1. ‘Sustainable Growth in
Connected Health and the
Economy’
Wednesday 8th May 2013 at 2pm

3. ‘Sustainable Growth in Connected Health and the Economy Workshop’
Wednesday 8 May 2013 at 2pm (registration and buffet lunch from 1.30 pm),
at the Loughview Suite, Jordanstown Campus (University of Ulster).
1.30pm Registration and Buffet
2pm Professor Jim McLaughlin (Chair) Introduction
2.05 Guest Speaker George MacGinnis – Continua Health Alliance/PA Consulting Group – ‘What
role will Connected Health play in driving our economy?’
2.30 Professor Jim McLaughlin (NIBEC): ‘Connected Health at Ulster and Growth in the NI
Economy’
2.45 Professor Chris Nugent (SERG): ‘Smart Environments and Ambient Assisted Living’
3.00 Professor Johnny Wallace (Comp & Eng.): ‘Growth in Collaborating with Healthcare
Providers’
3.15 Mr Stephen McComb (CHIC): ‘The Role of Innovation in Growing NI Connected Health’
3.30 Guest Speaker Professor Brian Caulfield (UCD): ‘A New Connected Health Infrastructure in
the Republic of Ireland’
3.40 Discussion and Wrap-up
4pm -5pm There will also be a tour of the SERG and NIBEC Laboratories

4. (www.eri.ulster.ac.uk)
Director: Professor Jim McLaughlin

5.  £200 m annual income
 £40-60m per annum research income
 4 campuses; 3000 staff and 25,000 students
 127,000 alumni
 Distance learning through Campus One
 17 research institutes
 6 Faculties: Computing & Engineering; Life and Health Sciences; Arts;
Social Sciences; Art, Design and the Built Environment Ulster Business
School
 The 2008 Research Assessment Exercise confirmed the strength and
quality of our research and the advances that we are continually making.
Facts in Figures about Ulster

6.  Ulster is a university with a national and
international reputation for excellence,
innovation and regional engagement.
 We make a major contribution to the economic,
social and cultural development of Northern
Ireland and play a key role in attracting inward
investment.
 Our core business activities are teaching and
learning, widening access to education, research
and innovation and technology and knowledge
transfer.
Overview of Ulster

7. Life and Health Sciences in Northern
Ireland – Need for Strategy
Randox LaboratoriesHSC Innovations
Almac
lmac Diagnostics
Fusion Antibodies
Gambro
MDS Pharma Services
Norbrook
Perfecseal
Warner Chilcott
BootRooms.com
Intelesens
James Leckey Design
Blue Scope Medical Technologies
Diabetica
Tomcat Systems
Health Tek
Quality Healthcare at Home
Universities
Hospitals
Of over 900 companies in Northern Ireland’s vibrant ICT sector, more than 100
are international investors, including SAP, Fujitsu, Openwave, Microsoft,
Cybersource (VISA) and BTI Systems.
Combined turnover - £500m
5000 jobs
DRIVERS

8. • Business
•Business Models,
Economic
Assessment
• Nursing
•Biomedical Science
•Sports Science
•Personalised
Medicine
• Computing
Science
• AAL, Big
Data, Cloud
• Engineering
• Sensors, Wireless,
Integrated Point of
Care Systems,
Embedded
Systems
Engineering
Computing
Science
Business
Nursing
(And Life
Sciences)
Professor Jim
McLaughlin: Ulster
Lead

9. Healthcare
Lifestyle
Technology
Sweet spot
Connected Health at Ulster (Executive):
Will include 3 other representitives
Prof. Chris Nugent: Computing
Science/Intelligent Algorithms and
Connected Health; Large Grant holder
(£5M) and major experience in human
sensor based trials
Prof Jim McLaughlin:
(Physicist) Medical Sensors; Micro
and nanodevices; NIBEC Director
Large Multi-million projects (£23M);
17 patents and founder of ST+D Ltd
Professor Brendan McCormack (Nursing) research work
focuses on gerontological nursing, person-centred nursing
and practice development and he serves on a number of
international editorial boards, policy committees, and
development groups in these areas
Since 2008
Over £15M into
Connected
Health

