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Social networks and
collaborative platforms for
data sharing in radiology
ERIK RANSCHAERT, MD, PhD, CIIP
RADIOLOGIST, ETZ Hospital, Tilburg the Netherlands
EuSoMII President
Era of online information sharing
• We have become accustomed to sharing many types of
information via the Internet.
• Society finds this means of information exchange efficient
and desirable.
• Acceptance of this type of exchange of confidential
information indicates a reasonable level of trust by users of
this technology.
• Paradigm shift towards sharing of data
2
Cloud
technology
Processing
power Big data
Sharing
data
SHIFTS in society caused by digital revolution
TECHNOLOGY shift PARADIGM shift
Technology shift in healthcare/radiology
Traditional image storage
“Siloed” architecture
o Intensive & expensive to manage
o Low utilization of HW & storage
o Vulnerable to failure & downtime
o Inefficient bandwidth
o Different for each site
Cloud-based image storage
“Virtualized” grid architecture
o Shared & cost-effective storage capacity
o Adaptive, self-healing, self-managing
o High speed
o Infrastructure is managed independent from application
o Single point of access: EPR, Portals
o Elimination of redundancy
Site 1 Site 2 Site 3
…
Site 1 Site 2 Site 3
…App 1 App 1 App 1 App 1 App 10 App 1 App 1 App 1 App 1 App 10
Cloud based storage platform
Source: SIIM Webinar Jan 28, 2016: “Real world challenges and benefits of cloud technologies” 6
Cloud-based archiving of data needed
• Storing requirements are gradually more demanding :
• Production of medical imaging will continue to increase
• New techniques are producing large data volumes
• Hybrid imaging: PET-CT, PET-MRI
• Other “-ologies” also want to store digital images
7
Any-ology
• Other specialties have needs for
both static & cine image storage
& retrieval
• Added value for collaboration
• More unified management of
data and images needed
• Yet not sufficiently addressed
by current methodologies, e.g.
problems of standardisation
Radiology Dermatology Ophthalmology
Oncology Cardiology Pathology
Otorhinolaryngology Neurosurgery Gastro-enterology
Source: SIIM Webinar Jan 28, 2016: “Real world challenges and benefits of cloud technologies” 8
Evolution of medical image sharing
Evolution of medical image sharing
Evolution of medical image sharing
Evolution of medical image sharing
Evolution of medical image sharing
Paradigm shift in healthcare
Current hospital-centric model Collaborative care model
14Source: SIIM Webinar Jan 28, 2016: “Real world challenges and benefits of cloud technologies”
Care
pathways
AI-based
solutions
Interoperable
data sources
Patient
Portal
2nd
opinion
s
Pharma
and HC
IndustryEpisodic
Departments
Proprietary
Data silos
Patients
Hospital centric
Why to share IMAGE & DATA?
• Patients are using the Web, mobile access to information
• Easy gathering of images from hospital
• Easy to obtain second opinions
Patient empowerment
• Broader market
• Increasing collaboration and specialty-oriented hospitals
• Personalized medicine
Telehealth
• Easy referral process to outside facilities
• Avoid redundancy
Easy access via cloud to
information
• Trauma & stroke patients: faster, treatment preparation
• Hospital as gateway to fluently organised patient-centric care
Liquid data, elegant
transfer of studies
• Principle of open science = sharing of data and knowledge
• Data needed for training, testing and validating of algorithms
• Labelled and validated data need to be shared among developers and institutions
Research and AI
15
Imaging data are only relevant when analysed in relevant context
Paradigm shift in society and healthcare
• Storing and viewing have
become commodity
• Steadily growing role of sharing
data and images in value chain
• Data are moving from storage
to intelligence
Integrate
Automate
Transfer &
collaborate
Visualise
Ingest & store images
Cloud storage – providers
• Amazon Web Services (AWS)
• Microsoft Azure (MA)
• Google Cloud Platform (GCP)
• lowest cost of storage
• most compliant with regulations
• API’s adapted to healthcare
services
CLOUD-based
image and medical
data management
platforms
Web-based secured imaging
