Derma stem skincare

How to Restructure the Matrix of the Skin From the Cellular Level

Christian: Probably the best place to start is what our vision was when we began working
on DermaStem 2-3 years ago. After discovering the natural role of stem cells in the body
and shaping this into a whole concept that is getting increasingly accepted in the field of
medicine and science in general, we pursued the investigation of various natural
compounds to then develop StemFlo and MigraStem.

And as we we're doing all this work, we were also working on something that would have
an affect on the skin. We know that stem cells go in virtually every single tissue and organ
of the body and the skin being one of the largest, if not the largest organ of the body, then
obviously stem cells are playing a key role in the renewal and regeneration of the skin.

Not only this, the skin is one of the organs in the body that renews itself the fastest. Every
month or 2 we have a new skin. So there is a very, very significant activity of stem cells in
the renewal process of the skin.

For that reason, what we had in mind was to go back in nature and study the ingredients
used in skin care known to have a good effect on the skin – that were already known for
their beneficial effect on the skin. What we wanted to see was which of these ingredients
supported the natural role of stem cells in the skin.

Then if we can take all these plants, all these herbal components and combine this into an
entirely natural skin care product without absorbing any toxins in the body. We forget
sometimes the skin, although it appears like a strong barrier, will absorb things. If you
touch grease, it doesn't go through your skin, the same if you touch water, it doesn't go
through. But it's somewhat of an illusion, as if somebody has a heart attack and you put
nitroglycerin on the skin on the shoulder, within 9 seconds it's in the heart.

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So the skin at the same time as it's a barrier, it's also very, very permeable to certain
compounds. We wanted to have something that was entirely natural, so that if we applied
it on the skin, we are not going to expose the skin to anything that could be toxic or risky in
any way.

The aim of all this and the reason why we wanted to have stem cell technology and tap
into it is because of the process of aging in the skin. If I summarize that in very simple
terms, it is the degradation of components of the matrix of the skin, which is made
essentially of a family of complex polysaccharides and one of the main polysaccharides is
hyaluronic acid.

Attached to this you also have collagen and elastin and they form as a whole, the soft
skeleton of the skin which the muscles and everything in the skin is attached to. If the
layers of the skin become detached from that soft skeleton, then you get and sometimes
it's just at a microscopic level, but you get sagging skin and after a while, you get wrinkles.
If you don't have a good matrix of the skin, then you can not absorb and retain as much
moisture as young skin.

All of that leads to the formation of wrinkles. Our concept was if we can go and support the
natural role of stem cells in the skin, which would then support the natural restructuring of
the skin with strong collagen, natural hyaluronic acid, then we would end up with a much
greater accumulation of moisture and hydration in the skin, a better firmness in the skin
and ultimately wrinkle reduction.

That was the concept and as you will see when we come back with the study of the clinical
trial, we were so right on with what we wanted to do it's actually gone beyond our
expectations. That was the aim, so let's talk a little bit about what we mean when we say
we wanted to embed stem cell technology into an all natural skin care product.

There are a lot of products out there that claim to be natural. The point here is not to
diminish them or say anything negative about them as there are a lot of products from
companies who have really attempted to create an all natural product and have done not
too bad of a job at it.

The problem is simply that it is quite a challenge. When we started on that path we
realized ourselves it was really quite a challenge. Let me say a few words about this, again
not to criticize anyone, but to really understand that when we say we have a product that
is all natural, people may not realize the size of the challenge and the accomplishment
that it is.


All skin care products are essentially the same -- it's an oil phase, that's made from olive
oil, or coconut oil, for example, and then blended with a water phase, which would
essentially be the water with which you extracted various plants, a tea for example. If you
put a drop of olive oil in a cup of tea, you end up with a drop of oil floating in a cup of tea,
it does not give you an emulsion, an emulsion being a very stable blend of oil and water.
Which is what you find in any kind of lotion that you use, they are emulsions.

In order to blend them together, we need to use chemicals which have the property to be
soluble in water and in liquids. A good example is soap. If you have grease on your hands
and you put your hands under water with soap, then soap will dissolve the grease on your
skin and will also be dissolved by the stream of water, so essentially, it cleans your hands.

So soaps are emulsifiers, but we know if you put soap on your skin and don't remove it
and rinse it properly, we know it is also drying for the skin. That's the flip side of using
those chemical emulsifiers is that they dry the skin. There is this misconception out there,
actually it's more than misconception, it's made out to be this way.

