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What you need to know about kidney/renal failureWhat you need to know about kidney/renal failure
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  1. ASSIGNMENT DIETETICS TOPIC: DIETARY MODIFICATIONS OF RENAL DISORDERS Semester V Session 2015-2019
  2. KIDNEYS Introduction to Kidneys Human kidneys are bean-shaped organs located near the middle of the back on both sides where they are protected by lower ribs and cushioned by the surrounding muscles and fat. Each kidney is about the size of a clenched fist and weighs about 150 grams. Each kidney has about one million nephrons, which are tiny, filtering units. In the nephrons, capillaries or tiny blood vessels intertwine with tubules, which are urine-carrying tubes. The nephrons make it possible for the kidneys to filter the body’s entire blood supply. Function of Kidneys Kidneys mainly process the waste products and excess fluid in your blood. The waste products result from our body’s metabolic processes. In addition, waste is also a by-product of the food we eat. Our body uses food for energy and self-repairs. After it has absorbed what it needs from the food, the remaining waste products are sent to the blood. A complicated chemical exchange takes place as the blood is filtered by the nephrons. The filtering process removes the waste, toxins and excess water from the blood to form urine. Urine flows from the kidneys to the ureters and then stored in the bladder until we urinate. In addition, the kidneys regulate the chemical balance in our body. They release three important hormones:  Erythropoietin aids in red blood cell formation  Renin, maintains a normal blood pressure  The active form of Vitamin D, which helps keep our bones strong
  3. ACUTE RENAL DISEASES Definition “Acute renal disease also called acute renal failure happens when your kidneys suddenly the ability to eliminate excess salts, fluids, and waste materials from the blood” This elimination is the core of your kidneys’ main function. Body fluids can rise to dangerous levels when kidneys lose their filtering ability. The condition will also cause electrolytes and waste material to accumulate in your body, which can also be life-threatening. Acute renal failure can be life-threatening and requires intensive treatment. However, it may be reversible. If you’re in good health otherwise, recovery is possible. Symptoms The symptoms of acute renal failure include:  Bloody stools  Breath odor  Generalized swelling or fluid retention  Fatigue  Pain between ribs and hips  Hand tremor  Bruising easily  Changes in mental status or mood, especially in older adults  Decreased appetite  Decreased sensation, especially in your hands or feet  Prolonged bleeding
  4.  Seizures  Nausea  vomiting  Slow sluggish movements  High blood pressure  A metallic taste in your mouth Risk factors The chances of acquiring acute kidney failure are greater if you’re an older person or if you have any of the following long-term health problems:  Kidney disease  Diabetes, especially if it’s not well controlled  High blood pressure  Heart failure  Morbid obesity  Liver disease Causes Acute renal diseases can occur for many reasons. Among the most common reasons are:  Acute tubular necrosis (ATN)  Severe or sudden dehydration  Toxic kidney injury from poisons or certain medications  Autoimmune kidney diseases, such as acute nephritic syndrome and interstitial nephritis  Urinary tract obstruction Reduced blood flow can damage your kidneys. The following conditions can lead to decreased blood flow to your kidneys:  Low blood pressure  Burns  Dehydration  Hemorrhage  Injury  Septic shock  Serious illness  Surgery
  5. Certain disorders can cause clotting within your kidney’s blood vessels, and this can lead to acute renal failure. These conditions include:  Hemolytic uremic syndrome  Idiopathic thrombocytopenic thrombotic purpura (ITTP)  Malignant hypertension  Transfusion reaction  Scleroderma  Some infections, such as septicemia and acute pyelonephritis, can directly injure your kidneys.  Pregnancy can also cause complications that harm the kidneys, including placenta previa and placenta abruption. Prevention Preventing and treating illnesses that can lead to acute renal diseases having a healthy lifestyle that includes regular physical activity and a sensible diet can help to prevent kidney failure. Work with your doctor to manage existing medical conditions that could lead to acute renal diseases. Diagnosis If you have acute kidney failure, you may have generalized swelling. The swelling is due to fluid retention. Using a stethoscope, your doctor may hear crackling in the lungs. These sounds can signal fluid retention. Results of laboratory tests may also show abnormal values, which are new and different from baseline levels. Some of these tests include:  Blood urea nitrogen (BUN)  Serum potassium  Serum sodium  Estimated glomerular filtration rate (EGFR)  Urinalysis  Creatinine clearance  Serum creatinine An ultrasound is the preferred method for diagnosing acute kidney failure. However, abdominal X-ray, abdominal CT scan, and abdominal MRI can help your doctor determine if there’s a blockage in your urinary tract. Certain blood tests may also reveal underlying causes of acute kidney failure.
