4. Introduction
īą SSc is a multisystemic ,autoimmune disease affecting small
arteries,microvessels and fibroblasts resulting in vascular
obliteration,collagen accumulation and scarring (fibrosis) of
skin and internal organs.
ī§ Chronic systemic disorder of unknown etiology.
ī§ Leads to hidebound skin,damage of GIT,Lungs,Kidney,Heart
ī§ Skin induration limited to fingers( sclerodactyly)
ī§ No skin induration (sine scleroderma)
ī§ RAYNAUDâS phenomenon is predominant feature seen.
ī§ Serologic specificity of the disease is the presence of ANA and
anticentromere antibody
5. Brief history
ī§ Scleroderma is derived from the greek words skleros
(hard or indurated) and derma (skin).
ī§ HIPPOCRATES first described this condition as thickened
skin.
ī§ First detailed description by Carlo Curzio in 1752.
ī§ Term scleroderma --- Giovambattista Fantonetti
ī§ Systemic nature of the disease was described by Robert
H.Goetz.
6. Epidermiology
ī§ SSc is an acquired sporadic disease that has a worldwide distribution
ī§ Prevalence and incidence of SSc appears to be greater in populations of
European ancestry and lower in Asian group
ī§ Estimated 100,000 cases in U.S with incidence of 18.7 -22.8 per million per
year
ī§ Incidence is higher and more aggressive among African American in U.S
7. cont
ī§ Like other connective tissue diseases, SSc shows a female predominance( 3 :
1), most pronounced in the childbearing age group and declines after
menopause.
ī§ The most common age of onset is b/w 30-50yrs
ī§ The incidence is higher in blacks than in whites
ī§ Furthermore, blacks are more likely to have the diffuse cutaneous form of SSc
associated with interstitial lung involvement and a worse prognosis.
8. Cont
īą Tager R.E et al in a study on âClinical and Laboratory manifestations of systemic sclerosis in
Black South Africansâ
ī§ Total of 63 patients
ī§ Female : male 5:1
ī§ Mean age of onset 36years
ī§ 41 patients had DcSSc
ī§ 18 patients had LcSSc
ī§ 4 were unclassified
ī§ 56% had pulmonary fibrosis
ī§ 37% had myositis
ī§ 98% were ANA positive
ī§ 7 of the 8 known deaths occurred in patients with dcSSc
9. Cont
īą Adelowo O.O et al in a retrospective study â
ī§ Diffuse(8) â 57.1%
ī§ Limited(3) â 21.4%
ī§ Undifferentiated(2) â 14.3%
ī§ Sine Scleroderma(1) â 7.2%
ī§ Female- 85.7%
ī§ Male- 14.3%
ī§ Age range 26-69yrs, mean 40.3yrs
10. Etiology
īĩ Exact etiology is unclear.
īĩ Environmental factors are triggers or acclerators of SSc - silica exposure,
vinyl chloride, trichloroethylene,epoxy resins,benzene
īĩ Radiation exposure /radiotherapy
īĩ CMV, HHV 5, human parvovirus B19
īĩ Drugsâ bleomycin, pentazocine. l-tryptophan, cocaine, rapeseed oil
īĩ Common in coal and gold miners.
īĩ Silicon breast inplants
īĩ Genetics
11. Pathogenesis of Systemic Sclerosis
ī§ Susceptible host
ī§ Triggering event
ī§ Activation immune system
ī§ Endothelial cell activation
ī§ Activation fibroblasts
ī§ Obliterative vasculopathy and Fibrosis (increased collagen deposition)
12. Microangiopathy
ī§ Vascular involvement in SSc is extensive, involves multiple vascular beds, and
has important clinical consequences.
ī§ Endothelial injury results in dysfunctional production of endothelium-
derived vasodilatory (nitric oxide and prostacyclin) and vasoconstricting
(endothelin-1) substances, as well as increased expression of intercellular
adhesion molecule 1 (ICAM-1) and other surface adhesion molecules.
13. Cont
ī§ Enhanced permeability
ī§ Transendothelial leucocyte diapedesis
ī§ Activation of the coagulation and fibrinolytic
cascade
ī§ Platelet aggregation-- thromboxane
ī§ Smooth muscle cell proliferate
ī§ Basement membrane thickens
ī§ Fibrosis of adventitial layers
14. Cont
ī§ The vasculopathic process affects
ī§ capillaries
ī§ arterioles
ī§ and even large vessels in many organs
ī§ resulting in reduced blood flow, tissue ischemia, and generation of profibrotic
factors.
