic a a n d In d ia .
•   G G L h a s s o f a r f il e d 4 1 D M F s (D r u g M a s t e r F il e s )w it h t h e
    U S -F D A.
Diverse Product Portfolio
Segment Revenue Break-Up
St r e n g t h b e yo n d Nu m b e r s

•   G r o w t h in n e t s a l e s d r iv e n b y r o b u s t g r o w t h in S p e c ia l t y &
    G e n e r ic s b u s in e s s e s in t h e d o m e s t ic a n d g l o b a l m a r k e t s


•   B o o k e d o u t -l ic e n s in g in c o m e r e l a t e d t o G B R 5 0 0 o f 1 1 1 .2 c r o r e
    a s a g a in s t 8 9 .5 c r o r e (r e l a t e d t o G R C 1 5 3 0 0 )in Q 1 F Y1 1 . T h e
    r e m a in in g U S $ 2 5 m il l io n w il l b e b o o k e d in Q 2 F Y1 2


•   L a t in Am e r ic a n a n d C a r ib b e a n m a r k e t s s a l e s w it n e s s e d r o b u s t
    gro w th d ue to lo w bas e


•   L AT AM R e g io n t o b e E B ID T A n e g a t iv e f o r n e x t 2 y e a r s a s it is s t il l
    in in v e s t m e n t p h a s e . T h u s im p l y in g r o b u s t r e v e n u e g r o w t h
    p o t e n t ia l in t h e l o n g e r t e r m
•   M a n a g e m e n t g u id a n c e f o r g r o w t h o f 2 5 % g r o w t h in U S in F Y
    2 01 2 d u e t o :
     – L a u n c h o f k e y p r o d u c t s : M a l a r o n e & C u t iv a t e in Q 3 F Y1 2
         a n d Q 4 F Y 1 2 r e s p e c t iv e l y
Share Price Data
Financial Snapshot
Trend in EBITDA and PAT Margins
•   Gl e n m a r k       h as      v a r io u s      prod ucts             in      c l in ic a l
    d evelo pmen t s tages .
     – C r o f e l e m e r c o m p l e t e d it s P h a s e III c l in ic a l t r ia l s a n d
        is e x p e c t e d t o l a u n c h in b e g in n in g o f F Y 1 3 .
     – Al s o r e c e iv e d        $ 1 5 m n f r o m S a l ix P h a r m a f o r
        u p g r a d in g m a n u f a c t u r in g f a c il it y t o m e e t h ig h
        e x p e c t e d d e m a n d o f Cr o f e l e m e r .
•   L a u n c h e d t w o p r o d u c t s in Q 1 F Y 1 2 i.e . V o r t h T P & D o r ig e n
    in t h e o r t h o p a e d ic s e g m e n t .
•   r e c e iv a b l e d a y s h a v e d r o p p e d t o 1 2 5 f r o m 1 4 0
•   S e t t l e m e n t o f l im it e d       c o m p e t it io n p r o d u c t s l ik e
    F l u t ic a s o n e P r o p io n a t e l o t io n (m a r k e t s iz e U S $ 4 4 m n )
    a n d H y d r o c o r t is o n e B u t y r a t e c r e a m (m a r k e t s iz e
    U S $ 3 8 m n ) w o u l d a l s o p e p u p t h e g r o w t h in t h e n e x t 2
    years
•   L a s t f is c a l it l a u n c h e d 1 9 p r o d u c t s a n d             plan s      to
    l a u n c h 1 5 p r o d u c t s in c u r e n t f is c a l .
Valuation Matrix
Salesforce Productivity
Prescription Ranking
Strengths                                              Risks
S t r o n g R & D p ip e l in e                   D e l a y in p r o d u c t a p p r o v a l s

Pl a n s t o l a u n c h 7 p r o d u c t s        R is in g c o m p e t it io n in t e n s it y
a n d f il e 1 5 -2 0 AN D A’s in F Y 1 2
                                                  Fr a g m e n t e d Ma r k e t S h a r e
S a t is f a c t o r y p r o s p e c t s f o r
                                                  R a p id P r ic e E r o s io n
o u t -l ic e n s in g d e a l s
                                                  Ad v e r s e v e r d ic t in t h e
F o c u s o n n ic h e s e g m e n t s in t h e
                                                  o n g o in g T a r a k a L it ig a t io n
U S m a r k e t w h e r e p r ic e e r o s io n
is n o t s t e e p in c l u d e s :               H ig h l y r e g u l a t e d m a r k e t
o r a l c o n t r a c e p t iv e s
Co n t r o l l e d S u b s t a n c e s
Dermato lo gy
LUPIN
Formulations Business

P r o m o t e d b y D r . D e s h B a n d h u G u p t a , a f ir s t g e n e r a t io n
e n t r e p r e n e u r , L P C is In d ia ’s f if t h l a r g e s t c o m p a n y b y
d o m e s t ic s a l e s .



G l o b a l F o r m u l a t io n s b u s in e s s c o n s t it u t e s c l o s e t o 8 4 %
o f L u p in ’s o v e r a l l b u s in e s s m ix , a n d in t e r m s o f
g e o g r a p h ie s , U S A is it s l a r g e s t m a r k e t o u t s id e In d ia . 6 7 % o f
t h e o v e r a l l b u s in e s s o f t h e C o m p a n y c o m e s f r o m
In t e r n a t io n a l M a r k e t s
Active Pharmaceutical Ingredients
                   ( API)
•   AP I s p a c e is d r iv e n b y t h e t w o As ia n g ia n t s C h in a a n d
    In d ia .
•   Th e      C o m p a n y ’s   w id e     prod uct      bas k et     c o m p r is in g
    f o r m u l a t io n s f r o m C V S , C N S , An t i-As t h m a , An t i-T B ,
    D ia b e t o l o g y , D e r m a t o l o g y , G I, a n d o t h e r t h e r a p y
    segments

