1. Chapter 29:
Disorders of the Kidney in HIV
Infection
Amanda Valliant, MD
Nephrology Fellow
Fellows’ Curriculum
1.16.2013
2. Roadmap
• HIV and AKI
• Electrolyte Disturbances
• Medication Toxicity
• Thrombotic Microangiopathy and HIV
• HIV-Associated Nephropathy
• Immune-Complex Mediated GN
• Hepatitis C Co-Infection
4. HIV and AKI: Epidemiology
Prior to HAART, AKI was typically due to sepsis, volume
depletion, medication toxicity
AKI more common in HIV-infected hospitalized patients (6 %
versus 2.7% in 2003 study)
Ambulatory HIV patients
Single center study—at least 1 episode of AKI in 71 of 754
patients (9.4%) in a 2-year period (2000-2002)
Francescini, et al. Kidney Int 2005; 67:1526
5. HIV and AKI
• Most common causes similar to the general
population (ATN and prerenal states)
• Francescini study (2 year prospective):
– Prerenal states include true volume depletion,
cirrhosis, heart failure (39%)
– ATN ischemic and nephrotoxic (37%)
– Crystalluria with obstruction (5%)
– Interstitial Nephritis (5%)
6. HIV and AKI: Outcomes
- Inpatient mortality significantly higher among HIV-infected patients with
AKI compared to those without AKI (2003, New York, 27% vs 4%)
- Long-term mortality higher among HIV-infected individuals with AKI
- National sample of US veterans from 1986-2006 (>17K patients)
- Hospitalized patients who survived 90 days after discharge
- AKI occurred in 18% (3060 patients)
- 334 patients with AKI required dialysis
- Average f/u was 5.7 years after discharge, HIV-infected patients
with AKI significantly more likely to die (56% versus
47%)
- ESRD and cardiovascular events also more common among
HIV-infected patients with AKI
Choi, et al. Kidney Int 2010; 78:478
8. Electrolyte Disturbances
-Prior to HAART, hyponatremia was the most common electrolyte
disturbance in HIV
- Volume depletion was the most common cause
- SIADH, idiopathic and related to lung infections and malignancy
-Hyperkalemia is most commonly associated with treatment or prophylaxis
for PJP with pentamadine or trimethoprim-sulfamethoxazole
-Electrolyte depletion due to tubular dysfunction associated with a number
of agents used to treat HIV or infectious complications
- Tenofovir, foscarnet, amphotericin, pentamidine
- Hypophosphatemia, hypomagnesemia, hypocalcemia can be
severe and symptomatic, require aggressive replacement
11. HAART
- Indinavir (Crixivan) and Atazanavir (Reyataz) can cause
crystalluria and AKI (protease inhibitors)
- Tenofovir (Truvada—an NRTI) can cause AKI with or without
proximal tubular dysfunction
- Fanconi syndrome, with associated risks of osteomalacia,
occurs most commonly with tenofovir
Meta-analysis of 17 studies examining TDF safety
shows a significantly greater loss of kidney function
with TDF (0.7% risk difference with 95% CI 0.2-1.2)
Also demonstrated with didanosine (Videx—NRTI)
12. Other Medications
- Herpes simplex or CMV Treatments
Acyclovir – ATN/crystalluria
Foscarnet – Nephrogenic DI, electrolyte disturbances
Cidofovir – Proximal Tubular Damage
- Anti-Pseudomonal Drugs
Trimethoprim-Sulfamethoxazole AIN
Pentamadine nephrotoxic ATN in 25% of patients
Trimethoprim
crystals in the
urine
14. Thrombotic Microangiopathy (TMA) of HIV
-TTP and adult HUS are considered part of a spectrum of disease known as
“thrombotic microangiopathies” (TMA) because they have similar clinical and
histological characteristics, both result in endothelial cell damage
- Intravascular platelet clumping leads to clinical pentad of MAHA,
thrombocytopenia, fever, neurological and renal dysfunction
-TMA is rare in healthy people
- Mortality is >95% if untreated
- Treatment with plasma exchange dramatically improves prognosis and survival
- TMA has been associated with bacterial toxins, immune complexes,
autoimmune disorders, cancer and antineoplastic therapy, organ and marrow
transplantation, drugs (IFN, ticlopidine, quinine, simvastatin, rifampicin)
-Association between TMA and HIV first recognized in 1984, both TTP and HUS
