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National Food and Nutrition Policy:
Balancing the Role of Research,
Nutrition Science and Public Health
Today’s Presenters and Topics:
Joanne Slavin, PhD, RD, Professor, Department of Food Science and
Nutrition, University of Minnesota
The Widespread Effects of Food and Nutrition Policy on Public Health
Connie Weaver, PhD, Distinguished Professor and Department Head,
Nutrition Science, Purdue University
The Importance and Deficiencies of Consistent, Systematic Evaluation
Processes in Policymaking
Roger Clemens, DrPH, CFS, CNS, FACN, FIFT, FIAFST, Adj Professor,
Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy
The Role of Scientific Research in Food and Nutrition Policy
Moderated by:
Chase Purdy, Politico
Objectives and Key Takeaways:
• Former Dietary Guidelines Advisory Committee
members will discuss how nutrition science and
research shapes U.S. food policy issues;
• Today you will learn about the role federal agencies
play in making food and nutrition policy
recommendations;
• You will leave today with insights into the science and
process related challenges faced when creating the
DGAC Report; and
• Finally, past DGAC members will convey their opinions
on the newly released 2015 DGAC Report, and
recommendations on how to move forward.
Joanne Slavin, PhD, RD
Professor
Department of Food Science
and Nutrition
University of Minnesota
April 1, 2015
jslavin@umn.edu
The Widespread Effects of Food and Nutrition
Policy on Public Health
Disclosures for Joanne Slavin
AFFILIATION/FINANCIAL
INTERESTS
(past 12 months)
CORPORATE
ORGANIZATION
Grants/Research Support: American Pulse Association,
Novartis Consumer Health
Scientific Advisory
Board/Consultant:
Atkins, Tate and Lyle, Midwest
Dairy Association, Alliance for
Potato Research and Education
Speakers Bureau:
Stock Shareholder:
Other 1/3 interest in Slavin Sisters
Farm, 119 acres, Walworth, WI
From the Science to Me
The Science Policy Me
There is no perfect diet!
• Humans are omnivores, like pigs, and are adaptable
to a wide range of foods
• Humans have survived and prospered on all kinds of
diets, mostly reflecting access to food supply
– Traditional Arctic diet: 80% of kcals from fat
– Traditional African diet: 80% of kcals from carbohydrate
• Because of concerns with fat and cardiovascular
disease, U.S. diet has moved from higher fat (42% of
kcal in 1972) to lower fat (32% of kcal in 2000) – but
more calories
Dietary Guidance—A Historical Perspective
1894 - Dr. W.O. Atwater specified amount of protein and total
calories in a good diet, but left unspecified the division of
calories between fats and carbohydrates
1902 - “evils of overeating may not be felt at once, but sooner
or later they are sure to appear – perhaps in general debility,
perhaps in actual disease”
1902 - “ordinary food materials…make a fitting diet, and the
main question is to use them in the kinds and proportions
fitted to the actual needs of the body”
Recommended variety, proportionality and moderation,
measuring calories, and an affordable diet focused on
nutrient-rich foods, less fat, sugar and starch.
Nutritional science – nutrients to prevent deficiency
diseases
1941:
– National Academy of Sciences began issuing
“Recommended Dietary Allowances” – quantity of
nutrients a person needed to consume daily to
ensure basic good health, proper growth and
reproductive success, and to prevent nutrient
deficiency diseases.
– Nutritional deficiency diseases have been virtually
eliminated in the U.S., thanks to enrichment of
refined grains and other fortification strategies.
Nutrient Adequacy
- Meet nutrient needs without exceeding calorie needs
- Dietary Reference Intakes (DRIs)
- Acceptable Macronutrient Distribution Ranges (AMDR)
- Protein: 10 - 35% of kcal
- Carbohydrates: 45 - 65% of kcal
- Fat: 20 - 35% of kcal
- Recommended Dietary Allowance (RDA)
- Adequate Intake (AI)
- Tolerable Upper Level Intake (UL)
Senate Select Committee on Nutrition and Human Needs –
Dietary Goals the United States (1977)
• Increase carbohydrates to 55%–60% of energy
• Reduce fat to 30% of energy
• SF, MF, PUFAs – 10%/10%/10%
• Reduce cholesterol to 300 mg/day
• Reduce sugar consumption by 40%
• Reduce salt consumption to 3 g/day – 1200 mg
sodium
Toward Healthful Diets, FNB, 1980
• “The Board expresses its concern over
excessive hopes and fears in many current
attitudes toward food and nutrition. Sound
nutrition is not a panacea. Good food that
provides appropriate proportions of nutrients
should not be regarded as a poison, a
medicine, or a talisman. It should be eaten
and enjoyed.”
Dietary Guidelines for Americans 1980 - 2010
1980
1985
1990
1995
2000
2005
2010
Development of Dietary Guidelines Policy
DGAC
Advisory Report
submitted to the
Secretaries of
USDA & HHS
USDA & HHS
write the
Policy
Document
DGAC is
chartered DG’s
implemented
through Federal
programs
DGAC
Charter
DGAC
Public Meetings:
Review of the
Science
Evidence-based Methodology Used to Review the Science
Public comments encouraged/collected
Dietary Guidelines
for Americans, 2010
(TBD)
U.S. Department of Agriculture
U.S. Department of Health and
Human Services
www.dietaryguidelines.gov
The
New
“Pyramid”
Total Diet 2010 DGAC Conclusions – not evidence-
based
Key Topics:
- Overweight/obese nation
- Develop healthy dietary patterns in childhood and
adolescence
- Maintain energy intake within calorie needs
- Maximize nutrient density by emphasizing whole
grains, vegetables, fruits, milk/milk products, and oils
- Reduce solid fats and added sugars and sodium
- Flexible eating patterns
Chapter 3
Foods and Food Components to Reduce
Chapter 4
Foods and Nutrients to Increase
Comparison of Consumption
to Recommendations
DGAC 2015
• “Settled science” – may not see much change on
nutrient levels
• Movement to whole foods and away from
nutrients
• Topics such as sustainability, gluten, vegan diets,
and food processing have been discussed and may
be included in 2015 DGA
2015 DGAC – Dietary patterns, foods and nutrition,
and health outcomes
• The US population should consume dietary patterns
that are:
– Rich in vegetables, fruits, whole grains, fish/seafood,
legumes, and nuts
– Moderate in dairy products (e.g. low and non-fat dairy)
and alcohol and
– Lower in red and processed meat and
– Low in sugar-sweetened foods and beverages and refined
grains
2015 DGAC – Food and nutrient intakes, and health:
Current status and trends
• The US population has low intakes of certain key nutrients – vitamin
D, potassium, fiber, calcium, and for females also iron. These low
intakes are a public health concern because inadequate intakes are
linked to health problems
• The US population over consumes sodium and saturated fat. Excess
intakes of these nutrients are also linked to health problems
• Many of the food groups that are good sources of under consumed
nutrients are consumed in low amounts by the US population
• Many of the food groups and food categories that have high levels
of sodium, saturated fat, and added sugars are consumed in high
amounts
1943: Basic Seven
Margaret Mead:
“People don’t eat
nutrition – they eat
food”
Basic 7 did not specify
the number of
servings of each food
group needed daily
1940s1950s-1960s
1970s
1992
Food for
Young
Children
1916
2005
Food advice: Evolution of USDA’s
Food Guidance – Moderation and Variety
MyPlate.gov (6/2/11)
Conclusions
• Evidence-based reviews are limited in our ability to define
“healthy foods”
• Recommendations for less added sugar and solid fats are based
on empty calories, not health outcomes – USDA modeling
• Since nutrition research does not support that vegetarian diets
are healthier than animal based diets, there is a movement to
“sustainability” as the reason to support plant-based diets
• Solving important nutrition problems will require partnerships
based on trust among academics, the government, commodity
groups, and food companies
The Importance and Deficiencies of
Consistent, Systematic Evaluation
Processes in Policymaking
Connie M. Weaver, Ph.D.
