This document discusses eicosanoids, which are oxygenation products of arachidonic acid. It specifically focuses on prostaglandins and leukotrienes. Prostaglandins and leukotrienes are local hormones derived from arachidonic acid that have many functions, including roles in inflammation, smooth muscle tone, blood coagulation, reproduction, and GI secretion. The document outlines the pathways and enzymes involved in their biosynthesis, including the roles of cyclooxygenase and lipoxygenase. It also discusses the actions and clinical applications of various prostaglandins.
4. INTRODUCTION
Eicosanoids
(20 carbons) are found in the
animal kingdom and a variety of plants.
The eicosanoids are oxygenation products
of acid arachidonic (AA) polyunsaturated
fatty acid.
Acid
arachidonic is released from
membrane by phospholipase A2 (PLA2).
5. PROSTAGLANDINS & LEUKOTRIENES
Localhormones - very active,many
functions..
Autacoids from 20 C PUFA
Prostaglandins
Prostacyclin
Thromboxanes
Leukotrienes
38. PHOSPHOLIPIDS
ARACHIDONIC
ACID
CYCLOOXYGE LIPOOXYGEN
NASE ASE
Zileuton
LEUKOTRI
ENES
LEUKOTRIE
Monteleuk NE
PROSTAGLANDINS
astZafirleu RECEPTOR
kast
Chromoglyc MAS
ate T
Nedochromi CEL
l L
Editor's Notes
Pathways of arachidonic acid (AA) release and metabolism.