Combination drugs containing Paracetamol and Aspirin, displayed in Figure 1, are widely used analgesics with anti-inflammatory properties for treatment of migraines. Both active ingredients have a similar mode of action, whereby they inhibit the cyclooxygenase (COX) enzyme, by preventing the production of prostaglandins which cause pain, inflammation, and fever. UV/Vis spectrometry is a fast and commonly used technique in quality control laboratories for routine analysis of purity and quantity of components within various stages of a product’s manufacture in many industries.
Combination drugs containing Paracetamol and Aspirin, displayed in Figure 1, are widely used analgesics with anti-inflammatory properties for treatment of migraines. Both active ingredients have a similar mode of action, whereby they inhibit the cyclooxygenase (COX) enzyme, by preventing the production of prostaglandins which cause pain, inflammation, and fever. UV/Vis spectrometry is a fast and commonly used technique in quality control laboratories for routine analysis of purity and quantity of components within various stages of a product’s manufacture in many industries.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
This article is all about what AI trends will emerge in the field of creative operations in 2024. All the marketers and brand builders should be aware of these trends for their further use and save themselves some time!
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
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Dr. behnam aghabeigi birmingham seeking answers to facial arthromyalgia
1. Facial arthromyalgia (FAM) or the temporomandibular joint pain problems
syndrome is a very common condition in which individuals grumble of
soreness in addition to discomfort in a single or both temporomandibular
joints (TMJ), often with limitation of jaw opening informs Dr. Behnam
Aghabeigi Birmingham. The disease is certainly four times more prevalent in
ladies compared to males where there are numerous reports linking these
kind of signs and symptoms to undesirable life events, anxiety or perhaps the
lack of emotional assist. This condition can occur individually or even with
some other non-muscular non-joint agony within the facial skin (atypical
facial pain, AFP) or tooth (atypical odontalgia, AO). All these may also be
regularly associated with idiopathic head, back and neck ache, irritable bowel
along with pruritus. The actual facial pains would be better governed with
tricyclic anti-depressants even in the lack of depression4 Recently we have
shown that these sufferers also have disadvantaged removal involving
conjugated tyramine, a natural trait marker noticed in endogenous
depression5 suggesting a common metabolic disruption predisposes to both
soreness as well as depression.
2. Nonetheless, the actual underlying biochemical systems leading to both pain and joint
dysfunction continue being set up. In an attempt to account for the joint pain as well
as malfunction Dr. Ben Aghabeigi Birmingham's focus has been drawn to studies
declaring to signify that mental strain in addition to discomfort within creatures were
associated with an elevated building of free radical@-’ and also by the actual
commentary that stress induced damage to the gastric mucosa had been linked to free
radical production. ‘,i” Additionally, there have been studies that free radical activity
inside synovial fluid from the knee joints of rheumatoid patients correlates with the
seriousness of the condition.” A free radical can be any kind of molecule or atom
consisting of one or higher unpaired electrons making it highly sensitive. A lot of
biological molecules for example O2 or H,O are non-radicals, filled with simply
matched electrons.
Besides triggering ache within animals, within vitro tests demonstrate that free
radicals depolymerise hyaluronic acid generating reduced synovial fluid viscosity,”
which can hinder lubrication along with result in meniscal hesitation and also
clicking, as formerly suggested by Toller. . There has also been facts that free radicals
are linked with cartilage damage14 and that they can easily encourage bone
resorption.” Moreover, the particular display of the presence of eicosanoids in a variety
of inflamation related joint diseases,” which will become the product of a free radical
and or neuropeptide synovitis, would probably fit their particular identified role as
one of the vital mediators of chronic algesia and hyperalgesia.
3. And then we have reviewed the chance that FAM may, partly, result from the actual
unacceptable production of free-radicals within inclined people.
