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neonatal physiology and transition period
1. NEONATAL PHYSIOLOGY AND TRANSITION
PERIOD
Under guidence of Dr neelam dogra ma’am
Presented by anuradha pandey
2. LEARNING OBJECTIVE
physiological changes which take place following
birth and appreciate the unique aspects of
neonatal physiology including:
1) limited reserve capacity for temperature
control, cardiovascular and respiratory function
2)variable and individualized fluid requirements
3) implications of hepatic and renal immaturity
3. INTRODUCTION
NEWBORN-first 24 hrs of life
NEONATE-from birth to under four weeks(<28 days)
TERM NEONATE-between 37 to < 42 gestational week
PRETERM NEONATE-<37 gestational week irrespective
ofBW
POST TERM NEONATE-> or egual to 42 gestational week
LOW BIRTH WEIGHT(LBW)<2500 GRAM irrespective of birth weight
VERY LOW BIRTH WEIGHT(VLBW)<150O GRAM
EXTREMELY LOW BIRTH WEIGHT(ELBW)< 1000 GRAM
5. FETAL CIRCULATION
AIM
Oxygenated placental blood is preferentially delivered to the brain,myocardium and
upper torso
lower oxygen tension blood distributed to the lower body and placenta
Preferential splitting is achieved via intra- and extracardiac shunts that direct
blood into two parallel circulations (the left ventricle providing 35% and the right
65% of cardiac output. )
Fetal cardiacoutput is therefore measured as a combined ventricular output closure
of the intracardiac (foramen ovale) and extracardiac shunts (ductus venosus and
ductus arteriosus)
6. FETAL CIRCULATION
(PARALLEL CIRCULATION)
Oxygenated blood via umbilical vein either through the liver or via the ductus
venosus to reach IVC
blood remains on the posterior wall of the inferior vena cava, allowing it to be
directed across the foramenovale into the left atrium by the Eustachian valve
blood passes left ventricle and aorta to supply the head and upper torso.
deoxygenated blood returning from the SUPERIOR vena cava and myocardium via
the coronary sinus is directed through the right ventricle and into the pulmonary
artery.
Most of this blood is returned to the descending aorta via the ductus arteriosus;
( 8-10%of total cardiac output passes through the high-resistance pulmonary
circulation.)
Blood in the descending aorta either supplies the umbilical artery to be
reoxygenated at the placenta or continues to supply the lower limbs.
7. PHYSIOLOGICAL CHANGES AT BIRTH
UMBILICAL VESSELS- IMMEDIATELY AFTER CLAMPING:
constrict in response to stretching and increased oxygen content at delivery
large low-resistance placental vascular bed removed from the circulation
increase SVR
Reduction of blood flow along ductus venosus (passive closure over the following 3-7 days),reduced
blood flow in IVC
Lung expansion
drops pulmonary vascular resistance
increase in blood returning to the LA
These two changes reduce right atrial and increase left atrial pressures, functionally closing the
foramen ovale within the first few breaths of life
8. TRANSITION AT BIRTH
Successful transition from fetal to postnatal circulation requires
clamping of umbilical cord and removal of the placenta
increased pulmonary blood flow,
Shunt closure
9. RESPIRATORY CHANGES
What part do each of these factors
play in initiation of respirations in the
Mechanical
Chemical
Sensory/ Thermal
IInniittiiaattiioonn
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BBrreeaatthhiinngg
neonate?
10. CHANGES AT BIRTH….MECHANICAL
Compression of fluid from the fetal lung during vaginal delivery
establishes the lung volume
As the chest passes
through the birth canal
the lungs are compressed
Subsequent recoil of the
chest wall produces
passive inspiration of air
into the lungs
Negative inspiratory pressures of up to 70-100 cm H2O are initially
required to expand the alveoli (LaPlace’s relationships) which
facilitate lung expansion by overcoming:
airways resistance
inertia of fluid in the airways
surface tension of the air/fluid interface in the alveolus
11. CHEMICAL EVENTS
1. With cutting of the cord, remove oxygen supply
2. Asphyxia occurs
3. CO2 and O2 and pH = ACIDOSIS
4. Acidotic state-- stimulates the
respiratory center in the medulla and
the chemoreceptors in carotid artery to
initiate breathing
12. SENSORY / THERMAL EVENTS
Thermal--the decrease in
environmental temperature after
delivery is a major stimulus of breathing
Tactile--nerve endings in the skin
are stimulated
Visual--change from a dark world to
one of light
Auditory--sound in the extrauterine
environment stimulates the infant
13. BIOPHYSICAL CHANGE CONTINUED
1)Alveolar distension, cortisol and epinephrine further stimulate type II
pneumocytes to produce surfactant
2)Expiration
initially active,
pressures of 18-115 cm H2O generated
amniotic fluid forced out from the bronchi.
