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H.Pylori
Classification:
Domain Bacteria
Phylum proteobacteria
Class Epsilonproteobacteria
Order Campylobacterales
Family Helicobacteriaceae
Genus Helicobater
Classification:
Helicobacteraceae:
Genera:
Helicobacter, Wolinella, Flexispira,S
ulfurimonas, Thiomicrospira, and
Thiovulum
Microbiology of H. pylori
- Genome
-Morphology
-Cell envelope, and LPS
-Growth requirements
- Metabolism
CLINICAL ASPECTS OF H. PYLORI
ASSOCIATED DISEASES
• Acute and chronic gastritis
-Acute gastritis
-Chronic gastritis
• Peptic ulcer disease
-Gastric ulcers
-Duodenal ulcers
• Gastric MALT lymphoma
• Atrophic gastritis, intestinal
metaplasia, gastric cancer
Natural History of Helicobacter pylori Infection
Role of H. pylori Virulence
Factors
cag A (“cytotoxin associated gene A”)
VacA (vacuolating cytotoxin A)
H.pyloriPathogenesis of
H.pyloriPathogenesis of
Ph d class
Ph d class
Ph d class
Ph d class

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Ph d class