More Related Content More from Bhupendra Shah (6) Sle7. SlICC clinic criteria for
SLE
Clinical manifestation Immunologic manifestation
Acute cutaneous
Chronic cutaneous
Oral ulcer
Serositis
Alopecia
Synovitis
Renal
Neurologic
Hemolytic anemia
Leucopenia
thromcytopenia
ANA
Anti-ds DNA
Anti-Sm
Antiphospholipid
Low serum complement
Positive DCT
4 CRITERIA AT ALEAST 1 CRITERIA
EACH FROM CLINICAL AND
IMMUNOLOGICAL
BIOPSY PROVEN LUPUS
NEPHRITIS+ANA/ANTI DS DNA
13. Types of systemic sclerosis
Characterstics Limited cutaneous Diffuse cutaneous
Skin involvement Limited distal to elbow Diffusely involve
Raynauds
phenomenon
Precedes the skin
involvement
Coincident
ILD Mild Common and severe
Renal crisis Rare Common
Antibodies Anticentromere Ab Anti-topoisomerase
Ab.
17. Treatment
Definative supportive
Disease modifying therapy
Glucocorticoids:only if
indicated
Cyclophosphamide:for ILD
Mehtotrexate/mycophenol
ate mofetil:little benefit
Antifibrotic therapy:D-
penicillamine
Vascular therapy:Calcium
channel blocker
gastrointestinal :
Pulmonary artery
hypertension:
Renal crisis:
18. Treatment
No any treatment to significantly alter the
course the natural history of disease.