ī§ Thus, widespread capillary malformation and loss, obliterative vasculopathy
of small and medium-sized arteries, and failure to repair damaged vessels are
hallmarks of SSc.
15. Inflammation and cellular immunity
ī§ Circulating CD4 T cells show a TH2 polarised immune response
ī§ Secretes IL4 and IL13
ī§ Induces production of TGF B
ī§ Promotes collagen synthesis
ī§ Antinuclear antibodies occur in virtually all patients with SSc
ī§ Autoantibodies are targeted against the following antigens
ī§ Topoisomerase 1
ī§ Centromere proteins
ī§ RNA polymerase I and III
16. Fibrosis
īĩ Fibrosis affecting multiple organ distinguishes SSc from other connective
tissue diseases.
īĩ Fibrosis characteristically follows, and is thought to be a consequence of,
autoimmunity and vascular damage.
īĩ The process, characterized by progressive replacement of normal tissue
architecture with dense connective tissue, accounts for substantial morbidity
and mortality
21. Diffuse cutaneous systemic sclerosis
It is characterized by
ī§ Proximal skin thickening however distal and proximal
extremity and often the trunk and and the face can be
affected
ī§ The skin changes and the disease course has tendency to
rapidly progress after Raynaudâs phenomenon
ī§ early appearance of visceral involvement
ī§ poor prognosis
22. Limited cutaneous systemic sclerosis
ī§ Symmetric restricted fibrosis - affecting the distal extremities and face/neck
ī§ Prolonged delay in appearance of distinctive internal manifestation
ī§ Prominence of calcinosis and telangiectasia
ī§ Good prognosis
ī§ CREST syndrome
27. Localised form
ī§ Morphea
ī§ Generalized / pansclerotic morphea
ī§ Linear scleroderma - En coup de saber
ī§ Progressive hemifacial atrophy
28. Morphea
ī§ A rare skin condition that causes reddish or purplish patches on the skin.
ī§ Tends to affect only the outermost layers of the skin â the dermis and the
fatty tissue just beneath the dermis.
ī§ Location
īē Abdomen, chest and back
īē Face, Arms and legs
29. Signs of morphea -
ī§ Hardening and thickening of the skin.
ī§ Discoloration of the affected skin to look
lighter or darker than the surrounding area.
ī§ Oval-shaped patches that may change colors
and gradually develop a whitish center.
ī§ Linear patches, especially when on arms
and legs
ī§ Loss of hair and sweat glands in the
affected area over time.
33. Clinical features
īą RAYNAUDâS PHENOMENON:
ī§ Episodic vasoconstriction in the fingers and toes.
ī§ Tip of the nose , earlobes can also be affected.
ī§ Triggers â exposure to cold,ī¯ temperature,stress,vibration.
ī§ ī frequency ,severity in winter.
ī§ Typical attack : PALLOR īŽ CYANOSIS īŽ ERYTHEMA.
ī§ Vasoconstriction īŽ ischemia īŽ reperfusion.
ī§ women > men
ī§ PRIMARY âexaggerated physiological response to cold.
ī§ SECONDARY --complication of SScâĻ
34. Cont
ī§ Primary â no underlying causes
ī§ Positive family h/o
ī§ Absence of digital necrosis
ī§ No ulceration , gangrene
ī§ Negative ANA test
ī§ Secondary ---- > 30 yrs
ī§ More severe
ī§ Assosciated with ischemia,infarction of digits.
ī§ NAIL FOLD MICROSCOPY â normal with regularly spaced vascular loops â
primary,distorted widened ,irregular loops,dilated lumen,vascular dropouts.
ī§ Raynaud like abn. Activity ---pulmonary,renal ,GIT,coronary
38. Skin features
ī§ Clinically evident skin thickening is the HALLMARK of SScâ
distinguishes it from others..
ī§ Symmetrical
ī§ In diffuse type â edema replaced by skin thickening..distal to proximal â
centripetal fashion.
ī§ Skin is firm ,coarse and thickened.
ī§ Darkly pigmented extremities and trunk.
ī§ Diffuse tanning in the absence of exposure to sun âvery early feature.
ī§ Vitiligo like hypopigmentation âin dark skinned individuals.