Purdue University
West Lafayette, IN USA
weavercm@purdue.edu
Disclosures for Connie Weaver
AFFILIATION/FINANCIAL
INTERESTS
(past 12 months)
CORPORATE
ORGANIZATION
Grants/Research Support: NIH, DRI, Nestle,
Tate & Lyle
Scientific Advisory
Board/Consultant:
NOF, ILSI, Showalter,
Pharmavite
Speakers Bureau:
Stock Shareholder:
Other
Outline
• Evidence-based approach
• Difficulties encountered with evidence-based
approach in nutrition
The Philosophy Behind
an Evidence-based System
• Rules are set “up front” then followed, rather
than having a preconceived idea and then
finding the papers to support the idea.
• If one follows the rules, any trained scientist
should come to the same conclusion.
Hierarchy of
Evidence
RCT
Double Blinded
RCT
Cohort Study
Case Control
Case Series
Case Report
Expert Opinion
Weaker
Evidence
Stronger
Evidence
Evidence-based Medicine Hierarchy
Consistency ends here!
No Consistent Literature Retrieval
or Grading Systems
• NIH-AHRQ
• FDA-own system for health claims
• Various other approaches
Slavin Nutr J 14:15, 2015
Nutrition Evidence Library (NEL) Process
32
Formulate
Systematic
Review
Questions
•Exploratory
searches
•Public
comment
•Dialogue with
experts
•Analytical
Framework
•PICO
Literature
Search and
Sort
•Identify study
eligibility criteria
•Determine
search strategy
•Search for
relevant studies
•List included
studies
•List excluded
studies and
rationale
Extract
Evidence
From
Studies
Create
evidence
worksheets
Summarize
and
Synthesize
the Evidence
•Assess quality
of individual
studies
•Assess
applicability
•Summarize
and synthesize
evidence
Develop
and Grade
Conclusion
Statements
Define Research Recommendations
Dietary Guidelines Advisory Committee Since 2010:
Grade Strength of Evidence
• Quality
– Scientific rigor and validity
– Consider study design and execution
• Quantity
– Number of studies/sample sizes
• Consistency of findings across studies
• Impact
– Importance of studied outcomes/magnitude of effect
– Magnitude of effect
• Generalizability
Grades: 1. STRONG; 2. MODERATE; 3. LIMITED
PubMed search of scientific literature Jan 2000-Dec 2014
• Search term + bone + child + adolescence
• Excluded: reviews, animal studies, non-English
• Subcommittees reviewed abstracts and
excluded
- If not RCT or observational study
- No bone outcomes
- Interventions <6 mo.
- Drug trials of disease states
ASN Scientific Statements
Example of Development of Peak Bone Mass
Level of Evidence Description
A: Strong One large, well-conducted, generalizable, RCT
OR
Multiple RCTs or trials with few limitations
B: Moderate Multiple prospective cohort studies.
OR
Meta-analysis of prospective cohort studies.
C: Limited Multiple prospective cohort studies from diverse populations that have
limitations.
OR
One well-designed prospective study.
OR
Multiple cross-sectional or case-controlled studies with few limitations.
OR
Meta-analysis with design limitations.
D: Inadequate Methodologic flaws
OR
Insufficient data.
Evidence Grade
Differences in process for
evaluating scientific evidence can
lead to different conclusions
Example: Choosing different end
points concern over salt
2010 Dietary Guidelines Advisory
Committee Conclusions
• A strong body of evidence has documented that
in adults, as sodium intake decreases, so does
blood pressure.
• A moderate body of evidence has documented
that as sodium intake decreases, so does blood
pressure in children, birth to 18 years of age.
• The reduction from 2,300 mg to 1,500 mg per
day should occur gradually over time. [about 750
mg/1000kcal]
IOM Committee on Consequences
of Sodium Reduction in Populations
– Released May 14, 2013
• Calls for national action to reduce sodium
content of foods - average intake 3400 mg Na/d
• Evidence weak to strive for less than 2300 mg
Na/d – need more studies between 1500 and
2300 mg/d
Focused on disease outcomes beyond blood
pressure
2015 DGAC
Sodium Recommendations
<2300 mg/day
There is NO guarantee of
consensus conclusions even if
you use same process and end
points
What is the Relationship Between Calcium
and Vitamin D and Hip Fracture?
Women’s Health Initiative RCT of CaD
(n=68,719 postmenopausal women)
Prentice et al., Osteopor Int 24:567, 2013
• All subjects including those
taking own supplements
• >5 Year CaD Intervention-related
Health Outcomes in Subjects
Adherent & Not Taking Baseline
Supplements
No relationship
Large benefit
Difficulties of Applying Evidence-
Based Medicine Approach to
Nutrition
Ranking of Study Type
• The RCT is given greatest weight because
it is the only design that permits strong causal
inference
• But for nutrition, that often means sacrificing
control of the independent variable (nutrient diet)
in favor of the dependent variable (health
outcome)
RCT Trials are Designed for a
Compound That:
• Works quickly
• Usually pinpointed to 1
pathway or 1
mechanism of action
• That is: a drug
Features of RCTs for Drugs
• Tested in or applied to sick people
• Test agent is contrasted with its absence
compared to a nutrient where there can be no
nutrient-free state
• Sharply defined primary outcome measure
• Effect size usually large compared to a nutrient
• Response characteristic is usually monotonic
across plausible intakes
Contrasts
• Drug – drug-added state is contrasted with
drug-free state
• Nutrient – “high” intake is contrasted with
“low” intake;
Effect Size
• Drug- usually large
• Nutrient – usually small, but
— public health impact may nevertheless be large
— aggregate effect across multiple
— systems is itself often large
Consequence
• When changes are small, testing for isolated
nutrient effects requires large, expensive,
lengthy studies if effects in isolated systems are
to be found statistically significant.
INTAKE
EFFECT
Study Design & the Threshold
the control group
must be deficient
The Ethical Problem
• Placing the control group on a clearly
inadequate intake
Underreporting error for energy intake in overweight boys and girls was 35+18%
EIas%ofTEE
Girls Boys
Reported EI
Weight adjusted
MEI
TEE by DLW
Singh, 89(6):1744-1750, 2009
Concern with Diet Assessment
for Observational Studies
Controlled Feeding Studies
• Historically ranked highest for evidence
for nutrients/diet
• Minimizes confounders and allows study
of range of known intakes
Animal Studies
• Can have controlled diet and sufficiently
long duration for cancer outcome
measures.
