QUESTION 7a: Two modules of the PKS that makes avermectin are shown, as well as the final
polyketide product (Figure from Zhang et al. 2015. Microb Cell Fact 14:152). What would the final
product look like if we mutated the dehydratase (DH) domain in module 2 such that it no longer
worked? You only need to redraw the highlighted region of the molecule. (1pt) Q7b: What would
the final product look like if we added an enoyl reductase domain in original module 2 (depicted
above in question 7a )? What would the final product look like if we added an enoyl reductase and
mutated the keto reductase domain module 2 so that it was no longer functional? You only need to
draw that part of the molecule. (2pts).
AUDIENCE THEORY -CULTIVATION THEORY - GERBNER.pptx
QUESTION 7a Two modules of the PKS that makes avermectin ar.pdf
1. QUESTION 7a: Two modules of the PKS that makes avermectin are shown, as well as the final
polyketide product (Figure from Zhang et al. 2015. Microb Cell Fact 14:152). What would the final
product look like if we mutated the dehydratase (DH) domain in module 2 such that it no longer
worked? You only need to redraw the highlighted region of the molecule. (1pt) Q7b: What would
the final product look like if we added an enoyl reductase domain in original module 2 (depicted
above in question 7a )? What would the final product look like if we added an enoyl reductase and
mutated the keto reductase domain module 2 so that it was no longer functional? You only need to
draw that part of the molecule. (2pts)