•   P l a n t s h if t f r o m G o a t o In d o r e S E Z

•   M e d ic is P h a r m a t o u s e L u p in R & D p l a t f o r m f o r U S $ 2 0
    m il l io n
    T o m a r k e t E l i L il l y ’s H u m in s u l in p r o d u c t s in d o m e s t ic
    mark et wo rth 1 25

•    S ig n e d a n a g r e e m e n t w it h N a t c o P h a r m a t o j o in t l y
    c o m m e r c ia l is e a g e n e r ic e q u iv a l e n t G S K ’s c a n c e r d r u g
    T y k e r b w o r t h U S $ 1 1 3 .6 m il l io n
Valuation

•  O n t h e U S f r o n t , t h e l a u n c h o f Al l e r n a s e
•  N e w p r o d u c t l a u n c h e s e s p e c ia l l y O c s w il l d e t e r m in e
   t h e c o u r s e . T h e l a u n c h o f g e n e r ic F o r t a m e t (a n t i-
   d ia b e t ic )a n d Z ip r a s id o n e (a n t i-p s y c h o t ic )in t h e c u r r e n t
   f is c a l a n d T r ic o r (a n t i c h o l e s t e r o l )a n d C o m b iv ir (a n t i-
   r e t r o v ir a l )in F Y 1 3 w il l b e k e y t r ig g e r s t o w a t c h o u t
   for.
• L a u n c h e d 6 n e w p r o d u c t s in Ja p a n l a s t f is c a l a n d
   p l a n s f o r 6 t o 7 in F Y 1 2
• S u p r a x s a l e s g r e w 3 0 % a n d An t a r a in s in g l e d ig it
• F il e d 4 AN D As t a k in g t o t a l t o 1 5 2
     – 51 appro ved
   P l a n s t o l a u n c h 8 t o 9 p r o d u c t s in U S b e t w e e n Q 2 F Y 1 2 –
   Q 4 F Y1 2
  S o u t h Af r ic a s a l e s in c r e a s e d b y 4 7 %
Valuation Matrix
Strengths
                                                                    Risks
•   G iv e n it s h e a l t h y
    g e o g r a p h ic m ix (8 0 % s a l e s     •   E a r l ie r t h a n e x p e c t e d
    f r o m In d ia , U S & Ja p a n )               G e n e r ic    c o m p e t it io n   in
•   D if f e r e n t ia t e d p r o d u c t s        Suprax
    a n d r o b u s t f in a n c ia l            •   IN R a p p r e c ia t io n w o u l d
    m e t r ic s .                                   h u r t , g iv e n it s e x p o s u r e
•    B ig p r o d u c t r o l l o u t in             to glo bal markets
    t h e U S , in c l u d in g n ic h e /P IV   •   Re a s o n a b l e e x p o s u r e t o
    oppys                                            the                       d o m e s t ic
•   G r o w t h in e m e r g in g                    f o r m u l a t io n s        market
    m a r k e t s (in c l u d in g In d ia )&        (c 3 0 % o f s a l e s )
    Ja p a n                                     •   In a b il it y t o e f f e c t iv e l y
•   M a r g in im p r o v e m e n t b y              s cale        up     the       Ky o w a
    b a c k e n d in g s o u r c in g t o            o p e r a t io n s o r An t a r a
    In d ia f r o m Ja p a n & r is in g             s ales .
    US s a l e s
GlaxoSmithKline
Stock Data
 Market Cap             Rs179.4bn/US$4.0bn


 Share Outstanding                    84.7


 52-week Range (Rs)              2478/1842


 Free Float(%)                        49.3


 FII(%)                               16.8


 Sensex Return 12m(%)                  5.2
IN T R O D U C T IO N
 GSK Pharma is the 4th largest formulations company in
 India,      with a strong presence in segments like
 dermatology, respiratory and vaccines. Its parent has
 one of the richest product and R&D pipelines among
 Pharma companies worldwide .T h e c o m p a n ie s in t h e
 p r o c e s s o f e x p a n d in g it s p r e s e n c e in t h e
 l if e -s t y l e s e g m e n t l e d b y n e w l a u n c h e s
 f r o m t h e p a r e n t 's p o r t f o l io , l a u n c h o f
 b r a n d e d g e n e r ic s a n d in -l ic e n s in g .
GSK Pharma is a 50% subsidiary of GSK Plc ( UK) and is
being currently managed by Dr. Hasit Joshipura ( MD) .
Maintaining a leading presence in India and sustaining one
of the highest               p r o f it a b il it y a n d r e t u r n
r a t io s in t h e in d u s t r y d e s p it e m in is c u l e
p r e s e n c e in t h e h ig h -g r o w t h l if e -s t y l e
s e g m e n t s is t h e k e y      a c h ie v e m e n t .
SPECIALLTY OF BUSINESS

GSK derives majority of its business from acute
   therapeutic s e g m e n t s a n d h a s v e r y l it t l e
   p r e s e n c e in t h e c h r o n ic s e g m e n t s .
G S K d e r iv e s 9 5 % o f it s r e v e n u e s f r o m a c u t e
   t h e r a p e u t ic s e g m e n t s       w it h    d o m in a n t
   p r e s e n c e in An t i-in f c e t iv e s , d e r m a t o l o g y ,
   p a in m a n a g e m e n t a n d V it a m in s .
It r a n k s n o .1 in d e r m a t o l o g y s e g m e n t , n o .3
   in    P a in     man agemen t                an d      V it a m in s
   s e g m e n t s a n d n o 5 in AI a n d r e s p ir a t o r y
   segments.
SPECIALLTY OF BUSINESS
G S K is a m o n g t h e l a g g a r d s w h e n it c o m e s t o
   laun ch o f n ew                      p r o d u c t s . GS K h a s
   laun ch ed very few n ew pro d ucts o ver th e
      l a s t 4 y e a r s c o m p a r e d t o it s p e e r s .
It h a s l a u n c h e d 5 n e w p r o d u c t s (in c l u d in g
   l in e e x t e n s io n s ) a n n u a l l y o v e r t h e l a s t 4
   years .
R a m p -u p in d o m e s t ic f o r m u l a t io n s r e v e n u e s
   is d r iv e n l a r g e l y b y e x is t in g p r o d u c t s .