• But relevance to humans?
• Invasive procedures
• Mechanistic
Future Needs
• Good biomarkers are the most needed tool in
research related to diet and health. Current
biomarkers for intake and health outcome
measures range from weak to moderately good.
Even the better ones need validation.
Many Kinds of Evidence
Basic
Research
Translational
Research
Efficacy
Studies
Effectiveness
Research
How does
it work?
Can it be
studied in
people?
Specific
effects?
How good
is the
translation?
Best recommendations
use the totality of
evidence with liberal
doses of critical thinking
and LOGIC!
The Role of Scientific Research
in Food and Nutrition Policy
Roger Clemens, DrPH, CFS, CNS, FACN, FIFT, FIAFST
Adj Professor, Pharmacology and Pharmaceutical Sciences,
USC School of Pharmacy, Los Angeles
clemens@usc.edu
Disclosures for
Roger Clemens
AFFILIATION/FINANCIAL
INTERESTS
(past 12 months)
CORPORATE ORGANIZATION
Grants/Research Support: None
Scientific Advisory
Board/Consultant:
Abbott Nutrition, Almond Board of California,
California Walnut Commission, Coca-Cola
(manuscript preparation), Corn Refiners Association
(honorarium for EB15), FMC Corp, McDonalds Corp,
Mushroom Council, Spherix Consulting, and
Numerous Law Firms
Speakers Bureau: Extensive Media Outlets (pro bono)
Stock Shareholder: None
Other
None
 The opinions and comments presented do not reflect
those of the Dietary Guidelines Advisory Committees,
the USDA and CNPP, or HHS.
 The opinions and comments expressed reflect
evidence and perspectives as a member of the 2010
Dietary Guidelines Advisory Committee and as the
sole food scientist on that committee.
Disclaimer
1930
 Examine the Dietary Guidelines for Americans, 2010 and determine topics for which new
scientific evidence is likely to be available that may inform revisions to the current
guidance or suggest new guidance.
 Place its primary focus on the systematic review and analysis of the evidence published
since the last DGAC deliberations.
 Place its primary emphasis on the development of food-based recommendations that
are of public health importance for Americans ages 2 years and older.
 Prepare and submit to the Secretary of Health and Human Services and the Secretary
of Agriculture a report of technical recommendations, with rationales, to inform the
development of the 2015 Dietary Guidelines for Americans. DGAC responsibilities include
providing authorship for this report; however, responsibilities do not include
translating the recommendations into policy or into communication and outreach
documents or programs.
Charge to the 2015 DGAC
http://www.health.gov/dietaryguidelines/2015-binder/2015/chargeCommittee.aspx
June 2013
Assessing the Evidence
 Observational claims are not necessarily validated via
clinical trials.
 Clinical studies among small populations do not necessarily
translate to total population (think public policy)
 Common words like “association,” “related,” and “relative
risk” imply strength, yet upon review the work is generally
quite weak
 “Definitive solution will not come from another million
observational papers or a few small randomized trials”
Ioannidis JPA BMJ 2013;347: doi: 10.1136/bmj.f6698
 Systematic reviews and meta-analyses
 Different inclusion/exclusion criteria impact results
 Different statistical approaches and choices of
covariates impact results
 Dietary exposures are not accurate
 Associations  Causes
Research Bias
Nicklas et al., J Nutr 2014; doi: 10.3945/jn.114.194068
It is…important to not be distracted by questions
that we have not been asked to address.
What was Asked?
What’s missing in many [meta analysis and systematic review]
studies published since 2010 DGAC?
 Undefined and inconsistent
outcomes
 Intention to treat analysis
 Complete case analysis
 Unexplained discontinuances
 Imputed baseline data extended
beyond current analysis
 Multiple imputations in analyses
Kaiser et al. Obes Rev 2013; doi: 10.1111/obr.12048.
Ecological Relation of Water Intake with
Prevalence of Overweight/Obesity: 1961-2000
Rise in obesity rates (round markers) and bottled water consumption (square markers). USA
Consumer Confusion
Confidence
Confusion
IFIC 2012:
• Three out of four consumers feel that changes in nutritional
guidance makes it hard to know what to believe
• Half believe it is easier to do their own taxes than to figure out
how to eat healthfully
International Food Information Council Foundation 2012 Food & Health Survey . Consumer Attitudes Toward Food
Safety, Nutrition & Health
http://www.foodinsight.org/Content/3840/2012%20IFIC%20Food%20and%20Health%20Survey%20Report%20of%20Fin
dings%20(for%20website).pdf
Do Scripted Diets Work for Policy?
What about Low-fat Diets?
2015 DGAC Meeting 5, September 16, 2014
Comments
 Chowdhury: “My take on this would be that it’s not
saturated fat that we should worry about” in our diets.
 Hu: The findings should not be taken as “a green light”
to eat more steak, butter and other foods rich in
saturated fat. … looking at individual fats and other
nutrient groups in isolation could be misleading,
because when people cut down on fats they tend to eat
more bread, cold cereal and other refined carbohydrates
that can also be bad for cardiovascular health.
 Hu: “The single macronutrient approach is outdated.
I think future dietary guidelines will put more and more
emphasis on real food rather than giving an absolute
upper limit or cutoff point for certain macronutrients.”
 Hu: People should try to eat foods that are typical of the
Mediterranean diet, like nuts, fish, avocado, high-fiber
grains and olive oil.
Rajiv Chowdhury, PhD
Cardiovascular Epidemiologist
University of Cambridge
Frank Hu, MD, PhD
Professor of Nutrition and
Epidemiology
Harvard University
http://acsh.org/2014/03/huge-new-re-evaluation-saturated-fat-heart-risk-finds-link/
March 18, 2014
 Cholesterol is not a nutrient of concern for
overconsumption.
 Saturated fat is still a nutrient of concern for
overconsumption, particularly for those older than
the age of 50 years.
Dietary Cholesterol and Saturated Fat
 There is insufficient evidence that an exchange of
sugar for non-sugar carbohydrates results in lower
body weights (a calorie = a calorie)
 Observational (cross-sectional) studies suggest a
possible relationship between consumption of sugar-
sweetened beverages (SSB) and body weight; no
supporting RCTs
 Insufficient evidence to support a difference between
liquid and solid sugar intake and body weight control
Added Sugars and Body Weight
Key reference: van Baak & Astrup. Obes Rev 2009; 10 Suppl 1:9-23
Sugar in Research
Yangetal.,JAMAInternMed2014;doi:10.1001/jamainternmed.2013.13563
Conclusions:
• Increased calories … from added sugar … associated with increased risk of
CVD mortality
• Consumption of SSB (aka sugar) is associated with elevated CVD mortality
Recommendation
• Limit intake of calories … from added sugar
Headlines:
Drink just one 12-ounce
can of sugary soda
every day, and you
might be unwittingly
increasing your risk of dying
from heart disease,
suggests a new study.
