Healthcare is an art and a science. What many in the industry don’t understand is that systems and processes can coexist with personalized care. Quality improvement methods can be as effective in healthcare as they have been in other industries (e.g., agriculture, manufacturing, etc.). Quality improvement in healthcare is not just achievable, it’s an absolute necessity given the amount of wasteful spending in the U.S. on healthcare. Organizations can reduce this wasteful spending while improving their processes by applying these five guiding principles: Facilitate adoption through hands-on improvement projects. Define quality and get agreement. Measure for improvement, not accountability. Use a quality improvement framework and PDSA cycles. Learn from variation in data. By using these principles and starting small, organizations can quicken the pace of quality improvement in healthcare.