BioPharmic is developing a blood substitute called Blood BackUp to address unmet needs in situations where donated blood is not readily available. Blood BackUp is a hemoglobin-based solution designed to restore blood volume and oxygen carrying capacity through rapid intravenous infusion. Initial animal studies in pigs demonstrated Blood BackUp's ability to safely and effectively restore oxygen levels similarly to donated red blood cells. BioPharmic is seeking funding to complete the product development process, including additional animal studies and pursuing FDA approval.
17. Dosage and Administration One unit of Blood BackUp is equivalent to 50 grams of synthetically modified hemoglobin, which is approximately the same mass of hemoglobin delivered by one unit of red blood cells. Blood BackUp will be administered intravenously to patients by a healthcare professional. Based on dose ranging studies, the most rapid rate comprises of the infusion of 20 units in 20 minutes during rapid hemorrhaging. This dose is equivalent to 2 times the blood volume of an average adult.
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19. First, hemoglobin is extracted from red blood cells and filtered to remove impurities. This purified hemoglobin is then chemically modified and purified using a multi-step process to create a polymerized form of hemoglobin.
