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Epidemiologic and Public HealthBasis of Screening for Diseases
Definition The presumptive identification of unrecognized defect or disease by the application of tests, examinations or procedures which can be applied rapidly, to sort out apparently well persons who probably have a disease, from those who probably do not.
Objectives of Screening To ensure early detection of a disease among individuals, so that prompt treatment may be instituted e.g. Screening for cervical cancer, breast cancer, hypertension etc. This is also called “Prescriptive Screening”. To protect the community from disease that the person being screened has, also called “Prospective Screening”; e.g. screening the blood units for HIV. For entry into certain forms of occupations (armed services, industries, etc.) with a view to “weed out” those who are unfit or whose existing health status may be adversely affected by occupational conditions.
Requirements of Tests used for Screening A Screening test should be Valid : It should be “accurate”, i.e. should measure correctly what it intends to. It should have high sensitivity, specificity, and positive & negative predictive values. Reliable (Precise) : It should give consistent results when repeated applications are made Practical : The test should be easily administered by even persons with ordinary training, should be innocuous, acceptable and should give fairly quick results. Efficient : The amount of inputs (in terms of expenses and time) should result in reasonable amount of
Requirements of Tests used forScreening Yield : is the amount of previously unrecognized disease that is diagnosed as a result of the screening effort Yield will depend on Sensitivity and specificity of the test, Prevalence of the disease (If screening is applied to a high risk group, the yield will be better) and availability of medical care (if medical care has not been available to the community being screened, a large number of people with the disease will be diagnosed).
Borderline /Cut OffBimodal Distribution: NormalMix of D+ and D-, ie,False +ve and false –veThe point at which distribution DiseasedIntersect is known as A„Cut off‟ BCut off at A – Highly sensitive ECut Off at B - Specific Borderline Unimodal Distribution C C – Borderline D D – Disease So whether cut off Should at C or D Normal
Considerations for a screeningprogramme The condition should be an important health problem. There should be an acceptable and effective treatment. Facilities for confirming the diagnosis and for treatment should be available. There should be recognizable latent / early symptomatic stage. There should be a suitable screening test or examination available. The test should be acceptable. The natural history of the condition, including development from latent to apparent disease, should be adequately understood. There should be an agreed policy regarding whom to treat as patients. The cost of case finding (including final diagnosis and treatment) should be economically balanced vis - a – vis the expenditure on medical care as a whole. Case finding should be a continuing process and not “once and for all” project.
Biases in ScreeningProgrammes Lead time bias Lead time is defined as the interval between the point a condition is detected through screening and the time it would normally have been detected due to appearance and reporting of signs and symptoms. If early detection has no effect on the course of disease then it will be like giving the patient a few more years of sickness and apprehension rather than health! (e.g. HIV detection).
Lead TimeDisease Onset First Possible Final Critical Usual Time of OutcomeDetection Point Diagnosis Diagnosis Screening Time Lead Time