Presentatie Prof.dr. BJM Mulder en Prof.dr. MC DeRuiter

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CVON

Prevention of Thoracic Aortic Aneurysm Formation. The THORA - study

Health & Medicine

Principal investigators Dr. MJ Goumans, Molecular Cellbiology, LUMC Prof. dr. B Loeys, Clinical Genetics, RUNMC Prof. dr. CVC Bouten, Biomedical Engineering, TU/e Prof. dr. AH Zwinderman, Clinical Epidemiology, Biostatistics & Bioinformatics, AMC Disciplines: basic science- clinical practice Cardiology, Pathomorphology, Developmental Biology, Genetics, Thoracic Surgery, Biostatistics, Bioengineering, Computational Modelling Participating centers nationwide AMC, LUMC, UMCG, RUNMC, EMC, UMCU, TUE Consortium THORA

Health Care problem ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],THORA

Research questions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],THORA

Translation THORA Development pathomorphology Genetics Disease Modeling Outcome and Prevention Animal Human Mice Models Fibrillin1 -/- Fibulin 4 -/- Enos -/- ENG/ALK5 -/- Confetti lineage tracing crossed with Cre-lines Expression studies Microarray RNA Lineage specific signaling pathways Whole genome sequencing (blood, families) ,[object Object],[object Object],[object Object],[object Object],MRI/echo functional studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Macro/microscopic phenotyping BioBank, Fresh tissues Retrospective study ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Computational models of hemodynamics Prediction of aneurysm formation ,[object Object],[object Object],[object Object],[object Object],Clinical and surgical risk models for subgroups

Focus areas Dutch Heart Foundation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],THORA

Perspective ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],THORA

WP 1a: MRM Jongbloed (LUMC), J Lindeman (LUMC), J Essers (EMC) WP 1b: MM Bartelings (LUMC), RJM Klautz (LUMC), BJ Bouma (AMC), AJJC Bogers (EMC) WP 2a: RMW Hofstra (UMCG), AV Postma (AMC) WP 2b: CMA van Ravenswaay (UMCG), WS Kerstjens (UMCG) WP 3a: FPT Baayens (TUE), BP Hierck (LUMC), J Essers (EMC) WP 3b: FN van de Vosse (TUE), PH Schoof (UMCU), J Kluin (UMCU), M Groenink (AMC), AP van Dijk (RUNMC) WP 4a: MJ Goumans (LUMC), AH Zwinderman (AMC) WP 4b: PG Pieper (UMCG), JJM Takkenberg (EMC), MG Hazekamp (LUMC/AMC), J Timmermans (RUNMC), BJ Bouma (AMC), DR Koolbergen (LUMC/AMC) THORA Participants

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