3 variables of free radical creation were calculated in patients introducing with
obvious indications of FAM and/or a history of idiopathic oro-facial pain (AFP and
AO): (I) Systemic free radical activity has been researched with a evaluation of the
free radical production of 2,3-dihydroxybenzoic acid (DHB) from an oral dose of
aspirin compared to the standard aspirin metabolic product 2,5-DHB.
Intra-articular free radical activity ended up being researched by 2 strategies by Dr.
Behnam Aghabeigi Birmingham.
1 was a thiobarbituric acid (TBA) assay of saline TMJ aspirates to test for intra-
articular manufacture of lipid peroxidation products” and (III) the second was
measurement of the production of intra-articular hyperalgesic eicosanoids PGE,,
LTB, and 15-HETE.
Material and techniques employed by Dr. Ben Aghabeigi Birmingham
Sufferers
4. Three sets of individuals had been enrolled for this study. Systemic free radical
activity had been studied within the first group of sufferers that were identified as
having chronic FAM and/or other idiopathic oro-facial pain in excess of 3-4 months
duration. Intra-articular free radical activity was analyzed in groups II and III which
comprised sufferers along with unilateral signs and symptoms of TMJ pain which
had been unresponsive to 12 weeks tricyclic antidepressant therapy and also were
undergoing TMJ arthroscopy under general anaesthesia. All the subjects provided
their informed permission and none had some other joint disease or even known as
well as alleged history of allergy to aspirin. Moral acceptance had been acquired for
all those procedures.
Group I (systemic free radical activity): 10 pain people (age range 26-64, mean 41.8 +
11; 9 females, 1 male) as well as 10 healthy, age- in addition to sex-matched volunteers
without any former status for idiopathic soreness had been enrolled as controls (age
ranges 29-60, mean 42.129.6). These kinds of people along with handle subjects had
10 ml of venous blood drawn in heparinised tubes and voided their particular
bladders to provide a urine trial. Every single subject was then administered an oral
measure of 1.2 g of aspirin after 2 h repeat blood and urine samples were gathered.
The blood samples were centrifuged directly plus the plasma in addition to urine
samples stored at - 70°C up to assayed for 2,3-DHB.
5. Group II included eighteen individuals (age range 22-49, mean 33.2+ 8.1; 13 ladies, 5
men). Two hours just before arthroscopy the people had been given 1.2 g of Aspirin
orally to guarantee equilibration amongst the plasma along with synovial fluid. At
arthroscopy 1 ml of typical saline was inserted into the joint spaces bilaterally,
authorized time to mix with the synovial water as well as aspirated through the very
needle. Specimens with obvious contamination with blood had been dumped. The
aspirate volumes were determined, 50 ul taken out regarding haemoglobin assay as
well as the rest was centrifuged straight prior to the supernatants had been kept at -
70°C. A venous blood sample had been pulled directly into heparinised tubes
simultaneously as the synovial aspirates were collected, centrifuged plus the plasma
kept at -70°C before assayed regarding lipid peroxidation products by TBA assay.
Group III was comprised of fifteen sufferers (age ranges 15-41, mean 28.3 +7.4; 9
women, six males). Synovial aspirates were being amassed as referred to above along
with stored with regard to hyperalgesic eicosanoid evaluation, specially prostaglandin
E2 (PGE2), leukotriene B, (LTB,) and 15-hydroxyeicosatetraenoic acid ( 15HETE). Most
of these subjects wouldn't receive aspirin due to the would-be inhibitory relation to
eicosanoid creation.
Biochemical descriptions by Dr. Ben Aghabeigi Birmingham
6. (a) Measurement regarding plasma as well as urine Measurement involving plasma
along with urine 2,3- and 2,5-dihydroxybenzoic acid (DHB) was with a amendment
of the ways of Grootveld and Halliwell” applying HPLC coupled to electrochemical
diagnosis. Most samples were utilised immediately or perhaps placed at - 70°C until
evaluated.