10. A
Dr Abbes Amira
B
Mr Mark Beattie
Professor Norman Black
Dr Raymond Bond
Dr Adrian Boyd
Mr William Burns
Dr Tony Byrne
C
Dr Darryl Charles
Dr Liming Chen
Professor Vivien Coates
Dr. Damien Coyle
D
Mr Richard Davies
Dr Dorian Dixon
Dr Mark Donnelly
E
Professor Omar Escalona
F
Dr Dewar Finlay
G
Dr Brendan Galbraith
Dr Leo Galway
H
Dr Leane Hoey
K
Professor George Kernohan
L
Dr Briege M Lagan
M
Prof Paul Maguire
Dr Suzanne Martin
Professor Tanya McCance
Dr. Paul McCullagh
Professor Sally McClean
Professor Brendan McCormack
Professor James McLaughlin
Professor Helene McNulty
Prof Brian Meenan
Dr Vidar Melby
Liz Mitchell
Dr George Moore
Dr Anne Moorehead
N
Dr Peter Nicholl
Professor Chris Nugent
S
Professor Bryan Scotney
Professor Marlene Sinclair
Dr Paul Slater
Dr Eamon Slevin
T
Dr Laurence Taggart
Dr Maria Truesdale-Kennedy
W
Professor Eric Wallace
Professor Jonathan Wallace
Dr Haiying Wang
Dr Mary Ward
Dr Alan Webb
Z
Dr Huiri Zheng
Connected Health at Ulster:
(Main Academic Members - 50):

11. Education: Postgraduate
Below are a range of our most promising Post Graduate courses
and modules which form part of the Connected Health-Ulster’s
offering. We also over numerous PhD’s in the Area
 Health Informatics (PgCert/PgDip/MSc)
 Health and Wellbeing (PgDip/MSc)
 Health Promotion and Public Health (PgCert/PgDip/MSc)
 Human Nutrition (PgDip/MSc)Non-Medical Prescribing (PgCert)
 Psychology (Health)
 (PgDip/MSc)Nursing Credit Bearing ModulesRespiratory Health
(PG Certificate)
 Sport and Exercise Nutrition (Postgraduate Diploma/MSc)
 Biomedical Engineering (PgDip/MSc)

12. Dean of Computing
and Engineering
Professor R. Millar
Engineering Research
Institute
Director :
Professor Jim
McLaughlin
NIBEC
Director Professor Jim
McLaughlin
ECRE
Acting Director :
Dr Alistair McIlhagger
AMFo0R
Group Leader Dr Alan
Leacock
Computing Science
Research Institute
Professor Bryan
Scotney

13. The ERI Faculty Dr Dorian Dixon
Nanocomposites
and Polymer
drug Delivery
Systems
Prof James
Davis: Bio
sensing and
diagnostics
Dr Patrick Dunlop:
Biosensors
Prof. Brian
Meenan:
Biomaterials and
Tissue
Engineering
Prof. Paul Maguire:
Nanofabrication and
Plasma Technology
Prof Jim
McLaughlin:
Nanotechnology
related to carbon
and nano-sensor
fabrication
Prof Pagona
Papankonsta
niou:
Nanotubes
and
Nanodevices
Dr Patrick
Lemoine:
Nano-tribology
and nano-
microscopy
Dr Tony
Byrne:
Photocatalysi
s and Clean
Technology
Dr Adrain Boyd
Nano based-
biomaterials
Alan Brown:
Microfluidics
Dr George
Burke: Cell
Biology
Dr Davide
Mariotti:
Nanoparticle
s and
Plasma
Physics
Dr Abbess Amira
Embedded
Systems in
Connected Health
Dr Alistair
McIlhagger:
Composites /
NIACE
Dr Alan
Leacock:
Metal
Forming /
NIACE
Dr Edward
Archer:
Composites /
NIACE