ī§ Pigment loss spares perifollicluar areas â salt and pepper appearance of
skin âscalp ,upperback ,chest.
ī§ Obliteration of appendages of hair.
ī§ Loss of transverse creases on dorsum of fingers
39. ī§ FACE â mauskopf appearance â
ī§ Skin is firmly bound to subcutaneous fat â
thinning and atrophy.
ī§ MACULAR telangiectasia âlocalised scleroderma
ī§ ATROPHY of skin â slow healing ulceration on
extensor surface of PIP joints.,volar pads.
ī§ DIGTIAL pits â healed ischemic ulcers.
ī§ Resorption of terminal phalanges â acro osteolysis.
ī§ Calcium deposits in skin ,soft tissue..
CREST syndrome â calcium hydroxyapatite crystals.
ī§ Finger pads,palms,extensor surfaces.
ī§ Firm ,non tender subcutaneous lumpsâ ulcerate through skin âchalky white
matter.
43. Musculoskeletal
ī§ Generalized arthralgia and morning
stiffness
ī§ Erosive arthropathy has been
demonstrated to occur in some series in
as many as 29 percent of patients.
ī§ An inexorable loss of hand function is
the rule as skin thickening worsens and
the underlying joints become tethered
and restricted in motion.
44. ī§ Insidious muscle weakness, both proximal and
distal, occurs in many patients with systemic
sclerosis secondary to disuse atrophy
ī§ Subcutaneous calcinosis occurs in around 40
percent of patients with long-standing limited
scleroderma and less frequently in diffuse
disease
46. Gastrointestinal
ī§ 90% Pts.
ī§ Asymptomatic /weight loss
ī§ Abn motility of intestines.
ī§ Prominent atrophy ,fibrosis of smooth muscle,intact mucosa,obliterative small
vessel vasculopathy â all over GIT .
ī§ Oropharyngeal â common
âĸ Xerostomia
âĸ ī¯Oral aperture
âĸ Periodontal disease
ī§ GERD â early
âĸ ī¯LES pressure
âĸ ī¯ clearance
âĸ Increased emptying time.
ī§ Gastroparesis â early satiety
47. Git
ī§ GASTRIC VASCULAR ECTASIAs â seen in the antrum.
âĸ Subepithelial lesions
âĸ Diffuse small vessel vsculopathy
âĸ Watermelon appearance
âĸ Recurrent GI bleed occult
ī§ Fat ,protein malabsorption,vitamin b12
ī§ Wide mouth sacculations in the colon occur âperforation.
ī§ Pneumatosis cystoides intestinalis
ī§ Primary biliary cirrhosis may coexist.
ī§ May present with recurrent acute abdominal pain.
48.
49.
50. Small bowel scleroderma
Location:
īĩ Most common duodenum.
Pathology:
Preferential atrophy of the inner circular smooth muscle layer
relative to the outer longitudinal layer
Contraction of the longitudinal layer result in foreshortening
of the bowel & packing of valvulae conniventes.
Motility disorder:
īĩ Decreased peristalsis (fluoroscopy).
īĩ Delayed small bowel transit time.
Radiological manifestations:
īĩ Hidebound sign (crowding of valvulae conniventes).
īĩ Small bowel dilatation (mega-duodenum or mega-
jejenum).
54. Pulmonary features
âĸ Leading cause of death.
âĸ ILD,PAH
âĸ Less frequently âaspiration pneumonitis , pulmonary hemorrhage ,
obliterative bronchiolitis , pleural involvement , restrictive ventilatory
defect due to chest wall fibrosis , spontaneous pneumothorax.
âĸ ī broncho alveolar carcinoma
âĸ Asymptomatic until advanced.
âĸ Most frequent symptoms of pulmonary inv. Are subtle .
īĩ Crackles at lung base.
âĸ PFT for detection -- ī¯FVC, ī¯ DLCO ,,,DLCO ī¯ī¯ī¯ FVC
55. Intestitial lung disease
ī§ 90% cases at autopsy, HRCT â85%cases.
ī§ 16-43% are affected.
ī§ NORMAL FLOW RATES.
ī§ At risk are male sex, African American,diffuse skin involvement,severe
GERD,topoisomerase I autoAb.
ī§ Rapid progression in first 3 yrs of onset âwhen FVC ī¯ 30% /year.
