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ASPECTOS TÉCNICOS
 DE LOS BLOQUEOS
    EPIDURALES




 Dra. Marta Perepérez
   Sº de Anestesia y
     Reanimación
  CLÍNICA UBARMIN
ESPACIO EPIDURAL




     “Injected material displaces the dura forward and inward,
 producing a stretch of the nerve roots that leads to lysis of neural
                            adhesions.”
Rabinovitch DL, Peliowski A, Furlan AD. Influence of lumbar epidural injection volume on pain relief for radicular leg pain
                                and/or low back pain. Spine J. 2009 Jun; 9 (6): 509-17.
FÁRMACOS


          FALTA DE CONSENSO

A FAVOR MAYORITARIAMENTE DE MEZCLA DE:
               CCO + AL
FÁRMACOS
             DOLOR → LA REACCIÓN INFLAMATORIA
                             ↓
        ALIVIO → INTERRUPCIÓN SÍNTESIS DE CITOQUINAS
    Burnett C. Recent advancements in the treatment of lumbar radicular pain. Curr Opin Anaesthesiol, 2008, Aug; 21 (4):452-6.

                                                               ↓
                                            CCO → DISMINUYEN:
•      El edema
•      La vasodilatación capilar
•      La proliferación de fibroblastos
•      La cicatrización
•      La síntesis de PLA2
FÁRMACOS
                                         ¿QUÉ CCO?




 Depo-Medrol

ND VE

   Trigon




Manchikant L. Role of Neuraxial Steroids in Interventional Pain Management. Pain Physician, 2002; 2:182-199.
FÁRMACOS
                              ¿QUÉ PERIODICIDAD?
Manchikant L. Role of Neuraxial Steroids in Interventional Pain Management. Pain Physician, 2002; 2:182-199.
FÁRMACOS
                                       ¿QUÉ PERIODICIDAD?
Marinangeli F, Ciccozzi A, Donatelli F, Paladini A, Varrassi G. Clinical use of spinal or epidural steroids. Minerva Anestesiol. 2002
                                                      Jul-Aug;68(7-8):613-20.



                            Steroidal toxicity seems to be related to the
                            polyethylenic glycole vehicle. Anyway, slow release
                            formulations contain less concentrated polyethylenic
                            glycole. The epidural administration, a correct dilution
                            of steroid with local anesthetics solution and/or saline
                            solution, and a limited number of injections (no more
                            than three) allows a significant reduction of steroid
                            neurotoxicity.
FÁRMACOS

                              CCO DE ACCIÓN PROLONGADA
Noe CE, Haynsworth RF Jr. Comparison of epidural Depo_medrol vs. Aqueous betamethasone in patients with low back pain. Pain
                                                  Pract. 2003 Sep; 3 (3):222-5

                              ↓
           ACETATO DE METILPREDNISOLONA (40-80 mg) Y
               ACETÓNIDO DE TRIAMCINOLONA (80 mg)
 Robinson D et al.The effects of different doses of lumbosacral epidural steroids for patients with lumbosacral radiculopathy and
                 spinal stenosis. Ameriacan Academy of Pain Medicine. 22nd Annual Meeting. February 22-25, 2006.
Owlia M B, Salimzadeh A, Alishiri Gh, Haghighi A. Comparison of two doses of corticosteroid in epidural steroid injection for lumbar
                                         radicular pain. Singapore Med J 2007; 48 (3) : 24-45.
FÁRMACOS

                          AL
                           ↓
               PROS Y CONTRAS DE LOS AL:

• Capacidad de romper el círculo vicioso: Dolor muscular,
  espasmo, isquemia, dolor
• Beneficio psicológico
• Comprobación de la inyección epidural
• CONTRAS: HipoTA, bloqueo sensitivo y motor prolongado
                              ↓
                         VOLUMEN
                              ↓
              DEPENDE DE LA VÍA DE ABORDAJE
VÍAS DE ABORDAJE