Agency Statement
2010 DGAC RCTs report that added sugars are not different from other
calories in increasing energy intake or body weight. Systematic
reviews in this area are also inconsistent.
EFSA 2012 …a cause and effect relationship has not been established
between total sugar intake and body weight gain
WHO 2015
(Te Morenga et al, 2014)
‘Trials in children, which involved recommendations to reduce
intake of sugar sweetened foods and beverages, had low
participant compliance to dietary advice; these trials showed no
overall change in body weight.’
German Nutrition Society 2012 In general, meta-analyses are inconsistent. The most recent
meta-analysis concludes that the risk-increasing effect is limited
to individuals with initially already increased BMI or existing
overweight, respectively
American Heart Association,
American Diabetes Association
2012
At this time, there are insufficient data to determine conclusively
whether the use of NNS [non-nutritive sweeteners] to displace
caloric sweeteners in beverages and foods reduces added sugars
or carbohydrate intakes, or benefits appetite, energy balance,
body weight, or cardiometabolic risk factors.
Sugar in Context
Percentiles of Usual Caffeine Intake
by Age: Consumers Only
0
100
200
300
400
500
600
2-11 12-17 18-29 30-34 35-39 40-49 50-59 60+
mgCaffeine/d
Age (years)
10th
25th
50th
75th
90th
* Data Source: NHANES 2007-2010; n=13,923
Courtesy of V.L. Fulgoni III, PhD, Nutrition Impact, LLC, August 5, 2013
 Question
 What is the relationship between usual coffee/caffeine consumption
and health?
 Conclusion
 Moderate evidence from observational studies indicates that
caffeine intake is not associated with risk of preterm delivery .
Grade Moderate
 Higher caffeine [>300 mg/d] intake is associated with a small
increased risk of miscarriage, stillbirth, low birth weight, and small
for gestational age births.
 These data should be interpreted cautiously due to potential recall
bias in case-control studies and confounding by smoking and
pregnancy signal symptoms.
Grade Limited
Caffeine & Pregnancy
SC 5: Food Sustainability and Safety
Greenwood DC et al., Eur J Epidemiol. 2014; doi: 10.1007/s10654-014-9944-x
Maslova E et al., Am J Clin Nutr. 2010; doi: 10.3945/ajcn.2010.29789
Coffee and Health History
(1975 – 2015)
 Early years identified many potential health effects of coffee and
caffeine consumption
 The preponderance of medical & scientific evidence clearly
supports the position that moderate daily coffee consumption
(about 3 - 5 cups), as part of a varied, balanced diet, is safe and is
not associated with any adverse human health consequences
 EFSA (January 2015)
• Single doses of caffeine up to 200 mg and daily intakes of up to 400
mg do not raise safety concerns for adults in Europe
• For pregnant women, caffeine intakes of up to 200 mg / d do not raise
safety concerns for the unborn child
 Sustainable diets:
 A pattern of eating that promotes health and well-being
and provides food security for the present population
while sustaining human and natural resources for future
generations.
 Diets higher in plant-based foods, such as vegetables,
fruits, whole grains, legumes, nuts, and seeds, and lower
in calories and animal based foods is more health
promoting and is associated with less environmental
impact than is the current U.S. diet.
Food Sustainability
Congress and DGAC Sustainability
Source: 113th Congress 2nd Session. House of Representatives. Report 113-468.
June 4, 2014. Pages 51-52
reject
 Food Production (based on 2002 statistics)
 Additional 7.4 million acres harvested cropland
needed to meet basic food groups
 Additional 8.9 million acres needed to support
vegetable recommendations
 Additional 4.1 million acres needed to support
fruit recommendations
 Sufficient cropland devoted to wheat could be reduced by
5.6 million acres
 Farm milk production must increase by 107.7 billion
pounds
Agricultural Challenges - 2010
Page 136
Buzby, Wells and Vocke. Economic Research Report No. (ERR-31), November 2006
 Develop and expand safe, effective, and sustainable
agriculture and aquaculture practices to ensure availability
of recommended amounts of healthy foods to all segments
of the population. (Policy document)
 Aquaculture:
 Globally, nearly 50% of the fish consumed relies on aquaculture
farms
 Domestically, about 20% of aquaculture production is marine
species; the remainder is freshwater species
 Some statistics suggest that harvesting of wild fish is not
sustainable (need 155,000 tons edible portions of [low Hg] fish per
year  345,000 tons of fresh fish, e.g., primarily salmon)
 Exceeds annual global salmon supply by ~50%
 Increase environmentally sustainable production of
vegetables, fruits, and fiber-rich whole grains. (DGAC)
Sustainability of Dietary Guidelines
 Must interconnect in policymaking
that extends beyond nutrition.
 Must leverage interdisciplinary
expertise that embraces knowledge,
technology and innovation plus
sections outside of the food system
to achieve a more encompassing
food system
 Develop a strong evidence-based
approach to decision making
 Engage global harmonization
guidelines in regionally, culturally
appropriate practices in food supply
USDA Budget
Food, Nutrition & Health
 Secondary Education
Challenge
 Community Food Projects
 Higher Education Challenge
 1890 Capacity
 Food Safety, AFRI
 Climate Variability and Change,
AFRI
 Food Security, AFRI
 Foundational Program, AFRI
 Alaska Native & Native
Hawaiian Institutions
 Federally Recognized Tribes
Extension Program
 Hispanic-Serving Institutions
Education
 Multicultural Scholars
 National Needs Graduate
Fellowships
 New Technologies for Ag
Extension
 Rural and Community
Development, SBIR
 Tribal Colleges Education Equity
 Tribal Colleges Extension
 Tribal Colleges Research
 FDA Investment
 Further scientific knowledge about potential
food hazards
 Expand on best safety practices
 Better understand how consumers access,
prepare, and use the foods they serve and eat
 CFSAN Research Strategic Plan
 Globalization of the food supply chain
 Changing industry processes
 Consumer preferences for fresh and minimally
processed foods
Science & Research (Food)
Where’s
Food
Science
and
Nutrition?
Immediacy
 Sustainability
 Resource management
(land, water, energy)
 Cultivars compatible with
climate dynamics
 Biodiversity
 Supply chain (e.g., grains,
fish  price stability)
 Globalization of food
supply
 R&D investment
 New technology and
innovation
 Political tension  unstable
food supply
 Food security policy
 Poverty  Inadequate
food  Decline physical
and mental development
 Rural development  
hunger
 Urgency for public and personal health
 Urgency for collaborative funding
 Urgency for the next generation
Call to Action
“A coordinated strategic plan that includes all sectors of society, including
individuals, families, educators, communities, physicians and allied health
professionals, public health advocates, policy makers, scientists, and small and large
businesses (e.g., farmers, agricultural producers, food scientists, food
manufacturers, and food retailers of all kinds), should be engaged in the
development and ultimate implementation of a plan to help all Americans eat well,
be physically active, and maintain good health and function.