Collaborative platforms
Preferably open-source SW
Interoperability is prerequisite
Cloud-based medical imaging platforms
• Cloud PACS
• Cloud VNA
• ZFP DICOM Web-based viewer
• Workflow analytics
• Provider network
• Scalable and secure
• Instant access to medical images and
data everywhere
• MEDICAL IMAGING ECOSYSTEM
Google Cloud technology partners
• Works with Google Cloud Platform (GCP), but also AWS
and Microsoft as technology partners
• « Open source » TMIS (Translation Medical Imaging
Server) – only for clients
• Integration of « silos » from medical imaging,
pathology, clinical genomics -> precision medicine
• 360° view of patient: collaboration between
radiologists, pathologists, surgeons, oncologists by
sharing and visualizing patient data with relevant clinical
contaxt
• Present in 12 countries: USA, UK (+15 NHS trusts),
Spain, Mexico, Peru Jorge Cortell and his wife
Osimis
• Orthanc medical imaging server,
open source
• Sébastien Jodogne
• Prize-winning (2015, MIT Boston)
• Lify enterprise imaging platform
• Microsoft Azure
• Google Cloud
AWS and medical data
• Agreement between Philips and
Amazon Web Services (AWS)
• Delivery of back-up service for
hospitals to store data in cloud, at
high tempo
• Improved protection of patient
data
• Increased need for storage
capacity due to complex imaging
techniques
25
Evolution in Healthcare
• PACS:
• Availability of cloud-based enterprise platforms in different formats
• Progressive move from hardware to virtual machines and services
• Digital infrastructure:
• Services offered by local providers (telco providers, data centers)
• Services offered by Google (GCP), Microsoft (MA) , Amazon (AWS)
• Progressive move from local machines to cloud machines
• Diagnosis:
• Move from local knowledge to automated and virtual knowledge
• Artificial Intelligence
Artificial Intelligence
and the importance of data sharing
Development process of AI algorithms
Concept
phase
Learning
phase
Testing
phase
Application
phase
Validation dataTraining datasets Test datasets
Goal of algorithm?
input
?
output
?
Training and test
datasets?
Input-output data
• The learning and testing steps require datasets in the form of pairs:
(input datai, output datai)i=1,N
• The learning dataset allows creation/adjustment of the decision model
• The test dataset evaluates the performance of the model
(because output datai is the truth about input datai )
• These datasets can be very diverse in nature
Radiology: early adopter of AI
• DL has exponentially grown from image analysis
• ImageNet
• Radiology is therefore at the forefront in medicine
• Abundance of data, mostly preserved in « silos »
• Data can be shared technically
AI Startups
Major roadblocks for AI
EuSoMII Annual Meeting, Rotterdam, Nov 3, 2018
Hospital:
“How much data do you need?”
AI developers:
“How much data do you have?”
Challenge to get data
• What datasources are currently accessible?
• Which image data are curated and labelled?
• What’s the role of the large cloud service providers?
• What is the role of hospitals and HC providers and radiological
societies?
Medical Image Databases and Biobanks
• UK Biobank
• Nationale Kohort
• The Cancer Imaging Archive (TCIA)
• Centre d’Acquisition et de Traitement des Images (CATI)
• FLI-IAM (France Life Imaging – Information Analysis and Management)
• NIH Image Gallery
• NCI Visuals Online
• CDC Public Health Image Library (PHIL)
• HON Media Gallery
• Health Education Assets Library (HEAL)
https://www.cna-aiic.ca/en/nursing-practice/overview-of-library-
resources/public-resources/images-and-image-banks
UK can lead in Radiology AI. Here’s how...Hugh Harvey, 2017, Medium - http://bit.ly/2CoKJE8
Industry partnerships
• Dominant industry vendors form
strategic partnerships with academic
institutions.
• GE, IBM Watson, Philips and many
others have created deals to allow data
access in return for funding research.
• In Europe we can see EU/industry
partnerships forming with the academy
Shift in healthcare market
• Shift of data sharing to higher level: artificial intelligence (AI)
• Where, how, at what price will the intelligence SW be
available?
• For what purposes will it be available?
• Discrimination?
