A prefix is a group of letters added to the beginning of a root word that changes the word's meaning. Root words can have prefixes and suffixes added to form new words. Prefixes like "un" mean "not", while prefixes like "pre" mean "before in time". There are no strict rules for prefix usage but understanding a prefix's meaning can help determine the correct word. Stress is usually placed on the root word when adding prefixes, not on the prefix itself.