  6. Treatment Your treatment will depend on the cause of your acute renal disease. The goal is to restore normal kidney function. Preventing fluids and wastes from building up in your body while your kidneys recover is important. In the majority of cases, a kidney specialist called a nephrologist makes an evaluation. Diet Your doctor will restrict your diet and the amount of liquids you eat and drink. This will reduce the buildup of toxins that the kidneys would normally eliminate. A diet high in carbohydrates and low in protein, salt, and potassium is usually recommended. Medications Your doctor may prescribe antibiotics to treat or prevent any infections that occur at the same time. Diuretics may help your kidneys eliminate fluid. Calcium and insulin can help you avoid dangerous increases in your blood potassium levels. Dialysis You may need dialysis but it’s not always necessary and it will likely only be temporary. Dialysis involves diverting blood out of your body into a machine that filters out waste. The clean blood then returns to your body. If your potassium levels are dangerously high, dialysis can save your life. Dialysis is necessary if there are changes in your mental status or if you stop urinating. You may also need dialysis if you develop pericarditis or inflammation of the heart. Dialysis can help eliminate nitrogen waste products from your body. CHRONIC RENAL DISEASE Definition Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood, which are then excreted in your urine. When chronic kidney disease reaches an advanced stage, dangerous levels of fluid, electrolytes and wastes can build up in your body. Symptoms
  7. Signs and symptoms of chronic kidney disease develop over time if kidney damage progresses slowly. Signs and symptoms of kidney disease may include:  Nausea  Vomiting  Loss of appetite  Fatigue and weakness  Sleep problems  Changes in how much you urinate  Decreased mental sharpness  Muscle twitches and cramps  Swelling of feet and ankles  Persistent itching  Chest pain, if fluid builds up around the lining of the heart  Shortness of breath, if fluid builds up in the lungs  High blood pressure (hypertension) that's difficult to control Causes Chronic kidney disease occurs when a disease or condition impairs kidney function, causing kidney damage to worsen over several months or years. Diseases and conditions that cause chronic kidney disease include:  Type 1 or type 2 diabetes  High blood pressure  Glomerulonephritis , an inflammation of the kidney's filtering units (glomeruli)  Interstitial nephritis , an inflammation of the kidney's tubules and surrounding structures  Polycystic kidney disease  Prolonged obstruction of the urinary tract, from conditions such as enlarged prostate, kidney stones and some cancers  Vesicoureteral reflux, a condition that causes urine to back up into your kidneys  Recurrent kidney infection, also called pyelonephritis Kidney cancer: It is also called renal cancer is a disease in which kidney cells become malignant (cancerous) and grow out of control, forming a tumor. Almost all kidney cancers first appear in the lining of tiny tubes (tubules) in the kidney. This type of kidney cancer is called renal cell carcinoma. Kidney failure:
  8. Kidney failure occurs when your kidneys lose the ability to filter waste from your blood sufficiently. Body becomes overloaded with toxins if your kidneys can’t do their regular job. This can lead to kidney failure and even be life-threatening if it’s left untreated. PhosphateandCalciumimbalance: Phosphorus imbalance refers to conditions in which the element phosphorus is present in the body at too high a level (hyperphosphatemia) or too low a level (hypophosphatemia). Hyper phosphotemia: Having a high level of phosphate or phosphorous in your blood is known as hyperphosphatemia. Phosphate is an electrolyte, which is an electrically charged substance that contains the mineral phosphorous. Hypocalcemia: It is a condition in which the calcium level in your blood is above normal. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work. RenalDiseasedue to other diseases: Diabetic nephropathy Nephropathy is a general term for the deterioration of proper functioning in the kidneys. At an advanced level, this is called end-stage renal disease or ESRD. ESRD often stems from diabetes, with diabetes causing just under half of all cases. Diabetic nephropathy can affect people with both type 1 and type 2 diabetes. Renal osteodystrophy: It is a bone disease that occurs when your kidneys fail to maintain proper levels of calcium and phosphorus in the blood. It's common in people with kidney disease and affects most dialysis patients. Hypertensive Nephropathy: It is a disease of the kidneys. The vasculature of the kidneys is damaged with an increase in blood pressure. DIALYSIS The word ‘dialysis’ means filtering, or the selective removal of certain substances from the blood. If by artificial means, we can remove enough of the poisonous wastes, water and salts that have built up due to kidney failure, then a reasonable level of health can be restored.
