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Estimation of glomerular filtration rate

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Estimation of glomerular filtration rate

  1. 1. Renal function, in nephrology, is an indication of the state of the kidney and its role in renal physiology.
  2. 2. It is the volume of fluid filtered from the renal Glomerular capillaries into the Bowman's capsule per unit time.
  3. 3.  It is calculated by measuring any chemical that has a steady level in the blood, and is freely filtered but neither reabsorbed nor secreted by the kidneys  GFR is typically recorded in units of volume per time.
  4. 4.  Serum creatinine level are used in measuring GFR.  is produced naturally by the body.  It is freely filtered by the glomerulus.  But it is actively secreted by the peritubular capillaries in very small amounts so creatinine clearance overestimates actual GFR by 10-20%
  5. 5.  Problems with creatinine (varying muscle mass, recent meat ingestion, etc.) have led to evaluation of alternative agents for estimation of GFR
  6. 6.  The GFR can be determined by injecting inulin into the plasma.  its rate of excretion is directly proportional to the rate of filtration of water and solutes across the Glomerular filter.  In early stage renal disease, the inulin clearance may remain normal due to hyper filtration in the remaining nephrons  Incomplete urine collection is an important source of error in inulin clearance measurement.
  7. 7.  Protein secreted by most cells in the body that is freely filtered at the glomerulus and not reabsorbed equations have been developed linking estimated GFR to serum cystatin C levels
  8. 8.  One method of determining GFR from creatinine is to collect urine (usually for 24-hours) to determine the amount of creatinine that was removed from the blood over a given time interval.  Creatinine clearance (CCr) is calculated from the creatinine concentration in the collected urine sample (UCr), urine flow rate (V), and the plasma concentration (PCr).
  9. 9.  Example: A person has a plasma creatinine concentration of 0.01 mg/ml and in 1 hour produces 60ml of urine with a creatinine concentration of 1.25 mg/mL.
  10. 10.  http://www.nlm.nih.gov/medlineplus/ency/article/00 7305.htm  http://en.wikipedia.org/wiki/GFR

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