Here I show to you very interesting research news and medical utility. We can see the future of the epigenetics and molecular medicine. Universidad Pontificia Bolivariana Medicina School

1. EPIGENETICS ALTERS GENES
IN RHEUMATOID ARTHRITIS //
ANXIETY LINKED TO
SHORTENED TELOMERES,
ACCELERATED AGING

4. INTRO
 Telomeres are located at the end of
eukaryotic chromosomes
 Epigenetics not affect de DNA
sequence but vary its expresion
 Short telomeres are a marker of
cellular aging
Cytosine methylation
Process used in epigenetic

5. EPIGENETICS ALTERS
GENES IN RHEUMATOID
ARTHRITIS
 Rheumatoid arthritis is an
autoimmune disease in which
joints, usually including those of
the hands and feet, are
symmetrically inflamed
 The immune system attacks the
tissue that lines and cushions
joints

6. EPIGENETICS ALTERS
GENES IN RHEUMATOID
ARTHRITIS
 DNA methylation is the addition of
a methyl group at the 5 position of
cytosine pyrimidine ring
 This modification can be inherited
through cell division
 DNA methylation also plays a
crucial role in the development of
almost all cancers
 The Cytosine methylation decrease
gene expression

7. EPIGENETICS ALTERS
GENES IN RHEUMATOID
ARTHRITIS
 The researchers had evaluated
the autoimmune process in
fibroblast-like synoviocytes
(FLS) isolated from the site of
the disease in RA
 FLS interact with the immune
cells in RA
 They looked and compared the
methylation patterns with
patients with non
inflammatory joint disease

8. EPIGENETICS ALTERS
GENES IN RHEUMATOID
ARTHRITIS
 They found hypomethylation of individual genes
was associated with increase gene expression
and occurred in multiple pathways critical to
inflammatory responses
 They concluded: : Differentially methylated
genes can alter FLS gene expression and
contribute to the pathogenesis of RA

9. PERSONAL PERSPECTIVE
 This inflammatory disease affect
million of people in the world. Many
investigations are searching therapies
to RA. Epigenetics can be the way to
find a cure

10. ANXIETY LINKED TO
SHORTENED TELOMERES,
ACCELERATED AGING
 The cellular aging is correlated with
the shortening of telomeres and the
free radicals too
 Cell DNA doubles before the division
is not able to copy all of the telomere
sequence and as a result, the
telomere becomes shorter at each
replication, the loss of about 50 to
200 nucleotides in each cycle of cell
division

11. ANXIETY LINKED TO
SHORTENED TELOMERES,
ACCELERATED AGING
 A cause of aging are the shortened telomeres.
They shorten with each cell replication that
makes and in a determinate moment they are
very short and this is the aging
 When the telomeres are too short, or damaged,
it activates an emergency system specific for the
irretrievable breakdown of DNA, the cycle stops
and the cell enters the phase of aging

12. ANXIETY LINKED TO
SHORTENED TELOMERES,
ACCELERATED AGING
 Researches had obtained blood samples from
5243 women
 Using the samples the researchers analyzed
telomere lengths
 Having a high phobic anxiety level was associated
with significantly shorter telomere lengths

13. ANXIETY LINKED TO
SHORTENED TELOMERES,
ACCELERATED AGING
 Olivia Okereke MD said: “… This study is notable
for showing a connection between a common
form of psychological stress -- phobic anxiety --
and a plausible mechanism for premature aging.
However, this type of study design cannot prove
cause-and-effect or which problem came first --
the anxiety or shorter telomeres.“
 The results are a prove for correlation between
external factors how stress and anxiety with the
length of telomeres

14. PERSONAL PERSPECTIVE
 Well as the anxiety is related to aging, should be
also many other disorders that affect people and
medicine can come in and play a role in this,
trying to make a patients emotional valuation
when reaching consultation and try to help them
overcome their emotional distress and related
diseases so avoid these factors

15. MEDICAL UTILITY
 With all the epigenetic investigations we can
think in a cancer future cure because the
DNA methylation play an important role in
the development of this disease

16. MEDICAL UTILITY
 The doctors must to do a correct promotion and
prevention of diseases caused for cellular aging
and a correct emotional valoration to the patient
to avoid stress and states that can accelerate the
aging

17. MEDICAL UTILITY
 The epigenetic investigations are opening
the doors to new treatments for different
pathologies. With the researches some day
we will can treat a lot of diseases with
manipulation of genome

18. MEDICAL UTILITY
 With all this investigations in the future we will
can find specific target sites for drugs
interactions and find a cure or an new effective
therapy

19. BILBIOGRAFIAS
 ANXIETY LINKED TO SHORTENED TELOMERES, ACCELERATED
AGING, ScienceDaily, (July 11,2012), Available on web:
http://www.sciencedaily.com/releases/2012/07/120711210102.htm
 EPIGENETICS ALTERS GENES IN RHEUMATOID ARTHRITIS,
ScienceDaily, (July 3, 2012), Available on web:
http://www.sciencedaily.com/releases/2012/07/120703172549.htm
 http://www.epigenetica.org/?page_id=150
 MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7. ed.
Medellín: UPB. Fac. de Medicina, 2012. 300 p.
 BERLOW, Robert. BEERS H, Mark. The merk manual of medical
information. USA. 1997.1509p.

20. Thanks!!....