8. Generations Drugs Spectrum 1 st (Quinolone) Nalidixic acid Cinoxacin Gram-ve but not Pseudomonas species 2nd Norfloxacin Ciprofloxacin Enoxacin Ofloxacin Gram- ve(including Pseudomonas species), some Gram+ (S. aureus) and some atypicals 3rd Levofloxacin Sparfloxacin Moxifloxacin Gemifloxacin Same as 2 nd generation with extended Gram+ve and atypical coverage 4th *Trovafloxacin Same as 3 rd generation with broad anaerobic coverage
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11. Drug interactions Drugs increasing levels of FQL FQL increasing the levels of : Theophyline Antidepressants NSAIDS Imipramine corticosteroids Caffene Theophyline Warfarin (INR –monitored)
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