ī§ HRCT more sensitive,reticular linear opacities in lower lobes,mediastinal
lymphadenopathy,ground glass appearance.
ī§ Non specific interstitial pneumonitis âbetter prognosis.
ī§ KLâ 6 ,a glycoprotein in type II pneumocytes and alveloar macrophages â
earlier detection of ILD
56. Pulmonary Arterial Hypertension
ī§ Mean Pulmonary arterial pressure > 25 mm Hg at rest.
ī§ 12-25% have PAH
ī§ In assosciation with ILD/solitary.
ī§ Usually downhill course âRHF âdeath.
ī§ At risk are â Ls SSc with anticentromere antibodies,late age of onset,severe raynauds,U1 â
RNP,U3 RNP fibrillarin,B23 Ab.
ī§ Asymptomatic,exertional dyspnea.
ī§ PASP >40 mm Hg at rest in 2d echo.
ī§ Decreased DLCO
ī§ Right heart catheterisation can accurately detect the presence of PAH
ī§ Increased BNP, N-t BNP levels
ī§ Prognosis is determined by the degree of pulmonary artery pressure elevation.
57. Renal features
ī§ HTN,chronic non progressive proteinuria.
ī§ SCLERODERMA renal CRISIS âdreadful complication of SSc.
ī§ 20-25% pts
ī§ < 4 yrs of onset of diseases
ī§ Survival <10 % until ACEI
ī§ It is due to OBLITERATIVE VASCULOPATHY of renal cortical arteries.
ī§ ī¯RBF īŽ JGA hyperplasia īŽ renin secretion īŽ RAAS īŽ renal
vasoconstriction īŽmalignant HTN.
ī§ ī¯RBF īŦ vasospasm,dehyration,hypotension.
ī§ At risk -- african american,male,diffuse skin involvement,ab to RNA
polymerase III
ī§ Impending renal crises â palpable tendon friction rubs,pericardial effusion,new
unexplained anemia,thrombocytopenia.
58. Renal
ī§ Presentation âabrupt onset of malignant HTN,severe headache,blurred
vision,chest pain.
ī§ 10% normal BP â normotensive renal crises.
ī§ Urinalysis -- proteinuria,microscopic hematuria,fragmented RBCs
ī§ Rapidly progressive oliguric renal failure follows.
ī§ Creatnine > 3 mg/dl at presentation âpoor prognosis.âpermanent hemodialysis
âhigh mortality,
ī§ Prompt use of ACEI to make BP under control before renal failure occurs â
imporved prognosis.
59. Cardiac
ī§ Myocardial ,pericardial ,conduction abnormalities, seen in 10%
ī§ Can occur secondary to renal ,pulmonary involvement.
ī§ LVDD is frequent.
ī§ LVDD âdue to HTN ,myocardial fibrosis.
ī§ Asymptomatic until HF ,arryhthmias occurs.
ī§ Myocarditis in assosciation with inflammatroy polymyositis.
ī§ Conduction defects due to fibrosis of conduction system.
ī§ Pericardial effusion âsymptomsâ rarely tamponade.
60.
61. Other disease manifestations
ī§ Dry eyes,dry mouth âSICCA complex.
ī§ Biopsy of the minor salivary glands âfibrosis rather than lymphocytic
infitration.(sjogrenâs syndrome)
ī§ Hypothyroidism âfibrosis of gland.
ī§ CNS is generally spared . Sensory trigeminal neuropathy due to
fibrosis /vasculopathy can occur.
ī§ Pregnancy -adverse outcomes
ī§ Cardiopulmonary complications, new onset renal crises can occur.
ī§ Erectile dysfunction in the male.
63. Differential diagnosis
īą Based on vascular changes:
ī§ PRIMARY raynaudâs phenomenon
ī§ physical trauma âjack hammer
ī§ chemical exposure
ī§ drugs toxins â toxic oil syndrome,ergotamine,Bblockers ,carbidopa,5HT .
ī§ SLE,DM/PM,RA.,cryoglobulinemia.
īą Based on skin changes
ī§ localized scleroderma
ī§ scleroderma like skin changes
ī§ metabolic âgenetic disorders âscleredema/scleromyxedema
īą Based on visceral involvement
ī§ idiopathic pulmonary HTN
ī§ idiopathic pulmonary fibrosis
ī§ sarcoidosis
ī§ amyloidosis
64. Laboratory features
ī§ Anemia â frequent
ī§ Most common is mild normocytic /microcytic anemia âchronic inflammation
ī§ Serum iron is low or normal,ferritin is elevated.
