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Aspirin
1.
2. Analgesic: (of a drug) acting to relieve pain.
Antipyretic: (chiefly of a drug) used to
prevent or reduce fever.
Anti-inflammatory: (chiefly of a drug) used to
reduce inflammation.
http://www.aspirin.com/scripts/pages/en/pain/
html_how_does_aspirin_work.php
3. Common side effects include:
irritation of the stomach or bowel
indigestion
nausea (feeling sick)
However, less than 10% of people taking aspirin experience these side effects.
Less common side effects of aspirin include:
worsening of asthma caused by narrowing of airways
vomiting
inflammation (swelling) of the stomach
bleeding in the stomach
bruising
Allergic reaction
In some cases aspirin can cause an allergic reaction, although this is more common
in people who have asthma.
To avoid the side effects of aspirin stick to basic foods and take the aspirin after a
meal.
4.
c400 BC In Greece Hippocrates gives women willow leaf tea to relieve the
pain of childbirth.
1763 Reverend Edward Stone of Chipping Norton near Oxford gives dried
willow bark to 50 parishioners suffering rheumatic fever.
1823 In Italy the active ingredient is extracted from willow and named salicin.
1853 Salicylic acid made from salicin by French scientists but it is found to
irritate the gut.
1893 German scientists find that adding an acetyl group to salicylic acid
reduces its irritant properties.
1899 Clinical trials are successfully completed. aspirin launched.
1914 International trade in pharmaceuticals interrupted by the outbreak of
World War I. Australian pharmacist G. R. Nicholas wins a competition to find a
new way of producing aspirin.
1930s Bayer's patent on acetyl salicylic acid runs out. It becomes a generic
drug.
1974 First evidence of aspirin's effects in preventing heart attacks: Professor
Elwood.
1982 English scientist Professor Sir John Vane and two Swedish colleagues, Sune
Bergström and Bengt Samuelsson win Nobel prize for discovering the role of
aspirin in inhibiting prostaglandin production.
1995 American researchers find evidence that aspirin protects against bowel
cancer.
1997 aspirin is now used for lots
5. To ensure that aspirin works and is safe use, it goes through
three main stages of testing.
1.) The drugs are tested using computer models and human
cells grown in the laboratory. Many substances fail this test
because they damage cells or do not seem to work.
2.) Drugs that pass the first stage are tested on animals. In the
UK, new medicines have to undergo these tests. But it is illegal
to test cosmetics and tobacco products on animals. A typical
test involves giving a known amount of the substance to the
animals, then monitoring them carefully for any side-effects.
3.) Drugs that have passed animal tests are used in clinical
trials. They are tested on healthy volunteers to check they are
safe. The substances are then tested on people with the illness
to ensure they are safe and that they work.