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Interventional Ultrasound in
Infertility
Hesham Al-Inany, M.D, PhD
Focus of this lecture
• Not talking about emerging technology
Interventional ultrasound in infertility
Interventional ultrasound in infertility
Interventional ultrasound in infertility
But talking about current Procedures
• Before IVF
• For IVF
• After IVF
PCOS
• Injection of warm sterile saline (75C) into the
ovarian stroma under TVUS monitoring using
ovum pickup needle.
• Ovulation has been achieved in 73.1% of
clomiphene citrate resistant PCOS cases and
resulted in pregnancy in 26.9% of these cases.
No adverse effects were recorded and the
procedure was tolerable in most cases
Difficulties encountered
Non stimulated ovaries;
Difficult accessibility; abdominal pressure
Recurrence rate is high (after 6 month)
Cyst aspiration
• Some cysts appear after administration of
GnRH analogues , due to the flare up effect,
they may result in delay of down regulation
and failure of the estradiol level to drop , in
these cases TV cyst aspiration is our usual
practice
Entirely cystic adenxal mass
• Transvaginal ultrasound cyst aspiration can be
proposed as an alternative for surgery for
women with:-
• Previously diagnosed as having extensive
pelvic adhesions or peritoneal cyst
• Pregnant women before 14 weeks gestation
• Persistent cyst after OC use for 3 month
Not suitable
• If the cyst recurred
• If CA125 more than 35
• If not entirely cystic
Aspiration of Hydrosalpinx
• In women who are identified to have visible
hydrosalpinges by US during COH, aspiration
of hydrosalpinges during oocyte collection
may be effective in improving pregnancyrate
(Hammadieh et al, 2008)
Aspiration of endometriotic cysts
• Larger caliber of needle
• Takes longer time
• Difficult to empty
• Sometimes u need to inject saline
• Risk of infection
• Recurrence rate is high
• Injection of sclerosing material e.g alcohol?
Three Steps management
• TVUS aspiration
• Followed by medical treatment
• Followed by laparoscopic cystectomy or IVF
• Has not been evaluated till now
Transcervical metroplasty
• Asymptomatic woman: no treatment
• Prophylatic metroplasty before IVF has been
proposed
• US guidance can be an alternative to
hysteroscopic metroplasty
Interventional ultrasound in infertility
IVF procedure
Ovum Pick up
• General anesthesia or sedation or none
• TV U/S guided: corner stone for OPU
• Single or double aspiration needle
Interventional ultrasound in infertility
Interventional ultrasound in infertility
Difficulties encountered
• High inaccessible ovaries; abdominal pressure,
tenaculum manipulation of cervix pulling
down ovary
• Fibroids, adenomyosis ( proper precycle
evaluation, myomectomy)
• No follicles on aspiration; expect with poor
response, older age , low E2 levels; flushing of
the follicle
Complications
• Pain: Severe 3% (Ludwig 2006)
• Bleeding; vaginal site bleeding; pressure, pack, rarely
sutures (2.8%, Ludwig 2006), ureteral injury
• Injury; vaginal perforation, iliac vessels, retro-
peritoneal haematoma (Azem 2000)
• Infection; pelvic abscess, tuboovarian abscess
( Dicker 1993; 14 out of 3,656),usually with aspiration of
endometriotic cysts or hydrosalpinx
• Ovarian torsion
• OHSS
ET under US
Ultrasound guided ET
• Full bladder to straighten the utero-cervical
angle
• Trans-abdominal U/S
• Special catheters ecchogenic
It is evidence Based
• Two recent meta-analysis one by our group,
found a higher live birth , ongoing pregnancy,
clinical pregnancy & implantation rates and
easier transfers with ultrasound guided
technique (Abousetta , Brown 2007).
After IVF
• What can interventional US offer??
Ectopic pregnancy
• Ectopic pregnancy after IVF are usually
diagnosed very early and before being
undisturbed
• Transvaginal intratubal injection of
methotrexate under sonographic guidance is
feasible
• Can be alternative to Laparoscopy
• However, systemic methotrexate is easier and
effective
SER or MFPR
• Done at 7 weeks
• Easy , simple rapid
• Only by aspiration , no injection of potassium
chloride
Complications
• Bleeding
• Vanishing twin(14.4%)
• Abortion (4%)
Aspiration of ascitic fluid in OHSS
• When there is distress app 3 litres
• Aspiration + IV human albumen
• TV U/S guided
• Simple no anesthesia
• Might need to repeat
• Severe cases have decreased markedly due
protocol of coasting and Antagonist
Coelocentesis
• Between 6 -12 weeks
• Advantage of early Prenatal diagnosis(< 10w)
• 95% success rate bet 7 - 10weeks
• Low rate of contamination by maternal cells.
Coelocentesis
• Early amnio and CVS not performed before
10weeks
• Less traumatic to embryo & placenta
• Fetal loss = 0r < that in early amnio.
Interventional ultrasound in infertility
Interventional ultrasound in infertility
Conclusion
• Interventional ultrasound is becoming more
and more in use
• Advancement in technology will extend its use
in different applications
Thank You
Thank You

