Diese Präsentation wurde erfolgreich gemeldet.
Wir verwenden Ihre LinkedIn Profilangaben und Informationen zu Ihren Aktivitäten, um Anzeigen zu personalisieren und Ihnen relevantere Inhalte anzuzeigen. Sie können Ihre Anzeigeneinstellungen jederzeit ändern.
ANTIBIOTICS 
6th year - 2015 - D2 
Basel Abu Fares 
Bashar Mudallal
Empiric Antimicrobial Therapy 
• Choose antibiotic(s) to cover for most likely and 
lethal organisms for the type of infec...
Classification 
• Cell Wall Inhibitors 
• Glycopeptides 
• Protein Synthesis Inhibitors 
• Topoisomarase Inhibitors 
• Ant...
Cell Wall Inhibitors 
•Include : 
-penicillins 
-cephalosporins 
-carbapenems 
-glycopeptides
Penicillins
Cephalosporins (IV/PO) 
• 1st generation: cephalexin/cefazolin (mostly GP, 
some GN) 
• 2nd generation: cefuroxime/cefurox...
Carbapenems 
(broad coverage: GP, GN and 
anaerobes) 
•imipenem (+ Pseudomonas) 
•meropenem (+ Pseudomonas) 
•ertapenem
Glycopeptides 
(all GP and C. difficile– the 
oral form) 
• vancomycin
Protein Synthesis Inhibitors 
• 50S ribosome inhibitors 
-Macrolides 
-Lincosamides 
• 30S ribosome inhibitors 
-Aminoglyc...
Macrolides 
[GP, Hemophilus, and atypical bacteria 
(Legionella, Chlamydophila, 
Mycoplasma)] 
• erythromycin 
• clarithr...
Lincosamides 
•clindamycin (most GP, GN 
anaerobes) 
•chloramphenicol (broad-spectrum) 
•linezolid (for resistant GP infec...
Aminoglycosides 
(GN aerobic bacilli) 
•gentamicin 
•tobramycin 
•amikacin
Tetracyclines 
(GP, syphilis, 
Chlamydophila, Rickettsia, 
Mycoplasma) 
•doxycycline/tetracycline
Topoisomarase Inhibitors 
•Flouroquinolones 
•Rifampin 
•Metronidazole
Fluoroquinolones 
(GN – although resistance becoming a huge 
problem) 
• ciprofloxacin (+ Pseudomonas) 
• norfloxacin (fo...
Rifampin 
(GP mostly, H. Inf., N. 
meningitidis and mycobacteria)
Metronidazole 
(anaerobes incl. C. difficile; 
Trichomonas, Entamoeba)
Anti-metabolites 
•Trimethoprim-sulfamethoxazole 
•Nitrofurantoin
TMP/SMX 
(GN bacilli, S. saprophyticus, 
Enterococcus)
Nitrofurantoin 
•(GN bacilli, S. saprophyticus, 
Enterococcus)
Anti-mycobacterials
Sulfones
Antibiotics for Selected 
Bacteria
Others 
• treatment for C. Difficile: 
metronidazole OR oral vancomycin; 
consider both in serious infection
Resources 
• Toronto Notes 2014
THANK YOU 
The End
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Antibiotics: classification and spectrum of action
Nächste SlideShare
Wird geladen in …5
×