People have been very well trained to use moisturizer thinking that as the name implies
it's moisturizing your skin, but most of the time if you really think about it, the amount of
water you have in your skin and that you lose from your skin everyday is such that by
applying a pea size or quarter size amount of lotion on your face, there's not enough water
in there to really hydrate your skin. So really what moisturizers do is seal your skin to
prevent further water loss and your skin feels softer right after you've applied it. But as you
certainly have noticed, it's something you need to do many times a day and certainly every
day.

So it does not build moisture in your skin, it just makes it feel better when you use it and
the flip side is that over time, the reason why we need to keep using it is because it is
drying for the skin, but I'll come back to that later.

Most emulsifiers because of this property are actually irritants for the skin. Many of them
are very well known and if we go into the database of chemicals used in skin care, many
emulsifiers are considered skin irritants. Now, once we used emulsifiers and blended the
oil with water, then we have our emulsion, which is essentially our lotion. But again, often
times, this is made from oils like olive oil or coconut oil, then blended with a tea, which is
some sort of water extraction. These are all great nutrients for bacterial growth. So we
need to prevent bacterial growth and keep stability of the product over time and that is
probably where the biggest challenge is.

So, traditionally, what is being used is a lot of toxic chemicals and their level of toxicity
can vary. They are all considered safe by the FDA, but at the same time almost all of them


are to some extent considered carcinogenic. One of them, probably the most common if
you take most skin care products and you look at them, you will see listed under various
ingredients and the various names, you will see various forms of parabens.

Parabens are considered safe, however over the past few years there's a growing body of
evidence showing that parebens can be linked to breast tumors, at least the greatest
concentration of parabens have been found in many breast tumors.

So, the point here is that it's difficult to prove that something is actually negative, probably
more so because of the lobbying that would be around these compounds because it's very
difficult to go around them. It would be a challenge for the entire skin care industry, so
they're considered safe and all of this can continue. But we wanted to avoid using them.
But in most products, you will find them simply because emulsifying your lotion and then
preserving it are 2 things that are essential in the making a solution.

And at the end of it, there's the fragrance and here a lot of times we can find natural
fragrances, but again, the problem with natural fragrances is that they're not constant over
time. Every lot, for example if you use jasmine flower oil, a beautiful smell, but every single
lot, every single season, will have a slight variation in the smell. So because of that, we
need to get used to some sort of a fluctuation in the aroma of the product and most
people don't want to see that. Essentially they go back to standardized, often synthetic
essences which smell very good, but they are not natural. So we really wanted to go
entirely natural.

Even when we look at products that are for a large extent, natural, they resort to a natural
version of some ingredients like glycerin for example. But glycerin again, glycerin is
very well known to dry the skin. If you put a bucket of glycerin in the room, it's going to
absorb all the moisture from the room.

You put it on your skin, it absorbs the moisture from your skin. There's a tag line which has
been connected to glycerin which is drying your skin from the inside. It's in many natural
products, but again we wanted to avoid using glycerin.

Wax is often used to give some consistency to products and also as an emulsifier. Wax is
a sealer for the skin, so we don't want to put that on the skin. I won't continue, I think you
get the picture here that there's a lot of effort been out out there to do something natural
and the full extent of it is that in the end, you just can't go around it, you have to use some
levels of chemistry in the product. We took the challenge of going natural without a
compromise. I like to call it 'natural to an obsession,' because during the process of doing
it, that's what it felt like sometimes.

So now I'll stop the comparisons with anyone, the point was not to diminish other products
out there, as much as to clearly show that in spite of all the effort people have done out
there, there is truly not a fully natural skin care product. When we developed DermaStem
and we say it is all natural, it is truly quite a feat to have accomplished this.

So what we have as the basis of DermaStem, for the oil phase, we have virgin organic
coconut oil, we have organic Nilotica butter, which is a form of Shea butter known also
in French as the burn tree. The butter coming from the nut of the Shea tree is known to be
so good on the skin that by itself can remove scars from burns on the skin. What we


wanted to do with this all natural base for the serum in which we would add our stem cell
complex and our other active ingredients, we wanted that the skin care itself, the lotion,
the base, be on it's own, even if nothing else was added to it, we want it to be made out of
ingredients that are all beneficial to the skin.

Hence the use of virgin organic coconut oil, organic Nilotica butter and organic Cacao
butter. Cacao butter is an ingredient that has been used for a long time in the Amazon
rainforest to protect the skin against the sun. So these 3 oil ingredients represent the oil
base of DermaStem.

