2. Marc Imhotep Cray, M.D.
Cough
2
Cough—forceful release of air from lungs—is a sudden, often
involuntary reflex and a major defense mechanism
Airway irritation activates reflex, which forcefully removes irritants, by
stimulating airways, which then activates afferent nerves going from
respiratory passages through vagus nerve to medulla
Activated cough receptors in medulla drive a reflex that initiates
inspiration (2.5 L of air) increases contraction of diaphragmatic,
abdominal, and intercostal (rib) muscles increases lung pressure and
emits air and irritants (at 100 mph)
3. Marc Imhotep Cray, M.D.
Cough (2)
3
Coughs triggered by drainage of mucus from nasal passages into airways
are treated with cough suppressants (antitussives)
Infection-related coughs (eg, in bronchitis) last for approximately 2 weeks
Persistent, chronic coughs (eg, in smokers) must be evaluated
Coughs occurring with blood, chest pain, shortness of breath, weight
loss, or dyspnea may indicate serious disease
Coughs in infants may indicate a serious lung disorder
4. Marc Imhotep Cray, M.D. 4
Etiology of Chronic Cough With a Normal Chest
Radiograph
Cause Prevalence
Postnasal drip 28-41%
Asthma 24-33%
GERD 10-21%
Chronic bronchitis
Postinfectious (often, viral URI)
bronchial hyperresponsiveness
5-10%
10%
Bronchiectasis 4%
ACE inhibitors, tracheomalacia,
eosinophilic bronchitis,
psychogenic, etc
5%
Redrawn after Raffa RB. Netter's Illustrated Pharmacology, Updated
Ed. Elsevier, 2014
5. Marc Imhotep Cray, M.D. 5
Causes of Chronic Cough With Abnormal Chest
Radiograph
6. Marc Imhotep Cray, M.D.
Cough Suppressants (Antitussive Agents)
6
Cough suppressants are opioids that reduce sensitivity of central cough
receptors to peripherally activated afferents
Receptor desensitization disrupts reflex and minimizes coughing
Opioids include
opiates (morphine and drugs derived from opium poppy plant, such as
hydromorphone, hydrocodone, and codeine) and
synthetic drugs that mimic effects of morphine
Opioids desensitize central cough receptors, reduce airway mucous secretion,
and alter mucous composition
7. Marc Imhotep Cray, M.D.
Antitussive Agents (2)
7
Opioids also produce many adverse effects, including
analgesia
addiction
sedation
euphoria
respiratory depression
nausea & vomiting and
Constipation
Doses of opioids needed to suppress cough are lower than doses that
evoke most of undesirable effects, particularly analgesia and addiction
Dextromethorphan, a morphine derivative and glutamate antagonist,
suppresses cough center and has fewer adverse effects than other opioids,
which accounts for its popularity in over-the counter preparations
9. Marc Imhotep Cray, M.D.
Other Cough Suppressants
9
Benzonatate [Tessalon]
Benzonatate is a glycerol derivative chemically similar to procaine
Benzonatate reduces activity of peripheral cough receptors and also
appears to reduce threshold of central cough center
Diphenhydramine
Diphenhydramine is an H1-receptor antagonist; however, antitussive
activity is probably not mediated at this receptor
Diphenhydramine acts centrally to decrease sensitivity of the cough
center to afferents
11. Marc Imhotep Cray, M.D.
Further study:
11
eLearning:
Unit 7: Drugs Used In Disorders Of The Respiratory System. In: Digital Guidebook 2015
Integrated Scientific and Clinical Pharmacology
IVMS MedPharm Cloud Folder
Notes:
Drugs Used In Disorders Of The Respiratory System Notes
Autacoids, Ergots, Anti-inflammatory Agents, and Immunosuppressive Agents Notes
o Histamine and its Antagonists
o Eicosanoids