Phosphofructokinase is a highlyregulated enzyme in the glyc.pdf

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Phosphofructokinase is regulated by the ratio of ATP to ADP in glycolysis. ADP is most likely to activate phosphofructokinase, while ATP is most likely to inactivate it, as high ATP levels indicate sufficient energy while high ADP levels signal energy is needed. This is an example of allosteric regulation which allows glycolysis to respond dynamically to energy demands on the cell.

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Phosphofructokinase is a highly-regulated enzyme in the glycolysis pathway. Its activity is affected
by the ratio of ATP to ADP (or AMP). a. Which molecule, ATP or ADP, is most likely to activate
phosphofructokinase? b. Which is most likely to inactivate it? i. In 2-3 sentences explain your
reasoning for parts ' a ' and ' b ': c. What type of regulation is this called? d. What is the
advantage(s) of this type of regulation?

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