We also wanted to make the water base of DermaStem special, so instead of water, we
used juices. So we have Mamaku juice from a fern growing in New Zealand, which by
itself has shown to be very regenerative to the skin. We have Aloe Vera juice, very well
known for its effect on the skin and the bulk of the liquid is a blend of about 12 different
berry juices, very well known for their anti-oxidant properties.

So when you look at the serum, you can see that it's sort of a deep mocha color, it's not
because there's chocolate in it, it's just a blend of all this color. If you're talking about
berries, you're talking about a deep purple color and with all the other components adding
a different contribution to the color, we ended up with the deep mocha color.

So Mamaku juice, berry juice and Aloe juice and these juices are actually used as the
basis to do the cold extraction of all the other herbs. So these are the base ingredients for
the serum. We needed to blend these oils and these water ingredients together into an
emulsion. When we brought our formula to the lab who was making the product, they
looked at all of this and said, this won't work, you need an emulsifier in the product. We
sent this list of ingredients to a consultant in the industry and they made the same
comment, it's mandatory in America through the FDA to put all your ingredients on the
label, and we see here that you don't have an emulsifier.

So this is what we did for the emulsifier. Again I'm mentioning this so that people can
measure the extent of the technological development that was made with DermaStem.


Our emulsifier is an Olive oil extract, which is very highly concentrated in saponins.
Saponins are this class of compounds found in many, many plants. There is for example,
the Soap plant in New Zealand the indigenous people would use. You simply rub the
leaves in your hands with water and it starts to foam. Any time a foam of that sort coming
from a plant, it's essentially made out of saponins. They are essentially a natural
emulsifier.

So we have saponins and lecithin which is an oily compound coming from rice or soy and
also has this natural property of being able to be soluble in both oil and water. Now, just
these ingredients would not make an emulsion by themselves, so we developed a process
that involves something that resembles homogenization and we are able to bring all of this
into a stable emulsion. I won't say too much about it because it is a proprietary process,
but the proof is in the pudding, we have a stable serum in a stable emulsion.

Now that we have all of this, we need to preserve it. What we did was one of the most
difficult processes and in the end, we found the solution in flowers. If we talk to people and
we say we need a natural preservative, what will immediately come to mind for anyone
with any background in botany are essential oils. Oils of cinnamon, rosemary, clove,
oregano -- these are all extremely anti-bacterial natural ingredients. The problem is that
most of them are also photo-sensitive. If you put them on your skin and go out into the sun
it can leave patches on the skin and can sometimes lead to burns on the skin.

The other thing is that to put them in a concentration high to give enough anti-bacterial
protection, you would smell like a cinnamon bun if you put cinnamon in it and like a pizza if
you put oregano in it. These are not fragrances that anybody would really enjoy wearing
on their face all day long, so they are not very suitable for a product like this.

Another very good candidate is grape seed extract. Some people may or not be aware,
but some people go as far as calling it the great grape seed extract fraud. Which is the
fact that when we take grape seed extract and you make it yourself -- you don't buy it –
and you test it's natural anti-bacterial properties, it doesn't work. When you buy it, it works.

So some people and we have done this ourselves, send it out to be analyzed and every
single one of these grape seed extract products available in the market place all contain
pereben, sodium benzoate and various components that are known to be preservatives.

So it's not the grape seed extract that's preserving the product, it's the preservatives in the
product that are preserving the product. A lot of time people that have natural skin care
products are unaware of that, they are sincere when they say they are all natural, but
grape seed extract really does not work as a natural preservative.

Again, I explain this just to lay out the complexity of the situation. What we did is observed
nature and asked the question, where in nature do we find strong anti-bacterial
components? We looked at the rainforest and in the rainforest we do see flowers that can
bloom, blossom and sometimes be in bloom for weeks at a time in an environment where
you have a lot of moisture, bacteria, a lot of fungal growth, but they don't have bacterial
and fungal growth, because a lot of these very delicate flowers contain very strong anti-
microbial components.


We researched and tested many of these flowers and finally were able to isolate some
flowers that have enough anti-bacterial properties to be added to the serum and provide a
significant anti-microbial component that is completely natural. There was also another
component developed by a friend of Shakahn, the good friend of mine who worked with
me together on DermaStem, which is an extract from bitter orange seed. And to this we
also applied a 3rd process called sunny pure, which we keep proprietary because we are
the only ones in the industry using it.

