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The MMR Vaccine by Lori Klongtruatroke Reisa Mohamed Andrew Reiter Marlylee Scudero Elaine Snyder
What is the MMR Vaccine? ,[object Object]
What is Measles? ,[object Object]
What is Mumps? ,[object Object]
What is Rubella? ,[object Object]
The war on infection ,[object Object],[object Object],People have used antibiotics to combat bacterial infections for almost a hundred years, Most bacteria is susceptible to this method of disease management. The successful use of antibiotics has saved lives.  Though with the invention of ABX, people would still get sick before they could develop antibodies fast enough to defend themselves from pathogens, and not all pathogens (viruses) are effected by ABX. Vaccines are now used for their benefits in prevention of some stubborn bacterial infections and for prevention against serious life threatening  viral infection.
What is a Vaccine? The First Vaccine (Smallpox) was created by Edward Jenner by method of taking a weaker form of a virus and injecting it into a none infected child, who then developed immunity to the stronger form of the same virus.  Today many viruses are used under the same theory as Jenner. A Vaccine is an antigen introduced to a none infected host for the purpose of creating antibodies. (vaccine, 2003) Pict: http://www.1st-art-gallery.com/thumbnail/223903/1/Edward-Jenner-1749-1823-Performing-The-First-Vaccination-Against-Smallpox-In-1796-1879.jpg)
What is MMRV  ,[object Object],Until 1971 the MMR was given as three separate vaccines. Before 1960 a vaccination for measles, mumps or rubella did not exist. Currently 2010 manufactures are Merk  as M-M-R II  GlaxoKlienSmith as Priorix Serum Institute of India as Tresivac Sanofi Pasture as Trimovax MMR contains 1,000 TCID 50  (tissue culture infectious doses) of measles virus; 12,500 TCID 50  of mumps virus; and 1,000 TCID 50  of rubella virus. sorbitol (14.5 mg), sodium phosphate, sucrose (1.9 mg), sodium chloride, hydrolyzed gelatin (14.5 mg), recombinant human albumin ( ≤ 0.3 mg), fetal bovine serum ( < 1 ppm) 25 mcg of neomyci… (atenuvax,2010) Image: http://a.abcnews.com/images/WN/apg_vaccine_080903_mn.jpg
Atenuvax for Measles  Measles vaccine is attenuated meaning it is “weakened” but still a living virus. This is done by “Cell culture adaption” Naturally the measles virus grows in the cells of tissue that lines the back off the throat, lungs, heart and skin. This allows for a strong virus that may be easily transmitted from host to host. (chop, 2010) Antigens grown by means of cell adaption Virulence is down graded from 1000x replication to 20x - 20 replications gives the body enough exposure to make  antibodies for a life times worth of protection. (chop, 2010) In 1962 Four million people were diagnosed with measles resulting in three thousand deaths. Between 1953 and 1964 the measles averaged 450 mortalities a year. (CDC,2010)
Mumpsvax for mumps ,[object Object],Mumps is also an attenuated antigen by “cell culture adaption.”  The Mumps Virus naturally replicates rapidly in the salivary glands, and the cells that line the upper respiratory system. this is why the pathogen produces the chipmunk like appearance in those infected. The mumps vaccine was developed by head Merk research Dr. Maurice Hilleman, whom took a culture sample from his infected daughter Jeryl Lynn and then replicated the virus, their by creating an attenuated antigen.(chop, 2010) 1964 - 212,000 mumps cases were reported causing deafness in 1:1000 infected.  1967 – mumps vaccine was licensed  (cdc, 2007) Dr. Maurice Hilleman Life magazine life.com
Meruvax II for Rubella Meruvax II for Rubella is also attenuated by process of cell cultured Adaption  The rubella virus replicates naturally at full strength in the human epithelial cells that line the back of the throat, and easily spread with a cough from one host to the next. Rubella was 1 st  taken at full strength live viruses from and then replicated in a  Medium that consists of human embryonic fibroblast cells. This process was first used in England circa 1960. (chop, 2010) The rubella vaccine is week enough that an estimated 1000 first term pregnant woman were mistakenly injected with vaccine and there were no reported birth defects in full term babies vs. of 1000 woman who acquired the virus and were not vaccinated, 847 cases reported birth defects.
Rubella continued  1964 – 65 rubella epidemic resulted in 20,000 infants born with (CRS) on genital rubella syndrome. In as a result there were  - 2,100 neonatal deaths - 11,250 miscarriages - 3,580 blind - 1,800 mentally retarded 2000 – only 6 reported cases of CRS  (cdc, 2010)
When Can the MMR Vaccine Be Given? ,[object Object],[object Object],[object Object]
When Can the MMR Vaccine Be Given? ,[object Object],[object Object],[object Object]
MMR Vaccine Side Effects Per the Center for Disease Control ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of CDC Side Effects ,[object Object],[object Object]
What if there is a moderate or severe  reaction? ,[object Object],[object Object],[object Object]
Contraindications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MMR & Autism ,[object Object],[object Object],[object Object],[object Object]
MMR Vaccine  Options for Prevention  of Side Effects Linked to Autism ,[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
References Continued ,[object Object]

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MMR Slide Show (Final)

  • 1. The MMR Vaccine by Lori Klongtruatroke Reisa Mohamed Andrew Reiter Marlylee Scudero Elaine Snyder
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7. What is a Vaccine? The First Vaccine (Smallpox) was created by Edward Jenner by method of taking a weaker form of a virus and injecting it into a none infected child, who then developed immunity to the stronger form of the same virus. Today many viruses are used under the same theory as Jenner. A Vaccine is an antigen introduced to a none infected host for the purpose of creating antibodies. (vaccine, 2003) Pict: http://www.1st-art-gallery.com/thumbnail/223903/1/Edward-Jenner-1749-1823-Performing-The-First-Vaccination-Against-Smallpox-In-1796-1879.jpg)
  • 8.
  • 9. Atenuvax for Measles Measles vaccine is attenuated meaning it is “weakened” but still a living virus. This is done by “Cell culture adaption” Naturally the measles virus grows in the cells of tissue that lines the back off the throat, lungs, heart and skin. This allows for a strong virus that may be easily transmitted from host to host. (chop, 2010) Antigens grown by means of cell adaption Virulence is down graded from 1000x replication to 20x - 20 replications gives the body enough exposure to make antibodies for a life times worth of protection. (chop, 2010) In 1962 Four million people were diagnosed with measles resulting in three thousand deaths. Between 1953 and 1964 the measles averaged 450 mortalities a year. (CDC,2010)
  • 10.
  • 11. Meruvax II for Rubella Meruvax II for Rubella is also attenuated by process of cell cultured Adaption The rubella virus replicates naturally at full strength in the human epithelial cells that line the back of the throat, and easily spread with a cough from one host to the next. Rubella was 1 st taken at full strength live viruses from and then replicated in a Medium that consists of human embryonic fibroblast cells. This process was first used in England circa 1960. (chop, 2010) The rubella vaccine is week enough that an estimated 1000 first term pregnant woman were mistakenly injected with vaccine and there were no reported birth defects in full term babies vs. of 1000 woman who acquired the virus and were not vaccinated, 847 cases reported birth defects.
  • 12. Rubella continued 1964 – 65 rubella epidemic resulted in 20,000 infants born with (CRS) on genital rubella syndrome. In as a result there were - 2,100 neonatal deaths - 11,250 miscarriages - 3,580 blind - 1,800 mentally retarded 2000 – only 6 reported cases of CRS (cdc, 2010)
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.