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Retrosynthetic Analysis of Organic Synthesis ,[object Object],[object Object],[object Object]
[object Object],[object Object]
Retrosynthetic analysis Disconnection of T.M. Intermediate Starting material  Synthesis tree
3.2 Common terms in retrosynthetic analysis ,[object Object],[object Object],[object Object],[object Object]
Factors in Design of Synthesis ,[object Object],[object Object],[object Object],[object Object]
Reactions involved in Synthesis ,[object Object],[object Object]
Major Ionic Reactions for Carbon
Pericyclic Reactions ,[object Object],[object Object],[object Object]
Rearrangements Useful in Synthesis
Criteria for Evaluating Synthetic Methods ,[object Object],[object Object]
Key Points in Designing Synthesis ,[object Object],[object Object],[object Object],[object Object]
Grignard and related organometallic reagents ,[object Object],[object Object],[object Object],[object Object],[object Object]
Organometallic and Ylide Methods of Carbon-Carbon Bond Formation
Stereochemistry  of Grignard Addition
Orthometallation Cross Coupling (Suzuki Rxn 1,4-Addition
Acetylides and Nitriles
Wittig Reaction
Carbonyl Activation and Enolate Chemistry in Carbon-Carbon Bond Formation
 
Regiospecificity in Enol Ether Formation
Carbanion Generators
Alkylation of Carbanion CH 3 -OSO 2 F methyl fluorosulfonate oxirane (epoxide) CH 3 -OSO 2 O-CH 3 dimethyl sulfate (R-OTs) toluene-p-sulfonates (or tosylates) R-OSO 2 CH 3 (R-OMs) methanesulfnates (or mesylates) R-X alkyl halide Structure Alkylating agent
Enolate Anions in Carbonyl Addition Reactions ,[object Object],[object Object],[object Object]
Aldol Condensation
Claisen Condensation
Michael Addition
4. Robinson annulation - a special class of Michael additions which lead to one six-membered ring fused to another
Functional Group Interconversion ,[object Object],[object Object],[object Object],[object Object]
General Pattern of Reduction
Reductions with Hydride Reagents
Carbocations in Synthesis ,[object Object],[object Object],[object Object]
Free Radical and Pericyclic Reactions ,[object Object],[object Object],[object Object]
Alkene Metathesis ,[object Object]
Protection Groups ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Retrosynthesis
Synthesis
 
 
 
 
 
 
 
 

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Organic Synthesis