We've developed a process where by exposing the product to certain specific sound
waves, we can inactivate bacteria and provide stability for the product. As a result, the
product has a very good shelf life with absolutely no chemical preservatives.

As I said before, as it stands alone, if we didn't put anything else in this product, it
basically stands as a fantastic product for the skin, moisturizing the skin, treating the skin,
keeping the skin soft with a strong emollient, but that was the base to which we added our
stem cell technology.

Our approach was to go back and look at all these herbal components known in the
industry to bring great beneficial properties to the skin, increase collagen in the skin,
increase elastin in the skin, increase elasticity, increase moisture, increase the healing
ability of the skin, all the components known to have an effect on the skin. Our hypotheses
was maybe these components are acting not specifically in collagen formulation or any of
these other aspects of the skin, but they're acting by supporting the function of skin stem
cells which then lead to the natural restructuring of the skin. We wanted to restructure the
skin from within, the way mother nature intended.

We looked at many of them and of all of those we looked at, we found that AFA, which is
the very basis for StemEnhance, by itself, whole AFA having a great effect, is actually the
most potent of all of them. Another product called old man's weed coming from
Australia/NZ, Fucoidan, coming from a poly saccharide from one specific sea weed and
Aloe Vera, had the strongest effect on supporting the proliferation of skin stem cells. By
themselves, only AFA had a very strong effect, but when we blended them all together,
that's when the effect was the highest.


We then exposed these 4 ingredients to other ingredients that had shown a very small
effect, not enough to be used individually, but we wanted to see if there was any synergy.
And to our great surprise, what we saw is that when we included components like Vanilla,
Maqui berry, Cacao powder and Colostrum to the blend, they really supported skin stem
cell proliferation. That became what we referred to as the stem cell complex, a blend of
natural ingredients that supports the very stem cells in the skin that on a day to day basis
are going to renew the skin.

Then we wanted to add something stronger to this, pure cytokines. Some people would
say it's not natural, but what I mean by natural is that it's not chemistry, they're not
chemicals that are going to have a negative effect on the skin. These cytokines are
produced by bacteria so it is produced in a very natural way. They are the very cytokines
of human origin. By that I mean, we take a human gene and implant that into ecoli, a
bacteria and then we make that bacteria produce these cytokines. These cytokines are
the very cytokines that your own stem cells are going to produce when they are in the
process of renewal and when they are supporting the actual regeneration and repair of the
skin.

It's a complex of 6 of them and they are normally know to be very rapidly degraded when
they are applied to the skin. So, to make them more effective, we worked with colleagues
in Asia to micro-encapsulate -- actually its a nano-encapsulation -- these cytokines are
nano encapsulated that will penetrate the skin, and once in the skin as the capsule
dissolves, then these cytokines actually release in the skin where they do their work.

When I say these capsules penetrate the skin, there is also another aspect which was
developed, which is the inclusion in DermaStem of an all natural penetrant. What I mean
by this is that if you put Cacao butter or olive oil or coconut oil and you put that on your
skin, you will see that it does not penetrate the skin very quickly.

You will have this feeling of oily residue on your skin for quite some time. So we added an
all natural penetrant, orange oil for example, tangerine oil, and other oils that are known to
really accelerate the penetration of the skin sometimes by up to 900-1000%. By having
these ingredients in DermaStem, it also allows for the penetration of these nano
encapsulated cytokines into the skin.

Blended altogether the cytokines and the stem cell complex, we end up with an
enhancement of around 200% in the proliferation of skin stem cells which is quite


impressive. Now as we studied all these different ingredients, many of them did not have
an effect on skin stem cells, never the less, they are still very well known for their effect
on the skin, so we included them as simply regenerative ingredients in DermaStem.

We're talking about Moringa and Amla, very well known in ayurverdic medicine and used
in various ways but one is applying it directly to the skin. Also Rosa Mosquera, very well
known in South America and today throughout the world. Rosa Mosquera alone on the
skin has been shown to remove scars. And Sangre de Drago, coming from a tree that
grows in South America.

I've had the chance to go a number of times to South America and it is one of the most
unique tress in the area, very impressive. The highest cause of death for people in the
rainforest is accidentally hitting themselves with a machete. Often times, they will cut down
to the artery and the bleeding is quite substantial. So they will look for Sangre de Drago,
cut it with the machete and the tree will bleed a sap that is visually identical to blood. They
take the sap, apply it to the cut and it's going to stop the bleeding quasi instantaneously
and if you reapply enough Sangre de Drago, then in about a week to 10 days, the wound
is completely healed without scars.