PHYSIOLOGICAL CHANGES LEAD TO-
increasing blood flow
and initiating the cardiovascular changes
.
14. SHUNT CLOSURE
physiological reverse shunt from left to right commonly occurs.
FORAMEN OVALE
completely closed in 50% of children by 5 years
remains probe patent in 30% of adults,
can facilitate paradoxical embolus and potential stroke.
DUCTUS ARTERISUS-
drop in pulmonary artery pressure and increase in SVR reverses flow
across the ductus arteriosus from L TO R
affected by blood oxygen content
circulating prostaglandins. E2
Functional closure occurs by 60 hours in 93% of term infants.,4-8
weeks permanent structural closure occurs via endothelial destruction
and subintimal proliferation.
15. CARDIOVASCULAR CHANGES
1. Pressure
in RA decreases
2. Blood flows
to the lungs
4. Pressure in the
LA increases RT
Flow of blood from
the lungs
3. Ductus Arteriosus
begins to constrict
5. Increase pressure
in the LA forces
the foramen ovale
to close
16. SHUNT CLOSURE
IMPORTANT-stimulus
such as hypoxia, acidaemia or structural anomaly can increase
pulmonary vascular resistance and potentially re-open the ductus arteriosus or
foramen ovale. which allows a right-to-left shunt, which worsens hypoxia
. Eg seen in persistent pulmonary hypertension of the newborn.
17. NEONATAL MYOCARDIAL FUNCTION
term neonatal cardiac output is approximately 200 ml/kg/minute
fewer myofibrils in a disordered pattern,
Less mature sarcoplasmic reticulum and transtubular system -nt
dec CA-ATP ACTIVITY,dependent on exogenous ionized calcium
follows the Franke Starling relationship of filling pressure to stroke volume, but
on a much flatter section of the curve compared with adults. i.e limited increase in
stroke volume for a given increase in ventricular filling volume.
dependent on heart rate to increase cardiac output and cardiac output can
respond to increased ventricular filling.
3 month parasympathetic vervous system effect more developed than
sympathetiv
Baroreceptors not well developed compared to chemoreceptorsfurther depressed
under anaesthesia-bradycardia
18. Ventricular maturation and associated
ECG changes
The fetal heart - right-side dominant, with the right ventricle
responsible for 65% of cardiac output in utero.
The neonatal ECG reflects
RAD
R wave dominance in lead V1
S wave dominance in lead V6.
At 3-6 months
the classical LAD pattern established
as ventricular hypertrophy occurs in response to increased systemic
vascular resistance
19. LOW CARDIAC RESERVE-Left
ventricle has high tone has limited contractile
reserve due to;-
Reduced no of alpha receptors
High level of circulating cathecholamines
Limited recruitable stroke volume
Immature calcium transport system
Dec ventricular compliance
effect of parasympathetic nervous system is more
predominent
Beta adrenergic receptors are more developed
than alpha thus respond better to dobutamine and
isiproterenol
20. MYOCARDIAL METABOLISM
neonates can tolerate hypoxia better due to
High concentration of glycogen
More effective utilisation of anaerobic metabolism
Hence can be resusitated easily if oxygenation and
perfusion are reestablished
Oxygen consumption increases after birth(at neutral
temperature )
Full term child
At birth-6ml/kg/min
10 days-7 ml/kg/min
4 week-8 ml/kg/min
22. FETAL RESPIRATORY SYSTEM
ALVEOLAR DEVELOPMENT
Continues even after birth
At birth 24 million alveoli
increases fivefold in -300
million by 8 years of age
Initally increases in no
,further increase by inc in
size and airway development
Lungs develop from the third
week of gestation with
completion of the terminal
bronchioles by week 16
23. FETAL RESPIRATORY SYSTEM
SURFACTANT
type I and II pneumocytes are distinguishable only by 20-22 weeks
