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Mci5004 biomarkers infectious diseases

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MCI5004 MOLECULAR BIOMARKERS IN CLINICAL RESEARCH Biomarkers in Infectious Diseases
Biomarkers - aims ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Molecular diagnostic markers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Problems with diagnostic markers ,[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnostic markers ,[object Object],[object Object]
Markers of disease severity ,[object Object],[object Object],[object Object]
Genetic susceptibility ,[object Object],[object Object],[object Object],[object Object],[object Object]
Genetic susceptibility ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Genetic susceptibility ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pathogen virulence – lines of evidence ,[object Object],[object Object],[object Object],[object Object]
Pathogen virulence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathogen virulence – molecular markers ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
 
 
[object Object],[object Object]
D222G (H1) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
D222G (H1) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hua Yang 2010 PLOS Currents. Mutated D222G on reference virus – still maintain predominant affinity for alpha 2,6 receptors
Y Itoh et al. Nature 460 , 1021 - 1025 (2009) doi:10.1038/nature08 260 Pathological examination of the lungs of infected cynomolgus macaques.
H1N1 2009 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
H1N1 2009 ,[object Object],[object Object]
Maines 2009 H1N1 2009 binding pattern similar to 1918 virus but lower affinity
PB2 ,[object Object],[object Object],[object Object],[object Object],[object Object]
PB2 ,[object Object],[object Object],[object Object],[object Object]
[object Object]
Virulence markers - approaches ,[object Object],[object Object],[object Object],[object Object],[object Object]
Virulence markers ,[object Object],[object Object]
Founder effect ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Molecular markers for epidemiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
STEC outbreak, Germany ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Whole-genome sequencing ,[object Object],[object Object],[object Object],[object Object],[object Object]

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