ī§ Iron deficiency anemia âoccult GI bleed (WATERMELON STOMACH),chronic esophagitis.
ī§ Macrocytic anemia â vitmainb12,folate,bacterial overgrowth,drugs
ī§ Acute microangiopathic anemia âmechanical traumaârenal crises
ī§ Thrombocytopenia ,leukopenia âDRUG toxicity.
ī§ ESR is normal
ī§ Increased ESR âMYOSITIS ./MALIGNANCY
ī§ E/U/R, urinalysis
65. others
ī§ Cxray â insensitive for detection of early ILD
ī§ HRCT of the chest â
ī§ more sensitive
ī§ Reticular linear opacities predominantly in the lower lobes
ī§ Mediastinal lymphadenopathy
ī§ Ground glass opacification
ī§ Lung Function Test,
ī§ BAL , LUNG BIOPSY.
66. ANTINUCLEAR ANTIBODIES
ī§ All patients of SSc
ī§ Highly specific are anti topoisomerase âI (Scl 70) and anti centromere
Ab
ī§ Specific ab profile remains stable over time.
ī§ Topoisomerase I ab 31% of dcSSc ,13% of lcSSc
ī§ Anticentromere ab in 38% of lcSSc,2% of dcSSc.
ī§ No direct pathogenic role has been established for SSc associated
autoantibodies..
ī§ Antibody titers correlate with disease severity .
67. Diagnosis
ī§ Diagnosis on clinical grounds.
ī§ Presence of skin induration with a characteristic symmetrical distibution
pattern,typical visceral organ manifestation-establishes the diagnosis with high
certainity.
ī§ Full thickness biopsy â required for diagnosis of
scleredema,scleromyoxedema,nephrogenic systemic fibrosis.
ī§ lcSSCâ CREST for diagnosis
ī§ Nail fold microscopy for differentiation from primary raynaudâs
ī§ Diffuse edema of fingers..
ī§ SSc sine sclerodermaâ anticentromere ab
68. Diagnostic criteria
ī§ The AMERICAN COLLEGE OF RHEUMATOLOGY (ACR) criteria for
the classification of systemic sclerosis.
ī§ One major criteria, two or more minor criteria for diagnosis.
ī§ MAJOR criterion : PROXIMAL scleroderma âcharacterized by
SYMMETRICAL thickening,tightening and induration of the skin of
the fingers and the skin proximal to the MCP /MTP joints. these
changes may affect the entire extremity,face,neck,trunk.
ī§ MINOR
ī§ 1.SCLERODACTYLY â thickening,induration,tightening of the skin
limited only to fingers.
ī§ 2.DIGITAL PITTING SCARS/LOSS OF SUBSTANCE FROM THE FINGER
PAD .
ī§ 3.BIBASILAR PULMONARY FIBROSIS- reticular pattern of linear or
lineonodular densities in basilar portions of the lung on CXR.diffuse
mottling/honey comb lung not attributable to primary pulmonary
disease
69. Treatment
ī§ No therapy has been shown significantly to alter the natural h/o SSc till date.
ī§ Multiple interventions are avialable in alleviating the symptoms âslowing
progression of organ damage.
ī§ Treatment approaches to be individually tailored.
ī§ Optimal management â prompt, accurate diagnosis,classification, risk stratify,
early recogtion of organ based complications,regular monitoring of progression,
disease activity,response to treatment, and patient education.
ī§ Holistic approach is needed.
ī§ Combination of drugs are used.
70. Disease modifying treatments
ī§ Immunosuppressive agents âmodest or no benefit in Rx of SSc.
ī§ Glucocorticoids - ī¯ stiffness and aching in pts with early stage disease.
ī§ Do not influence the progression of skin/internal organ involvement.
ī§ ârisk of scleroderma renal crises at high doses.
ī§ Avoid if possible.
ī§ Low dose ,brief periods.
ī§ Cyclophosphamide âdaily oral/IV in SSc related ILD.
ī§ Reduces the progression of ILD ,stabilises,improvement in skin induration.
ī§ Early stage SSc/extensive pulmonary involvement âcandidate
ī§ Rx for 6- 12 months ,optimal duration not known.