It is important that any strategic plan is evidence-informed, action-oriented, and
focused on changes in systems in these sectors” USDA
 Abbott: Well, let’s see, we have on the bags. Who’s
on first, What’s on second, I Don’t Know is on third…
Where are we now?
William "Bud" Abbott &
Lou Costello
1938
While Diet Is Linked to Health, Much Confusion Exists
About What to Eat and Under What Circumstances!!
Thank you for attending today.
Are there any questions?

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National Food & Nutrition Policy: Balancing the Role of Research, Nutrition Science and Public Health

  • 1. National Food and Nutrition Policy: Balancing the Role of Research, Nutrition Science and Public Health
  • 2. Today’s Presenters and Topics: Joanne Slavin, PhD, RD, Professor, Department of Food Science and Nutrition, University of Minnesota The Widespread Effects of Food and Nutrition Policy on Public Health Connie Weaver, PhD, Distinguished Professor and Department Head, Nutrition Science, Purdue University The Importance and Deficiencies of Consistent, Systematic Evaluation Processes in Policymaking Roger Clemens, DrPH, CFS, CNS, FACN, FIFT, FIAFST, Adj Professor, Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy The Role of Scientific Research in Food and Nutrition Policy Moderated by: Chase Purdy, Politico
  • 3. Objectives and Key Takeaways: • Former Dietary Guidelines Advisory Committee members will discuss how nutrition science and research shapes U.S. food policy issues; • Today you will learn about the role federal agencies play in making food and nutrition policy recommendations; • You will leave today with insights into the science and process related challenges faced when creating the DGAC Report; and • Finally, past DGAC members will convey their opinions on the newly released 2015 DGAC Report, and recommendations on how to move forward.
  • 4. Joanne Slavin, PhD, RD Professor Department of Food Science and Nutrition University of Minnesota April 1, 2015 jslavin@umn.edu The Widespread Effects of Food and Nutrition Policy on Public Health
  • 5. Disclosures for Joanne Slavin AFFILIATION/FINANCIAL INTERESTS (past 12 months) CORPORATE ORGANIZATION Grants/Research Support: American Pulse Association, Novartis Consumer Health Scientific Advisory Board/Consultant: Atkins, Tate and Lyle, Midwest Dairy Association, Alliance for Potato Research and Education Speakers Bureau: Stock Shareholder: Other 1/3 interest in Slavin Sisters Farm, 119 acres, Walworth, WI
  • 6. From the Science to Me The Science Policy Me
  • 7. There is no perfect diet! • Humans are omnivores, like pigs, and are adaptable to a wide range of foods • Humans have survived and prospered on all kinds of diets, mostly reflecting access to food supply – Traditional Arctic diet: 80% of kcals from fat – Traditional African diet: 80% of kcals from carbohydrate • Because of concerns with fat and cardiovascular disease, U.S. diet has moved from higher fat (42% of kcal in 1972) to lower fat (32% of kcal in 2000) – but more calories
  • 8. Dietary Guidance—A Historical Perspective 1894 - Dr. W.O. Atwater specified amount of protein and total calories in a good diet, but left unspecified the division of calories between fats and carbohydrates 1902 - “evils of overeating may not be felt at once, but sooner or later they are sure to appear – perhaps in general debility, perhaps in actual disease” 1902 - “ordinary food materials…make a fitting diet, and the main question is to use them in the kinds and proportions fitted to the actual needs of the body” Recommended variety, proportionality and moderation, measuring calories, and an affordable diet focused on nutrient-rich foods, less fat, sugar and starch.
  • 9. Nutritional science – nutrients to prevent deficiency diseases 1941: – National Academy of Sciences began issuing “Recommended Dietary Allowances” – quantity of nutrients a person needed to consume daily to ensure basic good health, proper growth and reproductive success, and to prevent nutrient deficiency diseases. – Nutritional deficiency diseases have been virtually eliminated in the U.S., thanks to enrichment of refined grains and other fortification strategies.
  • 10. Nutrient Adequacy - Meet nutrient needs without exceeding calorie needs - Dietary Reference Intakes (DRIs) - Acceptable Macronutrient Distribution Ranges (AMDR) - Protein: 10 - 35% of kcal - Carbohydrates: 45 - 65% of kcal - Fat: 20 - 35% of kcal - Recommended Dietary Allowance (RDA) - Adequate Intake (AI) - Tolerable Upper Level Intake (UL)
  • 11. Senate Select Committee on Nutrition and Human Needs – Dietary Goals the United States (1977) • Increase carbohydrates to 55%–60% of energy • Reduce fat to 30% of energy • SF, MF, PUFAs – 10%/10%/10% • Reduce cholesterol to 300 mg/day • Reduce sugar consumption by 40% • Reduce salt consumption to 3 g/day – 1200 mg sodium
  • 12. Toward Healthful Diets, FNB, 1980 • “The Board expresses its concern over excessive hopes and fears in many current attitudes toward food and nutrition. Sound nutrition is not a panacea. Good food that provides appropriate proportions of nutrients should not be regarded as a poison, a medicine, or a talisman. It should be eaten and enjoyed.”
