Pulmonary Tuberculosis

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Transmission ,[object Object],[object Object],[object Object],[object Object],[object Object]

Classification of Drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Isoniazid ,[object Object],[object Object],[object Object]

Mechanism of action ,[object Object],[object Object]

Resistance ,[object Object],[object Object],[object Object]

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]

Excretion ,[object Object],[object Object],[object Object]

Excretion cont. ,[object Object],[object Object],[object Object],[object Object]

Adverse Effects ,[object Object],[object Object],[object Object]

Age dependency >60 2.5 55 1.75 45 1.09 35 .59 25 0.13 age % incidence

Drug Interaction ,[object Object]

Rifampin ,[object Object],[object Object]

Resistance: ,[object Object]

Pharmacokinetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Adverse Effects: ,[object Object],[object Object]

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WARNING! Rifampin and Isoniazid are the most effective drugs for the treatment of TB, The drug enjoys high patient compliance and acceptability. But these 2 drugs should never be given alone! They are always used in combination because resistance occurs to one drug alone very rapidly. They are used in combination with each other initially as well as other drugs. Bacilli must become resistant to two drugs in order to remain viable. Statistically, the chances are verv small of the bacilli becoming resistant to both. . Prophylaxis is with one drug usually isoniazid.

2nd Line Drugs: Not as effective and have more toxicity ,[object Object],[object Object],[object Object],[object Object],[object Object]

para- Aminosalicylic Acid ,[object Object],[object Object],[object Object]

Adverse effects ,[object Object],[object Object],[object Object],[object Object]

Third Line Drug s - least effective and most toxic ,[object Object],[object Object],[object Object]

Adverse effects ,[object Object]

Cycloserine ,[object Object],[object Object],[object Object],[object Object],[object Object]

Chemoprophylaxis of TB Used only in high risk groups ,[object Object],[object Object],[object Object],[object Object]

Chemotherapy of TB ,[object Object],[object Object]

Treatment ,[object Object],[object Object],[object Object],[object Object]

Other Resources ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pulmonary Tuberculosis

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Pulmonary Tuberculosis