    .
SPECIALLTY OF BUSINESS


N e w l a u n c h e s : G S K l a u n c h e d t w o in   n o v a t iv e
   p r o d u c t s , n a m e l y Revol e (o r a l
                                          ad             platelet
   gen erato r) an d               Votrient (o n c o     l o g y ) in
   Ju l y ’1 1 .
In a d d it io n , t h e c o m p a n y h a s a l s o     laun c h a
   bran d ed          g e n e r ic a n d a d e r m a      prod uct
   f r o m t h e S t ie f e l p o r t f o l io .

GS K     r e m a in s o n t r a c k t o        laun c h        e ig h t
  b r a n d e d g e n e r ic s in C Y 1 1 .
Prescription ranking of GSK
Top 10 brands of GSK
VALUATION
Year to Dec                  CY 09E     CY 10E   CY 11E   CY12E
 12

Net Revenue(Rs mn            19078       21511   25146    28798
 10

Net Profit (Rs mn)            5097       5606     703     8415
 8

Dil.EPS(Rs)                   59.1        68.3    83.9    99.3
                                                             Column 1
 6                                                            Column 2
                                                              Column 3
% Chg YoY                     8.1         15.5    22.8    18.5
 4


P/E(X)                        35.9        31.1    25.3    21.4
 2


EV/EBITDA(X)                  23.9        20.9    16.4    13.3
 0
         Row 1       Row 2            Row 3       Row 4
Distribution and Reach


GSK derives 60% of its revenue from metros and Class-I
  towns compared with an industry average of 63% .
  O v e r t h e p a s t f o u r y e a r s r e v e n u e C AG R
  f o r a l l g e o g r a p h ie s h a s l a g g e d        the
  in d u s t r y a v e r a g e . H o w e v e r , G S K 's C Y 1 0
  g r o w t h in a l l g e o g r a p h ie s w a s in h ig h e r
  d o u b l e d ig it s .
Improvement in MR productivity

G S K 's r e v e n u e p o s t e d C AG R o f 8 .7 % o v e r
   C Y 0 4 -1 0 a n d it s s a l e s f o r c e p o s t e d C AG R
   of           5 .9 %     over          C Y0 4 -1 0 ,     im p l y in g
   im p r o v e m e n t in s a l e s f o r c e p r o d u c t iv it y .

In 2 0 0 4 , G S K d e r iv e d IN R 6 .5 m r e v e n u e p e r M R ,
   w h ic h r o s e t o IN R 7 .7 m in C Y 1 0 . G S K 's
   c u r r e n t M R p r o d u c t iv it y is a r g u a b l y o n e
   o f t h e b e s t in t h e in d u s t r y .
Cadila Healthcare
STOCK DATA
Cadila is amongst one of the largest domestic pharma
   companies in India with a strong focus on the global
 INTRODUCTION
   generics opportunity.
Th e c o m p a n y is g r a d u a l l y b u il d in g it s
   p r e s e n c e in t h e r e g u l a t e d g e n e r ic markets
   beginning with the US and France It a l s o p l a n s t o
   t a p s o m e u n iq u e o p p o r t u n it ie s t h r o u g h it s
   Jv s       w it h N y c o m e d , H o s p ir a .B a y e r a n d
   Bh a r a t S e r u m s .

It is p r o m o t e d b y Mr. Pankaj Patel.

H is k e y a c h ie v e m e n t is S u s t a in in g s t r o n g
   g r o w t h a n d r e t u r n r a t io s c o u p l e d w it h a
   v e r y c o n s e r v a t iv e , l o w -r is k m a n a g e m e n t .
             .
SPECIALLTY OF BUSINESS
Cadila is among the top three players in two of the largest
     therapeutic segments, CVS and GI.

The company ranks first in the fast growing gynecology
  Segment.

C a d il a 's in t e r n a t io n a l     b u s in e s s , g iv e n it s
   s t r o n g c h e m is t r y s k il l s a n d p r a g m a t ic m ix
   of        it s     g e o g r a p h ic      presence             an d
   p a r t n e r s h ip s .
The top 3 therapeutic segments, CVS, GI and gynecology,
 Prescription ranking of Cadila
 contribu about half of Cadila's domestic formulations
 revenue.         Ot h er lar g e s eg m e n t s u c h as
 r e s p ir a t o r y a n d a n t i-in f e c t iv e ,
 c o n t r ib u t e 1 1 % a n d 1 0 % r e s p e c t iv e l y t o
 t o t al r ev en u e. Ov er t h e p as t 1 0 ye ar s ,
 t h e c o n t r ib u t io n o f C V S a n d G Is e g m e n t s t o
  r e v e n u e r o s e f r o m 2 4 % t o 3 7 % w h il e t h a t
 o f r e s p ir a t o r y a n d               a n t i-in f e c t iv e
 s e g m e n t s f e l l f r o m o v e r 3 2 % in F Y0 1 t o
 l e s s t h a n 2 1 % in F Y1 0 .
Prescription ranking of Cadila
Distribution and Reach



Cadila derives 65% of its revenue from metros and class-I
 town compared with 63% of the industry average. In the
 past four years, revenue CAGR for all geographies except
  metros were in line or marginally better than that of the
 industry average.
Valuation      FY10   FY11   FY12   FY13
summary
EPS(IN Rs)     24.7   37.7   40.5   52.9
PE(X)          35.4   25.2   21.6   16.5
Target PE(X)   38.6   27.5   23.6    18
EV to          24.8   20.5    17    12.6
EBITDA(X)
Price to       11.8   8.9    6.8    5.2
book(x)
RoNW(%)         37    38.7   34.3   34.7
Improvement in MR productivity
Cadila's domestic formulations business revenue posted
  9.2% CAGR over FY04-10 and its sales force posted
  11.3% CAGR, implying negative productivity of the
  workforce.