  • 13. Dietary Guidelines for Americans 1980 - 2010 1980 1985 1990 1995 2000 2005 2010
  • 14. Development of Dietary Guidelines Policy DGAC Advisory Report submitted to the Secretaries of USDA & HHS USDA & HHS write the Policy Document DGAC is chartered DG’s implemented through Federal programs DGAC Charter DGAC Public Meetings: Review of the Science Evidence-based Methodology Used to Review the Science Public comments encouraged/collected Dietary Guidelines for Americans, 2010 (TBD) U.S. Department of Agriculture U.S. Department of Health and Human Services www.dietaryguidelines.gov The New “Pyramid”
  • 15. Total Diet 2010 DGAC Conclusions – not evidence- based Key Topics: - Overweight/obese nation - Develop healthy dietary patterns in childhood and adolescence - Maintain energy intake within calorie needs - Maximize nutrient density by emphasizing whole grains, vegetables, fruits, milk/milk products, and oils - Reduce solid fats and added sugars and sodium - Flexible eating patterns
  • 16. Chapter 3 Foods and Food Components to Reduce
  • 17. Chapter 4 Foods and Nutrients to Increase
  • 18. Comparison of Consumption to Recommendations
  • 19. DGAC 2015 • “Settled science” – may not see much change on nutrient levels • Movement to whole foods and away from nutrients • Topics such as sustainability, gluten, vegan diets, and food processing have been discussed and may be included in 2015 DGA
  • 20. 2015 DGAC – Dietary patterns, foods and nutrition, and health outcomes • The US population should consume dietary patterns that are: – Rich in vegetables, fruits, whole grains, fish/seafood, legumes, and nuts – Moderate in dairy products (e.g. low and non-fat dairy) and alcohol and – Lower in red and processed meat and – Low in sugar-sweetened foods and beverages and refined grains
  • 21. 2015 DGAC – Food and nutrient intakes, and health: Current status and trends • The US population has low intakes of certain key nutrients – vitamin D, potassium, fiber, calcium, and for females also iron. These low intakes are a public health concern because inadequate intakes are linked to health problems • The US population over consumes sodium and saturated fat. Excess intakes of these nutrients are also linked to health problems • Many of the food groups that are good sources of under consumed nutrients are consumed in low amounts by the US population • Many of the food groups and food categories that have high levels of sodium, saturated fat, and added sugars are consumed in high amounts
  • 22. 1943: Basic Seven Margaret Mead: “People don’t eat nutrition – they eat food” Basic 7 did not specify the number of servings of each food group needed daily
  • 23. 1940s1950s-1960s 1970s 1992 Food for Young Children 1916 2005 Food advice: Evolution of USDA’s Food Guidance – Moderation and Variety
  • 25. Conclusions • Evidence-based reviews are limited in our ability to define “healthy foods” • Recommendations for less added sugar and solid fats are based on empty calories, not health outcomes – USDA modeling • Since nutrition research does not support that vegetarian diets are healthier than animal based diets, there is a movement to “sustainability” as the reason to support plant-based diets • Solving important nutrition problems will require partnerships based on trust among academics, the government, commodity groups, and food companies
  • 26. The Importance and Deficiencies of Consistent, Systematic Evaluation Processes in Policymaking Connie M. Weaver, Ph.D. Purdue University West Lafayette, IN USA weavercm@purdue.edu
  • 27. Disclosures for Connie Weaver AFFILIATION/FINANCIAL INTERESTS (past 12 months) CORPORATE ORGANIZATION Grants/Research Support: NIH, DRI, Nestle, Tate & Lyle Scientific Advisory Board/Consultant: NOF, ILSI, Showalter, Pharmavite Speakers Bureau: Stock Shareholder: Other
  • 28. Outline • Evidence-based approach • Difficulties encountered with evidence-based approach in nutrition
  • 29. The Philosophy Behind an Evidence-based System • Rules are set “up front” then followed, rather than having a preconceived idea and then finding the papers to support the idea. • If one follows the rules, any trained scientist should come to the same conclusion.
  • 30. Hierarchy of Evidence RCT Double Blinded RCT Cohort Study Case Control Case Series Case Report Expert Opinion Weaker Evidence Stronger Evidence Evidence-based Medicine Hierarchy Consistency ends here!
  • 31. No Consistent Literature Retrieval or Grading Systems • NIH-AHRQ • FDA-own system for health claims • Various other approaches Slavin Nutr J 14:15, 2015
  • 32. Nutrition Evidence Library (NEL) Process 32 Formulate Systematic Review Questions •Exploratory searches •Public comment •Dialogue with experts •Analytical Framework •PICO Literature Search and Sort •Identify study eligibility criteria •Determine search strategy •Search for relevant studies •List included studies •List excluded studies and rationale Extract Evidence From Studies Create evidence worksheets Summarize and Synthesize the Evidence •Assess quality of individual studies •Assess applicability •Summarize and synthesize evidence Develop and Grade Conclusion Statements Define Research Recommendations Dietary Guidelines Advisory Committee Since 2010:
  • 33. Grade Strength of Evidence • Quality – Scientific rigor and validity – Consider study design and execution • Quantity – Number of studies/sample sizes • Consistency of findings across studies • Impact – Importance of studied outcomes/magnitude of effect – Magnitude of effect • Generalizability Grades: 1. STRONG; 2. MODERATE; 3. LIMITED
  • 34. PubMed search of scientific literature Jan 2000-Dec 2014 • Search term + bone + child + adolescence • Excluded: reviews, animal studies, non-English • Subcommittees reviewed abstracts and excluded - If not RCT or observational study - No bone outcomes - Interventions <6 mo. - Drug trials of disease states ASN Scientific Statements Example of Development of Peak Bone Mass
  • 35. Level of Evidence Description A: Strong One large, well-conducted, generalizable, RCT OR Multiple RCTs or trials with few limitations B: Moderate Multiple prospective cohort studies. OR Meta-analysis of prospective cohort studies. C: Limited Multiple prospective cohort studies from diverse populations that have limitations. OR One well-designed prospective study. OR Multiple cross-sectional or case-controlled studies with few limitations. OR Meta-analysis with design limitations. D: Inadequate Methodologic flaws OR Insufficient data. Evidence Grade
  • 36. Differences in process for evaluating scientific evidence can lead to different conclusions Example: Choosing different end points concern over salt
  • 37. 2010 Dietary Guidelines Advisory Committee Conclusions • A strong body of evidence has documented that in adults, as sodium intake decreases, so does blood pressure. • A moderate body of evidence has documented that as sodium intake decreases, so does blood pressure in children, birth to 18 years of age. • The reduction from 2,300 mg to 1,500 mg per day should occur gradually over time. [about 750 mg/1000kcal]
  • 38. IOM Committee on Consequences of Sodium Reduction in Populations – Released May 14, 2013 • Calls for national action to reduce sodium content of foods - average intake 3400 mg Na/d • Evidence weak to strive for less than 2300 mg Na/d – need more studies between 1500 and 2300 mg/d Focused on disease outcomes beyond blood pressure
  • 40. There is NO guarantee of consensus conclusions even if you use same process and end points
  • 41.
  • 42. What is the Relationship Between Calcium and Vitamin D and Hip Fracture? Women’s Health Initiative RCT of CaD (n=68,719 postmenopausal women) Prentice et al., Osteopor Int 24:567, 2013 • All subjects including those taking own supplements • >5 Year CaD Intervention-related Health Outcomes in Subjects Adherent & Not Taking Baseline Supplements No relationship Large benefit
  • 43. Difficulties of Applying Evidence- Based Medicine Approach to Nutrition
  • 44. Ranking of Study Type • The RCT is given greatest weight because it is the only design that permits strong causal inference • But for nutrition, that often means sacrificing control of the independent variable (nutrient diet) in favor of the dependent variable (health outcome)
  • 45. RCT Trials are Designed for a Compound That: • Works quickly • Usually pinpointed to 1 pathway or 1 mechanism of action • That is: a drug
  • 46. Features of RCTs for Drugs • Tested in or applied to sick people • Test agent is contrasted with its absence compared to a nutrient where there can be no nutrient-free state • Sharply defined primary outcome measure • Effect size usually large compared to a nutrient • Response characteristic is usually monotonic across plausible intakes
  • 47. Contrasts • Drug – drug-added state is contrasted with drug-free state • Nutrient – “high” intake is contrasted with “low” intake;
  • 48. Effect Size • Drug- usually large • Nutrient – usually small, but — public health impact may nevertheless be large — aggregate effect across multiple — systems is itself often large
  • 49. Consequence • When changes are small, testing for isolated nutrient effects requires large, expensive, lengthy studies if effects in isolated systems are to be found statistically significant.
