The CMS Hospital Infection Control and Antibiotic Stewardship Program 2022 will discuss the many changes to the infection control standards that went into effect in November 2019, including a new requirement to have an antibiotic stewardship program. The CMS Hospital Infection Control and Antibiotic Stewardship Program 2022 will cover in-depth the Infection Control Worksheet from CMS. The CMS Hospital Infection Control and Antibiotic Stewardship Program 2022 will cover the CDC vaccine storage and handling toolkit and the CDC procedures for cleaning and disinfecting reusable medical devices. Finally, infection control issues related to COVID-19 will be discussed.