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Update on breast cancer english presentation

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Update on breast cancer english presentation

  1. 1. Vida! Educational Series – Promoting Good Health Welcome! - We will begin shortly If viewing by internet: for technical help: 520-626-0167 Please complete surveys: http://streaming.biocom.arizona.edu/
  2. 2. Update in Breast Cancer Ana Maria Lopez, MD, MPH, FACP Associate Dean, Outreach and Multicultural Affairs Professor of Medicine and Pathology Medical Director, Arizona Telemedicine Program
  3. 3. Educational Objectives 1. Learn what is breast cancer 2. Discuss risks to breast cancer 3. Outline prevention measures for breast cancer
  4. 4. What is breast cancer?
  5. 5. breastcancer.org
  6. 6. http://geneticpeople.com/?tag=breast-cancer
  7. 7. gatheringbasket.org
  8. 8. buyletrozole.eu
  9. 9. What causes breast cancer? • Causes and risk factors
  10. 10. Risk Factors • Age: • 95% in women 40yo + • highest in 70-74 yo • FH • Personal history • Genetic risk: • BRCA 1/2, TP 53, ATM • Nulliparous • 1st full term pregnancy after 35 yo • No lactation • HRT • Alcohol • Overweight/obesity • Physical inactivity
  11. 11. 70% of breast cancers are in patients without identifiable risk factors
  12. 12. Risk Calculators • www.cancer.gov/bcrisktool NCI/NSABP
  13. 13. Hereditary Breast Cancer Risks 5-10% of all breast cancers • Ashkenazi Jewish descent • 3 or more 1st or 2nd degree relatives • 1st degree relative with bilateral breast cancer • 2 or more 1st or 2nd degree relatives with ovarian cancer • Male breast cancer
  14. 14. BRCA 1 and BRCA 2 • Code for DNA repair • Presence of gene, increases the risk of getting breast cancer up to 80% in her lifetime • BRCA1 or BRCA2 mutations make up about half of all cases of inherited breast cancer • associated with ovarian cancer and prostate cancer • can be inherited either from the mother or the father.
  15. 15. Other Inherited Genes • TP53 gene • codes for the tumor suppressor protein p53 • Mutations cause Li-Fraumeni syndrome: associated with early onset breast cancer • Ataxia Telangiectasia (ATM) gene Females with one defective copy of the ATM gene and one normal copy of the gene are at increased risk for breast cancer.
  16. 16. concurringopinions.com
  17. 17. ph-insider.blogspot.com
  18. 18. presstv.ir
  19. 19. ecosnobberysucks.c om
  20. 20. ladycarehealth.com
  21. 21. pdahealthware.com
  22. 22. Prevention
  23. 23. Prevention: saves us from the pain of being sick --Unknown
  24. 24. health.usf.edu
  25. 25. Prevention Studies • Tamoxifen • Raloxifen: STAR (Study of Tamoxifen and Raloxifene) • Raloxifene is as effective as tamoxifen in reducing invasive but not nonivasive (DCIS) BC risk • Both drugs reduce invasive BC risk by about 50% • Raloxifene: 36% fewer uterine cancers, 29% fewer blood clots • Both increase blood clots.
  26. 26. Aspirin • In an epidemiologic study, aspirin appeared to lower breast cancer risk • Need prospective trial
  27. 27. Vitamin D • Helps with calcium absorption to maintain bone density • In clinical trials
  28. 28. Fat • WINS • Low fat diet (< 30%) • 5Y FU: new breast cancers--9.8% low-fat diet; 12.4% standard diet (24% reduction) • largest risk reduction – 42%--in ER negative tumors
  29. 29. What about soy? Flax? Phytoestrogens? • Eat what you like! • Eat healthy! • Do not change your diet drastically to include phytoestrogens. • There may be safety concerns re: pharmaceutically concentrated soy products
  30. 30. Lifestyle • Maintain a healthy weight • Decrease intake overall. Increase vegetables in specific (2/3 of plate) • Increase activity: 3-4 hours of exercise per week • Decrease alcohol intake
  31. 31. Early Detection
  32. 32. kodak.com Computer-aided detection and diagnosis (CAD)
  33. 33. canada.com Tomosynthesis (3D mammography)
  34. 34. Treatment
  35. 35. ultimateboxingresults.com
  36. 36. riskofbreastcancer.net
  37. 37. indianapublicmedia.org
  38. 38. dailymail.co.uk

Hinweis der Redaktion

  • National Cancer Institute and the National Surgical Adjuvant Breast and Bowel Project

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