have been reported in HIV-infected patients (no difference clinically from non-
infected patients)
15. Thrombotic Microangiopathy (TMA) of HIV
-Reports of the prevalence of TMA in HIV-infected patients varies from 1.4%
in the pre-HAART era to 7% in patients hospitalized with AIDS
- In the Collaborations in HIV Outcomes Research/US (CHORUS)
cohort of 6022 patients, only 17 (0.3%) had TMA (June 1997-May
2003)
- When compared to similar patients without TMA, they had:
● Lower mean CD4 counts (197 vs 439 cells/mm, p = 0.0009)
● Higher mean HIV RNA levels (4.6 vs 3.3 copies/mL, p = 0.0001)
● Greater incidence of AIDS (82% vs 55%, p = 0.025)
● Greater incidence of Mycobacterium avium complex
infection (18% vs 3%, p = 0.018)
● Greater incidence of Hepatitis C (29% vs 11%, p = 0.001)
● Greater incidence of death (41% vs 7%, p < 0.0001)
- In this cohort, 10 of 17 patients were white, 4 hispanic, 3 of African descent
Becker, et al. Clin Inf Dis, 2004; 39: 267-275
16. HIV-Associated Nephropathy
Tubular reticular endothelial cell inclusions
demonstrated in HIVAN, not collapsing FSGS
Tubular reticular endothelial cell inclusions
demonstrated in HIVAN, not collapsing FSGS
17. HIVAN
-First described in 1984 in patients with advanced HIV infection
-Collapsing form of focal sclerosing glomerulosclerosis (FSGS)
- Associated tubular microcysts and interstitial inflammation
- Typically presents with significant proteinuria, rapidly progressive
renal disease
- Usually in the setting of NORMAL BLOOD PRESSURES
- Normal to enlarged kidneys are typical
-Pathogenesis (hypothesized):
- Infection of kidney epithelial cells by HIV and expression in those
cells
-Transgenic mouse models suggest that HIV genes such as Nef
and Vpr are involved
- Genetic susceptibility (strongly favors black race)
18. HIVAN: Epidemiology
- Closely associated with black race, more so than any other cause of
ESRD outside of sickle cell disease
- Leading cause of ESRD in young African-American adults
- HAART has decreased the % of HIV-infected patients that have HIVAN
- Due to increasing numbers of HIV-infected patients, the annual
incidence of HIVAN is increasing (approximately 900 new cases per year)
-First described in 1984 as a complication of AIDS, but can occur in
acute seroconversion or in less advanced disease
19. HIVAN: Clinical Presentation
- USRDS data: Approx 90% of new ESRD cases due to HIVAN
occur in patient of African descent
- Advanced HIV disease (mean CD4 count 127, viral load >30K)
- Nephrotic range proteinuria
- Rapid decline in renal function, usually advanced at time
of diagnosis
- Hypertension, edema, hematuria are less common but can occur
20. HIVAN: Pathology
Figure 1. The pathology of HIVAN from human kidney biopsy samples. Typical
pathologic changes of HIVAN include global glomerular collapse with overlying
epithelial cell crowding and hypertrophy (left panel) as well as tubular microcystic
disease (right panel) (images courtesy of Dr Vivette D'Agati).
Kaufman, et al. Advances in CKD, 2002, 17; 1:36-43
21. HIVAN: Differential Diagnosis
- Study of 107 HIV-infected black patients with worsening renal function and
>3g of proteinuria biopsy results revealed the following:
- HIVAN (56%)
- Classic FSGS (21%)
- Membranoproliferative Glomerulonephritis (6%)
- Amyloidosis (4%)
- Diabetic Nephropathy (4%)
- Lupus-like Immune Complex GN (4%)
** Nearly 40% suspected clinically of having HIVAN did not
** Biopsy should be done unless there is a contraindication
Atta MG, et al. Am J Med 2005; 118:1288
22. HIVAN: Treatment
- In patients diagnosed with HIVAN not on HAART, this is the initial treatment
- Endorsed by KDIGO Clinical Practice Guidelines for GN
- Patients typically have another indication for starting HAART as well
- No randomized trials looking at HAART treatment
- Median survival higher among patients receiving HAART (18.4 vs 3.9
months) but in this retrospective study the serum creatinine was lower
among the HAART group and this was not adjusted for.