Zebra research platform
• Zebra has a database of +10 million de-identified imaging studies from
a variety of hospitals
• Ultimate vision: to create BLACK BOX in which a study comes in and
a diagnosis comes out.
• Goal is to develop hundreds of individual algorithms, for detection of
• breast cancer on mammography,
• malignant lung nodules on lung CT,
• brain tumours on MRI
• …
https://www.acpsem.org.au/documents/item/339
Clinical Research
Organisations
Health Insurance
companies
Healthcare providers
• Because Zebra can't build all of these applications on its own, the company published a
research platform on which it provides access to its large database of studies, as well as
storage, graphics processing unit (GPU) computing power and support for a variety of
research tools.
• They want to bring high-end research groups online to accelerate the pace and quality of the
algorithms that come out.
https://www.businesswire.com/news/home/20171124005066/en/Carestream-Joins-Zebra-Medical-Vision-Offering-Affordable
https://techcrunch.com/2018/06/07/zebra-medical-vision-gets-30m-series-c-to-create-ai-based-tools-for-radiologists/?guccounter=1
Carestream joins Zebra (2017)
• Carestream Clinical
Collaboration Platform offering
• Deep learning engine will assist
radiologists in delivering more
comprehensive clinical services
across a variety of clinical
domains.
Relevance of protecting Health Data
• “FastMRI” partnership between NYU (CAI2R) and Facebook A.I. Research to make MRI
scans 10x faster
• Combination of domain-specific expertise from different fields and industries
• Train artificial neural nets to recognize underlying structures and construct MR-images
with less data
• NYU provides FAIR with 3 million MR-images (knee, brain, liver)
https://www.healthimaging.com/topics/artificial-intelligence/facebook-nyu-collaborate-make-mri-faster-ai
What’s next?
• Will there be new players in the HC market ?
• Data processors?
• Cloud service providers?
• Insurance companies as new payers?
• What business model will succeed?
• Will there be a shift in who owns and manages the data
(patient vs. hospital)?
• Is there a future for blockchain?
What business model?
• AppStore model, application on request
• Pay per analysis = fee for each analysis
• Subscription fee = fee per package of monthly analyses
• License = pay for whole platform with limited # analyses
• Included with modality
• Included with PACS/RIS
Hospital
Patient EHR
Physician A Physician B
Blockchain for
health data
In the future, the patient will be able to define the rights and obligations associated with the data.
Omics
Data
Physician
Clinical Decision
Support
Predictive
Analytics
Researcher
Unstructured
Data
Patient
Radiologist
Lifestyle
Advice
SOPs
Validation
Bio-
specimen
CRO
Laboratory
Diagnostics
MRI/
Images
Real-time
DataDrug
Maker
Patient
Stratification
Cryptocurrency
A. Schumacher (2017) Blockchain & Healthcare. 2017 Strategy Guide for the Pharmaceutical
Industry, Insurers & Healthcare Providers. DOI: 10.13140/RG.2.2.12162.48327
Service Provider
In this model algorithms are able to mine enormous amounts of data from numerous sources and provide scientific
insight and BI to members of the blockchain
The patient blockchain
• Embleema (NY, 2018)
• 1st blockchain network to give patients complete control over health data
• HIPAA compliant
• $2/month subscription fee
• Patients can grant access to their medical data for trials and are compensated for doing so
Our patient surveys have shown
that 53% would agree to it if they
had a proper way to give their
consent to accelerating research.
https://healthcareweekly.com/embleema-blockchain-healthcare/
https://support.embleema.com/hc/en-us/articles/360007096714-Embleema-Launches-the-First-Personal-Health-Records-Blockchain-To-Give-Patients-Complete-Control-Over-Their-Health-Data-and-Be-at-the-Center-of-Clinical-Research
Google and others?
• Google and others believe that
delivering AI through the cloud
will be a big, lucrative trend in
computing in coming years.
BSR annual meeting 2018
New HC market players?
• Amazon sees a new grow
market in HC and will offer HC
services
• Own health insurance – first for
Amazon employees (500.000 !)
• “We have the size for influencing
the insurance companies. The
problem of the rising costs in HC is
only becoming worse. Innovation is
necessary”.
