Entrepreneurs and startups are crucial to economic growth and job creation. Yet despite the mythology that has built up around the disruptive power of startups, the overwhelming majority need to leverage the market presence and scale of larger, established enterprises if they are to be truly successful. Meanwhile, large companies are feeling pressure to innovate and become more entrepreneurial, yet find their culture and structures getting in the way. Large companies and entrepreneurs need to collaborate more effectively and take a journey towards more Open Innovation. But how? This Accenture presentation was made to the G20 Young Entrepreneurs Alliance Summit, Istanbul, Turkey on September 8, 2015.