It's a very, very powerful healing ingredient, very well known in South America and when
you use the dry sap of the tree, it is virtually about 90% OPC, the active ingredient in
grape seed extract, pycnogenol, that is well know. Not only is it very regenerative to the
skin, but it's also a very anti-oxidant to the skin.

Another key regenerative ingredient that we use that is very unique to DermaStem. I think
we are the first in America to use this ingredient. It's a proprietary ingredient, developed
with colleagues in Europe and it's a derivative of glucosamine. It is not glucosamine and
the reason why it's added is because of the matrix of the skin, hyaluronic acid. Hyaluronic
acid in young skin is very highly branched, it's like taking a pine branch with all the pine
needles on it. If you put that in water, and you lift it out, it will retain a lot of water.


If you took the same branch, without any needles, it wouldn't retain any water. That's
hyaluronic acid. High hyaluronic acid in the skin, in young skin, is highly branched, that's
why young skin looks young, plump, full of moisture. Strong healthy hyaluronic acid is
keeping the deeper layer of the dermis and the superficial layer of the dermis well
connected together which gives firmness to the skin and elasticity to the skin.

So if you add hydration, you increase elasticity and you have the hallmark of young skin.
As we age, we always make high hyaluronic acid in the skin, but we lose the ability of
making these branches. A lot of skin care products have hyaluronic acid in the skin care
itself. The problem is, it may add some to the skin, but it's not your native, hyaluronic acid
structure, which is what we need to rebuild the very matrix of the skin.

By simply adding key components of the branches, what was shown was that the skin can
absorb this glucosamine derivative and build a highly branched hyaluronic acid in the skin.
This would then lead to greater moisture retention in the skin and as you will see when we
talk about the results, we got exactly what we were looking for.

And to finish the whole package, it's very well known we need high anti-oxidant protection
for the skin, so we have a blend of all the berries we talked about before, we have
Hydroxytyrosol from Olive juice, Green tea, Amla, we have Vitamin E, we have a blend of
very strong anti-oxidants in DermaStem.

And finally, what we wanted to add, because it's known and available, there are some
plants that carry some significant sun protection. We did not go as far as testing
DermaStem to see if it has some level of SPF simply because we live in a world where so
many products have sun protection and we've become accustomed to using products with
SPF 20 30, as high as 60 so if we have a product here that has SPF 5 or 8, it's not that
relevant.

We did not do the study and can't put a number on it but there are natural plants like
Samambaia, Genistein from Soy, Green tea extract also contains compounds that have
very well established sun protection factors. So that's what we added into DermaStem.

We have an all natural product that has stem cell technology, regenerative ingredients,
strong anti-oxidants and some level of sun protection.

That's DermaStem.


At the beginning if you remember, the idea was to have something that would restructure
the skin, by restructuring the matrix of the skin, we can absorb more moisture and by
having a better integrity of the skin, we will increase the elasticity of the skin and all of
these together should equate to a reduction in wrinkles.

We went to an external 3rd party laboratory and we put DermaStem to the test. First, let
me say if you take these numbers they compare well to other skin care you can find on the
internet. Most people today, however, when they do studies on skin care, if you read
carefully, you will see that the data does not come from clinical trials, they do not do
clinical trials.

Often times they use surveys. Surveys that will ask the question for example to users, 'do
you think that your skin feels softer a month after use?', 'do you think your skin appears
younger or more radiant?' Obviously, this is extremely subjective so they end up with
results where they can quote, '90% of users have reported the feeling of a younger skin'
type statements.

All of these statements come from surveys that have obviously very little to no scientific
value, but they do this because if they put their product through real clinical trials, the
number would be so low they would have no marketing message, number 1 and number
2, surveys are much cheaper than clinical trials.

We wanted to take the real route of really testing the serum clinically, so you need to keep
it in mind when comparing these numbers. Directly coming out of the clinical trials, what
we have – and some of these results are statistically significant after 7 days -- after 28
days, we have a 30% increase in moisture retention in the skin, that is already at
29.something% at 14 days.


So here we have a very rapid restructuring of the skin in about 2 weeks and we get after
28 days, an average of 25% reduction in wrinkles and fine lines in the delicate areas of the
face, we're talking about the forehead, around the eyes, around the mouth, 25% reduction
in wrinkles. This is the average result coming out in the study.

