4. Objectives
Definition of Cancer and Tumor
Classification of cancer and tumor
Properties of cancer cell
Cancer cell VS normal cell
Causes of cancer
Signs and symptoms of cancer
Cell death (Apoptosis and necrosis)
Cancer in different organs
Cancer treatments
6. CANCER
An uncontrolled division of abnormal cells in a part of
the body is called cancer.
When good cells go bed.
Loss of Cell-cycle Control.
Before a cell divides, the DNA is checked to make sure
it has replicated correctly. (If DNA does not copy itself
correctly, a gene mutation occurs.
7. TUMAR
Tumor is an abnormal mass of tissue resulting from
uncontrolled division (cancer).
Tumor is of two types;
(1) Malignant tumor (cancerous)
(2) Benign tumor (non-cancerous)
8. (1) Malignant Tumor
Invade or spread to other parts of the body.
High rate of division.
Spread by forming Metastasis.
Cells travel through circulation.
Very difficult to treat.
9. Cancer Metastasis
Metastasis is the spread of cancer to other location in
the body.
The new tumors are called metastatic tumors, while
the original site is called primary tumor.
Basal lamina of epithelium normally provides barrier.
Malignant tumor cells break, free of attachments to
adjoining cells.
Attach to basal lamina.
Secrete enzymes that digest extracellular proteins.
Migrate into circulatory system.
12. (2) Benign Tumor
Do not spread to other part of the body.
Generally localized and of small size
Slow rate of division.
Cells that closely resemble, and may function, like
normal cells.
Do not break out of originating organ.
Easily to removed by surgery.
13. Classification of Cancer
Cancers are classified by the type of cell.
(1) Carcinoma
(2) Sarcoma
(3) Lymphoma and Leukemia
(4) Germ Cell Tumor
(5) Blastoma
14. Classification (Cont…)
(1) Carcinoma:
Cancers derived from epithelial cells.
(2) Sarcoma:
Cancers arising from connective tissue (i.e. bone,
cartilage, blood etc).
(3) Lymphoma and Leukemia:
These two classes of cancer arise from hematopoietic
(blood forming) cells.
15. Classification (Cont…)
(4) Germ Cell Tumor:
Cancers derived from pluripotent cells, most often
presenting in the testicles and ovary (seminoma and
dysgerminoma respectively).
(5) Blastoma:
Cancers derived from immature “precursor” cells or
embryonic tissue.
16. Properties of Cancer Cells
Cancer cells show uncontrolled mitotic divisions causing unorganised
growth.
Due to uncontrolled growth and division of cells, a tumor (also called
Neoplasm is generally formed).
They are far less adhesive than the normal cells.
They exhibit a number of alterations on cell surface, in the cytoplasm
and in their genes.
They do not undergo differentiation.
They lose the ability to communicate with other cells through chemical
signals.
They also lose sensitivity to anti-growth signals from surrounding cells.
They lose the adhesion molecules that keep them bonded to
neighboring cells.
Cancer arises from a loss of normal growth control.
17. Cont….
Cancer is a genetic disease:
–Inherited cancer
–Sporadic cancer
Cancer typically involves a change in gene expression/function:
–Qualitative change
–Quantitative change
lack of contact inhibition
Loss of limitations on the number of cell divisions
Ability to grow in culture (medium) – normal cells do not grow well in
culture.
In laboratory cultures, normal cells divide only when attached to a
surface.
Angiogenesis – secrete substances that cause blood vessels to grow
towards tumor.
23. Normal Cell VS Cancer Cell
.
Cells anchor to dish surface and
divide (anchorage dependent).
When cells have formed a
complete single layer, they stop
dividing (density-dependent
inhibition).
If some cells are scraped away,
the remaining cells divide to fill
the dish with a single layer and
then stop (density-dependent
inhibition).
25. Normal Cell VS Cancer Cell
Cells in culture and in vivo exhibit
contact-inhibition
Cancer cells lack contact inhibition
feedback mechanisms. Clumps or
foci develop.
26. Causes of Cancer
The great majority of cancers 90-95% cases, are due to
environmental factors.
The remaining 5-10% are due to inherited genetics.
28. (2) Inherited Genetics
Cancer is fundamentally a disease of tissue growth
regulation failure.
In order for a normal cell to transform into a cancer
cell, the genes that regulate cell growth and
differentiation must be altered.
The affected genes are divided into two broad
categories;
(i) Oncogenes
(ii) Tumor Suppressor Genes
29. (Cont…)
(i) Oncogenes:
Oncogenes are genes that promote cell growth and
reproduction.
