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Bilastine Medical Part-1.pptx

  1. Bilastine: A Novel, Highly Selective, Non-sedating Antihistamine
  2. Allergy • Also called as hypersensitivity. • People who have allergies have an immune system that reacts to a usually harmless substance in the environment. • This immune response is accompanied by a number of stressful symptoms, ranging from mild to severe to life- threatening
  3. Allergens • Substances that cause allergy are known as Allergens. • Examples of allergens include pollens, dust mite, molds, dander, pollutants, chemicals and foods.
  4. Allergic Rhinitis • Allergic rhinitis is an inflammation of the mucous membrane of the nose. • Allergic rhinitis involves reactions in the nasal mucosa from repeated allergen exposure that causes hypersensitivity. • These reactions may be seasonal or perennial.
  5. Causes of Allergic Rhinitis • Common allergens that cause Seasonal Allergic Rhinitis are grass pollens, tree pollens, wood pollens and mold spores. • Allergens that cause Perennial Allergic Rhinitis are pet dander, dust and household mites.
  6. Symptoms of Allergic Rhinitis • Stuffy, runny nose • Sneezing • Post-nasal drip • Red, itchy, and watery eyes • Swollen eyelids • Itchy mouth, throat, ears, and face • Sore throat • Dry cough • Headaches, facial pain or pressure • Partial loss of hearing, smell, and taste • Fatigue • Dark circles under the eyes
  7. Complications of Allergic Rhinitis Chronic nasal congestion in Allergic Rhinitis may produce • Asthma • Sinusitis • Otitis media/ Possible hearing loss • Nasal Polyposis • URTI • Sleep disturbance with or without daytime fatigue Allergic Rhinitis Otitis Media Nasal Polyposis Sinusitis Asthma URTI
  8. Complications of Allergic Rhinitis cont.. • Weakness • Discomfort or uneasiness • Irritability • Fatigue • Difficulty in concentrating • Decreased appetite
  9. Immune System of the Body • The immune system is the body's organized defense mechanism against foreign invaders, particularly infections. • Its job is to recognize and react to these foreign substances, which are called antigens (e.g. viruses, bacteria, foreign material). • Immune system helps to prevent infections and keeps body healthy. • The three main components of the immune system are 1) Antibodies, 2) Inflammatory cells, and 3) Inflammatory mediators
  10. Immune System of the Body cont… Antibodies: • Antibodies are the specific proteins created by the immune system to identify and bind to foreign substances (antigens). • Antibodies are also called as immunoglobulins IgG, IgM, IgA, IgD and Ig E. • Antibodies are specifically targeted against particular antigens. Immunoglobulins (Ig) destroy antigen by attaching to its surface, thereby making it easier for other immune cells to destroy it. • Antibodies are created and secreted by B cells. For eg. IgM and IgG are essential to fight the infection quickly, • IgE is involved in allergic response.