Chief
Technology
Officer Amazon
NRC, 6 april 2018
Join EuSoMII now!
www.eusomii.org

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Social networks and collaborative platforms for data sharing in radiology

  • 1. Social networks and collaborative platforms for data sharing in radiology ERIK RANSCHAERT, MD, PhD, CIIP RADIOLOGIST, ETZ Hospital, Tilburg the Netherlands EuSoMII President
  • 2. Era of online information sharing • We have become accustomed to sharing many types of information via the Internet. • Society finds this means of information exchange efficient and desirable. • Acceptance of this type of exchange of confidential information indicates a reasonable level of trust by users of this technology. • Paradigm shift towards sharing of data 2
  • 3. Cloud technology Processing power Big data Sharing data SHIFTS in society caused by digital revolution TECHNOLOGY shift PARADIGM shift
  • 4. Technology shift in healthcare/radiology Traditional image storage “Siloed” architecture o Intensive & expensive to manage o Low utilization of HW & storage o Vulnerable to failure & downtime o Inefficient bandwidth o Different for each site Cloud-based image storage “Virtualized” grid architecture o Shared & cost-effective storage capacity o Adaptive, self-healing, self-managing o High speed o Infrastructure is managed independent from application o Single point of access: EPR, Portals o Elimination of redundancy Site 1 Site 2 Site 3 … Site 1 Site 2 Site 3 …App 1 App 1 App 1 App 1 App 10 App 1 App 1 App 1 App 1 App 10 Cloud based storage platform Source: SIIM Webinar Jan 28, 2016: “Real world challenges and benefits of cloud technologies” 6
  • 5. Cloud-based archiving of data needed • Storing requirements are gradually more demanding : • Production of medical imaging will continue to increase • New techniques are producing large data volumes • Hybrid imaging: PET-CT, PET-MRI • Other “-ologies” also want to store digital images 7
  • 6. Any-ology • Other specialties have needs for both static & cine image storage & retrieval • Added value for collaboration • More unified management of data and images needed • Yet not sufficiently addressed by current methodologies, e.g. problems of standardisation Radiology Dermatology Ophthalmology Oncology Cardiology Pathology Otorhinolaryngology Neurosurgery Gastro-enterology Source: SIIM Webinar Jan 28, 2016: “Real world challenges and benefits of cloud technologies” 8
  • 7. Evolution of medical image sharing
  • 8. Evolution of medical image sharing
  • 9. Evolution of medical image sharing
  • 10. Evolution of medical image sharing
  • 11. Evolution of medical image sharing
  • 12. Paradigm shift in healthcare Current hospital-centric model Collaborative care model 14Source: SIIM Webinar Jan 28, 2016: “Real world challenges and benefits of cloud technologies” Care pathways AI-based solutions Interoperable data sources Patient Portal 2nd opinion s Pharma and HC IndustryEpisodic Departments Proprietary Data silos Patients Hospital centric
  • 13. Why to share IMAGE & DATA? • Patients are using the Web, mobile access to information • Easy gathering of images from hospital • Easy to obtain second opinions Patient empowerment • Broader market • Increasing collaboration and specialty-oriented hospitals • Personalized medicine Telehealth • Easy referral process to outside facilities • Avoid redundancy Easy access via cloud to information • Trauma & stroke patients: faster, treatment preparation • Hospital as gateway to fluently organised patient-centric care Liquid data, elegant transfer of studies • Principle of open science = sharing of data and knowledge • Data needed for training, testing and validating of algorithms • Labelled and validated data need to be shared among developers and institutions Research and AI 15 Imaging data are only relevant when analysed in relevant context
  • 14. Paradigm shift in society and healthcare • Storing and viewing have become commodity • Steadily growing role of sharing data and images in value chain • Data are moving from storage to intelligence Integrate Automate Transfer & collaborate Visualise Ingest & store images
  • 15. Cloud storage – providers • Amazon Web Services (AWS) • Microsoft Azure (MA) • Google Cloud Platform (GCP) • lowest cost of storage • most compliant with regulations • API’s adapted to healthcare services
  • 16. CLOUD-based image and medical data management platforms Web-based secured imaging Collaborative platforms Preferably open-source SW Interoperability is prerequisite
  • 17. Cloud-based medical imaging platforms • Cloud PACS • Cloud VNA • ZFP DICOM Web-based viewer • Workflow analytics • Provider network • Scalable and secure • Instant access to medical images and data everywhere • MEDICAL IMAGING ECOSYSTEM
  • 18.