In 2004, Cadila derived sales of INR4.1m per MR, which fell
  to INR3.6m in FY10.

Cadila's performance was below average, compared with
  the average of performances covered in the report .
                                   .
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Pharma Sector Insights: Formulation, API, NCE, NME, Drug Development Process

  • 1. Pharma Sector S e p t e m b e r ,1 2 2 0 1 1 S a l im H a j ia n i P r it i P iy u s h Jig a r S h a h
  • 2.
  • 3. Pharma Business Basics  Formulation Business ( Glenmark,Lupin)  API ( Active Pharma Ingredient)  NCE ( New Chemical Entity)  NME ( New Molecular Entity) 3
  • 4. Pharma Business Basics 1 .F o r m u l a t io n b u s in e s s : F o r m u l a t io n is t h e p r o c e s s in w h ic h d if f e r e n t c h e m ic a l s u b s t a n c e s ,in c l u d in g t h e a c t iv e d r u g ,a r e c o m b in e d t o t o p r o d u c e f in a l m e d ic a l p r o d u c t . 2 .AP I : An a c t iv e P h a r m a in g r e d ie n t (AP I)is t h e s u b s t a n c e o f a p h a r m a c e u t ic a l d r u g o r a p e s t ic id e t h a t is b io l o g ic a l l y a c t iv e . T e r m s in s im il a r u s e in c l u d e a c t iv e p h a r m a c e u t ic a l in g r e d ie n t (AP I)a n d b u l k a c t iv e in m e d ic in e ; in p e s t ic id e f o r m u l a t io n s a c t iv e s ubs tan ce may be us ed . 3 .N C E /N M E : A N e w c h e m ic a l e n t it y (N C E ), o r n e w m o l e c u l a r e n t it y (N M E ), is , a c c o r d in g t o t h e u .s . F o o d a n d d r u g a d m in is t r a t io n , a d r u g t h a t c o n t a in s n o a c t iv e m o ie t y t h a t h a s b e e n a p p r o v e d b y t h e F D A in a n y o t h e r a p p l ic a t io n s u b m it t e d u n d e r s e c t io n 5 0 5 (b ) o f t h e F e d e r a l f o o d , d r u g , a n d c o s m e t ic a c t .
  • 5. Drug Develo pmen t F o r m u l a t io n s t u d ie s in v o l v e d e v e l o p in g a p r e p a r a t io n o f t h e d r u g w h ic h is b o t h s t a b l e a n d a c c e p t a b l e t o t h e p a t ie n t . F o r o r a l l y taken d r u g s ,t h is us ually in v o l v e s in c o r p o r a t in g t h e d r u g in t o a t a b l e t o r a c a p s u l e . It is im p o r t a n t t o a p p r e c ia t e t h a t a tablet c o n t a in s a v a r ie t y of other s u b s t a n c e s a p a r t f r o m t h e d r u g it s e l f ,a n d s t u d ie s h a v e t o b e c a r r ie d o u t t o e n s u r e th at th e d rug is c o m p a t ib l e w it h t h eDrugo t h e r s u b s t a n c e s . Phase Manner Development of s e  C l in ic a l T r ia l P h a s e I D r u g L o a d  C l in ic a l T r ia l P h a s e II  C l in ic a l T r ia l P h a s e III (F e a s ib il it y o n t h e b a s is o f T e m p e r a t u r e ,h u m id it y ,o x id a t io n a n d p h o t o l y s is (U l t r a v io l e t c l e a r a n c e )
  • 6. Indian Pharma Story India Pharma sector will lead to US $ 21 b by 2015 The Indian Domestic Pharma Story is founded on 4 Pillars,What we call as 4 A'  Affordabability  Access  Awareness  Ailments
  • 7.
  • 8.
  • 9.
  • 10. Indian Pharma Market is growing CAGR @ 6% & will reach to 12,72,121,cr. Market by 2015.
  • 11.
  • 12.
  • 13. More Details on Ailments.
  • 14.
  • 15. USFDA Approval in Pharma sector? 1. USFDA approval is needed for launching medicine in open market in US. 2. Drugs are feasible on Temperature,Humidity,Oxidation. 3. Drugs are in line with Medical Formulation for curing the disease or reducing the impact of the diseases.
  • 16. Latest FDA Approvals ,Launch & Tie ups in Pharma Sector.  Glenmark gets USFDA approval for hypertensive drug.  Sun Pharma receive USFDA nod for generic proscar tablet.  Dr. Reddy's resolve patent litigation of generic Lipitor with Pfizer.  Lupin to Market Sanofi's CNS brands in Phillippines.  Dr. Reddy's launches Allegra D24 OTC Tablet in US Market.  Rainbaxy Launches Painkiller in Domestic Market.  Orchid restarts production of API Facility.
  • 17. The upcoming patent cliff : T h e l e a d in g g l o b a l p h a r m a c e u t ic a l f ir m s a r e f a c in g s o m e c h a l l e n g in g t im e s a s a s ig n if ic a n t n u m b e r o f p a t e n t s f o r b r a n d e d d r u g s a r e s e t t o e x p ir e o v e r t h e n e x t f iv e y e a r s . F r o m 2 0 1 1 -2 0 1 5 , t h e t o t a l v a l u e (a s m e a s u r e d b y a n n u a l s a l e s )o f p a t e n t e x p ir a t io n s is e x p e c t e d t o b e a r o u n d $ 1 0 0 b il l io n , a s ig n if ic a n t in c r e a s e f r o m $ 7 3 b il l io n in p a t e n t e x p ir a t io n s o v e r t h e p r e v io u s f iv e y e a r s . In d ia n p h a r m a c e u t ic a l c o m p a n ie s c a n c a p it a l iz e o n t h is o p p o r t u n it y d u e t o t h e ir f ir s t m o v e r a d v a n t a g e , s t r o n g p r o c e s s e n g in e e r in g s k il l s a n d a c c e s s t o l o w -c o s t t a l e n t .E x a :