(i) Plasma sample preparing on your DHB analysis. Samples (1 ml) were being
acidified together with 50 ul of 1 M HCI and also 20 ul of an internal regular of 3,4-
DHB (100 PM) added prior to samples were removed along with 10 ml of ethyl
acetate. The actual samples had been next centrifuged at 1500 g for 10 min prior to
upper organic layer was decanted into a clean dried up tube as well as lowered to
dryness within a stream of air in a water bath at 40°C. When dry the samples were
being redissolved inside 200 nl of mobile phase and also 50 ~1 of 1 M HCl had been
added ahead of assessment.
(ii) Urine sample preparation for DHB analysis. Samples (5 ml) had been acidified
together with 1 ml 1 M HCl before being removed twice with 10 ml of ethyl acetate.
The actual blended ethyl acetate extracts were being taken to dryness within a
stream of air inside a water bath at 40°C. The particular deposits had been
reconstituted in 250 ul of 0.2 M HCl and successively diluted 1 in 20 or 1 in 50 with
0.2 M HCl prior to ultimate assessment.
7. (iii) HPLC purification and electrochemical diagnosis of DHBs. Following the original
extraction involving both the plasma along with the urine samples, the HPLC is
purified of 2,3- and 2,5-DHBs were similar, using a insignificant changes on the
detection system to be able to help a solitary run resolution of the urinary degrees of
2,5-DHB because of for the considerable amounts of this aspirin metabolite seen in
urine. HPLC separations ended up run in isocratic conditions which has a
SpectraPhysics SP8800 pump with a Brownlee 5 pm ODS reverse phase column (250
x4.6 mm) coupled to an EDT equipment LCA 16 electrochemical sensor pre-loaded
with a glassy carbon performing electrode including a Ag/AgCl reference electrode
handled in the oxidation mode. The actual mobile phase was 30 mM sodium
titrate/27.7 mM sodium acetate buffer (pH 4.75) at a flow rate of 1 ml min- i. The
particular mobile phase was sparged with helium gas and the eluent monitored
electrochemically within an electrode potential of + 0.6 V.
When the urine samples were analysed it was seen to be easy to obtain quntifiable
peaks akin to 2,3- and 2,5-DHBs in a individual run once the recorder sensitivity was
diminished lo-fold after the elution of the 2,3-DHB peak.
At this time there were a couple of other assessments which were carried out by Dr.
Ben Aghabeigi Birmingham as well as his workforce relating to Synovial analyses for
lipid peroxidation these tests were Thiobarbituric acid test, Haemoglobin
measurement, Salicylate assat, Measurement of eicosanoids.
8. Discussion along with Aghabeigi dentist
We've got tested the amount of 2,3-DHB both in the particular circulation and in the
actual urine of the group of 10 sufferers attending a hospital for persistent idiopathic
oro-facial pain, both before and after the particular administration of 1.2 g of aspirin
along with these kinds of levels have been completely compared to age and sex-
matched control subjects . There was no sign that either group had variations in their
own inborn skills to metabolise Aspirin, as evaluated by way of manufacture of 2,5-
DHB, the main product of mammalian metabolism of aspirin. Nonetheless, there were
significantly higher levels of the free radical created 2,3-DHB within the plasma of the
patient group as compared to the control subjects. It has been proposed that the
production of 2,3-DHB from an oral dose of aspirin results from a free radical reaction
along with salicylate.” This may keep the hypothesis that patients along with
persistent idiopathic pain which is commonly stress related could deliver increased
free radicals and have some incapacity of their scavenging metabolism.
The particular urinary levels of 2,3-DHB had been greater within patients when
compared to the controls. Even though this was not mathematically important,
perhaps biochemically vital. We are not competent to comment additionally on the
complexity of urinary free radical metabolism, which probably needed some form of
clearance measurement.