  • 19. Google Cloud technology partners • Works with Google Cloud Platform (GCP), but also AWS and Microsoft as technology partners • « Open source » TMIS (Translation Medical Imaging Server) – only for clients • Integration of « silos » from medical imaging, pathology, clinical genomics -> precision medicine • 360° view of patient: collaboration between radiologists, pathologists, surgeons, oncologists by sharing and visualizing patient data with relevant clinical contaxt • Present in 12 countries: USA, UK (+15 NHS trusts), Spain, Mexico, Peru Jorge Cortell and his wife
  • 20.
  • 21. Osimis • Orthanc medical imaging server, open source • Sébastien Jodogne • Prize-winning (2015, MIT Boston) • Lify enterprise imaging platform • Microsoft Azure • Google Cloud
  • 22.
  • 23. AWS and medical data • Agreement between Philips and Amazon Web Services (AWS) • Delivery of back-up service for hospitals to store data in cloud, at high tempo • Improved protection of patient data • Increased need for storage capacity due to complex imaging techniques 25
  • 24. Evolution in Healthcare • PACS: • Availability of cloud-based enterprise platforms in different formats • Progressive move from hardware to virtual machines and services • Digital infrastructure: • Services offered by local providers (telco providers, data centers) • Services offered by Google (GCP), Microsoft (MA) , Amazon (AWS) • Progressive move from local machines to cloud machines • Diagnosis: • Move from local knowledge to automated and virtual knowledge • Artificial Intelligence
  • 25. Artificial Intelligence and the importance of data sharing
  • 26. Development process of AI algorithms Concept phase Learning phase Testing phase Application phase Validation dataTraining datasets Test datasets Goal of algorithm? input ? output ? Training and test datasets?
  • 27. Input-output data • The learning and testing steps require datasets in the form of pairs: (input datai, output datai)i=1,N • The learning dataset allows creation/adjustment of the decision model • The test dataset evaluates the performance of the model (because output datai is the truth about input datai ) • These datasets can be very diverse in nature
  • 28. Radiology: early adopter of AI • DL has exponentially grown from image analysis • ImageNet • Radiology is therefore at the forefront in medicine • Abundance of data, mostly preserved in « silos » • Data can be shared technically
  • 30. Major roadblocks for AI EuSoMII Annual Meeting, Rotterdam, Nov 3, 2018
  • 31. Hospital: “How much data do you need?” AI developers: “How much data do you have?”
  • 32.
  • 33. Challenge to get data • What datasources are currently accessible? • Which image data are curated and labelled? • What’s the role of the large cloud service providers? • What is the role of hospitals and HC providers and radiological societies?
  • 34. Medical Image Databases and Biobanks • UK Biobank • Nationale Kohort • The Cancer Imaging Archive (TCIA) • Centre d’Acquisition et de Traitement des Images (CATI) • FLI-IAM (France Life Imaging – Information Analysis and Management) • NIH Image Gallery • NCI Visuals Online • CDC Public Health Image Library (PHIL) • HON Media Gallery • Health Education Assets Library (HEAL) https://www.cna-aiic.ca/en/nursing-practice/overview-of-library- resources/public-resources/images-and-image-banks
  • 35. UK can lead in Radiology AI. Here’s how...Hugh Harvey, 2017, Medium - http://bit.ly/2CoKJE8 Industry partnerships • Dominant industry vendors form strategic partnerships with academic institutions. • GE, IBM Watson, Philips and many others have created deals to allow data access in return for funding research. • In Europe we can see EU/industry partnerships forming with the academy
  • 36. Shift in healthcare market • Shift of data sharing to higher level: artificial intelligence (AI) • Where, how, at what price will the intelligence SW be available? • For what purposes will it be available? • Discrimination?
  • 37.