  • 18. Benefits & Precautions of Patent Expiration to Indian Companies 1.Globally Competitive in the 1.Focus on Long Term & Niche generic business Segment. 2.The First Mover Advantage 2.Strong Competitive position 3.Low-Cost Manufacturing 3.Backward integration. Base 4.Deep and Low-cost talent Pool.
  • 19. Details on Precautions 1.Focus on Complex & Niche Segment : Long-term growth can be generated by focusing in specialized therapeutic areas and/or more complex molecules. 2.Strong Competitive Positioning : New drug delivery systems can be used to compete with drugs whose formulation patents have not expired. These segments tend to be less competitive, but development of such applications requires significant capabilities in both research and marketing. 3.Backward integration: Backward-integrated generic players with captive Active Pharmaceutical Ingredient ( API) manufacturing capabilities are likely to enjoy higher margins.
  • 20. Domestic Pharma Sector Growth Rate : 16.5% in 2010. Highest Market Share : Cipla Larges selling Brands : Cough Medication “Corex” ( Pfizer) Largest Growing Drugs : Abbott's insulin ( 27% rise) Novartis Voveran ( 6%)
  • 21. Important comments by Azaz Motiwala on Indian Pharma • T h e G l o b a l m a r k e t is e x p e c t e d t o g r o w b y 7 % t o 8 % o v e r n e x t 5 y r s . R e a c h in g a n a n t ic ip a t e d $ 1 .7 t r il l io n 2 . In d ia n c o n s u m e r s p e n d 1 % o f h is t o t a l in c o m e o n D r u g s & P h a r m a c e u t ic a l ,h o w e v e r r is e in p e r c a p it a in c o m e w il l t r ip l e t h e s a m e b y 2 0 2 0 . 3 . G o v e r n m e n t s l o n g t e r m v is io n o f m a k in g q u a l it y h e a l t h c a r e a f f o r d a b l e ,a t l e a s t 5 0 % o f In d ia n p o p u l a t io n s h o u l d b e c o v e r e d u n d e r h e a l t h in s u r a n c e b y 2 0 2 0 a g a in s t 1 5 % t o d a y . 4 . In d ia n h e a l t h c a r e in d u s t r y is e s t im a t e d t o b e w o r t h o f $ 2 7 5 .6 b il l io n . 5 . In d ia n p h a r m a in d u s t r y w il l b e in T o p 5 in t h e w o r l d b y 2 02 0. Azaz Motiwala ,F o u n d e r ,Ik o n M a r k e t in g C o n s u l t a n t
  • 22. Key Success factor for evaluation of Indian Pharma companies
  • 23. Price Movements for BSE Health care Index v/s BSE Sensex
  • 24. G L E N M AR K P H AR M A
  • 25. Introduction • R e s e a r c h -d r iv e n , g l o b a l , in t e g r a t e d p h a r m a c e u t ic a l co mpan y • L e a d in g p l a y e r in d is c o v e r y o f n e w m o l e c u l e s – N C E s (n e w c h e m ic a l e n t it y ) – N B E s (n e w b io l o g ic a l e n t it y ) – 1 3 m o l e c u l e s in v a r io u s s t a g e s o f p r e c l in ic a l & c l in ic a l d e v e l o p m e n t • S ig n if ic a n t p r e s e n c e in Br a n d e d G e n e r ic s acro s s E m e r g in g E c o n o m ie s • O u t -l ic e n s in g d e a l s w it h G l o b a l P h a r m a m a j o r s r e - a f f ir m s G l e n m a r k ’s s t r e n g t h in d is c o v e r y • 1 2 M a n u f a c t u r in g f a c il it ie s l o c a t e d in 4 c o u n t ir e s
  • 26. B u s in e s s M o d e l E l u c id a t e d
  • 27. Specialty Business : Drug Discovery • P r im a r il y f o c u s e d in t h e a r e a s o f – in f l a m m a t io n – m e t a b o l ic d is o r d e r s – p a in • R o b u s t p ip e l in e o f m o l e c u l e s (N C E ’s & N B E ’s ) – 7 m o l e c u l e s a r e in c l in ic a l t r ia l s s t a g e • P o t e n t ia l p e a k s a l e s o p p o r t u n it y f o r e a c h m o l e c u l e b e in g in t h e r a n g e o f U S D 1 -1 0 b il l io n
  • 29. Specialty Business :Formulations Business • C u r r e n t l y o r g a n iz e d a r o u n d f o u r r e g io n s – In d ia – L a t in Am e r ic a – Ce n t r a l Ea s t e r n Eu r o p e – S e m i R e g u l a t e d M a r k e t s o f Af r ic a /As ia F o c u s o n t h e r a p e u t ic a r e a s d ermato lo gy -c a r d ia c – a n t i-in f e c t iv e s -d ia b e t e s r e s p ir a t o r y -g y n e c o l o g y -C N S
