Papillary Thyroid Cancer/ Causes, Signs, Diagnosis, Treatment/ in summary

1. Papillary Thyroid
Cancer
M.A.Khachatryan

2. The anatomo-histological structure of
Thyroid Gland

3. Characteristics of Papillary Thyroid
Cancer
• 80% of TC
• Common in females
• Peak onset ages 30-50
• Follicular cell genesis
• Well-differentiated
• Minimally invasive
• Lymphogenic spread

4. Causes/ Risk Factors
• Family history/genetic defect maybe involved
• Radiation
• Men
• Older persons
AACE/AME/ETA Thyroid Nodule Guidelines, Endocr Pract.2010;16(Suppl1

5. Symptoms and Signs
• Few or no symptoms
• Small lump(nodule)
• Painless during palpation

6. Exams and Tests
• History
• Physical examination
• US
• FNA
• Thyroid function tests

7. PTC US Features
• Hypoechogenicity
• Inhomogeneous echo pattern
• Microcalcifications
• Absence of peripheral halo
• Irregular borders, blurred margins
• Often intranodular hypervascularity
• Regional lymphadenopathy

10. Cytology of PTC; Nuclear inclusion.

11. Primary treatment
• No prospective clinical trials have clearly
determined the “best treatment” of patients
with PTC
• Appropiate surgical planning
202 ENDOCRINE PRACTICE Vol. 7 No. 3 May/June 2001

12. Macroscopic pathology-photograph

13. Microscopic examination

14. Adjuvant Therapy
• Thyroid Hormone-suppresive therapy
• Radioiodine Remnant Ablation(131J)
202 ENDOCRINE PRACTICE Vol. 7 No. 3 May/June 2001

15. M.A.Khachatryan