CAUDAL      INTERLAMINAR   TRANSFORAMINAL
30-40mL        8-12mL          2-4 mL
VÍAS DE ABORDAJE




  EFICACIA SUPERIOR DE LAS VÍAS INTERLAMINAR Y TRANSFORAMINAL
  VS LA CAUDAL
  EFICACIA SUPERIOR DE LA VÍA TRANSFORAMINAL EN HERNIAS
  TRANSFORAMINALES Y EN ESTENOSIS DE CANAL
Lee JH, Moon J, Lee SH. Comparison of effectiveness according to different approaches of epidural steroid injection in
lumbosacral herniated disk and spinal stenosis. J Back Musculoskelet Rehabil. 2009;22(2):83-9.
VÍAS DE ABORDAJE

                  Abordaje intraforaminal


PARAPLEJIA          (Houten JK, Erico TJ. Paraplegia after lumbosacral nerve root
 block: report of three cases. Spine J 2002; 2:70-75.) ( Glaser SE and Falco F.
 Paraplegia following thoracoumbar transforaminal epidural steroid injection, pain
 Physician 2005; 8:309-314.) (Epidural Steroids in the Management of Chronic Spinal Pain: A
 Systematic review. Pain Physician 2007, 10:185-212.)


MAYOR DIFICULTAD TÉCNICA
COMPLICACIONES
                           3 TIPOS
•DERIVADAS DEL USO DE AL
•DERIVADAS DE LA TÉCNICA
•DERIVADAS DEL USO DE CCO
COMPLICACIONES: por la técnica




                                                                                           293.050 epidurales
                                                                                          de las cuales 27.975
                                                                                          eran para control de
                                                                                              dolor crónico




T. M. Cook, D. Counsell and J. A. W. Wildsmith. Major complications of central neuraxial block: report on the Third National
Audit Project of the Royal College of Anaesthetists. British Journal of Anaesthesia 102 (2): 179–90 (2009).
COMPLICACIONES: por el uso de CCO
COMPLICACIONES: otras

• CPPD
• REACCIONES VASOVAGALES
• DOLOR LOCAL O EXACERBACIÓN DE LA RADICULOPATÍA DURANTE LA
PUNCIÓN
• ARACNOIDITIS Y NEUROTOXICIDAD
• LIPOMATOSIS EPIDURAL
• MENORRAGIA O AMENORREA
CONCLUSIONES

• La inyección epidural conjunta de CCO y de AL se ha
  demostrado eficaz.
• Las 3 vías de administración son válidas.
• El tipo de CCO y la periodicidad de los BED deben
  individualizarse en cada centro: protocolización (Cohen
  SP, Hayek SM, Datta S, Bajwa ZH, Larkin TM, Griffith S, Hobelmann G, Christo PJ, White R. Incidence and root
  cause analysis of wrong-site pain management procedures: a multicenter study. Anesthesiology. 2010
  Mar;112(3):711-8.

• Es fundamental la adopción de medidas de
  seguridad para el paciente: s/t estudio preoperatorio,
  monitorización, ingreso 7-10 horas y seguimiento
  efectos secundarios.
GRACIAS
Kennedy DJ, Dreyfuss P, Aprill CN, Bogduk N. Paraplegia following image-guided transforaminal lumbar spine
epidural steroid injection: two case reports. Pain Med. 2009 Nov;10(8):1389-94.


OBJECTIVE: To present two case reports of a rare but devastating injury after image-guided,
lumbar transforaminal injection of steroids, and to explore features in common with previously
reported cases. BACKGROUND: Image (fluoroscopic and computed tomography [CT])-guided,
lumbar transforaminal injections of corticosteroids have been adopted as a treatment for radicular
pain. Complications associated with these procedures are rare, but can be severe. CASE

REPORTS: An 83-year-old woman underwent a fluoroscopically guided, left L3-L4, transforaminal
injection of betamethasone (Celestone Soluspan). A 79-year-old man underwent a CT-guided,
right L3-L4, transforaminal injection of methylprednisolone (DepoMedrol). Both patients
developed bilateral lower extremity paralysis, with neurogenic bowel and bladder, immediately
after the procedures. Magnetic resonance imaging scans were consistent with spinal cord
infarction. There was no evidence of intraspinal mass or hematoma.

CONCLUSION: These cases consolidate a pattern emerging in the literature. Distal cord and
conus injury can occur following transforaminal injections at lumbar levels, whether injection is on
the left or right. This conforms with the probability of radicular-medullary arteries forming an
arteria radicularis magna at lumbar levels. All cases used particulate corticosteroids, which
promotes embolization in a radicular artery as the likely mechanism of injury. The risk of this
complication can be reduced, and potentially eliminated, by the utilization of particulate free
steroids, testing for intra-arterial injection with digital subtraction angiography, and a preliminary
injection of local anesthetic.