14. NAMRI
NIBEC
NAMRI
ECRE
NAMRI
AmFOR
Engineering Research Institute
www.eri.ulster.ac.uk
Infrastructure (Nanofab and Characterisation):
£17M (since 2001)
£7M SRIF/RCIF
£8M Government and Industry
£3M EU
Major Projects
£13M (since 2001)
£5 M EU
£4M EPSRC
£4.8 M Industry/Government
Staff
5 Professors
3 Readers
6 Senior Lecturers
5 Lecturers (ECR’s)
Technology Transfer/Proof of Concept
£1.6M (since 2001)

15. Nanotechnology and
Integrated
Bioengineering Centre
(NIBEC)

16. Nanotechnology and Integrated
Bioengineering Centre (NIBEC)
Engineering Research Institute
£33million funding since 2001
EPSRC;
INI;
DEL;
Wellcome
Trust;
EU;
NSF (US Irl
Partnership)
BIS;
HEA;
SFI;
MRC;
Leverhulme;
R&D Office;
Industry;
Philanthropic

17. Multi-disciplinary
research centre
applying
nanotechnology and
bioengineering to
the following thrusts:

18. Our CH
History:
NIBEC founded in
1985 by Professor
John Anderson
Traced back to
Professor
Partridges idea of
mobile coronary
care
New building in
1994 and 2004
0.1
HR
0.1
HR
0.2
HR
0.2
HR
1
DAY
1
DAY
7
DAY
7
DAY
INTERVAL AFTER ONSETINTERVAL AFTER ONSET
PERCENTAGEALIVEPERCENTAGEALIVE
THE DISTRIBUTION OF ACUTE CORONARY DEATHS
Mc NEILLY (BELFAST), 1965-66, 818 DEATHS
THE DISTRIBUTION OF ACUTE CORONARY DEATHS
Mc NEILLY (BELFAST), 1965-66, 818 DEATHS
00
1010
2020
3030
4040
5050
6060
7070
8080
9090
100100
4433221100
00
100100
The Acute MIThe Acute MI
Myocardial
preservation %
Myocardial
preservation %
Average patient
response time
Average patient
response time
Hrs. from symptom onsetHrs. from symptom onset

19. History of
Success in CH

21. • M Health
• Clinical Trials
• Adoption Models
• Economic Assessment
• Spin Outs
• Electrode Fabrication and
Characterization
• Carbon Nanotube &
Graphene Growth
• Nanoparticles
• Telemetry: Bluetooth,
Wi-Fi and Propriety
RF
• Electronics
• Embedded Systems
• Pattern Recognition
• PlasmaTechnology
• Microfluidics
• Microfabrication
• Nanofabrication
• Surface Analysis
• Microscopy
• Chemical Analysis
MEMS and
Nanodevices
Smart Diagnostic
Devices
Smart Systems
Connected Health
Solutions
Fully Integrated
systems for Chronic
Health; Lifestyle and
Pharma Monitoring
Nanosensors
ECG, EMG, EEG,
Temp, Resp. Rate,
SpO2, PWV,
Biosensors, E Nose
The NIBEC Capability

22. CH Infrastructure
 NIBEC: Nanotechnology,
Microfluidics; Cell- /Micro- Biology
Laboratories; Microfabrication
Cleanrooms
 SMART WARD
 SMART Doctors Surgery
 SERG (SSRI): Ambient Assisted
Living
 Data Analysis/DSP/Labview
Project Laboratories
 Patient Testing Laboratories
 Terrace House and Playing Field
Testing
 Plans for new Innovation Centre
(Manufacturing)…Rapid Proto
typing