  • 50. INTAKE EFFECT Study Design & the Threshold the control group must be deficient
  • 51. The Ethical Problem • Placing the control group on a clearly inadequate intake
  • 52. Underreporting error for energy intake in overweight boys and girls was 35+18% EIas%ofTEE Girls Boys Reported EI Weight adjusted MEI TEE by DLW Singh, 89(6):1744-1750, 2009 Concern with Diet Assessment for Observational Studies
  • 53. Controlled Feeding Studies • Historically ranked highest for evidence for nutrients/diet • Minimizes confounders and allows study of range of known intakes
  • 54. Animal Studies • Can have controlled diet and sufficiently long duration for cancer outcome measures. • But relevance to humans? • Invasive procedures • Mechanistic
  • 55. Future Needs • Good biomarkers are the most needed tool in research related to diet and health. Current biomarkers for intake and health outcome measures range from weak to moderately good. Even the better ones need validation.
  • 56. Many Kinds of Evidence Basic Research Translational Research Efficacy Studies Effectiveness Research How does it work? Can it be studied in people? Specific effects? How good is the translation?
  • 57. Best recommendations use the totality of evidence with liberal doses of critical thinking and LOGIC!
  • 58. The Role of Scientific Research in Food and Nutrition Policy Roger Clemens, DrPH, CFS, CNS, FACN, FIFT, FIAFST Adj Professor, Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, Los Angeles clemens@usc.edu
  • 59. Disclosures for Roger Clemens AFFILIATION/FINANCIAL INTERESTS (past 12 months) CORPORATE ORGANIZATION Grants/Research Support: None Scientific Advisory Board/Consultant: Abbott Nutrition, Almond Board of California, California Walnut Commission, Coca-Cola (manuscript preparation), Corn Refiners Association (honorarium for EB15), FMC Corp, McDonalds Corp, Mushroom Council, Spherix Consulting, and Numerous Law Firms Speakers Bureau: Extensive Media Outlets (pro bono) Stock Shareholder: None Other None
  • 60.  The opinions and comments presented do not reflect those of the Dietary Guidelines Advisory Committees, the USDA and CNPP, or HHS.  The opinions and comments expressed reflect evidence and perspectives as a member of the 2010 Dietary Guidelines Advisory Committee and as the sole food scientist on that committee. Disclaimer
  • 61. 1930
  • 62.  Examine the Dietary Guidelines for Americans, 2010 and determine topics for which new scientific evidence is likely to be available that may inform revisions to the current guidance or suggest new guidance.  Place its primary focus on the systematic review and analysis of the evidence published since the last DGAC deliberations.  Place its primary emphasis on the development of food-based recommendations that are of public health importance for Americans ages 2 years and older.  Prepare and submit to the Secretary of Health and Human Services and the Secretary of Agriculture a report of technical recommendations, with rationales, to inform the development of the 2015 Dietary Guidelines for Americans. DGAC responsibilities include providing authorship for this report; however, responsibilities do not include translating the recommendations into policy or into communication and outreach documents or programs. Charge to the 2015 DGAC http://www.health.gov/dietaryguidelines/2015-binder/2015/chargeCommittee.aspx June 2013
  • 63. Assessing the Evidence  Observational claims are not necessarily validated via clinical trials.  Clinical studies among small populations do not necessarily translate to total population (think public policy)  Common words like “association,” “related,” and “relative risk” imply strength, yet upon review the work is generally quite weak  “Definitive solution will not come from another million observational papers or a few small randomized trials” Ioannidis JPA BMJ 2013;347: doi: 10.1136/bmj.f6698
  • 64.  Systematic reviews and meta-analyses  Different inclusion/exclusion criteria impact results  Different statistical approaches and choices of covariates impact results  Dietary exposures are not accurate  Associations  Causes Research Bias Nicklas et al., J Nutr 2014; doi: 10.3945/jn.114.194068
  • 65. It is…important to not be distracted by questions that we have not been asked to address. What was Asked? What’s missing in many [meta analysis and systematic review] studies published since 2010 DGAC?  Undefined and inconsistent outcomes  Intention to treat analysis  Complete case analysis  Unexplained discontinuances  Imputed baseline data extended beyond current analysis  Multiple imputations in analyses
  • 66. Kaiser et al. Obes Rev 2013; doi: 10.1111/obr.12048. Ecological Relation of Water Intake with Prevalence of Overweight/Obesity: 1961-2000 Rise in obesity rates (round markers) and bottled water consumption (square markers). USA
  • 67. Consumer Confusion Confidence Confusion IFIC 2012: • Three out of four consumers feel that changes in nutritional guidance makes it hard to know what to believe • Half believe it is easier to do their own taxes than to figure out how to eat healthfully International Food Information Council Foundation 2012 Food & Health Survey . Consumer Attitudes Toward Food Safety, Nutrition & Health http://www.foodinsight.org/Content/3840/2012%20IFIC%20Food%20and%20Health%20Survey%20Report%20of%20Fin dings%20(for%20website).pdf
  • 68. Do Scripted Diets Work for Policy? What about Low-fat Diets? 2015 DGAC Meeting 5, September 16, 2014
  • 69. Comments  Chowdhury: “My take on this would be that it’s not saturated fat that we should worry about” in our diets.  Hu: The findings should not be taken as “a green light” to eat more steak, butter and other foods rich in saturated fat. … looking at individual fats and other nutrient groups in isolation could be misleading, because when people cut down on fats they tend to eat more bread, cold cereal and other refined carbohydrates that can also be bad for cardiovascular health.  Hu: “The single macronutrient approach is outdated. I think future dietary guidelines will put more and more emphasis on real food rather than giving an absolute upper limit or cutoff point for certain macronutrients.”  Hu: People should try to eat foods that are typical of the Mediterranean diet, like nuts, fish, avocado, high-fiber grains and olive oil. Rajiv Chowdhury, PhD Cardiovascular Epidemiologist University of Cambridge Frank Hu, MD, PhD Professor of Nutrition and Epidemiology Harvard University http://acsh.org/2014/03/huge-new-re-evaluation-saturated-fat-heart-risk-finds-link/ March 18, 2014
  • 70.  Cholesterol is not a nutrient of concern for overconsumption.  Saturated fat is still a nutrient of concern for overconsumption, particularly for those older than the age of 50 years. Dietary Cholesterol and Saturated Fat
  • 71.  There is insufficient evidence that an exchange of sugar for non-sugar carbohydrates results in lower body weights (a calorie = a calorie)  Observational (cross-sectional) studies suggest a possible relationship between consumption of sugar- sweetened beverages (SSB) and body weight; no supporting RCTs  Insufficient evidence to support a difference between liquid and solid sugar intake and body weight control Added Sugars and Body Weight Key reference: van Baak & Astrup. Obes Rev 2009; 10 Suppl 1:9-23
  • 72. Sugar in Research Yangetal.,JAMAInternMed2014;doi:10.1001/jamainternmed.2013.13563 Conclusions: • Increased calories … from added sugar … associated with increased risk of CVD mortality • Consumption of SSB (aka sugar) is associated with elevated CVD mortality Recommendation • Limit intake of calories … from added sugar Headlines: Drink just one 12-ounce can of sugary soda every day, and you might be unwittingly increasing your risk of dying from heart disease, suggests a new study.
