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Bilastine: A Novel, Highly Selective,
Non-sedating Antihistamine
Allergy
• Also called as hypersensitivity.
• People who have allergies
have an immune system that
reacts to a usually harmless
substance in the environment.
• This immune response is
accompanied by a number of
stressful symptoms, ranging
from mild to severe to life-
threatening
Allergens
• Substances that cause allergy are
known as Allergens.
• Examples of allergens include
pollens, dust mite, molds, dander,
pollutants, chemicals and foods.
Allergic Rhinitis
• Allergic rhinitis is an
inflammation of the
mucous membrane of the
nose.
• Allergic rhinitis involves
reactions in the nasal
mucosa from repeated
allergen exposure that
causes hypersensitivity.
• These reactions may be
seasonal or perennial.
Causes of Allergic Rhinitis
• Common allergens that cause
Seasonal Allergic Rhinitis are
grass pollens, tree pollens,
wood pollens and mold
spores.
• Allergens that cause Perennial
Allergic Rhinitis are pet
dander, dust and household
mites.
Symptoms of Allergic Rhinitis
• Stuffy, runny nose
• Sneezing
• Post-nasal drip
• Red, itchy, and watery eyes
• Swollen eyelids
• Itchy mouth, throat, ears, and
face
• Sore throat
• Dry cough
• Headaches, facial pain or pressure
• Partial loss of hearing, smell, and
taste
• Fatigue
• Dark circles under the eyes
Complications of Allergic Rhinitis
Chronic nasal congestion in
Allergic Rhinitis may produce
• Asthma
• Sinusitis
• Otitis media/ Possible hearing
loss
• Nasal Polyposis
• URTI
• Sleep disturbance with or
without daytime fatigue
Allergic
Rhinitis
Otitis
Media
Nasal
Polyposis
Sinusitis
Asthma
URTI
Complications of Allergic Rhinitis cont..
• Weakness
• Discomfort or uneasiness
• Irritability
• Fatigue
• Difficulty in concentrating
• Decreased appetite
Immune System of the Body
• The immune system is the body's organized defense
mechanism against foreign invaders, particularly infections.
• Its job is to recognize and react to these foreign substances,
which are called antigens (e.g. viruses, bacteria, foreign
material).
• Immune system helps to prevent infections and keeps body
healthy.
• The three main components of the immune system are
1) Antibodies, 2) Inflammatory cells, and 3) Inflammatory
mediators
Immune System of the Body cont…
Antibodies:
• Antibodies are the specific proteins created by the immune
system to identify and bind to foreign substances (antigens).
• Antibodies are also called as immunoglobulins IgG, IgM, IgA,
IgD and Ig E.
• Antibodies are specifically targeted against particular
antigens. Immunoglobulins (Ig) destroy antigen by attaching
to its surface, thereby making it easier for other immune
cells to destroy it.
• Antibodies are created and secreted by B cells. For eg. IgM
and IgG are essential to fight the infection quickly,
• IgE is involved in allergic response.

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Bilastine Medical Part-1.pptx

  • 1.
  • 2. Bilastine: A Novel, Highly Selective, Non-sedating Antihistamine
  • 3. Allergy • Also called as hypersensitivity. • People who have allergies have an immune system that reacts to a usually harmless substance in the environment. • This immune response is accompanied by a number of stressful symptoms, ranging from mild to severe to life- threatening
  • 4. Allergens • Substances that cause allergy are known as Allergens. • Examples of allergens include pollens, dust mite, molds, dander, pollutants, chemicals and foods.
  • 5. Allergic Rhinitis • Allergic rhinitis is an inflammation of the mucous membrane of the nose. • Allergic rhinitis involves reactions in the nasal mucosa from repeated allergen exposure that causes hypersensitivity. • These reactions may be seasonal or perennial.
  • 6. Causes of Allergic Rhinitis • Common allergens that cause Seasonal Allergic Rhinitis are grass pollens, tree pollens, wood pollens and mold spores. • Allergens that cause Perennial Allergic Rhinitis are pet dander, dust and household mites.
  • 7. Symptoms of Allergic Rhinitis • Stuffy, runny nose • Sneezing • Post-nasal drip • Red, itchy, and watery eyes • Swollen eyelids • Itchy mouth, throat, ears, and face • Sore throat • Dry cough • Headaches, facial pain or pressure • Partial loss of hearing, smell, and taste • Fatigue • Dark circles under the eyes
  • 8. Complications of Allergic Rhinitis Chronic nasal congestion in Allergic Rhinitis may produce • Asthma • Sinusitis • Otitis media/ Possible hearing loss • Nasal Polyposis • URTI • Sleep disturbance with or without daytime fatigue Allergic Rhinitis Otitis Media Nasal Polyposis Sinusitis Asthma URTI
  • 9. Complications of Allergic Rhinitis cont.. • Weakness • Discomfort or uneasiness • Irritability • Fatigue • Difficulty in concentrating • Decreased appetite
  • 10. Immune System of the Body • The immune system is the body's organized defense mechanism against foreign invaders, particularly infections. • Its job is to recognize and react to these foreign substances, which are called antigens (e.g. viruses, bacteria, foreign material). • Immune system helps to prevent infections and keeps body healthy. • The three main components of the immune system are 1) Antibodies, 2) Inflammatory cells, and 3) Inflammatory mediators
  • 11. Immune System of the Body cont… Antibodies: • Antibodies are the specific proteins created by the immune system to identify and bind to foreign substances (antigens). • Antibodies are also called as immunoglobulins IgG, IgM, IgA, IgD and Ig E. • Antibodies are specifically targeted against particular antigens. Immunoglobulins (Ig) destroy antigen by attaching to its surface, thereby making it easier for other immune cells to destroy it. • Antibodies are created and secreted by B cells. For eg. IgM and IgG are essential to fight the infection quickly, • IgE is involved in allergic response.