23. Connected Health Themes
at Ulster
 Wireless Vital Signs Monitoring
 Point of Care Diagnostics Systems
 Sensor Technology
 M-Health
 Ambient Assisted Living
 Clinical Trialing
 Economic Assessment and Valuation
 Technology Transfer…spin outs and
licensing
 Personalized Medicine (BSRI)
 CTRIC and UUM (ISRC)

24. Sensor Technology
 ECG, EMG, EEG
 SpO2 (Reflective)
 PWV (piezo)
 Accelerometers
(MEMS- Motion)
 Respiration Rate
 GSR
 Cardiac Mapping
 Biosensors:
Glucose and
Cardiac Enzymes
via IDE’s
 Micro- SPR
 Micro-Raman
 Micro-E-nose
(plasma)
 Impedance
Micro-E-nose (plasma)
Connected Health Themes at Ulster
All about higher sensitivity &specificity – less false alerts

25. Key current research topics
 AF sensing/pattern
recognition
 Sleep Apnoea
early warning
 Smart MEWS
based multi-
sensing Algorithms
 De-hydration
Sensing
 NIBP systems
 Cardiac Mapping
 Multiple data analysis –
MVA, Big Data analytics
 Pulse Wave Velocity
 Remote Foetal monitoring
 Hypo- detection in
Diabetics
 Non-Invasive Glucose
Monitoring (IR)
 Novel Wearable Electrode
Systems
 Point of Care Diagnostics
– Microfluidic Systems

26. Key Underpinning Materials Areas
 Major nanotechnology laboratories
 Plasma Technology
 Graphene, CNT’s and DLC
 Metal Oxides
 Nanoceramics and nanoparticles
 Si nanoparticles
 Microfluidics – Integrated Optics/Impedance
 Nanomaterials Characterisation: TEM, SEM.
FIB, TOF SIMS, AFM, XPS, Raman,
Nanoindentor etc.
 Electrical Characterisation of Materials
 Electrode and antenna design

27. The NIBEC POC Cardiac
Enzyme Impedance
Microfluidics – Integrated optical and impedance
platforms;nanoparticle (CNT/Graphene/Si
amplification);and pattern recognition with
wireless communication systems.

28. CH Enabled AF Treatment for Patients with
a Passive Implantable Atrial Defibrillator
Regional Cloud Hospital
WAN Support
Mainframe Computer
Centre for
Connected
Health
Minimal Critical Care
Setting
AF Patient with an
Implanted PIAD
CH Assisted Cardioversion
with a Passive Implantable
Defibrillator (PIAD)PIAD
Interventional
Cardiology Experts

29. Public Access Defibrillation Reliability and
Effectiveness Enhancement by Connected Health
Key issues to address:
- AED device automatised regular maintenance/supervision by CH while in the emergency
box; AED could be used only once in 5 years or more.
- AED embedded knowledge based algorithms performance can be enhanced if supported
by a CH centre mainframe computer.
- Soft paramedic assistance from an emergency CH service, while live monitoring patients
vital signs and CPR parameters, would en enhance safety and effectiveness of CPR.
Centre for
Connected
Health
AED with
Embedded Internet
Cloud Emergency Services
AED
Maintenance
& SupervisionCH Assisted
CPR
CH Assisted PAD for the
AED Knowledge Base and
Live Expert Advice
Mainframe Computer

30. CH Enabled Cardiac Mapping for Early MI Detection
(within 90 minutes)
Cloud Emergency Services
WAN Support
Mainframe Computer
Centre for
Connected
Health
Patient with Chest Pain at His Home
Current Portable 28-Lead
Cardiac Mapping System
and Disposable Harness
Experts at the
Cardiac Centre
CH Assisted 28-Lead Cardiac Mapping
Smartphone Application for Live MI
Authorised Diagnosis