present only after 24 weeks,
the watershed time for pulmonary gas exchange and therefore
extra-uterine survival
production can be increased after 24 weeks by giving
betamethasone to the mother, thereby improving neonatal lung
function if premature delivery is anticipated
APPLIED
seen preterm babies
decreases the compliance
– risk for respiratory distress syndrome
, bronchopulmonary dysplasia
and pulmonary hypertension
24. RESPIRATORY SYSTEM
Diaphragm-two types of fibres
Type 1-slow twitch, highly
oxidative ,sustained contraction
,less fatigue
Type 2-fast twitch, low oxidative
,quick contraction and easily
fatigued
New born have 25% TYPE-1,
(PRETERM 10%),BY AGE OF TWO
YRS 55%
APPLIED-risk of diaphragmatic
fatigue during hyperventilation
26. NEONATAL AIRWAY
Larynx is funnel shaped
narrowest portion is cricoid –uncuffed tube
preferred(micro cuff useful ,costly)
Large size of the tongue-increases chances of
obstruction and difficult laryngoscopy
Higher level of larynx(c3 in preterm,c4 in term
and c5-c6 in adults)-straight blade more useful
Epiglottids- short,stubby,omega shaped,
angled over laryngeal inlet-control with
laryngeal blade more difficult
Tip of epiglottids lies at c1,with close
apposition with soft palate-allows
simultaneously sucking and breathing
Vocal cords angled-blind intubation ,tube may
lodge at anterior commisure
Large occiput-more flexion may lead to
obstruction
27.
28. DEVELOPMENTAL CHANGES OF
RIB CAGE
Chest wall development
Ribs oriented parallel and
unable to increase the
thoracic volume during
inspiration
At 2 yrs old associated with
standing and walking, ribs
are oriented oblique
Cartilaginous structure with
inward movement during
inspiration
29. NEONATAL LUNG MECHANICS
imbalance exists between chest wall rigidity and elastic recoil of
neonatal lungs. (CONTAIN IMMATURE ELASTIC FIBRES,thus tendency
to recoil)
increase closing capacity to the point of exceeding functional
residual capacity (FRC) until the age of 6.
To counteract this, neonates produce positive end expiratory
pressure(PEEP) via high resistance nasal airways and partial closure
of the vocal cords
Limited Inspiratory reserve volume
Minute volume is maintained by high respiratory rate
Respiratory fatigue common
30. Neonatal lung mechanics-gas exchange
immature in neonates,
total shunt estimate of 24% of the cardiac output at birth, reducing to 10% of
cardiac output at 1 week.
rapid reduction in shunt fraction improves arterial oxygenation and reduces the
effort of breathing.
implications during anaesthesia.
effective FRC is reduced( physiological PEEP and intercostal muscle tone is lost)
along with an increased shunt fraction and
High metabolic rate (6-8ml ofO2/kg/minute),
These factors contribute to a potential rapid desaturation in neonates under
anaesthesia.
31. Control of ventilation
Peripheral chemoreceptors
functional at birth but are initially silent because of high post delivery blood
oxygen content.
Receptor adaptation occurs over 48 hours,
APNOEA OF PREMATURITY
neonates exhibit periodic breathing pattern defined as an apnoea of less than 5
seconds often followed by tachypnoea.,
Premature neonates exhibit apnoeic episodes of more than 15 seconds or a
shorter period a/w fall in heart rate
due to loss of central respiratory drive
improves with maturity
may persist up to 60 weeks postconceptual age
Anaemia i.e. haematocrit<30% is any independent risk factor
32. RESPONSE TO HYPOXIA
characterized by
1)an initial increase in ventilation followed by a decrease in ventilation;
2).much rapid than adults due to low resting carbon dioxide
Response Varies with
temperature,
level of arousal
and maturity
.
33.