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Aspectos técnicos de los bloqueos epidurales

  • 1. ASPECTOS TÉCNICOS DE LOS BLOQUEOS EPIDURALES Dra. Marta Perepérez Sº de Anestesia y Reanimación CLÍNICA UBARMIN
  • 2. ESPACIO EPIDURAL “Injected material displaces the dura forward and inward, producing a stretch of the nerve roots that leads to lysis of neural adhesions.” Rabinovitch DL, Peliowski A, Furlan AD. Influence of lumbar epidural injection volume on pain relief for radicular leg pain and/or low back pain. Spine J. 2009 Jun; 9 (6): 509-17.
  • 3. FÁRMACOS FALTA DE CONSENSO A FAVOR MAYORITARIAMENTE DE MEZCLA DE: CCO + AL
  • 4. FÁRMACOS DOLOR → LA REACCIÓN INFLAMATORIA ↓ ALIVIO → INTERRUPCIÓN SÍNTESIS DE CITOQUINAS Burnett C. Recent advancements in the treatment of lumbar radicular pain. Curr Opin Anaesthesiol, 2008, Aug; 21 (4):452-6. ↓ CCO → DISMINUYEN: • El edema • La vasodilatación capilar • La proliferación de fibroblastos • La cicatrización • La síntesis de PLA2
  • 5. FÁRMACOS ¿QUÉ CCO? Depo-Medrol ND VE Trigon Manchikant L. Role of Neuraxial Steroids in Interventional Pain Management. Pain Physician, 2002; 2:182-199.
  • 6. FÁRMACOS ¿QUÉ PERIODICIDAD? Manchikant L. Role of Neuraxial Steroids in Interventional Pain Management. Pain Physician, 2002; 2:182-199.
  • 7. FÁRMACOS ¿QUÉ PERIODICIDAD? Marinangeli F, Ciccozzi A, Donatelli F, Paladini A, Varrassi G. Clinical use of spinal or epidural steroids. Minerva Anestesiol. 2002 Jul-Aug;68(7-8):613-20. Steroidal toxicity seems to be related to the polyethylenic glycole vehicle. Anyway, slow release formulations contain less concentrated polyethylenic glycole. The epidural administration, a correct dilution of steroid with local anesthetics solution and/or saline solution, and a limited number of injections (no more than three) allows a significant reduction of steroid neurotoxicity.
  • 8. FÁRMACOS CCO DE ACCIÓN PROLONGADA Noe CE, Haynsworth RF Jr. Comparison of epidural Depo_medrol vs. Aqueous betamethasone in patients with low back pain. Pain Pract. 2003 Sep; 3 (3):222-5 ↓ ACETATO DE METILPREDNISOLONA (40-80 mg) Y ACETÓNIDO DE TRIAMCINOLONA (80 mg) Robinson D et al.The effects of different doses of lumbosacral epidural steroids for patients with lumbosacral radiculopathy and spinal stenosis. Ameriacan Academy of Pain Medicine. 22nd Annual Meeting. February 22-25, 2006. Owlia M B, Salimzadeh A, Alishiri Gh, Haghighi A. Comparison of two doses of corticosteroid in epidural steroid injection for lumbar radicular pain. Singapore Med J 2007; 48 (3) : 24-45.
  • 9. FÁRMACOS AL ↓ PROS Y CONTRAS DE LOS AL: • Capacidad de romper el círculo vicioso: Dolor muscular, espasmo, isquemia, dolor • Beneficio psicológico • Comprobación de la inyección epidural • CONTRAS: HipoTA, bloqueo sensitivo y motor prolongado ↓ VOLUMEN ↓ DEPENDE DE LA VÍA DE ABORDAJE
  • 10. VÍAS DE ABORDAJE CAUDAL INTERLAMINAR TRANSFORAMINAL 30-40mL 8-12mL 2-4 mL
  • 11. VÍAS DE ABORDAJE EFICACIA SUPERIOR DE LAS VÍAS INTERLAMINAR Y TRANSFORAMINAL VS LA CAUDAL EFICACIA SUPERIOR DE LA VÍA TRANSFORAMINAL EN HERNIAS TRANSFORAMINALES Y EN ESTENOSIS DE CANAL Lee JH, Moon J, Lee SH. Comparison of effectiveness according to different approaches of epidural steroid injection in lumbosacral herniated disk and spinal stenosis. J Back Musculoskelet Rehabil. 2009;22(2):83-9.