  • 38. Zebra research platform • Zebra has a database of +10 million de-identified imaging studies from a variety of hospitals • Ultimate vision: to create BLACK BOX in which a study comes in and a diagnosis comes out. • Goal is to develop hundreds of individual algorithms, for detection of • breast cancer on mammography, • malignant lung nodules on lung CT, • brain tumours on MRI • … https://www.acpsem.org.au/documents/item/339
  • 39. Clinical Research Organisations Health Insurance companies Healthcare providers • Because Zebra can't build all of these applications on its own, the company published a research platform on which it provides access to its large database of studies, as well as storage, graphics processing unit (GPU) computing power and support for a variety of research tools. • They want to bring high-end research groups online to accelerate the pace and quality of the algorithms that come out.
  • 40. https://www.businesswire.com/news/home/20171124005066/en/Carestream-Joins-Zebra-Medical-Vision-Offering-Affordable https://techcrunch.com/2018/06/07/zebra-medical-vision-gets-30m-series-c-to-create-ai-based-tools-for-radiologists/?guccounter=1 Carestream joins Zebra (2017) • Carestream Clinical Collaboration Platform offering • Deep learning engine will assist radiologists in delivering more comprehensive clinical services across a variety of clinical domains.
  • 41.
  • 42.
  • 43. Relevance of protecting Health Data • “FastMRI” partnership between NYU (CAI2R) and Facebook A.I. Research to make MRI scans 10x faster • Combination of domain-specific expertise from different fields and industries • Train artificial neural nets to recognize underlying structures and construct MR-images with less data • NYU provides FAIR with 3 million MR-images (knee, brain, liver) https://www.healthimaging.com/topics/artificial-intelligence/facebook-nyu-collaborate-make-mri-faster-ai
  • 44. What’s next? • Will there be new players in the HC market ? • Data processors? • Cloud service providers? • Insurance companies as new payers? • What business model will succeed? • Will there be a shift in who owns and manages the data (patient vs. hospital)? • Is there a future for blockchain?
  • 45. What business model? • AppStore model, application on request • Pay per analysis = fee for each analysis • Subscription fee = fee per package of monthly analyses • License = pay for whole platform with limited # analyses • Included with modality • Included with PACS/RIS
  • 46. Hospital Patient EHR Physician A Physician B Blockchain for health data In the future, the patient will be able to define the rights and obligations associated with the data.
  • 47. Omics Data Physician Clinical Decision Support Predictive Analytics Researcher Unstructured Data Patient Radiologist Lifestyle Advice SOPs Validation Bio- specimen CRO Laboratory Diagnostics MRI/ Images Real-time DataDrug Maker Patient Stratification Cryptocurrency A. Schumacher (2017) Blockchain & Healthcare. 2017 Strategy Guide for the Pharmaceutical Industry, Insurers & Healthcare Providers. DOI: 10.13140/RG.2.2.12162.48327 Service Provider In this model algorithms are able to mine enormous amounts of data from numerous sources and provide scientific insight and BI to members of the blockchain
  • 48. The patient blockchain • Embleema (NY, 2018) • 1st blockchain network to give patients complete control over health data • HIPAA compliant • $2/month subscription fee • Patients can grant access to their medical data for trials and are compensated for doing so Our patient surveys have shown that 53% would agree to it if they had a proper way to give their consent to accelerating research. https://healthcareweekly.com/embleema-blockchain-healthcare/ https://support.embleema.com/hc/en-us/articles/360007096714-Embleema-Launches-the-First-Personal-Health-Records-Blockchain-To-Give-Patients-Complete-Control-Over-Their-Health-Data-and-Be-at-the-Center-of-Clinical-Research
  • 49. Google and others? • Google and others believe that delivering AI through the cloud will be a big, lucrative trend in computing in coming years. BSR annual meeting 2018
  • 50. New HC market players? • Amazon sees a new grow market in HC and will offer HC services • Own health insurance – first for Amazon employees (500.000 !) • “We have the size for influencing the insurance companies. The problem of the rising costs in HC is only becoming worse. Innovation is necessary”. Chief Technology Officer Amazon NRC, 6 april 2018
  • 51.
  • 52.
  • 53.