34. PERSISTENT PULMONARY HYPERTENSION OF
THE NEW BORN/PERSISTENT FETAL
CIRCULATION
PATHOPHYSIOLOGY
hypoxia, acidosis and inflammatory mediators
l/t persistent increase in pulmonary artery
pressure
persistent fetal circulation
Ppt condition-
birth asphyxia,
meconium aspiration
sepsis,
CDH,
maternal use of nsaids,
GDM,,casearen delivery
Leads to R TO L shunt resulting in profound
hypoxia,with elevated PCO2
36. MECONIUM ASPIRATION
Marker for chronic hypoxia in utero in third trimester due to
interferance in maternal circulation
passage of meconium in utero-fetus breathes in meconium
mixed amniotic fluid enters in pulmonary circulation
Leads to varying degree of respiratory distress
Increase in amount of amount of musle in blood vessels of
distal respiratory units
37. GUIDELINES FOR MANAGEMENT FOR
MECONIUM ASPIRATION
“If the baby is not vigorous (Apgar 1-3): Suction the
trachea soon after delivery (before many respirations
have occurred) for ≤ 5 seconds. If no meconium
retrieved, do not repeat intubation and suction. If
meconium is retrieved and no bradycardia present,
reintubate and suction. If the heart rate is low,
administer PPV and consider repeat suctioning. “
“If the baby is vigorous (Apgar >5): Clear secretions and
meconium from the mouth/nose with a bulb syringe
or a large-bore suction catheter. In either case, the
remainder of the initial resuscitation: dry, stimulate,
reposition, and administer oxygen as necessary.”
38. Thermogregulation
2.5-3.0 times higher surface area BW
limited insulating capacity from subcutaneous fat and
the inability of neonates to generate heat by shivering until 3 months of age.
Heat loss
1) radiation(39%)
2)convection (34%)
3)evaporation (24%) and
4)conduction(3%).
THERMOGENESIS
1)by limb movement and
2) by stimulationof brown fat (non-shivering thermogenesis).
39. R a d ia t io n
C o ld R o o m T e m p .
C o ld W a lls
C o ld Ite m s o n B ed
C o n d u c t io n
C o ld S c a le
C o ld X -ra y p la tes
C o ld B la n k e ts
C o n v e c t io n
B e d N e a r A ir V e n t
O x y g e n le ft o n
P a s s in g T ra ffic
E v a p o r a t io n
W e t D ia p e r
B a t h
T a c h y p n e a
B a b y
40. BROWN FAT
6% of term bodyweight (dec in preterm)
found in the interscapular region, mediastinum, axillae, vessels of the neck and
perinephric fat
highly vascular with sympathetic innervation
high mitochondrial content to facilitate heat generation
Non-shivering thermogenesis
.1. Skin receptors perceive a drop in
environmental temperataure
2. Transmit impulses to the central nervous
system
3. Which stimulates the sympathetic nervous
system
4. Norepinephrine is released at local nerve
endings in the brown
5. Metabolism of brown fat
6. Release of fatty acids
41. HEAT CONSERVATION
heat loss minimized by
increasing the temperature of the surrounding environment.
CAREFUL;- the environmental temperature exceeds neonatal
temperature then heat will be gained, which can be harmful as the
ability to sweat is present only after 36 weeks postconceptual age.)
by warming surrounding air and minimizing air speed across the
baby’s skin,
increasing ambient humidity and reducing air speed across the
neonate.
Insensible water loss through the skin can be minimized by putting
the preterm neonate in a plastic bag or covering the body,and
especially the head
42. Haematology
contains both adult (HbA) and fetal haemoglobin
HbF
70-80% upto 90% in preterm
four globin chains alpha2delta2
greater affinity for oxygen and helps maintain
the molecular structure and
function in a more acidic environment
facilitates oxygen transfer across the placenta
from maternal HbA.
replaced with HbA at approximately 6 month of
age.
Postdelivery,
increase in 2,3-diphosphoglycerate levels, shifting
the oxygen dissociation curve to the right,
43. HAEMATOPOIESIS
occurs in the liver in utero
but is restricted to bone marrow from 6 weeks post delivery,
thus limiting potential sites for haemoglobin synthesis.
PHYSIOLOGICAL ANAEMIA OF INFANCY
Occcurs around 8-10 week of age
HbF is lost faster than HbA is synthesized.
low levels of erythropoietin due to improved tissue oxygenation after birth
decreased lifespan of HbF-laden red blood cells
relative increase in the blood volume,
These factors contributes to the shrinking cellmass
44. Hepatic
Most enzymatic pathways are present
inactive at birth
become fully active at 3 months
Albumin level low-more free drug in circulation
Risk of hypoglycemia-low glycogen stores and dec synthetic function
UNCONJUGATED HYPERBILIRUBINEMIA
Unconjugated bilirubin levels rise during the first 48 hours
rapid breakdown of HbF
poor conjugating abilities of the immature liver.
exacerbated in presence of haemolysis, sepsis, dehydration or excessive bruising;
can cross the blood brain barrier
kernicterus and subsequent developmental delay.