  • 30. Specialty Business : Generics • G l e n m a r k G e n e r ic s L t d (G G L ), a s u b s id ia r y o f G l e n m a r k Ph a r m a • It c o m p r is e s o f U S G e n e r ic s , E u r o p e G e n e r ic s , AP I a n d O n c o l o g y b u s in e s s e s • G G L s M a r k e t in g S t r a t e g y : – d e v e l o p in g , m a n u f a c t u r in g , s e l l in g , a n d d is t r ib u t in g g e n e r ic p r o d u c t s t h r o u g h w h o l e s a l e r s , r e t a il e r s a n d p h a r m a c y c h a in s • G G L s f o c u s o n n ic h e b u s in e s s s e g m e n t s : – D e r m a t o l o g y ,H o r m o n e s ,C o n t r o l l e d S u b s t a n c e s , O n c o l o g y , M o d if ie d R e l e a s e P r o d u c t s • It m a r k e t s a r o u n d 6 5 AP Is g l o b a l l y , in c l u d in g t h e U S , v a r io u s c o u n t r ie s in t h e E U , S o u t h Am e r ic a a n d In d ia . • G G L h a s s o f a r f il e d 4 1 D M F s (D r u g M a s t e r F il e s )w it h t h e U S -F D A.
  • 33. St r e n g t h b e yo n d Nu m b e r s • G r o w t h in n e t s a l e s d r iv e n b y r o b u s t g r o w t h in S p e c ia l t y & G e n e r ic s b u s in e s s e s in t h e d o m e s t ic a n d g l o b a l m a r k e t s • B o o k e d o u t -l ic e n s in g in c o m e r e l a t e d t o G B R 5 0 0 o f 1 1 1 .2 c r o r e a s a g a in s t 8 9 .5 c r o r e (r e l a t e d t o G R C 1 5 3 0 0 )in Q 1 F Y1 1 . T h e r e m a in in g U S $ 2 5 m il l io n w il l b e b o o k e d in Q 2 F Y1 2 • L a t in Am e r ic a n a n d C a r ib b e a n m a r k e t s s a l e s w it n e s s e d r o b u s t gro w th d ue to lo w bas e • L AT AM R e g io n t o b e E B ID T A n e g a t iv e f o r n e x t 2 y e a r s a s it is s t il l in in v e s t m e n t p h a s e . T h u s im p l y in g r o b u s t r e v e n u e g r o w t h p o t e n t ia l in t h e l o n g e r t e r m • M a n a g e m e n t g u id a n c e f o r g r o w t h o f 2 5 % g r o w t h in U S in F Y 2 01 2 d u e t o : – L a u n c h o f k e y p r o d u c t s : M a l a r o n e & C u t iv a t e in Q 3 F Y1 2 a n d Q 4 F Y 1 2 r e s p e c t iv e l y
  • 36. Trend in EBITDA and PAT Margins
  • 37. Gl e n m a r k h as v a r io u s prod ucts in c l in ic a l d evelo pmen t s tages . – C r o f e l e m e r c o m p l e t e d it s P h a s e III c l in ic a l t r ia l s a n d is e x p e c t e d t o l a u n c h in b e g in n in g o f F Y 1 3 . – Al s o r e c e iv e d $ 1 5 m n f r o m S a l ix P h a r m a f o r u p g r a d in g m a n u f a c t u r in g f a c il it y t o m e e t h ig h e x p e c t e d d e m a n d o f Cr o f e l e m e r . • L a u n c h e d t w o p r o d u c t s in Q 1 F Y 1 2 i.e . V o r t h T P & D o r ig e n in t h e o r t h o p a e d ic s e g m e n t . • r e c e iv a b l e d a y s h a v e d r o p p e d t o 1 2 5 f r o m 1 4 0 • S e t t l e m e n t o f l im it e d c o m p e t it io n p r o d u c t s l ik e F l u t ic a s o n e P r o p io n a t e l o t io n (m a r k e t s iz e U S $ 4 4 m n ) a n d H y d r o c o r t is o n e B u t y r a t e c r e a m (m a r k e t s iz e U S $ 3 8 m n ) w o u l d a l s o p e p u p t h e g r o w t h in t h e n e x t 2 years • L a s t f is c a l it l a u n c h e d 1 9 p r o d u c t s a n d plan s to l a u n c h 1 5 p r o d u c t s in c u r e n t f is c a l .
  • 41. Strengths Risks S t r o n g R & D p ip e l in e D e l a y in p r o d u c t a p p r o v a l s Pl a n s t o l a u n c h 7 p r o d u c t s R is in g c o m p e t it io n in t e n s it y a n d f il e 1 5 -2 0 AN D A’s in F Y 1 2 Fr a g m e n t e d Ma r k e t S h a r e S a t is f a c t o r y p r o s p e c t s f o r R a p id P r ic e E r o s io n o u t -l ic e n s in g d e a l s Ad v e r s e v e r d ic t in t h e F o c u s o n n ic h e s e g m e n t s in t h e o n g o in g T a r a k a L it ig a t io n U S m a r k e t w h e r e p r ic e e r o s io n is n o t s t e e p in c l u d e s : H ig h l y r e g u l a t e d m a r k e t o r a l c o n t r a c e p t iv e s Co n t r o l l e d S u b s t a n c e s Dermato lo gy
  • 42. LUPIN
  • 43. Formulations Business P r o m o t e d b y D r . D e s h B a n d h u G u p t a , a f ir s t g e n e r a t io n e n t r e p r e n e u r , L P C is In d ia ’s f if t h l a r g e s t c o m p a n y b y d o m e s t ic s a l e s . G l o b a l F o r m u l a t io n s b u s in e s s c o n s t it u t e s c l o s e t o 8 4 % o f L u p in ’s o v e r a l l b u s in e s s m ix , a n d in t e r m s o f g e o g r a p h ie s , U S A is it s l a r g e s t m a r k e t o u t s id e In d ia . 6 7 % o f t h e o v e r a l l b u s in e s s o f t h e C o m p a n y c o m e s f r o m In t e r n a t io n a l M a r k e t s
  • 44.
  • 45. Active Pharmaceutical Ingredients ( API) • AP I s p a c e is d r iv e n b y t h e t w o As ia n g ia n t s C h in a a n d In d ia .
