5. Approach to Patient of PUO Painstaking History: A- Chronology of Symptoms. B- Occupational History. C- Travel History. D- Drug History. E- Geographical History. F- Past History
6.
7.
8.
9.
10.
11. 2- Neoplastic Disease: A. Leukemia B. Lymphoma C. Sarcoma D. Carcinomatosis E. Renal cell carcinoma F. Colon Cancer G. Pancreatic H. Hepatoma I. Metastic cancer
12. 3 - Autoimmune Disease: A. Juvenile Rheumatoid Arthritis (evanescent rash) B. Henoch-Schonlein Purpura C. Systemic Lupus Erythematosus D. Rheumatic Fever (Migratory Polyarthritis) E. Polymyalgia Rheumatica F. Temporal Arteritis G. Inflammatory Bowel Disease H. Reiter’s Syndrome
13. 4 - Heritable Disease Causes: A. Fabry’s Disease B. Familial Mediterranean fever C. Lamellar Ichthyosis D. Nephrogenic Diabetes Insipidus E. Anhydrotic ectodermal dysplasia F. Familial Dysautonomia
14. 5- Granulomatous Disease: A. Sarcoidosis B. Granulomatous Hepatitis C. Inflammatory Bowel Disease 7- Miscellaneous: A. Facticious Fever (Munchausen by proxy) B. Thyroiditis C. Neurogenic Fever D. Milk Allergy E. Behcet’s Syndrome F. Anicteric Hepatitis G. Pulmonary Embolism H. Deep Vein Thrombosis
15. Drug-Induced Fever 1- Antibiotic Induced Fever: A. Erythromycin B. Isoniazid C. Penicillin D. Nitrofurantoin E. Procainamide F. Quinidine
16. 2- Cardiovascular Medication Induced Fever: A. Atropine B. Captopril C. Clofibrate D. Hydralazine E. Hydrochlorothiazide F. Methyldopa G. Nifedipine
17. 3 - Miscellaneous Medications Inducing Fever: A. Allopurinol B. Antihistamines C. Aspirin D. Cimetidine E. Heparin F. Meperidine G. Phenytoin
26. Pyrexia of Unknown Origin 1- Types: A. Pyrexia of Unknown Origin: 1. Daily or Intermittent Fever >= 38.3 C (101F) 2. Duration for three consecutive weeks 3. No source by clinical evaluation a. Hospital evaluation for 3 days (previously 7) or b. Intensive outpatient evaluation for 7 days or c. Three outpatient visits
27. B. Nosocomial Fever or Unknown Origin: 1. Daily or Intermittent Fever >= 38.3 C (101F) 2. Hospitalized >1 day without fever on admission 3. Fever evaluation of 3 days of more C. Immune-Deficient Pyrexia of Unknown Origin: 1. Daily or Intermittent Fever >=38.3 C (101F) 2. Neutrophil count < 500 per mm3 3. Fever evaluation of 3 days of more
28. D. HIV-Associated Fever of Unknown Origin: 1. Daily or Intermittent Fever >= 38.3 C (101F) 2. Outpatient Fever >4 weeks or 3. Inpatient fever >3 days
29. Infection Microbiactoxins Mediators of inflammation Immune Reaction Monocytes / Macrophacites Endothelial Cells Pyogenic Cytokines I L-1, I L-6, INF, IFN Microbial Toxins Hypothalamic Endotelium
30. PG E2 Cyclic AMP Elevated Thermoregulator Set Point Heat Conservation Heat Production Fever
![PUO Definition ,[object Object],[object Object],[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)