31. Clinician Trust/Hospital Hospital/GP/Care
Home
Specialising
Dr Ganesh Manoharan
/ Prof J Adgey
Belfast Health and
Social Care Trust
Hospital Cardiology
Dr Hubert Curran
Senior Primary Care
Advisor to the
Performance
Management and
Service Improvement
Directorate of the
HSCB
Primary Health Care Primary Health Care
Dr David McEneaney
South Eastern Health
and Social Care Trust
Hospital Cardiology
Dr Roy Harper
South Eastern Health
and Social Care Trust
Hospital Diabetics
Sharon Foster (Clinical
Nurse)
McElwaine Industry Telehealthcare
Engagements with possible inclusion Dr Paddy Donnelly (Ulster); Dr Maurice O Kane CTRIC; Dr David McCance (RVH)
CLINICAL LINKS

32. Employing around 35-40 staff directly

34. Wireless Vital Signs
Platforms
 Intelesens has developed its
platform as the basis of OEM
products
 Short range or cellular telemetry
 Range of vital signs possible
 Respiration
 Blood oxygen (late 2007)
 Temperature
 Motion, activity and falls
 Cardiac output
 ECG
 Compact, light, easy to wear
ecg
respiration rate
temperature
SpO2
accelerometer
3. Innovation

35. Ubiquitous surveillance monitoring system
 Full ambulation
 Wi-Fi connectivity
 Simple, easy, unobtrusive, low-cost
 Alert management

37. Smart: ECG Pattern Recognition
 Bradyarrhythmia
 Ventricular Tachycardia
 Supra Ventricular Tachycardia
 Self-terminating Ventricular Fibrillation
 Asystole
 Atrial Flutter
 Atrial Fibrillation
 1st Degree Heart Block
 2nd Degree Heart Block
 3rd Degree Heart Block
Clinical Study complete with Ulster Hospital:
Dr Roy Harper and currently undergoing one at
UI and Dublin
•Congenital heart defects
•Congestive heart failure
•Heart muscle disease
•Heart valve disorders
•Other diseases, such as lung conditions
•External forces such as electric shock or severe
chest injury

38. Atrial Fibrillation captured with Aingeal device
Example of CSR captured: Cheyne-Stokes respiration

39. Employing around 60-70 staff directly

40. Heartsine
Corporate Headquarters:
HeartSine Technologies, Inc.
940 Calle Amanecer
Suite E
San Clemente, CA 92673
United States
Phone: 1.949.218.0092
Fax: 1.949.218.0093
Toll Free: 1.866.HRT.SINE
European
Office:
HeartSine Technologies, Ltd.
Canberra House
203 Airport Road West
Belfast, BT3 9ED
Northern Ireland
Phone: +44 (0)28 9093 9400
Fax: +44 (0)28 9093 9401
http://www.heartsine.com
The 1970’s NIBEC Vision

41. Recently purchased by Verathron
employed 60 staff directly (at one stage
over 100)

42. 80-Lead Technology Benefits:
for a complete view of the heart
Touchscreen color monitor
A 360º ECG
Non-U.S. Only
Recently acquired by Verathron

43. The Vision – Self Care Model
 Sensor – analysis –
diagnostics – feedback –
immediate therapy
 Vital signs alert and
immediate worn therapy
 For example – heart attack
and possible patch based
TPA delivery
 Or respiration rate and
dosage feedback for therapy
 Require POC diagnostics and
improved drug delivery
techniques
Worn Drug Therapy
Feedback
Cloud
Analytics
Worn
Vital
Signs
Detection

45. Founder and Managing Director: Dr. Suzanne Roghieh
Saffie-Siebert
Professor Jim McLaughlin Director and CSO
John Hartnett and Tim Brundle (Investors and Directors)
Scientists: Drs. Nessim Troabi-Pour; Mukhtar Ahmed;
Jeremy Hamill
SiSaf scooped a major prize – for development of an innovative
drug-delivery system at the Irish Technology Leadership Group’s
(ITLG) annual awards ceremony in Silicon Valley, California.