(ii) Tumor Suppressor Genes:
Tumor suppressor genes are genes that inhibit cell
division and survivals.
30.
31.
32. Signs and Symptoms
When cancer begins, it invariably produces no
symptoms.
Signs and symptoms only appear as the mass continues
to grow (tumor).
34. Cell Death
There are two types of cell death;
(1) Apoptosis
(2) Necrosis
35. Apoptosis (Programmed Cell Death)
Apoptosis is a tightly regulated form of cell death, also
called the programmed cell death. Morphologically, it is
characterized by chromatin condensation and cell
shrinkage in the early stage. Then the nucleus and
cytoplasm fragment, forming membrane-bound apoptotic
bodies which can be engulfed by phagocytes.
Initiated by signal transduction process.
Does not cause inflammation.
Ends with fragmentation of cell into smaller bodies.
36. Necrosis (Lethal Injury)
In contrast, cells undergo another form of cell death,
necrosis, swell and rupture. The released intracellular
contents can damage surrounding cells and often cause
inflammation.
Un-programmed cell death and living tissues. (opposite to
apoptosis).
Initiated by direct cell damage mostly physically.
Cause inflammation.
Ends with total cell lysis.
40. Lung Cancer
In 2013, 174,470 people died from lung cancer
Since 1987, more women have died from lung
cancer that breast cancer
Symptoms: persistent cough, blood-streaked sputum,
chest pain
42. Breast Cancer
1 out of 8 women will develop breast cancer
(lifetime risk)
1 in 227: birth to age 39
1 in 25: ages 40-59
1 in 15: ages 60-79
Detection: mammograms, regular breast self-exams
Symptoms: lump in the breast, thickening, dimpling,
skin irritation, distortion or tenderness
43. (Cont…)
Risk factors: family history, hyperplasia, long menstrual
history, obesity after menopause, oral contraceptives
Treatment: lumpectomy, radical mastectomy, radiation,
chemotherapy
Prevention: exercise
44. Colon And Rectal Cancers
Third most common cancer in men and women with over
148,610 new cases diagnosed in 2013
Risk factors: over 50 years old, obese, family history of
colon or rectum cancer or polyps, diets high in fats, low in
fiber, smoking, high alcohol consumption, lack of exercise
90% of colorectal cancers are preventable
45. (Cont…)
Treatment: radiation, surgery, and possible
chemotherapy
Prevention: regular exercise, a diet heavy in fruits and
plant-origin foods, a health weight, and moderation in
alcohol consumption
46. Prostate Cancer
Most common cancer in American men, excluding skin
cancer
In 2013, 234,460 new cases diagnosed
1 in 3 men will be diagnosed in their lifetime
Prostate is a muscular, walnut-sized gland the surrounds
part of the urethra. Its primary function is to produce
seminal fluid.
47. (Cont…)
Symptoms: nonspecific, weak or interrupted urine flow,
difficulty starting or stopping urination
Risk factors: age, race, nationality, family history, diet,
lifestyle, and vasectomy
Prevention: diet high in lycopenes, vitamin E
48. Skin Cancer
Long term effects of sun exposure can result in skin cancer
Malignant melanoma, deadliest form of skin cancer
Sun give off 3 types of harmful rays:
UVA
UVB
UVC
Prevention: limit exposure to harmful UV rays, drink
more fluids than usual, apply cool compresses to skin,
moisturize skin
49. (Cont…)
What to look for – The ABCD rule
Asymmetry – half of mole does not look like the other half
Border irregularity – the edges are uneven
Color – pigmentation is not uniform
Diameter – greater than 6mm
50. Testicular Cancer
Affects nearly 8,250 young men in 2013
Men between the ages 15-35 are at the greatest risk
Important to practice regular testicular self exams
Lance Armstrong Foundation “LiveStrong” campaign
to raise awareness
51. Ovarian Cancer
Fifth leading cause of cancer death for women, 20,180 new
cases diagnosed reported in 2012
Most common symptom is enlargement of the abdomen
Risk factors include: family history, age, childbearing,
cancer history, fertility drugs, talc use in genital area,
genetic predisposition
52. Cont….
Prevention: diet high in vegetables and low in fat,
exercise, sleep, stress management, and weight control
53. Cervical and Endometrial (Uterine)
Cancer
9,710 new cases of cervical cancer, 41,200 cases of
endometrial cancer in 2010
Pap test – cells are taken from the cervical region
Risk factors:
Cervical cancer: early age at first intercourse, multiple
sex partners, cigarette smoking, and certain STIs
Endometrial cancer: age, endometrial hyperplasia,
overweight, diabetes, and high blood pressure