  • 12. VÍAS DE ABORDAJE Abordaje intraforaminal PARAPLEJIA (Houten JK, Erico TJ. Paraplegia after lumbosacral nerve root block: report of three cases. Spine J 2002; 2:70-75.) ( Glaser SE and Falco F. Paraplegia following thoracoumbar transforaminal epidural steroid injection, pain Physician 2005; 8:309-314.) (Epidural Steroids in the Management of Chronic Spinal Pain: A Systematic review. Pain Physician 2007, 10:185-212.) MAYOR DIFICULTAD TÉCNICA
  • 13. COMPLICACIONES 3 TIPOS •DERIVADAS DEL USO DE AL •DERIVADAS DE LA TÉCNICA •DERIVADAS DEL USO DE CCO
  • 14. COMPLICACIONES: por la técnica 293.050 epidurales de las cuales 27.975 eran para control de dolor crónico T. M. Cook, D. Counsell and J. A. W. Wildsmith. Major complications of central neuraxial block: report on the Third National Audit Project of the Royal College of Anaesthetists. British Journal of Anaesthesia 102 (2): 179–90 (2009).
  • 16. COMPLICACIONES: otras • CPPD • REACCIONES VASOVAGALES • DOLOR LOCAL O EXACERBACIÓN DE LA RADICULOPATÍA DURANTE LA PUNCIÓN • ARACNOIDITIS Y NEUROTOXICIDAD • LIPOMATOSIS EPIDURAL • MENORRAGIA O AMENORREA
  • 17. CONCLUSIONES • La inyección epidural conjunta de CCO y de AL se ha demostrado eficaz. • Las 3 vías de administración son válidas. • El tipo de CCO y la periodicidad de los BED deben individualizarse en cada centro: protocolización (Cohen SP, Hayek SM, Datta S, Bajwa ZH, Larkin TM, Griffith S, Hobelmann G, Christo PJ, White R. Incidence and root cause analysis of wrong-site pain management procedures: a multicenter study. Anesthesiology. 2010 Mar;112(3):711-8. • Es fundamental la adopción de medidas de seguridad para el paciente: s/t estudio preoperatorio, monitorización, ingreso 7-10 horas y seguimiento efectos secundarios.
  • 19. Kennedy DJ, Dreyfuss P, Aprill CN, Bogduk N. Paraplegia following image-guided transforaminal lumbar spine epidural steroid injection: two case reports. Pain Med. 2009 Nov;10(8):1389-94. OBJECTIVE: To present two case reports of a rare but devastating injury after image-guided, lumbar transforaminal injection of steroids, and to explore features in common with previously reported cases. BACKGROUND: Image (fluoroscopic and computed tomography [CT])-guided, lumbar transforaminal injections of corticosteroids have been adopted as a treatment for radicular pain. Complications associated with these procedures are rare, but can be severe. CASE REPORTS: An 83-year-old woman underwent a fluoroscopically guided, left L3-L4, transforaminal injection of betamethasone (Celestone Soluspan). A 79-year-old man underwent a CT-guided, right L3-L4, transforaminal injection of methylprednisolone (DepoMedrol). Both patients developed bilateral lower extremity paralysis, with neurogenic bowel and bladder, immediately after the procedures. Magnetic resonance imaging scans were consistent with spinal cord infarction. There was no evidence of intraspinal mass or hematoma. CONCLUSION: These cases consolidate a pattern emerging in the literature. Distal cord and conus injury can occur following transforaminal injections at lumbar levels, whether injection is on the left or right. This conforms with the probability of radicular-medullary arteries forming an arteria radicularis magna at lumbar levels. All cases used particulate corticosteroids, which promotes embolization in a radicular artery as the likely mechanism of injury. The risk of this complication can be reduced, and potentially eliminated, by the utilization of particulate free steroids, testing for intra-arterial injection with digital subtraction angiography, and a preliminary injection of local anesthetic.