4. I N V I T A T I O N
Jean Lindenmann Symposium
September 27, 2004
to celebrate and honour
Jean Lindenmann’s 80th Birthday
We cordially invite you to attend this celebration
Otto Haller Peter Staeheli
Abteilung Virologie
Institut für Med. Mikrobiologie und Hygiene
UNIVERSITÄTSKLINIKUM FREIBURG
11. Nature. 1980 Mar 27;284(5754):316-20.
Synthesis in E. coli of a polypeptide with
human leukocyte interferon activity.
• Nagata S, Taira H, Hall A, Johnsrud L, Streuli M, Ecsodi J,
Boll W, Cantell K, Weissmann C.
Double-stranded cDNA prepared from the 12S fraction
of poly(A) RNA from interferon (IF)-producing human
leukocytes was cloned in Escherichia coli using the
pBR322 vector. One of the resulting clones had a 910-
base pair insert which could hybridise to IF mRNA and
was responsible for the production of a polypeptide
with biological IF activity. Up to 10,000 units IF activity
per g of cells was obtained from some clones.