  9. There are two forms of dialysis,  Peritoneal Dialysis, in which the body’s abdominal lining is used as a filter.  Haemodialysis, in which a special machine acts as a substitute for the kidneys DIETARY GUIDELINES FOR RENAL DISEASE NOT REQUIRING DIALYSIS DASH Diet: The DASH (Dietary Approaches to Stop Hypertension) Diet has been recommended by the National Kidney Foundation and approved by The National Heart, Lung and Blood Institute, The American Heart Association, the Dietary Guidelines for Americans, and also forms the basis for the USDA MyPyramid. Although it was first intended only to decrease 1) blood pressure and 2) reduce risk of cardiovascular diseases and stroke, studies on the DASH have demonstrated that the DASH diet also helps in 3) reducing risk of many cancers, 4) prevents kidney stone formation, and 5) helps to manage acute and chronic renal disease. The DASH diet should not be used by people on dialysis. Individuals on dialysis have a special dietary need that requires different diets. Here is the modified DASH diet for a 2,200 caloriediet of a renal disease patient: Food Group Daily Servings Calories/ Nutrients Serving Size Grains 6–8 80 calories 2 g of protein 150 mg of sodium, 30 mg of phosphorus 50 mg of potassium -1 Slice bread -½ hamburger bun or bagel -1 cup unsweetened cereal or -½ cup cooked cereal -½ cup cooked rice, pasta, or cereal -4 (2 inch) unsalted crackers Vegetables 4–5 (if only low potassium) 30 calories 2 g of protein 50 mg of sodium 50 mg of phosphorus. -½ cup cooked green beans, cabbage, cauliflower, beets or corn -1 cup cooked eggplant -1 cup raw cucumber, alfalfa
  10. Low potassium (less than 150 mg) sprouts, cabbage, cauliflower -1 cup raw leafy vegetable such as lettuce -¼ cup cooked or ½ cup raw mushrooms or onions Vegetables 1–2 (if only medium potassium) 30 calories, 2 g of protein, 50 mg of sodium, and 50 mg of phosphorus. Medium potassium (150 to 250 mg) -½ cup cooked broccoli, celery, green peas, summer squash, zucchini - 1 cup cooked turnips -1 cup raw broccoli, celery or zucchini Fruits 4–5 (if only low potassium) 60 calories 0 g protein 0 mg sodium 150 mg of phosphorus. Low potassium (less than 150 mg) Each serving is ½ cup unless mentioned -1 small apple, apple juice, or applesauce -Cranberries or cranberry juice -Fresh or light syrup canned pears -Fresh or Light syrup canned peaches -Grapes or grape juice -Pineapple -Strawberries -1 tangerine -Watermelon Fruits 1-2 (if only medium potassium) 60 calories, 0 g protein, 0 mg sodium, and 150 mg of phosphorus. Medium potassium (150 to 250 mg) -Berries -Cherries -Cantaloupe -Mango
  11. Each serving is ½ cup unless mentioned -Papaya -Grapefruit or grapefruit juice Lean meats, poultry, and fish 4 or less 75 calories 7 g of protein average of 65 mg of sodium 115 mg of potassium 70 mg of phosphorus -1 oz cooked beef, mutton or poultry -1 oz fresh or frozen fish, shrimp, lobster, crab, clam, tuna, unsalted salmon Other Protein Foods 2 or less 90 calories 7 g of protein average of 100 mg of sodium 100 mg of potassium 120 mg of phosphorus -1 large whole egg -¼ cup low-cholesterol egg substitute -1 ounce milk or yogurt -11/2 ounce cheese -¼ cup cottage cheese or tofu -1/3 cup or 1 ½ ounce unsalted nuts -2 tablespoons peanut butter Fats and oils 2–3 About 45 calories Very little protein 55 milligrams of sodium 10 milligrams of potassium 5 milligrams of phosphorus. -1 teaspoon soft margarine -1 teaspoon vegetable oil -1 tablespoon mayonnaise -1 tablespoon oil based salad dressing -2 tablespoon mayonnaise based salad dressing. Sweets and added sugars 5 or less per week These contain mostly carbohydrates and empty calories (calories that do not -1 tablespoon sugar -1 tablespoon jelly or jam -½ cup sorbet, gelatin