  • 46. Th e C o m p a n y ’s w id e prod uct bas k et c o m p r is in g f o r m u l a t io n s f r o m C V S , C N S , An t i-As t h m a , An t i-T B , D ia b e t o l o g y , D e r m a t o l o g y , G I, a n d o t h e r t h e r a p y segments • P l a n t s h if t f r o m G o a t o In d o r e S E Z • M e d ic is P h a r m a t o u s e L u p in R & D p l a t f o r m f o r U S $ 2 0 m il l io n T o m a r k e t E l i L il l y ’s H u m in s u l in p r o d u c t s in d o m e s t ic mark et wo rth 1 25 • S ig n e d a n a g r e e m e n t w it h N a t c o P h a r m a t o j o in t l y c o m m e r c ia l is e a g e n e r ic e q u iv a l e n t G S K ’s c a n c e r d r u g T y k e r b w o r t h U S $ 1 1 3 .6 m il l io n
  • 47.
  • 48.
  • 49. Valuation • O n t h e U S f r o n t , t h e l a u n c h o f Al l e r n a s e • N e w p r o d u c t l a u n c h e s e s p e c ia l l y O c s w il l d e t e r m in e t h e c o u r s e . T h e l a u n c h o f g e n e r ic F o r t a m e t (a n t i- d ia b e t ic )a n d Z ip r a s id o n e (a n t i-p s y c h o t ic )in t h e c u r r e n t f is c a l a n d T r ic o r (a n t i c h o l e s t e r o l )a n d C o m b iv ir (a n t i- r e t r o v ir a l )in F Y 1 3 w il l b e k e y t r ig g e r s t o w a t c h o u t for. • L a u n c h e d 6 n e w p r o d u c t s in Ja p a n l a s t f is c a l a n d p l a n s f o r 6 t o 7 in F Y 1 2 • S u p r a x s a l e s g r e w 3 0 % a n d An t a r a in s in g l e d ig it • F il e d 4 AN D As t a k in g t o t a l t o 1 5 2 – 51 appro ved P l a n s t o l a u n c h 8 t o 9 p r o d u c t s in U S b e t w e e n Q 2 F Y 1 2 – Q 4 F Y1 2 S o u t h Af r ic a s a l e s in c r e a s e d b y 4 7 %
  • 50.
  • 51.
  • 52.
  • 54.
  • 55. Strengths Risks • G iv e n it s h e a l t h y g e o g r a p h ic m ix (8 0 % s a l e s • E a r l ie r t h a n e x p e c t e d f r o m In d ia , U S & Ja p a n ) G e n e r ic c o m p e t it io n in • D if f e r e n t ia t e d p r o d u c t s Suprax a n d r o b u s t f in a n c ia l • IN R a p p r e c ia t io n w o u l d m e t r ic s . h u r t , g iv e n it s e x p o s u r e • B ig p r o d u c t r o l l o u t in to glo bal markets t h e U S , in c l u d in g n ic h e /P IV • Re a s o n a b l e e x p o s u r e t o oppys the d o m e s t ic • G r o w t h in e m e r g in g f o r m u l a t io n s market m a r k e t s (in c l u d in g In d ia )& (c 3 0 % o f s a l e s ) Ja p a n • In a b il it y t o e f f e c t iv e l y • M a r g in im p r o v e m e n t b y s cale up the Ky o w a b a c k e n d in g s o u r c in g t o o p e r a t io n s o r An t a r a In d ia f r o m Ja p a n & r is in g s ales . US s a l e s
  • 57. Stock Data Market Cap Rs179.4bn/US$4.0bn Share Outstanding 84.7 52-week Range (Rs) 2478/1842 Free Float(%) 49.3 FII(%) 16.8 Sensex Return 12m(%) 5.2
  • 58. IN T R O D U C T IO N GSK Pharma is the 4th largest formulations company in India, with a strong presence in segments like dermatology, respiratory and vaccines. Its parent has one of the richest product and R&D pipelines among Pharma companies worldwide .T h e c o m p a n ie s in t h e p r o c e s s o f e x p a n d in g it s p r e s e n c e in t h e l if e -s t y l e s e g m e n t l e d b y n e w l a u n c h e s f r o m t h e p a r e n t 's p o r t f o l io , l a u n c h o f b r a n d e d g e n e r ic s a n d in -l ic e n s in g .
  • 59. GSK Pharma is a 50% subsidiary of GSK Plc ( UK) and is being currently managed by Dr. Hasit Joshipura ( MD) . Maintaining a leading presence in India and sustaining one of the highest p r o f it a b il it y a n d r e t u r n r a t io s in t h e in d u s t r y d e s p it e m in is c u l e p r e s e n c e in t h e h ig h -g r o w t h l if e -s t y l e s e g m e n t s is t h e k e y a c h ie v e m e n t .
  • 60. SPECIALLTY OF BUSINESS GSK derives majority of its business from acute therapeutic s e g m e n t s a n d h a s v e r y l it t l e p r e s e n c e in t h e c h r o n ic s e g m e n t s . G S K d e r iv e s 9 5 % o f it s r e v e n u e s f r o m a c u t e t h e r a p e u t ic s e g m e n t s w it h d o m in a n t p r e s e n c e in An t i-in f c e t iv e s , d e r m a t o l o g y , p a in m a n a g e m e n t a n d V it a m in s . It r a n k s n o .1 in d e r m a t o l o g y s e g m e n t , n o .3 in P a in man agemen t an d V it a m in s s e g m e n t s a n d n o 5 in AI a n d r e s p ir a t o r y segments.
  • 61. SPECIALLTY OF BUSINESS G S K is a m o n g t h e l a g g a r d s w h e n it c o m e s t o laun ch o f n ew p r o d u c t s . GS K h a s laun ch ed very few n ew pro d ucts o ver th e l a s t 4 y e a r s c o m p a r e d t o it s p e e r s . It h a s l a u n c h e d 5 n e w p r o d u c t s (in c l u d in g l in e e x t e n s io n s ) a n n u a l l y o v e r t h e l a s t 4 years . R a m p -u p in d o m e s t ic f o r m u l a t io n s r e v e n u e s is d r iv e n l a r g e l y b y e x is t in g p r o d u c t s . .