Just to have an idea of what that means, because even myself I did not really know what
that meant. I was on a flight to Mexico in July. I had just received the results from the
clinical trials and I really did not how it compared to other products, knowing that the
internet is an area where you get a lot of information that is not accurate it's just meant to
carry a marketing message, so I just wanted to know what these numbers meant. By
chance, I started talking to a woman on the plane next to me and I asked her what she
was doing and she told me was the director of a very well known institute of cosmetology.
Just my luck, so I told her what we had, what the concept behind DermaStem was and
told her I had just got the results from the lab and here they are, no manipulation, no
statistical embellishment.

She looked at me silently for a second, then she told me it was unheard of. She carried
the message very clearly that if these are the numbers that we have, this is a real
breakthrough in the field of skin care. I'm just sharing with you the results of the clinical
trial and putting them into perspective. What we have with DermaStem, not only the
message about being truly all natural, but it's effect itself is unheard of.

Here we have something that is entirely natural and really record breaking in terms of its
effect on the skin. When I say the product is all natural it's also interesting to mention, we
are striving to have it all organic, so we could actually have the product certified as all
organic. It's a beautiful problem to have, but sometimes people are not aware of these
things, they are saying that organic is all there is to the story. There are actually a lot of
things in DermaStem that are actually wild harvested. And wild harvested, one could say,
is actually better than organic. They come directly from the wild with no touch from the
human hand, so it's more than organic.

These products that are wild harvested, most of the time cannot be certified organic
because one of the key criteria to be certified organic is to provide documentation that for
a certain number of years, the land did not receive any chemical fertilizer.

Obviously if you are harvesting from a wild forest, no such documentation exists and in the
absence of such documentation, you cannot get it certified organic. There are some
government bodies that go around this, but a lot of these ingredients are wild harvested,
we're working here to get them certified organic and once we have obtained the
certification for all these ingredients, most likely DermaStem has more than 95% of its
ingredients that are organic, so we will be able to get it certified organic.

At this point in time, we are still going through that process, but every single ingredient is
either wild harvested or organic as much as possible. Ingredients like lecithin (from Sor or
Rice), there are no organic sources of lecithin, so when we can't we don't, but every place
it's possible, the ingredients are organic.

How we apply DermaStem
In the study, the instructions we gave were to apply 1 pump to the delicate areas of the
face and then another pump to the rest of the face or 2 pumps around the delicate areas


of the face.

We wanted to avoid the habit of using lotion by putting in your hands, then on your face.
There are so many small creases in your skin, so it's going to get into the skin on your
hands that way. Apply it onto your finger tips, then spread it gently in the areas you want it.
It will penetrate the skin very easily. If you need to redistribute it, just add a drop of water
to your finger tip and redistribute the serum.

Refrigeration
The product does not need to be refrigerated. The product has enough natural
preservative to preserve it. The bottle is what we call an airless pump and when you
depress the activator and release some serum, it does not bring back ambient air into the
product. We did that to reduce all exposure of the product to bacteria, so it's going to have
a good shelf life.

The reason why we say it is better to put in the refrigerator is because it's alive. The plants
are all extracted using cold process extraction, a cold infusion. If you take tea and put it
into a cold cup of water, nothing is going to happen, you're not going to extract a lot from
the tea. If you take that same tea and put it into hot water and you will develop color very
rapidly, you will extract anti-oxidants very rapidly. The same is true for virtually every single
plant, you can get a great extraction if you boil or at least expose it to boiling or very, very
hot water.

There are a lot of natural and delicate components in plants that are sensitive to heat. The
biggest damage you can do to delicate components is oxidation. And oxidation is done by
oxygen, but it's catalyzed by light or heat. So heat is really one of the worst things you can
do to a plant if you really want to preserve all the very natural and bio active components
in a plant.

So what we did was develop a cold infusion process. If you were to put plants in a mortar
to crush the plant and added cold water you would end up with a cold tea. Because you're
crushing the plants, they slowly release their active compounds and if you do this for long
enough, you will end up with the same tea color as a warm or hot tea, that's how we do
our extractions.

The consequence of this is that you have delicate ingredients and components in the plant
that include the enzymes. So there is a live product. It's like leaving an avocado or apple
on your counter and 3 weeks later, it won't look as fresh as the first day, it would be better
in the refrigerator. That's the reality of DermaStem. It's fine if it's left at room temperature,
it's not a problem, however given that it's alive, the color and the aroma may change over
time so if possible, it's better to refrigerate it.

Thank you.


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Derma stem skincare

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