  12. There is no one diet that is good for everyone with kidney disease. Kidney disease is complicated and requires close monitoring by a dietitian and your doctor. Laboratory tests and follow-up evaluations are the only way to ensure your disease is being managed appropriately. Diet Basedon StagesofKidney Disease There are 5 stages of chronic kidney disease. The diet changes you need to make are based on your stage of kidney disease. Limit protein in all stages of kidney disease. This limits the amount of work your kidneys have to do. Foods that are high in protein are meat, poultry (chicken and turkey), fish, eggs, and dairy (milk, cheese, yogurt). Your healthcare provider will tell you how much protein to eat each day. Limit sodium intake to less than 2,300 milligrams (mg) each day. Ask your dietitian or healthcare provider how much sodium you can have each day. The amount of sodium you should have depends on your stage of kidney disease and whether you have hypertension. Table salt, canned foods, soups, salted snacks, and processed meats, like deli meats and sausage, are high in sodium. Limit the amount of phosphorus you eat. Your kidneys cannot get rid of extra phosphorus that builds up in your blood. This may cause your bones to lose calcium and weaken. Foods that are high in phosphorus are dairy products, beans, peas, nuts, and whole grains. Phosphorus is also found in cocoa, beer, and cola drinks. Your healthcare provider will tell you how much phosphorus you can have each day. Limit potassium if your potassium blood levels are too high. Your dietitian or healthcare provider will tell you if you need to limit potassium. Limit liquids as directed. Your healthcare provider may recommend that you limit liquids in stages 4 and 5 of kidney disease. If your body retains fluids, you will have swelling and fluid may build up in your lungs. This can cause other health problems, such as shortness of breath. DIETARY GUIDELINES FOR RENAL DISEASE NOT REQUIRING DIALYSIS As, kidneys are not able to get rid of enough waste products and fluids from your body. It is important that you have the right amounts of protein, calories, vitamins and minerals in your diet. Here are some general guidelines: provide good nutrition) -1 cup lemonade
  13. Protein Body needs protein for growth, building muscles and repairing tissue. After our body uses the protein in the foods we eat, a waste product called urea is left. Since our kidneys are not able to get rid of this urea, we may have too much in our blood. Dialysis and our diet are important to keep the urea level down. Along with the clearing of urea, our body loses proteins that are normally retained in your blood. We will need to eat more protein to replace what is lost. The type of protein we eat is also very important. High quality protein should be eaten at each meal. It comes from animal sources such as eggs, fish, chicken and meat. Low quality protein needs to be limited in our diet. It comes from plant sources such as vegetables and grains. Calories Calories give energy to our body. One source of calories is the food we eat. Another source is the sugar in dialysate solution that can affect our body because:  It takes extra fluid out of the body.  It is taken in by our body.  It can cause unwanted weight gain. Potassium Potassium is a mineral found naturally in foods that is dangerous when we have too much or too little. It is plentiful in dried fruits, dried beans and peas, nuts, meat, milk, fruits and vegetables and also in salt substitutes. Both high and low levels of potassium in our body are dangerous to our heart. Fluid and Sodium Sodium is a mineral that is found naturally in foods and can affect our blood pressure. It is found in large amounts in table salt and in canned foods and processed meats (cold cuts). Watching sodium content can help to control thirst and weight gain. It may also lower use of high-sugar solutions. Phosphorus Phosphorus is a mineral present in all foods. It is found in large amounts in milk, cheese, nuts, dried beans and peas. Eating foods high in phosphorus will raise the phosphorus in blood and this can cause calcium to be pulled from the bones. This will make bones weak and cause them to break easily. To help
  14. control the phosphorus in our blood, we may need to take medicine called a phosphate binder. It should be taken with meals and snacks as ordered by your doctor. A renal dietitian can also tell about protein foods that are lower in phosphorus. Vitamins and Minerals The dialysis treatment washes some water-soluble vitamins out of the body. If we are not getting all the vitamins and minerals we need from the foods we eat, vitamin and mineral supplements may be recommended. It is important to take only what is ordered and suitable for us. Certain vitamins and minerals can be harmful to persons on dialysis. Servings and foods recommended to dialysis patients