9. . In the past 10 years, saline aspirates of the upper joint space from the TMJ have
already been evaluated for the presence of numerous mediators of pathological
problems. Within this research project now we have in addition analysed saline
aspirates, from patients showing with a status for chronic FAM who have been
undergoing arthrostopic examination, for the possibility to create, in vivo, free
radicals and intra-articular eicosanoids. We think this technique can be fraught
together with complications, mainly because the volumetric yield from a collection of
TMJ aspirate is varied, within our case between 500 ul to 1050 ~1. The volume obtained
is maybe influenced by owner approach and also the patency of the joint space.
Even so, the mean level of the aspirates amassed through this study is way greater
than formerly reported” or than that gathered in the initial research designed in our
own laboratory.” Arthroscopic joint trauma, giving increase to haemoglobin as well as
cellular contamination of several of the biological materials was an illustration of an
significant supply of blunder. This has been controlled through the preoperative
aspirin and by ensuring that centrifugation in the aspirates has been completed
immediately, and also would likely additionally explain, a minimum of in part, in the
past noted uncommonly top degrees of inflammatory mediators that aren't applicable
for this condition. This is an crucial statement that has not formerly been commented
on by anybody else, that have found amounts of neuropeptides, prostaglandins and
leukotrienes to be large in TMJ synovial fluid than others based in the synovial fluid
gathered in the infected knee joint in gout.
10. An intriguing part of encouraging explanation for that involvement of free radicals
inside the pathogenesis connected with FAM is usually our demonstration of
significant intra-articular concentrations for the hyperalgesic mediator 15-
hydroxyeicosatetraenoic acid ( 15-HETE), whose combination includes the free
radical mediated process of lipid peroxidation of arachidonic acid, inside synovial
fluid. We were struggling to display a good both prostaglandin E2 (PGE,) or
leukotriene B4 (LTB,). It is worth repeating that the eicosanoid ranges found by past
researchers seem to be artifactually lifted even though compared to severe
inflamation related illness in other joints. Its of importance that hyperalgesia
induced by 15-hydroperoxyeicosatetraenoic acid ( 15-HPETE) in an experimental
animal can considerably prolong the particular algesic effect of substance P(SP)
creating a chronic discomfort model definitely not distinct to FAM. It's not
obstructed simply by non-steroidal anti-inflammatory analgesics apart from
dipyrone.
Furthermore, a SP antagonist can certainly stop this kind of result. These bits of
information associate with other studies that have identified neuropeptides within
the particular synovial water from your TMJ27,28 and also your own observation
which have established that the TMJ capsule is not merely richly innervated by
simply SP neuronal tissue, but some other neurogenic peptides including calcitonin
gene-related peptide, neuropeptide Y and also vasoactive digestive tract polypeptide.
11. One of the main scientific problems in managing FAM will be the poor reaction to
non-steroidal anti-inflammatory pain killers, which would correlate together with
the role of hyperalgesic 15-HPETE as being more valuable than the prostaglandins
such as PGE,. Mentioned previously generally there were no vital disparities between
systematic along with symptom-free joints with regards to TBA-RS, 15-HETE or
synovial fluid volume.
Regrettably, as it wasn't legally simple to obtain saline aspirates from the joints of
healthy age- and sex-matched pain-free older people, one can just hypothesize that
these degrees observed represent the particular pathological method. This absence of
difference shouldn't be fully shocking considering that a systemic biochemical
problem could be reflected in both joints at the ends of a single bone fragments.
Furthermore, the mirror imaging of inflamation related replies inside additional
combined joints in the body that don't have the unique anatomical along with
purposeful features regarding TMJ has been caused by neurophysiological
influences.
However, the presence of potential pain mediators inside the symptomless joints in
addition indicates value of additional factors including local neuropeptide or
perhaps cytokine release which is often based on asymmetrical masticatory function
and bruxism,
12. or style elements that affect central modulation for the pain experience.
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Article Resource:
http://behnamaghabeigi60.wordpress.com/2013/07/28/behnam-aghabeigi-
studies-patients-with-chronic-facial-pain/