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Interventional ultrasound in infertility

  • 2. Focus of this lecture • Not talking about emerging technology
  • 6. But talking about current Procedures • Before IVF • For IVF • After IVF
  • 8. • Injection of warm sterile saline (75C) into the ovarian stroma under TVUS monitoring using ovum pickup needle. • Ovulation has been achieved in 73.1% of clomiphene citrate resistant PCOS cases and resulted in pregnancy in 26.9% of these cases. No adverse effects were recorded and the procedure was tolerable in most cases
  • 9. Difficulties encountered Non stimulated ovaries; Difficult accessibility; abdominal pressure Recurrence rate is high (after 6 month)
  • 10. Cyst aspiration • Some cysts appear after administration of GnRH analogues , due to the flare up effect, they may result in delay of down regulation and failure of the estradiol level to drop , in these cases TV cyst aspiration is our usual practice
  • 11. Entirely cystic adenxal mass • Transvaginal ultrasound cyst aspiration can be proposed as an alternative for surgery for women with:- • Previously diagnosed as having extensive pelvic adhesions or peritoneal cyst • Pregnant women before 14 weeks gestation • Persistent cyst after OC use for 3 month
  • 12. Not suitable • If the cyst recurred • If CA125 more than 35 • If not entirely cystic
  • 13. Aspiration of Hydrosalpinx • In women who are identified to have visible hydrosalpinges by US during COH, aspiration of hydrosalpinges during oocyte collection may be effective in improving pregnancyrate (Hammadieh et al, 2008)
  • 14. Aspiration of endometriotic cysts • Larger caliber of needle • Takes longer time • Difficult to empty • Sometimes u need to inject saline • Risk of infection • Recurrence rate is high • Injection of sclerosing material e.g alcohol?
  • 15. Three Steps management • TVUS aspiration • Followed by medical treatment • Followed by laparoscopic cystectomy or IVF • Has not been evaluated till now
  • 16. Transcervical metroplasty • Asymptomatic woman: no treatment • Prophylatic metroplasty before IVF has been proposed • US guidance can be an alternative to hysteroscopic metroplasty
  • 19. Ovum Pick up • General anesthesia or sedation or none • TV U/S guided: corner stone for OPU • Single or double aspiration needle
  • 22. Difficulties encountered • High inaccessible ovaries; abdominal pressure, tenaculum manipulation of cervix pulling down ovary • Fibroids, adenomyosis ( proper precycle evaluation, myomectomy) • No follicles on aspiration; expect with poor response, older age , low E2 levels; flushing of the follicle
  • 23. Complications • Pain: Severe 3% (Ludwig 2006) • Bleeding; vaginal site bleeding; pressure, pack, rarely sutures (2.8%, Ludwig 2006), ureteral injury • Injury; vaginal perforation, iliac vessels, retro- peritoneal haematoma (Azem 2000) • Infection; pelvic abscess, tuboovarian abscess ( Dicker 1993; 14 out of 3,656),usually with aspiration of endometriotic cysts or hydrosalpinx • Ovarian torsion • OHSS
  • 25. Ultrasound guided ET • Full bladder to straighten the utero-cervical angle • Trans-abdominal U/S • Special catheters ecchogenic
  • 26. It is evidence Based • Two recent meta-analysis one by our group, found a higher live birth , ongoing pregnancy, clinical pregnancy & implantation rates and easier transfers with ultrasound guided technique (Abousetta , Brown 2007).
  • 27. After IVF • What can interventional US offer??
  • 28. Ectopic pregnancy • Ectopic pregnancy after IVF are usually diagnosed very early and before being undisturbed • Transvaginal intratubal injection of methotrexate under sonographic guidance is feasible • Can be alternative to Laparoscopy
  • 29. • However, systemic methotrexate is easier and effective
  • 30. SER or MFPR • Done at 7 weeks • Easy , simple rapid • Only by aspiration , no injection of potassium chloride
  • 31. Complications • Bleeding • Vanishing twin(14.4%) • Abortion (4%)
  • 32. Aspiration of ascitic fluid in OHSS • When there is distress app 3 litres • Aspiration + IV human albumen • TV U/S guided • Simple no anesthesia • Might need to repeat • Severe cases have decreased markedly due protocol of coasting and Antagonist
  • 33. Coelocentesis • Between 6 -12 weeks • Advantage of early Prenatal diagnosis(< 10w) • 95% success rate bet 7 - 10weeks • Low rate of contamination by maternal cells.
  • 34. Coelocentesis • Early amnio and CVS not performed before 10weeks • Less traumatic to embryo & placenta • Fetal loss = 0r < that in early amnio.
  • 37. Conclusion • Interventional ultrasound is becoming more and more in use • Advancement in technology will extend its use in different applications

Hinweis der Redaktion

  1. volume calculation using 3-dimensional VOCAL technique and on colour coding of each follicle (SonoAVC, GE )
  2. With no incidence of adhesions