  • 62. SPECIALLTY OF BUSINESS N e w l a u n c h e s : G S K l a u n c h e d t w o in n o v a t iv e p r o d u c t s , n a m e l y Revol e (o r a l ad platelet gen erato r) an d Votrient (o n c o l o g y ) in Ju l y ’1 1 . In a d d it io n , t h e c o m p a n y h a s a l s o laun c h a bran d ed g e n e r ic a n d a d e r m a prod uct f r o m t h e S t ie f e l p o r t f o l io . GS K r e m a in s o n t r a c k t o laun c h e ig h t b r a n d e d g e n e r ic s in C Y 1 1 .
  • 63.
  • 65. Top 10 brands of GSK
  • 66. VALUATION Year to Dec CY 09E CY 10E CY 11E CY12E 12 Net Revenue(Rs mn 19078 21511 25146 28798 10 Net Profit (Rs mn) 5097 5606 703 8415 8 Dil.EPS(Rs) 59.1 68.3 83.9 99.3 Column 1 6 Column 2 Column 3 % Chg YoY 8.1 15.5 22.8 18.5 4 P/E(X) 35.9 31.1 25.3 21.4 2 EV/EBITDA(X) 23.9 20.9 16.4 13.3 0 Row 1 Row 2 Row 3 Row 4
  • 67. Distribution and Reach GSK derives 60% of its revenue from metros and Class-I towns compared with an industry average of 63% . O v e r t h e p a s t f o u r y e a r s r e v e n u e C AG R f o r a l l g e o g r a p h ie s h a s l a g g e d the in d u s t r y a v e r a g e . H o w e v e r , G S K 's C Y 1 0 g r o w t h in a l l g e o g r a p h ie s w a s in h ig h e r d o u b l e d ig it s .
  • 68.
  • 69. Improvement in MR productivity G S K 's r e v e n u e p o s t e d C AG R o f 8 .7 % o v e r C Y 0 4 -1 0 a n d it s s a l e s f o r c e p o s t e d C AG R of 5 .9 % over C Y0 4 -1 0 , im p l y in g im p r o v e m e n t in s a l e s f o r c e p r o d u c t iv it y . In 2 0 0 4 , G S K d e r iv e d IN R 6 .5 m r e v e n u e p e r M R , w h ic h r o s e t o IN R 7 .7 m in C Y 1 0 . G S K 's c u r r e n t M R p r o d u c t iv it y is a r g u a b l y o n e o f t h e b e s t in t h e in d u s t r y .
  • 70.
  • 73. Cadila is amongst one of the largest domestic pharma companies in India with a strong focus on the global INTRODUCTION generics opportunity. Th e c o m p a n y is g r a d u a l l y b u il d in g it s p r e s e n c e in t h e r e g u l a t e d g e n e r ic markets beginning with the US and France It a l s o p l a n s t o t a p s o m e u n iq u e o p p o r t u n it ie s t h r o u g h it s Jv s w it h N y c o m e d , H o s p ir a .B a y e r a n d Bh a r a t S e r u m s . It is p r o m o t e d b y Mr. Pankaj Patel. H is k e y a c h ie v e m e n t is S u s t a in in g s t r o n g g r o w t h a n d r e t u r n r a t io s c o u p l e d w it h a v e r y c o n s e r v a t iv e , l o w -r is k m a n a g e m e n t . .
  • 74. SPECIALLTY OF BUSINESS Cadila is among the top three players in two of the largest therapeutic segments, CVS and GI. The company ranks first in the fast growing gynecology Segment. C a d il a 's in t e r n a t io n a l b u s in e s s , g iv e n it s s t r o n g c h e m is t r y s k il l s a n d p r a g m a t ic m ix of it s g e o g r a p h ic presence an d p a r t n e r s h ip s .
  • 75.
  • 76. The top 3 therapeutic segments, CVS, GI and gynecology, Prescription ranking of Cadila contribu about half of Cadila's domestic formulations revenue. Ot h er lar g e s eg m e n t s u c h as r e s p ir a t o r y a n d a n t i-in f e c t iv e , c o n t r ib u t e 1 1 % a n d 1 0 % r e s p e c t iv e l y t o t o t al r ev en u e. Ov er t h e p as t 1 0 ye ar s , t h e c o n t r ib u t io n o f C V S a n d G Is e g m e n t s t o r e v e n u e r o s e f r o m 2 4 % t o 3 7 % w h il e t h a t o f r e s p ir a t o r y a n d a n t i-in f e c t iv e s e g m e n t s f e l l f r o m o v e r 3 2 % in F Y0 1 t o l e s s t h a n 2 1 % in F Y1 0 .
  • 78. Distribution and Reach Cadila derives 65% of its revenue from metros and class-I town compared with 63% of the industry average. In the past four years, revenue CAGR for all geographies except metros were in line or marginally better than that of the industry average.
  • 79.
  • 80. Valuation FY10 FY11 FY12 FY13 summary EPS(IN Rs) 24.7 37.7 40.5 52.9 PE(X) 35.4 25.2 21.6 16.5 Target PE(X) 38.6 27.5 23.6 18 EV to 24.8 20.5 17 12.6 EBITDA(X) Price to 11.8 8.9 6.8 5.2 book(x) RoNW(%) 37 38.7 34.3 34.7
  • 81. Improvement in MR productivity Cadila's domestic formulations business revenue posted 9.2% CAGR over FY04-10 and its sales force posted 11.3% CAGR, implying negative productivity of the workforce. In 2004, Cadila derived sales of INR4.1m per MR, which fell to INR3.6m in FY10. Cadila's performance was below average, compared with the average of performances covered in the report . .
  • 82.