6. After 2 weeks of Digestion the
Mosquito Finds a New Host
7.
8. Eliminating Malaria Will Be More
Significant Than the Moon Landing
• Eliminating malaria will cost
more, take longer, and be more
challenging than landing on the
moon
• It will have a greater global
impact
9. In Science, the Key to Solving
Big Problems is Team Work
• Solving malaria requires multidisciplinary
teams focused on
– Prevention
– Detection
– Treatment
• Teams include
– Biologists, Chemists, Engineers, Physicists, Medical
Personnel, NGOs, and Funding
10. Center
for
Global
Health &
Diseases
International
Center of
Excellence for
Malaria
Research
12. Prevention: Idea and A Solution
• Project: Wide Distribution of Bednets
• Team: CWRU Center for Global Health & Diseases,
UNF, NBN
13. Prevention: Another Idea
• Project:
– Develop, perform, and test virtual (in silico)
screening for malaria vaccine candidates
• Team:
– CWRU Center for Global Health & Diseases
– CWRU Department of Biochemistry
– CWRU HPCC
– NIH (AI079388)
14. Prevention:
Solution
• Search millions of
compounds rapidly
to identify potential
malaria vaccines
using computers
17. Detection: Idea
• Project:
– Exploit physical properties of malaria to
develop cost-effective, field-ready device
for rapid detection
• Team:
– CWRU Center for Global Health & Diseases
– CWRU Physics
– CWRU Biomedical Engineering
– Wallace H. Coulter Foundation
– Clinical Translational Science Collaborative
(UL1RR024989)
19. Detection: A Solution
Sample
Polarizer
Detector
Laser
View of Hemozoin
Hemozoin
Randomly Oriented
Hemozoin
Magnet
20. Detection: A Solution
Sample
Polarizer
Detector
Laser
View of Hemozoin Magnet (0.5 Tesla)
Hemozoin
Aligned Hemozoin Reduces Amount of Polarized
Light Through a Sample
21. Treatment: The Problem
• Malaria parasites show resistance to all classes
of existing drugs
Getty Images
thelancet.com/malaria-elimination
23. Treatment: Idea
• Project:
– Screen drugs FDA-approved for other indications for anti-
malarial activity
– Screen natural treatments for anti-malarial activity
• Team:
– CWRU Center for Global Health & Diseases
– Curragh Chemistries (Cleveland, OH)
– University of Utah
– Medicines for Malaria Venture
– CWRU School of Medicine
Vision Fund
24. Treatment: A Solution
SU 11274 2
• Originally developed as a drug for leukemia
• Acts as an ATP competitive inhibitor of the catalytic activity of MET
3F C
H
N
H
N
N
(similar to Gleevec®)
• In vitro and In vivo studies confirm anti-malarial activity
Cl O
O
• Provisional patent filed 1
Cl O
N
H
O
N
NH
O 2S N
H
O
N
H
2
CN CN
BT Grimberg, et al, 2009
25. Treatment: A Solution
Fascaplysinopsis reticulata
Bromohomofascaplysin A Homofascaplysin A Fascaplysin
Lu, et al. 2011
26. Malaria is a
Disease of
Poverty
• Prevention
• Detection
• Treatment
29. You Can Be Part of Our Team!
• Learn More About
CWRU Center for Global
Health & Diseases
– case.edu/orgs/cghd
• Write to Congress
– President’s Malaria Initiative
– Global Fund
• Learn More about Bednets
– Nothingbutnets.net
How many of you have been to a malaria region.Ask a question
TALK ABOUT GLOBAL WARMINGwhelming majority of these under the age of 5Malaria is a disease of poverty 600,000,000.clinical casesExplain Heat map
Mostly children500 Million estimated cases1.2 Million Report Deaths per yearMany more unreported deathsThe overwhelming majority of these under the age of 5
19th CenturyUniversity Circle was known during the early 19th Century as Doan’s Corners, after Nathanial Doan, a member of the Connecticut Land Company, who settled his family and started a community here.The name "University Circle" began to take shape in the 1880s. Western Reserve University moved its campus from Hudson, Ohio, to Euclid Avenue in 1883. Case School of Applied Science moved from Downtown Cleveland to a site next to WRU in 1885. Their relocation led to the birth of an educational center and the creation of a new community called University Circle, named in part after these new institutions - but also the circular street intersection and trolley turnaround located Euclid Avenue and Doan Brook Boulevard (Martin Luther King Jr Boulevard today).[20]By the 1890s, the Western Reserve School of Design for Women (Cleveland Institute of Art) moved to University Circle, and the concept of developing a world-class arts and cultural center came to life. The concept became more concrete when Jeptha Wade, a trustee of Western Reserve University, set aside land for the Cleveland Museum of Art to be built in the Circle. The Historical Society (Western Reserve Historical Society) joined these institutions before the turn of the 19th to 20th century. [21][edit] 20th CenturyThe Circle began to grow rapidly in the early 20th century. The Cleveland Museum of Art opened its doors in 1916. By the 1920s and 1930s, nineteen educational and cultural institutions were located in the area, from the Cleveland Museum of Natural History to the Cleveland Hearing and Speech Center to the Cleveland Botanical Garden and others.The arrival of University Hospitals in 1931 (founded in 1866) led to health care becoming another center of innovation in University Circle. Less than one mile away from University Hospitals, the Cleveland Clinic had been serving its patients since 1921. Also in 1931 Severance Hall, home of the Cleveland Orchestra, was constructed at the corner of Euclid and East Blvd.[21] By 1950, 34 institutions had chosen University Circle as their home.[20] In 1967, Case School of Applied Science and Western Reserve University confederated to become Case Western Reserve University.[22][edit] 21st CenturyThe history of University Hospitals Case Medical Center is linked to the history of Cleveland. Founded in 1866, we were nurtured and supported by Cleveland's great industrial families of the late 19th and early 20th centuries – the same families that played key roles in the development of the city's noted civic and cultural institutions, including the Cleveland Museum of Art,
>1,000 bites per night, Moses 1996
Maybe add the amount of funding 109 Billion
Label buildings
2 minutes and the machine cost $200
For leukemia and GI tumors
Say out loud
workforce sick all the time taking days off to take sick children to the clinics for treatmentworkforce sick all the time taking days off to take sick children to the clinics for treatmentworkforce sick all the time taking days off to take sick children to the clinics for treatmentAnd many other diseases too