46. The SiSaf Difference
 Solubility – Improved up to 40%
 Biocompatibility – Organic Solid
Nanoparticles
 Active Delivery – Self beneficial
compound
 Control Release – Tailor made
release profile
 Penetration – Into and through skin
 Absorption – Improved through
localization and SR
 Localization – High concentrated
molecule

47. Headed up by Stephen McComb

48. Connected Health in Northern Ireland
Industry led research with global relevance
What is it?
CHIC is an Industry-led group which is
focused on collaborative research to
support the growth of the connected
health market. Funding is largely from
state aid.
Emerging Focus Areas
1.Integrated community care – joining
together existing and new technology
and process.
2.Point of Care Diagnostics – moving
diagnostics closer to the patient.
3.Vital Signs monitors - technology
development to support sign
identification, analysis and
communication.

49.  “Delivering leadership for the development of Connected and Mhealth
markets and practice across Europe and beyond”
 Joint MOU between DETI and DOH in Northern Ireland (better health and jobs)
 Setting up of a NI CH Eco System – Clinicians- Business- Academia
 Strong links with Boston – Finland – Catalonia – Manchester – NIMAC
 ECHAlliance Ecosystems – Manchester, Northern Ireland and more to be
announced.
ECH - Alliance
and
the new Northern
Ireland Connected
Health Eco System

52. EU-US eHealth Business
Marketplace – Boston USA 2012

53.  35 patents, 3 companies and many licences
 Created over 120 industry jobs across all 3
Connected Health spin-outs; Trained over research
100 staff for CH industries
 Saved lives, improved the quality of life and cut
costs - MATCH.
 Technologies are used by the Wellcome Trust,
CIMIT and various companies as exemplars of the
future of healthcare.
 The concept of Connected Health in Northern
Ireland was derived from much of our early work.
Their more recent work, with over 35 patents, has been
commercialised to companies such as Heartsine Inc.,
Samsung, Intelesens Ltd. Heartscape Inc., Tyco, SHL
Telemedicine, Phillips and Air Products. These companies’
products have now been well established and include the
world’s best selling disposable ecg electrode, telemedicine
based 12 lead electrodes, the most compact AED marketed
and a smart wireless chest based ecg, respiration rate,
temperatureandSpO2 monitor.
Professors McLaughlin, Anderson
and McAdams have a 25 year
history of developing successful
patent exploitation in the area of
medical sensors and electro-
stimulation devices, following the
impact that Pantridge, Adgey and
Anderson had on mobile coronary
care in Northern Ireland.
Impact of Connected Health @Ulster
This has inspired many initiatives such as the:
 BEST Centre, CHIC, ECHCampus (2009-2012) and now
the European Connected Health Alliance (2011-);
Northern Ireland Connected Health-ECO; culminating
with NIMAC which joint agreement between USA,
Finland, ROI, Northern Ireland, the Manchester and
Catalonia; Northern Ireland DHSSPSNI & DETI signing a
strategic and joint Connected Health MOU

56. The recipe for Connected
Health Device Innovation
 Good Product design – from concept to scale-up
 User needs – cost reduction (evidence) – regulatory
 Accurate and flexible business model
 A good users based - ECO system (smart market analysis)
 Miniaturised and robust technology
 Portable – Cloud based solutions – still some security issues
 High quality data analytics
 Early warning with clear patient & clinical benefits
 Smart Back-end systems
 And most of all functional & well designed (intuitive) and
meets all FDA – CE approvals and easily validated

57. Conclusion
 History of Success
 University of Ulster Capability and experience
 Strong Clinical Integration
 Technology Transfer – spin-outs – CHIC’s future Role
 ECHA- The Northern Ireland CH Eco System
 Finally - We need a systems and design approach to
adopting this new form of delivering Healthcare – with
sensors, diagnostics, communications, software,
clinical specifications, health economics, regulatory
drivers and business models all playing a key role to
drive our Healthcare Provision and Economy