  • 73. Agency Statement 2010 DGAC RCTs report that added sugars are not different from other calories in increasing energy intake or body weight. Systematic reviews in this area are also inconsistent. EFSA 2012 …a cause and effect relationship has not been established between total sugar intake and body weight gain WHO 2015 (Te Morenga et al, 2014) ‘Trials in children, which involved recommendations to reduce intake of sugar sweetened foods and beverages, had low participant compliance to dietary advice; these trials showed no overall change in body weight.’ German Nutrition Society 2012 In general, meta-analyses are inconsistent. The most recent meta-analysis concludes that the risk-increasing effect is limited to individuals with initially already increased BMI or existing overweight, respectively American Heart Association, American Diabetes Association 2012 At this time, there are insufficient data to determine conclusively whether the use of NNS [non-nutritive sweeteners] to displace caloric sweeteners in beverages and foods reduces added sugars or carbohydrate intakes, or benefits appetite, energy balance, body weight, or cardiometabolic risk factors. Sugar in Context
  • 74. Percentiles of Usual Caffeine Intake by Age: Consumers Only 0 100 200 300 400 500 600 2-11 12-17 18-29 30-34 35-39 40-49 50-59 60+ mgCaffeine/d Age (years) 10th 25th 50th 75th 90th * Data Source: NHANES 2007-2010; n=13,923 Courtesy of V.L. Fulgoni III, PhD, Nutrition Impact, LLC, August 5, 2013
  • 75.  Question  What is the relationship between usual coffee/caffeine consumption and health?  Conclusion  Moderate evidence from observational studies indicates that caffeine intake is not associated with risk of preterm delivery . Grade Moderate  Higher caffeine [>300 mg/d] intake is associated with a small increased risk of miscarriage, stillbirth, low birth weight, and small for gestational age births.  These data should be interpreted cautiously due to potential recall bias in case-control studies and confounding by smoking and pregnancy signal symptoms. Grade Limited Caffeine & Pregnancy SC 5: Food Sustainability and Safety Greenwood DC et al., Eur J Epidemiol. 2014; doi: 10.1007/s10654-014-9944-x Maslova E et al., Am J Clin Nutr. 2010; doi: 10.3945/ajcn.2010.29789
  • 76. Coffee and Health History (1975 – 2015)  Early years identified many potential health effects of coffee and caffeine consumption  The preponderance of medical & scientific evidence clearly supports the position that moderate daily coffee consumption (about 3 - 5 cups), as part of a varied, balanced diet, is safe and is not associated with any adverse human health consequences  EFSA (January 2015) • Single doses of caffeine up to 200 mg and daily intakes of up to 400 mg do not raise safety concerns for adults in Europe • For pregnant women, caffeine intakes of up to 200 mg / d do not raise safety concerns for the unborn child
  • 77.  Sustainable diets:  A pattern of eating that promotes health and well-being and provides food security for the present population while sustaining human and natural resources for future generations.  Diets higher in plant-based foods, such as vegetables, fruits, whole grains, legumes, nuts, and seeds, and lower in calories and animal based foods is more health promoting and is associated with less environmental impact than is the current U.S. diet. Food Sustainability
  • 78. Congress and DGAC Sustainability Source: 113th Congress 2nd Session. House of Representatives. Report 113-468. June 4, 2014. Pages 51-52 reject
  • 79.  Food Production (based on 2002 statistics)  Additional 7.4 million acres harvested cropland needed to meet basic food groups  Additional 8.9 million acres needed to support vegetable recommendations  Additional 4.1 million acres needed to support fruit recommendations  Sufficient cropland devoted to wheat could be reduced by 5.6 million acres  Farm milk production must increase by 107.7 billion pounds Agricultural Challenges - 2010 Page 136 Buzby, Wells and Vocke. Economic Research Report No. (ERR-31), November 2006
  • 80.  Develop and expand safe, effective, and sustainable agriculture and aquaculture practices to ensure availability of recommended amounts of healthy foods to all segments of the population. (Policy document)  Aquaculture:  Globally, nearly 50% of the fish consumed relies on aquaculture farms  Domestically, about 20% of aquaculture production is marine species; the remainder is freshwater species  Some statistics suggest that harvesting of wild fish is not sustainable (need 155,000 tons edible portions of [low Hg] fish per year  345,000 tons of fresh fish, e.g., primarily salmon)  Exceeds annual global salmon supply by ~50%  Increase environmentally sustainable production of vegetables, fruits, and fiber-rich whole grains. (DGAC) Sustainability of Dietary Guidelines
  • 81.  Must interconnect in policymaking that extends beyond nutrition.  Must leverage interdisciplinary expertise that embraces knowledge, technology and innovation plus sections outside of the food system to achieve a more encompassing food system  Develop a strong evidence-based approach to decision making  Engage global harmonization guidelines in regionally, culturally appropriate practices in food supply
  • 83. Food, Nutrition & Health  Secondary Education Challenge  Community Food Projects  Higher Education Challenge  1890 Capacity  Food Safety, AFRI  Climate Variability and Change, AFRI  Food Security, AFRI  Foundational Program, AFRI  Alaska Native & Native Hawaiian Institutions  Federally Recognized Tribes Extension Program  Hispanic-Serving Institutions Education  Multicultural Scholars  National Needs Graduate Fellowships  New Technologies for Ag Extension  Rural and Community Development, SBIR  Tribal Colleges Education Equity  Tribal Colleges Extension  Tribal Colleges Research
  • 84.  FDA Investment  Further scientific knowledge about potential food hazards  Expand on best safety practices  Better understand how consumers access, prepare, and use the foods they serve and eat  CFSAN Research Strategic Plan  Globalization of the food supply chain  Changing industry processes  Consumer preferences for fresh and minimally processed foods Science & Research (Food) Where’s Food Science and Nutrition?
  • 85. Immediacy  Sustainability  Resource management (land, water, energy)  Cultivars compatible with climate dynamics  Biodiversity  Supply chain (e.g., grains, fish  price stability)  Globalization of food supply  R&D investment  New technology and innovation  Political tension  unstable food supply  Food security policy  Poverty  Inadequate food  Decline physical and mental development  Rural development   hunger
  • 86.  Urgency for public and personal health  Urgency for collaborative funding  Urgency for the next generation Call to Action “A coordinated strategic plan that includes all sectors of society, including individuals, families, educators, communities, physicians and allied health professionals, public health advocates, policy makers, scientists, and small and large businesses (e.g., farmers, agricultural producers, food scientists, food manufacturers, and food retailers of all kinds), should be engaged in the development and ultimate implementation of a plan to help all Americans eat well, be physically active, and maintain good health and function. It is important that any strategic plan is evidence-informed, action-oriented, and focused on changes in systems in these sectors” USDA
  • 87.  Abbott: Well, let’s see, we have on the bags. Who’s on first, What’s on second, I Don’t Know is on third… Where are we now? William "Bud" Abbott & Lou Costello 1938
  • 88. While Diet Is Linked to Health, Much Confusion Exists About What to Eat and Under What Circumstances!!
  • 89. Thank you for attending today. Are there any questions?