ī§ Benefits īŧīž toxicities-bonemarrow suppression,opp infections,hemorhhagic
cystitis,bladder Ca.
71. Disease modifying treatments
ī§ Methotrexate â modest therapeutic benefit
ī§ Potential profibrotic effects --? Use in fibrotic phase
ī§ Mycophenolate mofetil â improvement in skin induration
ī§ Well tolerated
ī§ Immunomodulation â cyclosporine,azathioprine,extraxorporeal
photopheresis,thalidomide,rapamycin.
ī§ Immune ablation with high dose chemotherapy followed by autologous
peripheral stem cell reconstitution
ī§ Stem cell transplantation âexperimental.
72. Drugs that interfere with fibrotic
process
ī§ D penicillamine â antifibrotic agent
ī§ Immunosuppressive activity
ī§ Prevents cross linkage of collagen fibres.
ī§ Stabilises,improves skin induration
ī§ Prevents new organ involvement
ī§ Improved survival
ī§ No effect in early active SSc
ī§ 750 mg/d or 125mg every other day
ī§ Minocycline
ī§ Recombinant relaxin
ī§ IFN ī§
73. Vascular therapy
ī§ Dress warmly
ī§ Minimize cold exposure.,Avoid drugs
ī§ Biofeedback therapy.
ī§ CCBs âdiltiazem,nifedipine âADVERSE effects
ī§ ACEI ânot effective
ī§ ARBs âlosartan well tolerated.
ī§ īĄ1 blocker âprazosin
ī§ Sildenafil ,Fluoxetine ,Topical NTG, IV PROSTAGLANDINS.
ī§ Empiric treatment with statins,antioxidants
ī§ Low dose asprin,dipyridamole âuseful
ī§ Digital sympathetectomy in severe cases
ī§ Bosentan prevents new ulcers
74. Rx of GI complications
ī§ Elevate head end of the bed.
ī§ Eat frequent small meals
ī§ PPIs ,H2B at higher doses are effective.
ī§ Laser photocoagulation ârecurrent bleeding from watermelon
stomach
ī§ Metronidazole,erythromycin,tetracycline âbacterial overgrowth.
ī§ Parenteral nutrition in case of severe disease.
ī§ Hypomotility of the gut âoctreotide.
76. Rx of Renal Crises
ī§ Medical emergency
ī§ Outcome determined by amount of renal damage
ī§ Avoid NSAIDs,glucocorticoids
ī§ Rx âACEI ,short term dialysis.
ī§ Kidney transplantation.
77. Skin care
ī§ 5 mg prednisone
ī§ D penicillamine
ī§ Cyclophosphamide
ī§ Regular skin massage
ī§ Telangiectasia âlaser pulse dyed laser
ī§ Finger tip ulcerations âocclusive dressings
ī§ Infected ulcers âtopical Abs
ī§ Surgical debridement
ī§ No therapy effectvie in preventing the formation of calcific deposits.
78. Prognosis
ī§ Quite variable and difficult to predict
ī§ Cumulative survival
diffuse limited
5 yr 70% 90%
10 yr 50% 70%
ī§ Major cause of death
ī§ renal involvement
ī§ cardiac involvement
ī§ pulmonary involvement
79. Poor prognosis
ī§ Male gender
ī§ young age of onset
ī§ African american race
ī§ Extensive skin thickening
ī§ Truncal involvement
ī§ Visceral organ involvement
ī§ Topoisomerase I ab
ī§ Increased ESR ,anemia ,proteinuria on initial presentation âhigh mortalityâĻ
80.
81. ī§ The message I keep giving to people is that scleroderma is not a death
sentence. It is a terrible disease but you can live a productive and happy life
with the disease
īĩ Jason Alexander.
83. references
īĩ HARRISONS CLINICAL MEDICINE 18TH EDITION vol 2 pg 2752-2769
īĩ KUMAR AND CLARK 8TH EDITION pg 538-540
īĩ Tager RE, Tikly M. Rheumatology (Oxford); 38(5) . 397-400
īĩ Jacyk W K. J. Trop Med. Aug. 1979:82(2):42-44
īĩ Ladipo O. O. Dermatologica. 1976;153(3):196-201
īĩ Adelowo O. O, Oguntona S. Scleroderma(systemic sclerosis) among Nigerians.
Clin. Rheumatol. 2009;28:1121-1125