512

Teilen

Herunterladen, um offline zu lesen

Antibiotics: classification and spectrum of action

Herunterladen, um offline zu lesen

Antibiotics presentation

Ähnliche Bücher

Kostenlos mit einer 30-tägigen Testversion von Scribd

Alle anzeigen

Ähnliche Hörbücher

Kostenlos mit einer 30-tägigen Testversion von Scribd

Alle anzeigen

Antibiotics: classification and spectrum of action

  1. 1. ANTIBIOTICS 6th year - 2015 - D2 Basel Abu Fares Bashar Mudallal
  2. 2. Empiric Antimicrobial Therapy • Choose antibiotic(s) to cover for most likely and lethal organisms for the type of infection • Prior to obtaining laboratory results (usually reserved for serious infections) • Adjust antibiotic(s) based on C&S  if causative organism identified, use antibiotic to which organism is sensitive  if causative organism not identified, re-evaluate need for ongoing antimicrobial therapy (and continue with empiric antibiotic(s) if indicated)
  3. 3. Classification • Cell Wall Inhibitors • Glycopeptides • Protein Synthesis Inhibitors • Topoisomarase Inhibitors • Anti-metabolites • Anti-mycobacterials • Sulfones
  4. 4. Cell Wall Inhibitors •Include : -penicillins -cephalosporins -carbapenems -glycopeptides
  5. 5. Penicillins
  6. 6. Cephalosporins (IV/PO) • 1st generation: cephalexin/cefazolin (mostly GP, some GN) • 2nd generation: cefuroxime/cefuroxime (some GP and some GN, *anaerobes) • 3rd generation: cefixime/cefotaxime, ceftriaxone (good Streptococcalcoverage, mostly GN) and ceftazidime (no GP, mostly GN, Pseudomonas) • 4th generation: --/cefepime (most GP, most GN, Pseudomonas)
  7. 7. Carbapenems (broad coverage: GP, GN and anaerobes) •imipenem (+ Pseudomonas) •meropenem (+ Pseudomonas) •ertapenem
  8. 8. Glycopeptides (all GP and C. difficile– the oral form) • vancomycin
  9. 9. Protein Synthesis Inhibitors • 50S ribosome inhibitors -Macrolides -Lincosamides • 30S ribosome inhibitors -Aminoglycosides -Tetracyclines
  10. 10. Macrolides [GP, Hemophilus, and atypical bacteria (Legionella, Chlamydophila, Mycoplasma)] • erythromycin • clarithromycin • azithromycin
  11. 11. Lincosamides •clindamycin (most GP, GN anaerobes) •chloramphenicol (broad-spectrum) •linezolid (for resistant GP infections)
  12. 12. Aminoglycosides (GN aerobic bacilli) •gentamicin •tobramycin •amikacin
  13. 13. Tetracyclines (GP, syphilis, Chlamydophila, Rickettsia, Mycoplasma) •doxycycline/tetracycline
  14. 14. Topoisomarase Inhibitors •Flouroquinolones •Rifampin •Metronidazole
  15. 15. Fluoroquinolones (GN – although resistance becoming a huge problem) • ciprofloxacin (+ Pseudomonas) • norfloxacin (for UTI only) • respiratory fluoroquinolones (some GP, GN, "atypicals", Legionella, Mycoplasma, Chlamydophila) • levofloxacin • moxifloxacin (+ anaerobes)
  16. 16. Rifampin (GP mostly, H. Inf., N. meningitidis and mycobacteria)
  17. 17. Metronidazole (anaerobes incl. C. difficile; Trichomonas, Entamoeba)
  18. 18. Anti-metabolites •Trimethoprim-sulfamethoxazole •Nitrofurantoin
  19. 19. TMP/SMX (GN bacilli, S. saprophyticus, Enterococcus)
  20. 20. Nitrofurantoin •(GN bacilli, S. saprophyticus, Enterococcus)
  21. 21. Anti-mycobacterials
  22. 22. Sulfones
  23. 23. Antibiotics for Selected Bacteria
  24. 24. Others • treatment for C. Difficile: metronidazole OR oral vancomycin; consider both in serious infection
  25. 25. Resources • Toronto Notes 2014
  26. 26. THANK YOU The End
  • ameapandey

    Aug. 22, 2021
  • BarceeKiptui1

    Aug. 13, 2021
  • SherryPersaud

    Jun. 22, 2021
  • MishaFarooq

    Jun. 10, 2021
  • DrJiteshDewangan

    May. 26, 2021
  • DevikaRavichandran

    May. 26, 2021
  • ManuThakur25

    May. 16, 2021
  • YanlinMyint1

    May. 5, 2021
  • sayedkhalilkazemi

    Apr. 26, 2021
  • GayathriGayathri49

    Apr. 14, 2021
  • jeevanab2

    Apr. 7, 2021
  • AnirudhdhaSinh

    Mar. 14, 2021
  • MuhammadAasim14

    Feb. 28, 2021
  • JosephSawo1

    Feb. 26, 2021
  • NilakshiBhattacharjee

    Feb. 17, 2021
  • varshithar3

    Feb. 17, 2021
  • MohammadAfghanzada

    Feb. 3, 2021
  • NimotAdeyemi

    Jan. 19, 2021
  • Yasmeen1902

    Jan. 16, 2021
  • DRLHADAMS

    Dec. 23, 2020

Antibiotics presentation

Aufrufe

Aufrufe insgesamt

133.330

Auf Slideshare

0

Aus Einbettungen

0

Anzahl der Einbettungen

161

Befehle

Downloads

6.300

Geteilt

0

Kommentare

0

Likes

512

×