according to food groups Meat products People on dialysis need to eat more protein. Protein can help maintain blood protein levels and improve health. Eat a high protein food (meat, fish, poultry, fresh pork, or eggs) at every meal, or about 8-10 ounces of high protein foods every day. Even though peanut butter, nuts, seeds, dried beans, peas, and lentils have protein, these foods are generally not recommended because they are high in both potassium and phosphorus. Grains and Cereals Unless we need to limit our calorie intake for weight loss or manage carbohydrate intake for blood sugar control, we may eat, from this food group. Grains, cereals, and breads are a good source of calories. Most people need 6 -11 servings from this group each day. Avoid “whole grain” and “high fiber” foods (like whole wheat bread, bran cereal and brown rice) to help you limit your intake of phosphorus. Dairy products Limit the intake of milk, yogurt, and cheese to ½-cup milk or ½-cup yogurt or 1-ounce cheese per day. Most dairy foods are very high in phosphorus. The phosphorus content is the same for all types of milk – skim, low fat, and whole. If we do eat any high-phosphorus foods, take a phosphate binder with that meal. Dairy foods “low” in phosphorus:  Butter and tub margarine  Cream cheese  Heavy cream
  15.  Ricotta cheese  Brie cheese  Non-dairy whipped topping Some of the high fat foods listed above may not be good choices for cardiovascular diseases, cholesterol and obesity. Fruits All fruits have some potassium, but certain fruits have more than others and should be limited or totally avoided. Limiting potassium protects your heart. Eat 2-3 servings of low potassium fruits each day. One serving = ½-cup or 1 small fruit or 4 ounces of juice. Choose low potassium fruits:  Apple (1)  Berries (½ cup)  Cherries (10)  Fruit cocktail, drained (½ cup)  Grapes (15)  Peach (1 small fresh or canned, drained)  Pear, fresh or canned, drained (1 halve)  Pineapple (½ cup canned, drained)  Plums (1-2)  Tangerine (1)  Watermelon (1 small wedge) Limit or avoid high potassium fruits:  Oranges and orange juice  Kiwis  Nectarines  Raisins and dried fruit  Bananas  Melons (cantaloupe and honeydew) Fruit juices:  Apple cider  Cranberry juice cocktail  Grape juice  Lemonade
  16. Vegetables All vegetables have some potassium, but certain vegetables have more than others and should be limited or totally avoided. Limiting potassium intake protects your heart. Eat 2-3 servings of low-potassium vegetables each day. One serving = ½-cup. Choose low potassium vegetables:  Broccoli (raw or cooked from frozen)  Cabbage  Carrots  Cauliflower  Celery  Cucumber  Eggplant  Garlic  Green and Wax beans (“string beans”)  Lettuce-all types (1 cup)  Onion  Peppers-all types and colors  Radishes  Zucchini and Yellow squash Limit or avoid high potassium vegetables:  Potatoes (including French Fries, potato chips and sweet potatoes)  Tomatoes and tomato sauce  Winter squash  Pumpkin  Asparagus (cooked)  Avocado  Beets  Cooked spinach Sample menu plan for dialysis patients: Breakfast:  1/4 cup evaporated milk with 1/4 cup distilled water  1 box of cereal  1/2 cup of peaches
  17. Mid day snack:  5 vanilla wafers or  Graham cracker (1 ½ squares) Lunch:  Peanut butter sandwich (2 slices of bran bread and 2 tablespoon of peanut butter)  1/2 cup pears  1/2 cup fruit juice Evening snack:  1/2 cup apples or  1/2 cup canned applesauce Dinner:  Chicken sandwiches (2 slices of bran bread, 1/2 cup low sodium chicken and 2 tablespoons of mayonnaise)  1/2 cup carrots  1/2 cup cranberry juice Bed time snack:  5 vanilla wafers or  Graham cracker (1 ½ squares)
  18. REFRENCES https://www.kidney.org/atoz/content/nutripd http://www.kidneyfund.org/ https://www.livestrong.com/article/226045-what-are-good-dialysis-diet-foods-to-eat/ https://www.davita.com/kidney-disease/diet-and-nutrition/diet-basics/potassium,-phosphorus- and-the-dialysis-diet/e/10781 https://www.nkfs.org/kidney-disease/leading-causes-of-kidney-failure/causes-symptoms-and- treatment/ http://www.nephinc.com/food-lists.html https://medlineplus.gov/ency/article/002442.htm https://www.niddk.nih.gov/health-information/kidney-disease/kidney- failure/hemodialysis/eating-nutrition https://www.mayoclinic.org https://www.healthline.com
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