2. Parenteral drug administration
Parenteral drug administration means, any non-
oral of administration, but is generally interpreted
as relating to injecting directly into the body,
bypassing the skin and mucous membranes. The
common parenteral routes are intramuscular (IM),
subcutaneous (SC) and intravenous (IV).
4. What is hormonal drug?
Hormonal drug may include giving hormones
to the patient or using medications that
decrease the level of hormones in the body.
general sense, hormone therapy may be
used to treat some forms of cancer. It may
also be used for thyroid disorders, and
illnesses associated with hormone production
or use.
5. Types of hormonal injections
• Hormonal injections for breast
enlargement.
• Hormonal injection for birth control.
• Hormonal injections for weight loss.
• Hormonal injections for contraceptive.
• Hormonal injections for pregnancy.
• Hormonal injections for prostate cancer
etc.
6. Birth control injection
The birth control shot is an injection of a hormone
that prevents pregnancy. Each shot prevents
pregnancy for three months. The shot is also
known by the brand name Depo-Provera, or by
the name of the medicine in the shot, DMPA.
7. Benefits
• Highly effective at preventing pregnancy.
• Injected every 12 weeks.
• Minimal drug interactions.
• Decreased risk of iron deficiency anemia.
• Decreased risk of endometrial cancer.
9. Growth hormone injections weight loss
A few small studies have linked HGH injections with
fat loss and muscle gain. But the changes seen
were minimal -- just a few pounds -- while the
risks and potential side effects are not. And
experts warn that HGH is not approved by the
Food and Drug Administration (FDA) for weight
loss.
10. Hormonal injection for pregnancy
• An oil-based solution (sometimes called progesterone in oil)
• Widely used; the oldest, most established method of
progesterone delivery
• Injected into the once a day
• Require long, thick needle to penetrate layers of skin and fat
• Difficult to administer by yourself
• Injections may be painful
• Skin reactions are common
11. progesterone
Progesterone is a hormone. Hormones are chemicals made by
the body.
Progesterone plays a key role during pregnancy. In early
pregnancy, it helps your uterus (womb) grow and keeps it
from having contractions. In later pregnancy, progesterone
helps your breasts get ready to make milk. It also helps
your lungs work harder to give oxygen growing baby.
12. Injection types
There are two kinds of progesterone treatment:
• Vaginal progesterone may help reduce your risk
for premature birth.
• Progesterone shots may help reduce your risk for
premature birth.
13. Hormone therapy and prostate cancer
Hormones occur naturally in your body. They control
the growth and activity of normal cells. Cancer of
the prostate gland depends on the male hormone
testosterone to grow. So lowering the amount of
testosterone in the body can lower the risk of an
early prostate cancer coming back after
treatment.
14. There are different types of injections that lower testosterone
levels
• Luteinising hormone (LH) blockers – include goserelin
(Zoladex), buserelin (Suprefact).
• Gonadotrophin releasing hormone (GnRH) blockers –
degarelix (Firmagon),
• Anti androgens – include flutamide (also called Drogenil),
bicalutamide.
15. The contraceptive injection
• If used correctly, the contraceptive injection is more than
99% effective.
• It can be useful for women who might forget to take the
contraceptive pill every day.
• The contraceptive injection may provide some protection
against cancer of the womb and pelvic inflammatory
disease.
16. compositions
Contraceptive Injection contains
medroxyprogesterone acetate and estradiol
cypionate as its active ingredients.
Medroxyprogesterone acetate is a white to off-
white, odorless crystalline powder that is stable in
air and melts between 200°C and 210°C. It is
freely soluble in chloroform, soluble in acetone
and dioxane, sparingly soluble in alcohol and
methanol, slightly soluble in ether, and practically
insoluble in water.
17. DOSAE AND ADMINISTRATION
FIRST INJECTION
• Within first 5 days of the onset of a normal menstrual period, or
• Within 5 days of a complete first trimester abortion, or
• No earlier than 4 weeks postpartum if not breastfeeding.
SECOND AND SUBSEQUENT INJECTIONS
• Monthly (28 to 30 days) after previous injection, not to exceed 33 days.
• If the patient has not adhered to the prescribed schedule (greater than
33 days since last injection), pregnancy should be considered and she
should not receive another injection until pregnancy is ruled out.
• Shortening the injection interval could lead to a change in menstrual
pattern.
• Do not use bleeding episodes to guide the injection schedule.
18. Store at 20°-25°C (68°-77°F); excursions
permitted to 15-30°C (59-86°F)
19. Possible side effects include:
• Irregular menstrual periods, or no periods at all.
• Headaches.
• Nervousness.
• Depression.
• Dizziness.
• Acne.
• Changes in appetite.
• Weight gain.
20. Side effects from long term treatment
• Weight gain
• Memory problems
• Mood swings and depression
• Bone thinning (osteoporosis)
• Risk of earlier heart attack
21. Containers for hormonal injection
ideal properties
• Does not affect its contents
• No surface changes at temp. & pressure
associated with sterilization
• Should protect from light when the contents are
photosensitive
• Container should be cheap enough to dispose
after one use or be easy to clean & reuse
22. Types of containers
• Ampoules: single-dose glass containers
with capacity of 0.5-50ml.
• Made from neutral or soda glass.
• Liberate gas particles on opening.
• Sealed by heat fusion to exclude MO .
• Used for solutions or powders.
23. storage
Many hospital pharmacies are reluctant to store
parenteral fluids longer than 24 to 48 h because of
concern about possible microbial contamination.
We evaluated the safety of prolonged refrigerated
storage routinely in a hospital pharmacy and
stored at 4°C for up to 15 days.