Bilirubin levels gradually fall over the first 2weeks,
jaundice in term infants being rare beyond this period
45. Clotting factors
1) do not cross the placenta;
2)factors V, VIII and XIII are at adult concentrations before birth.
3)vitaminK-dependent clotting factors (II, VII, IX, X, protein C and S) are
initially low
# because of a lack of vitamin K stores and
# immaturehepatocyte function causing a prolongation in prothrombin time
.4)Platelet function diminished due to low levels of serotonin and adenine
nucleotides, despite platelet counts in the adult range
VITAMIN K PROPHYLAXIS
#Breast milk is a poor source of vitamin K
#Endogenous synthesis by the gut flora is not established for the first few weeks
after birth.
#protect against haemorrhagic disease of thenewborn
46. Renal
EXCRETORY FUNCTION
1 million nephrons is present by 34 weeks ’gestation.
The glomeruli and nephrons are immature at birth
Low GFR and limited concentrating ability.
Suseptible to both dehydration and volume overload
Lack of renal medulla osmotic gradient and absence of medullary tubules limit
urinary concentrating ability,half that of the adult (1200-1400 mOsm/kg)
Glycosuria and aminoaciduria are commonly detected because of immature active
transport pumps in the proximal tubule.
ENDOCRINOLOGY
Renal immaturity affects vitamin D formation and calcium homeostasis.
The fetus and neonate have a high calcium and phosphate requirement for bone
formation and growth.
47. BODY FLUID COMPOSITION
75% of TBW,80-85% IN PRETERM
Reduced to 60-65% BY one year
ECF:ICF IS 2:1,
The diuresis reduces the extracellular water
(30% of TBW) and ICF increases due to growth
of cellls-
reaches adult value by 1 yr
Blood volume
Full term-85 ml /kg
Preterm90-100 ml /kg(50 ml/kg is plasma)
important postnatal adaptation to facilitate
lung function and reduces the risks of
symptomatic patent ductus arteriosus,
necrotizing enterocolitis and bronchopulmonary
dysplasia
48. FLUID THERAPY
MAINTAINENCE FLUID-
70,80,90,120 ml/kg on day 1/3/5/7
Rest period-150ml/kg/24hr
Fluid choice
FIRST 48 hrs-10% glucose
Higher in pre term
Na and k 2-3 meq/100 ml
Beyond that-5% glucose(preterm higher glucose
requirement)
IMPORTANT-newborn of diabetic mother, small for
gestational age, glucose monitoring must
49. NERVOUS SYSTEM
precocious in development ,
continues to develop to achieve a full complement of cortical and brainstem cells
by 1 year.
neonatal cerebral circulation receiving one-third of cardiac output compared with
one-sixth of cardiac output in adults
The blood brain barrier is immature in the neonatal period
increased permeability to fat-soluble molecules
potentially increasing the sensitivity to certain anaesthetic drugs(
50. NERVOUS SYSTEM
Cerebral autoregulation is fully developed at term, maintaining cerebral perfusion
down to a mean arterial pressure of 30 mmHg, reflecting the lower blood pressures
found in neonates.
ANS better developed to protect against hypertension than hypotension because
the parasympathetic system predominates., reflected in the propensity of neonates
to bradycardia and relative vasodilation.
Delayed myelination-easier intraneural penetration of LA,short time of onset and
diluted conc as effective as concentrated
51. NOCICEPTION
pathways are developed by 24-28 weeks’ gestation,
The concept of neonatal nociception is now widely accepted, with adultlike
physiological stress and behavioural responses to a noxious Stimulus
Neonates undergoing awake nasal intubation increase mean arterial pressure
by 57% and intracranial pressure by a similar amount.
Noxious stimulus exposure in the neonatal period can also affect behavioural
patterns in later childhood, suggesting adaptive behaviour and memory for
previous experience
52. IMMUNOLOGIC ADAPTATION
Active acquired immunity
Pregnant woman forms antibodies herself
Passive acquired immunity
Mom passes antibodies to the fetus
Lasts for 4-8 months
Newborn begins to produce own immunity about 4 weeks of age