- In patients who are proteinuric or hypertensive, therapy with either an
ACEI or ARB is indicated; this should be up-titrated rapidly
- Not suggested to routinely treat with glucorticoids although some centers do
-Some experts use a trial of steroid in patients with progressive disease
who are nearing a need for RRT despite the treatments above
-Only small, uncontrolled studies conducted before HAART or early in the
HAART era have looked at glucocorticoids in this disease
24. Immune Complex Mediated
Glomerulonephritis
- Nearly 40% of HIV-infected patients with proteinuric kidney disease and
suspected HIVAN will have another diagnosis at biopsy
- Membranous Nephropathy
- Membranoproliferative and mesangial proliferative GN
- “Lupus-like” proliferative GN
- Rare cases of IgA Nephropathy
- Natural history of these diseases in HIV and response to HAART has not
been well studied
- In general, based on small case series reports, patients with non-HIVAN
kidney disease tend to have less advanced HIV, slower progression to
ESRD, less likely to be black
- “Lupus like” disease tends to be more aggressive and is more likely to be
seen in black patients
- In one cohort of 14 patients, 10 progressed to ESRD within one year
25. HIVICK
- HIVICK: HIV Immune Complex Kidney Disease
- Unique immune complex disease with a characteristic “ball in cup”
basement membrane reaction
- First described in a South African biopsy series
- Role of viral antigens in circulating immune complexes and the pathogenic
relationship between HIV and the development of HIVICK has not been
studied
28. Hepatitis C Co-Infection
- Associated with the development of both acute and chronic kidney
disease in large cohort studies of HIV patients
- Histologic patterns have NOT been studied in large groups
- MPGN is strongly associated with Hepatitis C infection in the general
population and is a common diagnosis in co-infection as well
- Classic findings that are clinically associated with cryoglobulinemia
and hypocomplementemia may be less common in coinfection
- Treatment of Hepatitis C associated MPGN in the setting of HIV has
not been well studied
- Plasmapheresis
- Corticosteroids
- Antiviral therapy for Hepatitis C
29. References
- Wyatt CM. www.uptodate.com, “Overview of Kidney Diseases in HIV-Infected
Patients”
- Kalyesubula R, Perazella M. Nephrotoxicity of HAART. AIDS Research and
Treatment, 2011.
- Wyatt CM. www.uptodate.com, “HIV-associated nephropathy (HIVAN)”
- Becker, et al. HIV-Associated Thrombotic Microangiopathy in the era of Highly
Active Antiretroviral Therapy: An Observational Study. Clin Inf Dis,
2004;39:267-275.
- Greenberg A, Cheung A. Primer on Kidney Diseases, 5th Edition. Elsevier
Health Sciences, 2009. Chapter 29: Disorders of the Kidney in HIV
Infection.
Editor's Notes
2 major effects: 1) effect on renal blood flow and GFR, 2) effects on the distal tubule directly (electrolyte wasting, impaired urinary acidification and concentration, eventual RTA)
Fanconi syndrome (also known as Fanconi's syndrome ) is a disease of the proximal renal tubules 1 of the kidney in which glucose , amino acids , uric acid , phosphate and bicarbonate are passed into the urine, instead of being reabsorbed. Fanconi syndrome affects the proximal tubule, which is the first part of the tubule to process fluid after it is filtered through the glomerulus. It may be inherited, or caused by drugs or heavy metals.2 Different forms of Fanconi syndrome can affect different functions of the proximal tubule, and result in different complications. The loss of bicarbonate results in type 2 or proximal renal tubular acidosis. The loss of phosphate results in the bone disease rickets (even with adequate vitamin D and calcium), because phosphate is necessary for bone development.