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18.1.2 Formed Elements Erythrocytes, leucocytes and platelets are collectively called formed elements (Figure 18.1) and they constitute nearly 45 per cent of the blood. Erythrocytes or red blood cells (RBC) are the most abundant of all the cells in blood. A healthy adult man has, on an average, 5 millions to 5.5 millions of RBCs mm–3 of blood. RBCs are formed in the red bone marrow in the adults. RBCs are devoid of nucleus in most of the mammals and are biconcave in shape. They have a red coloured, iron containing complex protein called haemoglobin, hence the colour and name of these cells. A healthy individual has 12-16 gms of haemoglobin in every 100 ml of blood. These molecules play a significant role in transport of respiratory gases. RBCs have an average life span of 120 days after which they are destroyed in the spleen (graveyard of RBCs). Leucocytes are also known as white blood cells (WBC) as they are colourless due to the lack of haemoglobin. They are nucleated and are relatively lesser in number which averages 6000-8000 mm–3 of blood. Leucocytes are generally short lived. We have two main categories of WBCs – granulocytes and agranulocytes. Neutrophils, eosinophils and basophils are different types of granulocytes, while lymphocytes and monocytes are the agranulocytes. Neutrophils are the most abundant cells (60-65 per cent) of the total WBCs and basophils are the least (0.5-1 per cent) among them. Neutrophils and monocytes (6-8 per cent) are phagocytic cells which destroy foreign organisms entering the body. Basophils secrete histamine, serotonin, heparin, etc., and are involved in inflammatory reactions. Eosinophils (2-3 per cent) resist infections and are also
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18.1.2 Formed Elements Erythrocytes, leucocytes and platelets are collectively called formed elements (Figure 18.1) and they constitute nearly 45 per cent of the blood. Erythrocytes or red blood cells (RBC) are the most abundant of all the cells in blood. A healthy adult man has, on an average, 5 millions to 5.5 millions of RBCs mm–3 of blood. RBCs are formed in the red bone marrow in the adults. RBCs are devoid of nucleus in most of the mammals and are biconcave in shape. They have a red coloured, iron containing complex protein called haemoglobin, hence the colour and name of these cells. A healthy individual has 12-16 gms of haemoglobin in every 100 ml of blood. These molecules play a significant role in transport of respiratory gases. RBCs have an average life span of 120 days after which they are destroyed in the spleen (graveyard of RBCs). Leucocytes are also known as white blood cells (WBC) as they are colourless due to the lack of haemoglobin. They are nucleated and are relatively lesser in number which averages 6000-8000 mm–3 of blood. Leucocytes are generally short lived. We have two main categories of WBCs – granulocytes and agranulocytes. Neutrophils, eosinophils and basophils are different types of granulocytes, while lymphocytes and monocytes are the agranulocytes. Neutrophils are the most abundant cells (60-65 per cent) of the total WBCs and basophils are the least (0.5-1 per cent) among them. Neutrophils and monocytes (6-8 per cent) are phagocytic cells which destroy foreign organisms entering the body. Basophils secrete histamine, serotonin, heparin, etc., and are involved in inflammatory reactions. Eosinophils (2-3 per cent) resist infections and are also
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RBC WBC 1. Granulocytes Neutrophils Eosinophil’s Basophils 2. Agranulocytes Lymphocytes Monocyte PLATELETS Blood is a bright red, viscous, slightly alkaline fluid that accounts for approximately 7 % of total body weightThe average human has 5 litres of blood (Average Blood Volume is 4 to 6 liters). It is a transporting fluid. Red colour is due to the presence of oxyhaemoglobin. Ph - 7.4 slightly alkaline. Specific gravity - 1.060 Viscosity is 5 times greater then the water i.e thicker than water. Blood is the only fluid tissue. Blood is a complex connective tissue in which living cells, the formed elements, are suspended in fluid componenet called plasma. Functions of Blood Transport of: Gases, nutrients, waste products Processed molecules Regulatory molecules. Regulation of pH and osmosis. Maintenance of body temperature. Protection against foreign substances. Clot formation. Blood composition 55% Plasma (fluid matrix of water, salts, proteins, etc.) 45% Cellular elements: Red Blood Cells (RBCs) (Erythrocytes) : 5-6 million RBCs/ml of blood. Contain hemoglobin which transport oxygen and CO2. White Blood Cells (WBCs) (Leukocytes) : 5,000-10,000 WBCs/ml of blood. Play an essential role in immunity and defense. Include: Granulocytes Neutrophils 40-70% Eosinophil's 0-1% Basophils 1-5% Agranulocytes Lymphocytes 25-40% T cells and B cells Monocyte 2-8% (phagocytes) Platelets (Thrombocytes) : Cellular fragments, 250,000- 400,000/ml of blood. Important in blood clotting.
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